nortriptyline / Generic mfg. 
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  • ||||||||||  Review, Journal, HEOR:  The impact of antidepressants on depressive symptom severity, quality of life, morbidity, and mortality in heart failure: a systematic review. (Pubmed Central) -  Aug 14, 2020   
    Out of the various antidepressants studied, which included sertraline, paroxetine, escitalopram, citalopram, bupropion, nefazodone, and nortriptyline, selective serotonin reuptake inhibitors seem to be a safe treatment option for patients with depression and HF. However, due to the variety of study designs as well as the mixed results for each antidepressant, more information for reducing depression severity, morbidity, and mortality and improving quality of life in patients with HF should be examined using robust large sample RCTs.
  • ||||||||||  [VIRTUAL] Impact of CYP2C19 and CYP2D6 polymorphism on antidepressants and antipsychotics exposure; a meta-analysis (Poster Area) -  Aug 5, 2020 - Abstract #ECNP2020ECNP_773;    
    The impact of the CYP2C19/CYP2D6 genotype on the plasma levels of fourteen antidepressants and antipsychotics supports an important role of preemptive CYP2C19/CYP2D6 genotyping in dose personalisation. The results obtained may be used as a scientific foundation for a prospective rediscussing of the dose recommendations for aripiprazole, haloperidol, risperidone, escitalopram, mirtazapine, and sertraline..
  • ||||||||||  nortriptyline / Generic mfg., gemcitabine / Generic mfg.
    Journal:  Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy. (Pubmed Central) -  Jul 22, 2020   
    Nortriptyline disrupts the lysosome, leading to accumulation of non-functional autophagosome, cathepsin B release and pineoblastoma cell death. Nortriptyline further synergizes with the antineoplastic drug gemcitabine to effectively suppress pineoblastoma in our preclinical models, offering new modality for this lethal childhood malignancy.
  • ||||||||||  [VIRTUAL] Treating Red Ear Syndrome with Oxygen () -  Jul 15, 2020 - Abstract #AHS2020AHS_282;    
    We hypothesize that oxygen treated the underlying trigeminal autonomic cephalalgia thus effectively treating the associated red ear syndrome. More research is necessary to confirm our findings.
  • ||||||||||  Trileptal (oxcarbazepine) / Novartis
    [VIRTUAL] Sphenopalatine Ganglion Block for the Treatment of SUNCT Syndrome in a Geriatric Patient () -  Jul 15, 2020 - Abstract #AHS2020AHS_262;    
    Patients with SUNCT can often be refractory to standard headache medications, and side effects from medications, drug interactions, and tolerability can be a limiting factor in the choice of oral treatments for elderly patients. SPG block is a safe, office-based, and non-invasive procedure that can be considered for treatment of pain in elderly patients with SUNCT.
  • ||||||||||  nortriptyline / Generic mfg.
    Enrollment open:  PeCon: Pediatric Concussion Outcomes (clinicaltrials.gov) -  Jul 14, 2020   
    P4,  N=100, Enrolling by invitation, 
    In addition to collecting data in a regulatory compliant manner, the registry creates a ready for use infrastructure for the conduct of future clinical trials in children and adolescents with migraine. Not yet recruiting --> Enrolling by invitation
  • ||||||||||  lithium / Generic mfg., nortriptyline / Generic mfg., Tirosint (levothyroxine) / IBSA Institute Biochemical SA
    Journal:  Synchrony Between Bipolar Mood Cycles and Lunar Tidal Cycles Ended After Initiation of Light Treatment and Treatment of Hypothyroidism. (Pubmed Central) -  Jul 2, 2020   
    After nortriptyline was discontinued, thyroid-stimulating hormone levels were normalized with treatment with levothyroxine, and consistent bright light treatment was started, the synchrony between mood cycles and lunar cycles disappeared, and rapid cycling eventually stopped. The possibility that lunar mood cycling is sometimes contingent on antidepressant treatment, decreased thyroid function, and certain types of light-dark cycles needs to be considered in future research on lunar tidal influences on the course of bipolar illness.
  • ||||||||||  amitriptyline / Generic mfg., gabapentin / Generic mfg.
    Retrospective data, Journal:  Gabapentin and Tricyclics in the Treatment of Post-Concussive Headache, a Retrospective Cohort Study. (Pubmed Central) -  Jun 18, 2020   
    Gabapentin and TCAs appear to have immediate effects on improving symptom burden, but long-term outcomes show similar improvement compared to those who are not prescribed medication. More rigorous prospective studies are required to better elucidate their efficacy.
  • ||||||||||  venlafaxine / Generic mfg.
    Review, Journal:  Effects of antidepressants on QT interval in people with mental disorders. (Pubmed Central) -  Jun 17, 2020   
    Large observational studies suggest increased mortality associated with all antidepressants (RR = 1.62, 95% CI: 1.60-1.63, number of adults: 1,716,552), high doses of tricyclic antidepressants (OR = 2.11, 85% CI 1.10-4.22), selective serotonin reuptake inhibitors (OR = 2.78, 95% CI: 1.24-6.24), venlafaxine (OR = 3.73, 95% CI: 1.33-10.45, number of adults: 4,040), and nortriptyline (OR = 4.60, 95% CI: 1.20-18.40, number of adults: 5,298). Evidence regarding the risk of QT prolongation in children is sparse.
