- |||||||||| amitriptyline / Generic mfg., nortriptyline / Generic mfg.
Journal: An investigation into the modulation of T cell phenotypes by amitriptyline and nortriptyline. (Pubmed Central) - Apr 23, 2021
Significantly higher levels of IL-16 (p<0.001) and lower levels of TNF-β (p<0.05) were observed in supernatants. This data indicates that both amitriptyline and nortriptyline modulate the phenotype and function of T-cells and this may have clinical relevance in the pathologies of its off-label applications.
- |||||||||| sertraline / Generic mfg.
Clinical, Review, Journal: Prevention of depression in adults with long-term physical conditions. (Pubmed Central) - Apr 22, 2021
Generalisation of results is limited as study populations and treatment regimes were very heterogeneous. Based on the results of this review, we conclude that for adults with long-term physical conditions, there is only very uncertain evidence regarding the implementation of any primary preventive interventions (psychological/pharmacological) for depression.
- |||||||||| Silenor (doxepin) / Currax
Journal: Elucidation of Degradation Behavior of Tricyclic Antidepressant Amoxapine in Artificial Gastric Juice. (Pubmed Central) - Apr 20, 2021
The degradation behavior of eight tricyclic antidepressants (TCAs; amitriptyline, amoxapine (AMX), imipramine, clomipramine, desipramine, doxepin, dothiepin, and nortriptyline) in artificial gastric juice was investigated to estimate their pharmacokinetics in the stomach...As for the degradation behavior, it was estimated that AMX was degraded into (II) via (I), i.e., (II) was the final product. The results are expected to be useful in clinical chemistry and forensic science, including the estimation of drugs to be used at the time of judicial dissection and suspected drug addiction.
- |||||||||| methylphenidate tablet / Generic mfg., risperidone / Generic mfg.
Review, Journal: Hair analysis of antidepressants and antipsychotics - overview of quantitative data. (Pubmed Central) - Apr 1, 2021
A harmonization on the investigated hair lengths as well as on the extraction protocol would be of favor to achieve better comparability. Although hair analysis research focused mainly on drugs abuse, contribution of more data on antidepressants and antipsychotics would help to gain better knowledge and assistance for other forensic investigators.
- |||||||||| Journal: Drugs for Parkinson's disease. (Pubmed Central) - Mar 10, 2021
It was concluded that the purposed fiber is highly efficient in analyzing traces of antidepressant drugs in urine and blood. No abstract available
- |||||||||| nortriptyline / Generic mfg., fluoxetine / Generic mfg., escitalopram / Generic mfg.
Journal: Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment. (Pubmed Central) - Mar 9, 2021
Lsamp, another IgLON family protein, increased in mouse dentate gyrus after fluoxetine treatment. These findings suggest that Negr1-Fgfr2 pathway plays a role in the modulation of synaptic plasticity induced by antidepressant treatment to promote therapeutic efficacy by rearranging connectivity in corticolimbic circuits impaired in depression.
- |||||||||| risperidone / Generic mfg., donepezil / Generic mfg.
[VIRTUAL] 9108 The Challenge of Clinical Pharmacology and Pharmacogenetics in Later Life () - Mar 8, 2021 - Abstract #APA2021APA_54;
The author has also worked for many years to reduce the prescription of antipsychotics to patients suffering from dementia accompanied by agitation. In the course of this talk the major drug metabolizing polymorphisms will be reviewed, emphasizing their potential for understanding drug-drug interactions and inter-individual pharmacokinetics.
- |||||||||| lithium carbonate ER / Generic mfg., sertraline / Generic mfg., nortriptyline / Generic mfg.
[VIRTUAL] Nortriptyline Therapy of Treatment-Resistant Depression: Two Case Reports () - Mar 7, 2021 - Abstract #CINP2021CINP_158;
He showed resistance to sertraline up to 100mg daily as well as quetiapine up to 300mg daily... These two cases suggest that treatment with TCAs, such as nortriptyline, may be useful in certain treatment-resistant depressed patients.
- |||||||||| metformin / Generic mfg., nortriptyline / Generic mfg., epinephrine / Generic mfg.
[VIRTUAL] DAG_SA_NKF2020submission () - Mar 2, 2021 - Abstract #NKFSCM2021NKF-SCM_547;
METHODS Medications at that time included metoprolol and nifedipine for hypertension, nortriptyline for chronic migraine, tacrolimus, mycophenolate and low dose prednisone for post-transplant immunosuppression...The patient was diagnosed with diabetes mellitus and started on metformin, in addition to diet and exercise modification...Serum metanephrines confirmed the diagnosis of pheochromocytoma: Epinephrine 517 (ULN < 95), norepinephrine 1,216 (ULN < 1,109), Dopamine 118 (ULN <20)...Post-transplant diabetes mellitus is often ascribed to steroids, tacrolimus, as well as other risk factors. Ultimately, we are reminded that when you hear hoofbeats, it is sometimes neither a horse nor a zebra.
