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- || Review, Journal: Spontaneous and induced degradation of dermal fillers: A review. (Pubmed Central) - Dec 9, 2024
Semipermanent fillers are poly-(D), l-lactic acid and calcium hydroxylapatite...Intralesional laser treatment supports the removal of permanent filler material as an alternative to surgery. Besides biocompatibility and toxicity, filler materials should also be assessed for degradation to improve patient safety.
- | Journal: Diamond Technique: A Triple Treatment for Neck and D (Pubmed Central) - Dec 5, 2024
While the authors assert the technique's safety and efficacy, the need for controlled studies is crucial. Rigorous, long-term studies are warranted to validate its effectiveness and safety compared with the existing approaches.
- | Journal: Treatment of Mid-Face Aging with Calcium Hydroxylapatite: Focus on Retaining Ligament Support. (Pubmed Central) - Nov 18, 2024
While injectable hyaluronic acid implants have been used to improve ligament support, calcium hydroxylapatite has one of the highest viscoelasticities when compared with other dermal fillers and can induce collagen synthesis, which could provide long-term laxity correction. In this preliminary report of a case series, our goal was to describe the use of calcium hydroxylapatite in different dilutions and combinations for different aging profiles to treat the midface as an alternative for hyaluronic acid injections and to describe the ultrasonographic behavior in the long run.
- | Journal, Head-to-Head: Microfocused Ultrasound With Visualization (MFU-V) and Hyperdilute Calcium Hydroxylapatite (CaHA-CMC) of the Lower Face and Submentum to Treat Skin Laxity: A Pilot Study Demonstrating Superiority of MFU-V First Followed by Hyperdilute CaHA-CMC. (Pubmed Central) - Nov 15, 2024
Administering MFU-V first, followed by hyperdilute CaHA-CMC six weeks later, is the optimal sequence for this combination therapy. Although both groups experienced increased elastin synthesis and aesthetic improvements, the order of treatments significantly impacted the outcomes, favoring the sequence used in Group A. This finding provides valuable insight for optimizing combination therapies in aesthetic dermatology.
- | Journal: Consensus Agreements on Regenerative Aesthetics: A Focus on Regenerative Biostimulation With Calcium Hydroxylapatite. (Pubmed Central) - Oct 31, 2024
Rather, the relative amounts, ratios, types, and organization are important to determine regenerative potential. Calcium hydroxylapatite is an example of an aesthetic injectable with evidence of regenerative capacity, as demonstrated by its ability to improve collagen type I/III ratios as well as induce the production of elastin and proteoglycans, which ultimately improve measures of skin quality.
- || Clinical, Journal: Comparative Bulk RNA-Seq Analysis of Poly-l-Lactic Acid Versus Calcium Hydroxylapatite Reveals a Novel, Adipocyte-Mediated Regenerative Mechanism of Action Unique to PLLA. (Pubmed Central) - Oct 31, 2024
Calcium hydroxylapatite is an example of an aesthetic injectable with evidence of regenerative capacity, as demonstrated by its ability to improve collagen type I/III ratios as well as induce the production of elastin and proteoglycans, which ultimately improve measures of skin quality. PLLA-SCA has a novel and unique signature, which supports a potential regenerative mechanism of action through its role in the modulation of adipocyte function.
- | Retrospective data, Journal: Optimized Calcium Hydroxylapatite Formulation and Its Injection Technique for Hand Rejuvenation: A Retrospective Study. (Pubmed Central) - Oct 25, 2024
PLLA-SCA has a novel and unique signature, which supports a potential regenerative mechanism of action through its role in the modulation of adipocyte function. Radiesse
- | Journal: An Innovative Treatment Using Calcium Hydroxyapatite for Non-Surgical Facial Rejuvenation: The Vectorial-Lift Technique. (Pubmed Central) - Oct 23, 2024
This approach targets a global repositioning of the facial structures by addressing distinct anatomical injection planes. It achieves a repositioning of the overall facial anatomy without requiring a substantial volumetric expansion.
- | Journal: Calcium Hydroxyapatite as a Co-adjuvant Treatment Option in a Patient With Morphea: A Report of a Case With a One-Year Follow-Up. (Pubmed Central) - Oct 21, 2024
Then, after reviewing the literature and consensus from the dermatologist, aesthetics physician, and alternative medicine expert, it was decided to use calcium hydroxylapatite-carboxymethylcellulose (Radiesse, Merz Pharmaceuticals GmbH, Frankfurt, Germany) in the affected area...Our initial approach demonstrates significant promise for regenerative biostimulation. Through collaboration, we have effectively integrated plastic surgery techniques, fillers, dermatologists, and alternative medicine perspectives to treat inflammatory diseases, providing a comprehensive and robust exploration of morphea treatment.
