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72 Diseases |  |
9 Trials |
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9 Trials |  |
809 News |  |
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- |||| nortriptyline / Generic mfg.
Clinical: This. Chronic pain patient here (autoimmune arthritis). Last night was spent laying in bed whimpering in pain. My "pain med" nortriptyline did nothing. Zero to alleviate my pain. Killing isn't the answer, but I get the desperation. (Twitter) - Jun 3, 2022
- || Review, Journal: Repurposing Autophagy Regulators in Brain Tumors. (Pubmed Central) - May 29, 2022
Sertraline and desipramine, depending on the neoplastic context, were demonstrated to either induce or inhibit autophagy. Collectively, these medications were associated with favorable therapeutic outcomes in a variety of cancer cell models, including brain tumors.
- | nortriptyline / Generic mfg.
Journal: Survival with extracorporeal membrane oxygenation during cardiopulmonary resuscitation following cardiac arrest due to nortriptyline overdose. (Pubmed Central) - May 25, 2022
Collectively, these medications were associated with favorable therapeutic outcomes in a variety of cancer cell models, including brain tumors. No abstract available
- | lithium carbonate ER / Generic mfg.
Trial completion, Enrollment change, Trial completion date: OPTIMUM: Optimizing Outcomes of Treatment-Resistant Depression in Older Adults (clinicaltrials.gov) - May 24, 2022
P4, N=742, Completed, Sponsor: Washington University School of Medicine
No abstract available Recruiting --> Completed | N=1500 --> 742 | Trial completion date: Dec 2021 --> Sep 2021
- || imipramine / Generic mfg., desipramine / Generic mfg., nortriptyline / Generic mfg.
Biomarker, Review, Journal: Biomarkers as predictors of treatment response to tricyclic antidepressants in major depressive disorder: A systematic review. (Pubmed Central) - May 18, 2022
Three nongenetic biomarkers were identified for imipramine...Moreover, biomarker studies generally use small sample sizes. To move forward, larger cohorts, pooled data or biomarkers combined with other clinical characteristics should be used to improve predictive power.
- | Journal: A rapid and versatile microfluidic method for the simultaneous extraction of polar and non-polar basic pharmaceuticals from human urine. (Pubmed Central) - May 15, 2022
Recoveries exceeded 78% for the target analytes, and the relative standard deviation (n = 4) was below 7% in all cases. Using five microliters of SLM, the microfluidic extraction system showed good long-term stability, and the same SLM was used for more than 18 consecutive extractions.
- | amitriptyline / Generic mfg.
Biomarker, Journal: The interplay between pharmacogenetics, concomitant drugs and blood levels of amitriptyline and its main metabolites. (Pubmed Central) - May 6, 2022
In patients at high CYP2D6 inhibition risk, the amitriptyline + nortriptyline concentration was, on average, 52% above the higher end of expected ranges. Practical construal of pharmacogenetics and drug interactions tantamount to aberrant metabolism can facilitate patient-tailored use of the established drug.
- lithium carbonate ER / Generic mfg.
*Augmenting Vs. Switching Antidepressant for Treatment Resistant Depression in Older adults: Results from the Optimum Study (Princess Ballroom F) - May 6, 2022 - Abstract #ASCP2022ASCP_224;
It is a model for balancing pragmatic and explanatory approaches for a successful clinical trial. Listening to a variety of stakeholder voices during every six-month advisory board meetings makes OPTIMUM highly relevant and patient-centered.
- Exploring Genetic Variation of Complex I as Potential Marker of Increased Mitochondrial Function Associated with Antidepressant-Induced Mania. (Palomino Ballroom 4-10) - May 6, 2022 - Abstract #ASCP2022ASCP_68;
We did not find strong support for the hypothesis of variations in C-I related nDNA linking to an increase in mitochondrial bioenergetics and AIM. However, this genetic analysis was likely underpowered.
- || Review, Journal: Depression and Long-Term Prescription Opioid Use and Opioid Use Disorder: Implications for Pain Management in Cancer. (Pubmed Central) - Apr 30, 2022
Existing evidence is inadequate to definitively recommend methylphenidate or novel agents, such as ketamine or psilocybin, as adjunctive treatments for cancer-related depression and pain...Buprenorphine and methadone are indicated for the treatment of opioid use disorder, and while they have not been systematically studied for treatment of opioid use disorder in patients with cancer pain, they do provide analgesia for cancer pain. While an interdisciplinary team approach to manage psychological stress may be beneficial, this may not be possible for patients treated outside of comprehensive cancer centers.