- |||||||||| topiramate / Generic mfg., nortriptyline / Generic mfg.
Clinical, Journal: Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss. (Pubmed Central) - Jan 28, 2021
In multimodal treatment of SSNHL, supplementing oral and IT steroid with migraine medications may result in greater improvements in lower frequency hearing thresholds and PTA. Furthermore, adjuvant migraine treatment can lead to decrease in number of IT injections, thus reducing procedure-related risks and complications.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie
Journal: Drugs for Migraine. (Pubmed Central) - Jan 23, 2021
Further research is required to promote knowledge on pregnancy effects on antidepressant pharmacokinetics. No abstract available
- |||||||||| glimepiride / Generic mfg.
Journal: Identification of off-patent drugs that show synergism with Amphotericin B or that present antifungal action against Cryptococcus neoformans and Candida spp. (Pubmed Central) - Jan 13, 2021
Harmless compounds, such as the antibiotic erythromycin was found to have synergic activity with AmB, not only against C. neoformans, but also against some Candida spp., in particular against C. albicans In parallel, we identified drugs that had antifungal activity against C. neoformans and found 43 drugs that completely inhibited the growth of this fungus, such as cliclopirox and auranofin. Our results expand our knowledge about antifungal compounds and open new perspectives in the treatment of invasive mycosis based on repurposing of off-patent drugs.
- |||||||||| Silenor (doxepin) / Currax
[VIRTUAL] QTc prolonging medications utilization and EKG obtainment at Vanderbilt Psychiatric Hospital () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4998;
The electronic medical record system will identify men and women 18 years of age and older over a 12-month period who were prescribed of one the following QTc prolonging medications: amitriptyline, citalopram, chlorpromazine, clozapine, dofetilide, doxepin, flecainide, haloperidone, lithium, nortriptyline, or ziprasidone...Data will be reviewed and used to calculate the percentage of patients who received orders to obtain an EKG while on prescribed QTc prolonging medications, as well as the change in msec on the EKG as a result of these medications. If accepted, the final results of this project will be presented at the 2020 ASHP Midyear Clinical Meeting.
- |||||||||| pethidine / Samaritan
Journal: Towards exhaustive electromembrane extraction under stagnant conditions. (Pubmed Central) - Nov 26, 2020
Stagnant EME was evaluated in combination with liquid chromatography-mass spectrometry (LC-MS) as a highly specific instrumental method, and provided evaluation data on methadone from blood samples in accordance with regulatory requirements (LOD: 0.4 ng/mL, LOQ: 1.4 ng/mL, RSD: 6-20%). This work has improved upon the design of stagnant EME, moving it further towards a viable in-field operation device.
- |||||||||| bromocriptine / Generic mfg., amantadine / Generic mfg.
Review, Journal: Pharmacological interventions for antisocial personality disorder. (Pubmed Central) - Oct 24, 2020
The studies also have methodological issues that severely limit the confidence we can draw from their results. Future studies should recruit participants on the basis of having AsPD, and use relevant outcome measures, including reconviction.
- |||||||||| [VIRTUAL] PILL ASPIRATION: BRONCHOSCOPIC CHARACTERISTICS OF IRON ASPIRATION COMPARED TO OTHER PILLS () - Oct 12, 2020 - Abstract #CHEST2020CHEST_2297;
The iron group had a greater percentage of cases with severe inflammation even though the mean duration from aspiration to bronchoscopy was similar in the two groups, as was the percentage of cases where residual pill material was found. Currently published cases describing severe long term sequelae of pill aspiration typically had a longer delay between the aspiration event and intervention.
- |||||||||| clonazepam / Generic mfg., nortriptyline / Generic mfg.
Clinical, Journal: Patient-reported responses to medical treatment in primary dystonia. (Pubmed Central) - Oct 1, 2020
Clonazepam, followed by baclofen and trihexyphenidyl is a useful pharmacologic option for primary dystonia. Levodopa can be considered for isolated limb dystonia.
- |||||||||| Silenor (doxepin) / Currax, amitriptyline / Generic mfg., nortriptyline / Generic mfg.