- || Review, Journal: Manufacturing Process of Hyaluronic Acid Dermal Fillers. (Pubmed Central) - Oct 16, 2024
Additionally, the review offers a comprehensive comparison of HA fillers with non-HA alternatives, including calcium hydroxylapatite, poly-l-lactic acid, and polymethyl methacrylate, highlighting the unique advantages and potential complications associated with each type. By presenting novel insights into the latest advancements and challenges in filler technology, this review aims to provide clinicians with a deeper understanding of filler properties, thereby guiding them in making informed decisions to optimize patient safety and aesthetic results.
- | Journal: Calcium Hydroxylapatite in Regenerative Aesthetics: Mechanistic Insights and Mode of Action. (Pubmed Central) - Oct 4, 2024
The key role of calcium ions as critical biocues in directing skin regeneration pathways is explored alongside an examination of the distinct physicochemical properties of CaHA-CMC. CaHA-CMC helps in tissue regeneration by providing calcium ions that act as key biological cues, promoting fibroblast activity and collagen production.
- | Journal: Pilot Study: Single-depth Superficial Ultrasound with Subdermal Injections of Diluted Calcium Hydroxylapatite for Improving Lower Face Skin Quality. (Pubmed Central) - Oct 4, 2024
No unexpected adverse events were reported. Combination treatment with single-depth superficial MFU-V and diluted CaHA in a single session significantly improved lower facial skin quality, as assessed by both objective and subjective outcome measures.
- | Retrospective data, Journal: HArmonyCa (Pubmed Central) - Oct 3, 2024
Combination treatment with single-depth superficial MFU-V and diluted CaHA in a single session significantly improved lower facial skin quality, as assessed by both objective and subjective outcome measures. This study shows that one treatment with HArmonyCa
- || Clinical, Journal, Head-to-Head: A Multicenter, Randomized, Double-Blind, Parallel-Grouped, Positive-Controlled, Non-Inferiority Clinical Study to Evaluate the Efficacy and Safety of Injectable Calcium Hydroxylapatite Microsphere Hydrogel Fillers in the Correction of Nasolabial Fold in Chinese Subjects. (Pubmed Central) - Sep 27, 2024
This study shows that one treatment with HArmonyCa This study confirms that Aphranel is an effective and safe treatment for correcting NLFs in Chinese subjects.
- | Journal: Long-term duration and safety of Radiesse (+) for the treatment of jawline. (Pubmed Central) - Sep 26, 2024
P=N/A
This study confirms that Aphranel is an effective and safe treatment for correcting NLFs in Chinese subjects. CaHA-CMC(+) produced clinically meaningful and long-lasting improvements in jawline contour and was well tolerated in patients through 60?weeks.
- | Journal: Intradermal Delivery of Calcium Hydroxylapatite With Fractionated Ablation. (Pubmed Central) - Aug 20, 2024
The noninvasive imaging techniques RCM and MPM successfully captured the presence of CaHA microspheres mid-dermis during the healing phase. They also demonstrated new collagen production around the microspheres, highlighting the effectiveness of these imaging approaches in monitoring such treatment over time.
- | Journal: Comparative Rheology of Hyaluronic Acid Fillers, Poly-l-lactic Acid, and Varying Dilutions of Calcium Hydroxylapatite. (Pubmed Central) - Aug 16, 2024
The versatility of CaHA-CMC through dilution may offer a customizable approach for clinical applications, providing practitioners with the ability to fine-tune the properties of fillers to meet specific patient needs and treatment goals. This study lays the groundwork for the potential future use of filler dilutional rheomodulation in clinical practice, tailored to patient- and application-specific needs.
- | Journal: Hyperdiluting Calcium Hydroxylapatite With Platelet-Rich Plasma and Hyaluronidase for Improving Neck Laxity and Wrinkle Severity. (Pubmed Central) - Aug 6, 2024
This study lays the groundwork for the potential future use of filler dilutional rheomodulation in clinical practice, tailored to patient- and application-specific needs. This is
- Inflammatory Filler Complications Revisited: Controversies, Literature Review, and Case Presentations (G104-G105) - Jul 18, 2024 - Abstract #EADV2024EADV_1447;
We advocate for the establishment of detailed guidelines that incorporate robust diagnostic and management strategies to improve patient safety and outcomes. Emphasizing the necessity to address both vascular and inflammatory complications offers a more holistic approach to patient safety with dermal fillers.