  • ||||||||||  amitriptyline / Generic mfg., carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
    Biomarker, Clinical, Journal:  Pharmacogenomics in chronic pain therapy: from disease to treatment and challenges for clinical practice. (Pubmed Central) -  Jun 4, 2020   
    To translate the pharmacogenetic testing into actionable clinical decisions, the Clinical Pharmacogenetics Implementation Consortium has been developing guidelines for several drug-gene pairs. This review will show the applicability of PGx in chronic pain from disease to treatment; report the drug-gene pairs with strongest evidences in the clinic; and the challenges for the clinical implementation of PGx.
  • ||||||||||  fluconazole / Generic mfg., nortriptyline / Generic mfg.
    Journal:  Known Antimicrobials Versus Nortriptyline in Candida albicans: Repositioning an Old Drug for New Targets. (Pubmed Central) -  May 22, 2020   
    Gene ontology analysis recognized the categories of ribosome biogenesis and spliceosome as enriched upon treatment with the tricyclic antidepressant, while mutants in oxidative stress response and general stress response were commonly retrieved upon treatment with any other drug. The data presented suggest that nortriptyline can be considered a "new" antimicrobial drug with large potential for application to in vivo infection models.
  • ||||||||||  nortriptyline / Generic mfg.
    Enrollment open:  Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (clinicaltrials.gov) -  May 18, 2020   
    P2,  N=400, Recruiting, 
    The data presented suggest that nortriptyline can be considered a "new" antimicrobial drug with large potential for application to in vivo infection models. Suspended --> Recruiting
  • ||||||||||  Journal:  Drugs for Depression. (Pubmed Central) -  May 13, 2020   
    Suspended --> Recruiting No abstract available
  • ||||||||||  Silenor (doxepin) / Currax, amitriptyline / Generic mfg.
    LONG TERM FOLLOW UP OF CYCLIC VOMITING SYNDROME: EVIDENCE FOR SYMPTOM CONTROL AND IMPROVED QUALITY OF LIFE () -  May 4, 2020 - Abstract #DDW2020DDW_4768;    
    This long term follow up study (mean 2.7 yrs.) of a large single center cohort of CVS patients was able to confirm that an overwhelming majority not only responded well to initial treatment but were being maintained on a reduced dosage- some with no medication- and were able to re-establish a good quality of life. This data indicates that CVS is not only treatable with the appropriate therapy but is a reversible entity when there is long term continuity of care.
  • ||||||||||  verapamil / Generic mfg., topiramate / Generic mfg., nortriptyline / Generic mfg.
    Clinical, Journal:  Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients. (Pubmed Central) -  Apr 28, 2020   
    The majority of patients with hyperacusis demonstrated symptomatic improvement from migraine prophylaxis therapy, as indicated by self-reported and audiometric measures. Our findings indicate that, for some patients, hyperacusis may share a pathophysiologic basis with migraine disorder and may be successfully managed with multimodal migraine prophylaxis therapy.
  • ||||||||||  nortriptyline / Generic mfg.
    Preclinical, Journal:  Preliminary Biochemical Description of Brain Oxidative Stress Status in Irritable Bowel Syndrome Contention-Stress Rat Model. (Pubmed Central) -  Apr 23, 2020   
    Furthermore, the biochemical ratios which are used to evaluate the effectiveness of an antioxidant system on oxidative stress could be described in this model. The correlations between the behavioral patterns and biochemical oxidative stress features could suggest that this may be a complex model, which can successfully mimic IBS symptomatology further providing evidence of a strong connection between the digestive system, enteric nervous system, and the central nervous system.
  • ||||||||||  nortriptyline / Generic mfg.
    Trial suspension:  Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (clinicaltrials.gov) -  Apr 22, 2020   
    P2,  N=400, Suspended, 
    The results of this study do not support pharmacogenetic CYP2D6 screening to accelerate dose adjustment for nortriptyline and venlafaxine in older patients with depression. Recruiting --> Suspended
  • ||||||||||  Journal:  Quality of Lactation Studies Investigating Antidepressants. (Pubmed Central) -  Apr 14, 2020   
    Of all tricyclic antidepressants, one study for amitriptyline and one for nortriptyline assessed these endpoints correctly...We conclude that the quality of the current literature on this topic does not meet the standards of the FDA. Studies of higher quality are needed to determine the extent of drug transfer to breast milk for antidepressants, so an adequate recommendation about use of these drugs during lactation can be given.
  • ||||||||||  Biomarker, Clinical, Review, Journal:  Antidepressant pharmacogenetics in children and young adults: A systematic review. (Pubmed Central) -  Mar 31, 2020   
    The antidepressant pharmacogenetics knowledge base in pediatric populations is still emerging, but results to date echo many of the gene-antidepressant associations identified in adult populations. Given ubiquitous prescribing of antidepressants in the care of children and adolescents with psychiatric disorders, further research on identifying new and confirming current gene-antidepressant associations are warranted.
  • ||||||||||  PK/PD data, Journal:  Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2. (Pubmed Central) -  Feb 22, 2020   
    Dose-corrected, steady-state serum concentrations of individual patients were analyzed retrospectively by linear regression including age, sex, and smoking for amitriptyline (n=503), doxepin (n=198), mirtazapine (n=572), venlafaxine (n=534), clozapine (n=106), quetiapine (n=182), and risperidone (n=136)...In addition, the ratios of nortriptyline/amitriptyline (P=0.001) and nordoxepin/doxepin (P=0.014) were significantly higher in smokers compared with nonsmokers...Hence, a different dosing strategy is required among smoking and nonsmoking patients. Nevertheless, the clinical relevance of the results remained unclear.