Clinical, Journal: Nortriptyline serum concentration as a predictor for cardiac risk in amitriptyline-treated patients. (Pubmed Central) - Sep 30, 2020
The effect of amitriptyline on ECG parameters may be explained by nortriptyline alone. Accordingly, with increasing nortriptyline concentrations, the potential risk for an atrioventricular block, a bundle branch block, and prolongation of QTc interval may increase significantly.
- |||||||||| amitriptyline / Generic mfg.
[VIRTUAL] Utilizing Telemedicine in an Interdisciplinary Academic Headache Center () - Sep 30, 2020 - Abstract #ANA2020ANA_343;
By continuing healthcare services through a telehealth platform, the patient has been able to make ongoing strides in learning and implementing self-care strategies to improve self-efficacy in managing her migraines and neck pain. She has implemented activity-pacing strategies, incorporated stress management strategies, and now identifies exercise and movement as beneficial to manage pain.
- |||||||||| Journal: LC-MS/MS METHOD FOR THE DETERMINATION OF ANTIDEPRESSANTS AND BENZODIAZEPINES IN MECONIUM. (Pubmed Central) - Sep 25, 2020
The authentic meconium samples tested positive for alprazolam, α-hydroxyalprazolam, clonazepam, diazepam, nordiazepam, fluoxetine, norfluoxetine, clomipramine and norclomipramine. Therefore, the present LC-MS/MS method allows a high throughput determination of the most common benzodiazepines and antidepressants in meconium, which could be useful in clinical and forensic settings.
- |||||||||| Journal: Developing and Validating a Fast and Accurate Method to Quantify 18 Antidepressants in Oral Fluid Samples Using SPE and LC-MS-MS. (Pubmed Central) - Sep 25, 2020
We developed and validated a comprehensive liquid chromatography-tandem mass spectrometry method for 18 antidepressants (amitriptyline, bupropion, citalopram, clomipramine, cyclobenzaprine, desipramine, desvenlafaxine, doxepin, duloxetine, fluoxetine, imipramine, mirtazapine, nortriptyline, paroxetine, sertraline, trazodone, trimipramine, venlafaxine) in oral fluid collected by Quantisal® oral collection devices...The authentic patient sample showed a percentage difference compared to the previously calculated concentration of 86.3-111%. This method provides for the rapid detection of 18 antidepressants and metabolites in OF, which is readily applicable to a routine laboratory.
- |||||||||| amitriptyline / Generic mfg., sertraline / Generic mfg., paroxetine / Generic mfg.
Journal, Adverse events: Antidepressant Medication Use and Development of Hyperglycemia and Diabetes Mellitus: A Japanese Adverse Drug Event Report Database Study (Pubmed Central) - Sep 8, 2020
Younger age group was associated with hyperglycemia/NODM for 5 antidepressants (imipramine, amitriptyline, maprotiline, duloxetine, and trazodone), and female was associated with the ADEs for trazodone, although these results should be interpreted cautiously. Healthcare personnel need to be aware that the use of antidepressants may lead to hyperglycemia/NODM.
- |||||||||| Silenor (doxepin) / Currax, amitriptyline / Generic mfg., paroxetine / Generic mfg.
Clinical, Journal: Extent and Predictors of Potentially Inappropriate Antidepressant Use Among Older Adults With Dementia and Major Depressive Disorder. (Pubmed Central) - Aug 30, 2020
More than 7% of older adults in the study sample initiated a potentially inappropriate antidepressant, and the authors identified a few individual-level factors significantly associated with it. Appropriately tailored interventions to address modifiable and nonmodifiable factors significantly associated with potentially inappropriate antidepressant prescribing are required to minimize risks in this vulnerable population.
- |||||||||| nortriptyline / Generic mfg.
Journal: Modulation of the NOP receptor signaling affects resilience to acute stress. (Pubmed Central) - Aug 15, 2020
These findings support the view that NOP activation during acute stress facilitates the development of depressive-related behaviors, whereas NOP blockade has a protective outcome. This study showed for first time that NOP antagonists are worthy of investigation as preemptive treatments in patients with severe risk factors for depression.
- |||||||||| bupropion / Generic mfg.
Review, Journal: Antidepressants for smoking cessation. (Pubmed Central) - Aug 15, 2020
Due to the high-certainty evidence, further studies investigating the efficacy of bupropion versus placebo are unlikely to change our interpretation of the effect, providing no clear justification for pursuing bupropion for smoking cessation over front-line smoking cessation aids already available. However, it is important that where studies of antidepressants for smoking cessation are carried out they measure and report safety and tolerability clearly.
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