- | Journal: Improved brachial skin hydration and appearance with hyperdiluted calcium hydroxylapatite. (Pubmed Central) - Jul 18, 2024
This study demonstrates the efficacy of CaHA in improving hydration of brachial skin after a single treatment. Despite the limitations of the sample size, the research contributes to the medical literature, highlighting the utility of the 3
- | Journal: Dual Functionalization of Hyaluronan Dermal Fillers with Vitamin B3: Efficient Combination of Bio-Stimulation Properties with Hydrogel System Resilience Enhancement. (Pubmed Central) - Jun 26, 2024
Polyvalent ingredients such as calcium hydroxylapatite (CaHA) or vitamin B3 (niacinamide) are notably used as bio-stimulants to improve skin quality attributes at the administration site...Original results of high translational relevance were generated herein using robust and orthogonal experimental methodologies (hydrogel degradation, functional benchmarking) and study designs. Overall, the reported results confirmed the dual functionalization role of vitamin B3 in cross-linked HA dermal fillers, with a significant enhancement of hydrogel system stability attributes and the deployment of potent bio-stimulatory capacities.
- | Journal: Dilutional rheology of Radiesse: Implications for regeneration and vascular safety. (Pubmed Central) - May 18, 2024
In conclusion, this study highlights the significant impact of aqueous dilution on the rheological properties of CaHA-CMC and its carrier gel. The findings support the clinical application of tailored dilutions to achieve desired outcomes, providing versatility and safety for aesthetic applications.
- || Review, Journal: The emerging role of biostimulators as an adjunct in facial rejuvenation: A systematic review. (Pubmed Central) - May 16, 2024
There is limited, quantifiable data, which fully illustrate the effect in these products. Although these agents are known to illicit inflammatory changes, more controlled studies are needed to better elucidate the biostimulatory capacity of such non-surgical treatments.
- || Review, Journal: Fillers impacting follicles: the emerging complication of filler-induced alopecia. (Pubmed Central) - Apr 14, 2024
Our study promotes awareness of filler-induced alopecia's rising incidence and offers practical insights and evidence-based recommendations for effective management. By equipping dermatologists with this knowledge, our aim is to improve patient outcomes and reduce adverse events in filler-based procedures.
- || Clinical, Review, Journal: Calcium Hydroxylapatite (CaHA) and Aesthetic Outcomes: A Systematic Review of Controlled Clinical Trials. (Pubmed Central) - Mar 28, 2024
Current evidence suggests that CaHA injections improve aesthetic results, including facial areas, such as nasolabial folds and jawline, and hands, with high levels of satisfaction. Considering the methodological limitations and heterogeneous comparisons groups, additional controlled clinical trials would contribute to a better understanding of the applications and advantages offered by CaHA.
- ||| Trial completion, Trial completion date, Trial primary completion date, Biopsy: Sculptra: Gene Expression Study Between Two Dermal Injectables Hydroxylapatite Semi-permanent Filler (clinicaltrials.gov) - Mar 22, 2024
P=N/A, N=21, Completed, Sponsor: Galderma R&D
Considering the methodological limitations and heterogeneous comparisons groups, additional controlled clinical trials would contribute to a better understanding of the applications and advantages offered by CaHA. Active, not recruiting --> Completed | Trial completion date: Apr 2023 --> Nov 2023 | Trial primary completion date: Feb 2023 --> Jul 2023
- | Journal, Combination therapy: Evaluating the Use of IncobotulinumtoxinA in Combination with Calcium Hydroxylapatite with Integral Lidocaine for Improving Chin Profile Projection Aesthetics. (Pubmed Central) - Mar 6, 2024
Based on our results, combined treatment with CaHA and Inco appears to be effective and well tolerated for improving the facial profile of subjects with chin retrusion. Treatment was associated with a high degree of patient satisfaction and was well tolerated.
- || Review, Journal: A systematic review of Radiesse (Pubmed Central) - Feb 23, 2024
The application of hyperdilutions on the neck, feet, arms, thighs, abdomen, and other body parts has been proven to provide a skin-tightening effect. However, despite their wide use with a good safety profile in clinical practice, recent trends and guidelines of diluted and hyperdiluted CaHA/CMC have yet to be supported by randomized controlled trials.