- nortriptyline / Generic mfg.
EVALUATING SHORT DURATION OF NORTRIPTYLINE IN TREATING PREGNANT WOMEN WITH INTRACTABLE DYSPEPSIA (Poster Hall - San Diego Convention Center) - Apr 25, 2022 - Abstract #DDW2022DDW_3096;
There was no significant difference between the basic characteristics of patients in the two groups (Table 1). 76% of all patients had Anxiety or a history of psychological problems.
- | amitriptyline / Generic mfg., nortriptyline / Generic mfg., prochlorperazine maleate / Generic mfg.
Journal: Application of Antisolvent Precipitation Method for Formulating Excipient-Free Nanoparticles of Psychotropic Drugs. (Pubmed Central) - Apr 24, 2022
Moreover, the average of the final particle sizes (DHf)av increased linearly with (logP). These findings are useful for predicting the size of nanodrugs prepared through the antisolvent precipitation method.
- | propafenone / Generic mfg., nortriptyline / Generic mfg.
Journal: Rationale and performances of a data-driven method for computing the duration of pharmacological prescriptions using secondary data sources. (Pubmed Central) - Apr 19, 2022
When compared to the RDD, the method had a lower median sensitivity of 2.29% (interquartile range 1.21-4.11%). The SEE showed good properties and may represent a promising tool to assess exposure status when information on treatment duration is not available.
- || nortriptyline / Generic mfg.
Clinical, Journal: Influence of adjuvant nortriptyline on the efficacy of electroconvulsive therapy: a randomized controlled trial and one-year follow-up. (Pubmed Central) - Apr 14, 2022
In our sample of severely depressed patients who were often medication resistant and suffering from psychotic depression, the addition of nortriptyline to ECT did not enhance its efficacy or prevent post-ECT relapse. Encouragingly, even in these patients ECT was highly effective and relapse rates were relatively low.
- | nortriptyline / Generic mfg., escitalopram / Generic mfg.
Journal: Depression and inflammation: Correlation between changes in inflammatory markers with antidepressant response and long-term prognosis. (Pubmed Central) - Apr 12, 2022
These findings support the importance of studying specific depressive symptoms to further explore the correlation between inflammation with differential antidepressant response in a subgroup of depression. Clinical Trial Registration number: GENDEP is registered at EudraCT2004-001723-38 (http://eudract.emea.europa.eu) and ISRCTN03693000 (www.controlled-trials.com).
- | nortriptyline / Generic mfg.
Journal: Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pH Domains with a Gibbs Phase Rule "Soft" Constraints. (Pubmed Central) - Apr 5, 2022
The results of the present investigation illustrate the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and so forth, on the aqueous solubility of drugs and interconversion of salts. Careful attention given to these factors can be helpful in the formulation of drug products.
- || Clinical, Retrospective data, Journal: Pharmacological management of fibromyalgia: a Bayesian network meta-analysis. (Pubmed Central) - Apr 1, 2022
According to published evidence, pregabalin and duloxetine evidenced the greatest improvement of the FIQ and SF36 Physical and Mental subscales, along with the lowest rate of adverse events leading to study discontinuation. The results must be interpreted in the light of possible adverse events with the use of these drugs.
- || atorvastatin / Generic mfg., nortriptyline / Generic mfg.
Clinical, Journal: The preventive effect of the combination of atorvastatin and nortriptyline in migraine-type headache: a randomized, triple-blind, placebo-controlled trial. (Pubmed Central) - Mar 30, 2022
In patients with migraine, prophylaxis with atorvastatin significantly improved the frequency of headache and QOL over 24 weeks compared with placebo with no effect on the intensity of headache. Statins seem to be a potential promising drug for prophylaxis of migraine headaches.
- || nortriptyline / Generic mfg.
Clinical, Review, Journal: A Scoping Review of Interventions for Spousal Bereavement in Older Adults. (Pubmed Central) - Mar 26, 2022
Findings were eclectic, with evidence supporting mindfulness techniques in a group format for emotional and life satisfaction outcomes; an individual, function-based therapy addressing sleep to improve emotion and function; an individual, writing-based emotional expression therapy for short-term improvement in emotion and function; nortriptyline for the treatment of bereavement-related major depressive disorder; a group-based, complicated grief therapy for this condition; an internet-based CBT intervention for prolonged grief; and pharmacotherapy for cardiovascular changes during bereavement. These findings highlight the small literature of methodologically strong intervention studies addressing spousal bereavement in older adults and the need for greater exploration of relevant biological, social, cognitive and behavioral factors to improve short and long term health outcomes.