- A randomized, comparative study describing the gene signatures of Poly-L-Lactic Acid (PLLA-SCA) and Calcium Hydroxylapaptite (CaHA)?in the treatment of nasolabial folds () - Feb 20, 2024 - Abstract #AAD2024AAD_3276;
This study suggests that PLLA-SCA and CaHA have differentially expressed gene signatures and unique mechanisms of action. PLLA-SCA upregulated more genes relating to regeneration and morphogenesis, whereas CaHA was more inflammatory and pro-inflammatory.
- | Journal: A Structured Approach for Treating Calcium Hydroxylapatite Focal Accumulations. (Pubmed Central) - Feb 17, 2024
PLLA-SCA upregulated more genes relating to regeneration and morphogenesis, whereas CaHA was more inflammatory and pro-inflammatory. The article offers a structured approach to manage CaHA focal accumulations.
- | Trial completion: Combined Focused Ultrasound and Calcium Hydroxylapatitie Filler for Skin Laxity and Volume Restoration (clinicaltrials.gov) - Feb 2, 2024
P1, N=20, Completed, Sponsor: University of California, Irvine
The article offers a structured approach to manage CaHA focal accumulations. Active, not recruiting --> Completed
- ||| Trial completion: Investigation of the Effectiveness and Safety of MRZF111 in the Treatment of D (clinicaltrials.gov) - Dec 25, 2023
P=N/A, N=117, Completed, Sponsor: Merz Aesthetics GmbH
Active, not recruiting --> Completed Withheld --> Completed
- || Review, Journal: Comparative Clinical and Histomorphologic Evaluation of the Effectiveness of Combined Use of Calcium Hydroxyapatite and Hyaluronic Acid Fillers for Aesthetic Indications. (Pubmed Central) - Nov 27, 2023
Hyaluronic acid and calcium hydroxylapatite (CaHA) have been used for in the field of soft tissue augmentation...Sequential injections of Belotero Volume (CPM-HA V) and CaHA had a relatively greater remodeling effect on one's skin compared with the simultaneous injections of CPM-HA V and CaHA. Simultaneous injection of the studied products is possible from the point of view of safety, but different levels of administration will be more optimal, which will provide a more pronounced remodeling effect on the skin.
- || Review, Journal: Cellulite: An Update on Pathogenesis and Management. (Pubmed Central) - Nov 22, 2023
In this review, the authors summarize the proposed etiologic factors, grading scales, and treatment options. Further well-designed studies are essential to improve our knowledge of the condition and lead to improved treatment strategies.
- ||| Trial completion: Evaluation of the Effectiveness and Safety of Diluted RADIESSE (clinicaltrials.gov) - Nov 18, 2023
P=N/A, N=152, Completed, Sponsor: Merz North America, Inc.
Further well-designed studies are essential to improve our knowledge of the condition and lead to improved treatment strategies. Active, not recruiting --> Completed
- | Journal: Fillers Around the Nose. (Pubmed Central) - Nov 9, 2023
Active, not recruiting --> Completed It is absolutely essential to choose carefully appropriate material and procedure for patients to obtain optimum results.
- || Review, Journal: A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for treatment of the face. (Pubmed Central) - Oct 28, 2023
Treatment of marionette lines, chin, pre-jowl, and corner of the mouth also tends to respond with a high degree of efficacy. Despite the recent trend, guidelines, and safety profile of diluted and hyperdiluted Radiesse , no randomized controlled trials have been published.
- | Journal: RELAX and FIRMNESS: The Combination of Muscle Relaxation with Botulinum Toxin and Collagen Biostimulation with Calcium Hydroxyapatite for the Treatment of the Cervical Region. (Pubmed Central) - Oct 12, 2023
There are several therapeutic modalities for neck rejuvenation, especially calcium hydroxylapatite...Minimization of punctures, patient comfort, and technique based on the anatomy of the platysma muscle underlie the technique. High rates of early satisfaction due to botulinum toxin (Relaxation) and late satisfaction due to CaHA (Firmness).
- || Review, Journal: The Role of Calcium Hydroxylapatite (Radiesse) as a Regenerative Aesthetic Treatment: A Narrative Review. (Pubmed Central) - Sep 18, 2023
When injected, Radiesse acts as a cell scaffold and clinically manifests as immediate restoration of depleted volume, improvements in skin quality and appearance, and regeneration of endogenous extracellular matrices. This narrative review contextualizes Radiesse as a regenerative aesthetic treatment, summarizes its unique use cases, reviews its rheological, material, and regenerative properties, and hypothesizes future combination treatments in the age of regenerative aesthetics.
- | Journal: Optimizing Skin Regenerative Response to Calcium Hydroxylapatite Microspheres Via Poly-Micronutrient Priming. (Pubmed Central) - Sep 12, 2023
2023;22(9):925-934. doi:10.36849/JDD.7405.
- The Comparative Dermal Stimulation Potential of Constant-Volume and Constant-Amount Diluted Calcium Hydroxylapatite Injections versus the Concentrated Form (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2892;
doi:10.36849/JDD.7405. Despite the efficacy being more pronounced till 1:3 dilution, hyperdiluted CaHA at any dilution ratio up to 1:19 can provide a higher fibroblast count than the negative control group.
- A prospective Double blind placebo control study to assess Efficacy and Safety of calcium hydroxylapetite in combination with microfocused ultrasound for striae distensae alba (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2852;
Despite the efficacy being more pronounced till 1:3 dilution, hyperdiluted CaHA at any dilution ratio up to 1:19 can provide a higher fibroblast count than the negative control group. The heating of tissue causes collagen in these zones to become denatured and contract with subsequent de novo collagen synthesis and tissue remodeling Calcium hydroxylapatite is a type of dermal filler composed of white 25
- | Retrospective data, Journal: Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Report. (Pubmed Central) - Aug 25, 2023
The guided SEFFI technique is standardized and minimally invasive, leading to very few complications. It constitutes a promising antiaging medical treatment that combines effectiveness, safety, and simplicity.
- | Preclinical, Journal: Biostimulating fillers and induction of inflammatory pathways: A preclinical investigation of macrophage response to calcium hydroxylapatite and poly-L lactic acid. (Pubmed Central) - Aug 18, 2023
Together, these findings indicate that the CaHA mode of action is a non-inflammatory response while PLLA initiates expression of several cytokines known to play a role in inflammation. Our study supports the concept that these two "biostimulatory" fillers follow distinct pathways and should be considered individually with regard to mechanism of action.
- || Trial completion: Effects of Calcium Hydroxylapatite on Cellulite Dimples in the Buttocks (clinicaltrials.gov) - Jul 17, 2023
P1, N=25, Completed, Sponsor: Kalpna Kay Durairaj, MD, FACS
Our study supports the concept that these two "biostimulatory" fillers follow distinct pathways and should be considered individually with regard to mechanism of action. Active, not recruiting --> Completed
- | Journal: The Comparative Dermal Stimulation Potential of Constant-Volume and Constant-Amount Diluted Calcium Hydroxylapatite Injections Versus the Concentrated Form. (Pubmed Central) - Jul 3, 2023
Active, not recruiting --> Completed Despite the efficacy being more pronounced till 1:3 dilution, hyperdiluted CaHA at any dilution ratio up to 1:19 can provide a higher fibroblast count than the negative control group.
- Facial Asymmetry: To Tweak Or Leave Alone? (Combining Minimally Invasive Techniques For Long-Term Results) () - Jul 3, 2023 - Abstract #WCD2023WCD_4708;
Calcium Hydroxylapatite and Hyaluronic Acid dermal fillers - to address bone resorption, lipoatrophy, and improve skin turgor... For patients whose facial asymmetry is very prominent, an appropriate combination of treatments with proper techniques helped achieve natural-looking results with high patient satisfaction.
- A new device containing calcium hydroxylapatite (CaHa) and hyaluronic acid (HA) to restore connective tissue: a Real Life Retrospective Study () - Jul 3, 2023 - Abstract #WCD2023WCD_3803;
For patients whose facial asymmetry is very prominent, an appropriate combination of treatments with proper techniques helped achieve natural-looking results with high patient satisfaction. The results of this study support the restoring and lifting potential of the hybrid CaHA for restoring connective tissue
- | Journal: Laser-Assisted and Device-Assisted Filler Delivery: A Histologic Evaluation. (Pubmed Central) - Jun 30, 2023
Among the devices and fillers studied, fractional CO2 laser and PLLA proved to be the most effective combination for laser/device-assisted filler delivery. Neither microneedling nor FRMN was effective as devices to enhance filler delivery.
- || Review, Journal: Using injectable fillers for chin and jawline rejuvenation. (Pubmed Central) - Jun 29, 2023
This review covers the use of hyaluronic acid, calcium hydroxylapatite, poly-l-lactic acid, and polymethyl methacrylate in the jawline...While the advantages of injectable fillers include relatively affordable cost, minimal patient discomfort, and limited recovery times, taking measures to prevent short- and long-term complications is necessary for optimal results. Understanding the benefits and limitations of injectable fillers in the jawline can help providers appropriately counsel and treat patients.