- | Journal: Relative frequency of drug-induced sleep disorders for 32 antidepressants in a large set of Internet user reviews. (Pubmed Central) - Mar 18, 2022
Our results could guide clinicians in appropriate choice of antidepressant drug for high DISD-risk patients in need of such treatment. These results may however be cautiously taken, considering the uncertain reliability and generalisability of web-based data.
- | budesonide / Generic mfg., nortriptyline / Generic mfg.
Journal: Nortriptyline enhances corticosteroid sensitivity of blood T cells from patients with chronic obstructive pulmonary disease. (Pubmed Central) - Mar 16, 2022
In conclusion, nortriptyline alone demonstrates anti-inflammatory effects on blood T lymphocytes from COPD patients. Nortriptyline may also potentiate the effects of glucocorticoids and overcome corticosteroid insensitivity.
- | methotrexate / Generic mfg.
Journal: A Prospective Study Examining the Effect of Selected Topical and Systemic Drugs on Pruritus Grading System Score and STAT 6 Expression in Patients of Prurigo Nodularis. (Pubmed Central) - Mar 15, 2022
The combination of different topical and oral agents resulted in a statistically significant change in severity, though individual drugs did not achieve statistically significant results. A combination of selected oral and topical agents can effectively control the severity of PN within one month, and this was found to correlate with STAT 6 expression.
- ||| nortriptyline / Generic mfg., duloxetine / Generic mfg., escitalopram / Generic mfg.
Would have responded w/ duloxetine, but saw your pt had a👎 experience. Unpacking prior experience w/ nortriptyline is where I would start since best data for TCAs (IMHO actual worsening of constipation is a literal crapshoot); totally support escitalopram if above classes 🚫 (Twitter) - Mar 11, 2022
- ||| nortriptyline / Generic mfg., duloxetine / Generic mfg., escitalopram / Generic mfg.
Thanks Doug! I tried duloxetine first - he thought it helped with pain but made constipation worse. He also had been on nortriptyline prior but didn’t like that either. Escitalopram? (Twitter) - Mar 11, 2022
- ||| Nortriptyline and desipramine cause less constipation than amitriptyline but I’d favor duloxetine for more predictable pain benefit and less constipation and treats A/D (Twitter) - Mar 10, 2022
- || nortriptyline / Generic mfg.
I really like nortriptyline too- but he reported he didn’t like it after a previous trial (Twitter) - Mar 10, 2022
- |||| nortriptyline / Generic mfg., dicyclomine / Generic mfg.
I still use TCAs (nortriptyline) to target pain if the constipation is controlled with other meds. Backup options include SNRI, dicyclomine prn (Twitter) - Mar 10, 2022
- || nortriptyline / Generic mfg.
Thanks! He didn’t feel any better with nortriptyline previously , I put in the behavioral health consult too! (Twitter) - Mar 10, 2022
- || Rexulti (brexpiprazole) / Lundbeck, Otsuka
Retrospective data, Review, Journal: Augmentation Strategies For Treatment Resistant Major Depression: A Systematic Review And Network Meta-Analysis. (Pubmed Central) - Mar 8, 2022
Acceptability was lower with ziprasidone, mirtazapine, and cariprazine. Further research and head-to-head studies should be considered to strengthen the best available options for TRD.
- | Zolinza (vorinostat) / Merck (MSD), Nerlynx (neratinib) / Puma, Knight Therap, Pierre Fabre, Zyflo (zileuton) / Chiesi
Journal: miRNA-mediated Drug Repurposing Unveiled Potential Candidate Drugs for Prolactinoma Treatment. (Pubmed Central) - Mar 4, 2022
Effects of the drugs on cell cycle phases and inhibition of PI3K/Akt pathway by all drugs gave us promising output for further studies using these drugs in the treatment of prolactinoma. This is the first study that reports miRNA-mediated repurposed drugs for prolactinoma treatment via in vitro experiments.
- | Journal: Nonopioid drugs for pain. (Pubmed Central) - Mar 3, 2022
This is the first study that reports miRNA-mediated repurposed drugs for prolactinoma treatment via in vitro experiments. No abstract available
- | bupropion / Generic mfg., nortriptyline / Generic mfg.
Retrospective data, Journal: Sex differences in smoking cessation: A Retrospective Cohort Study in a Psychosocial Care Unit in Brazil. (Pubmed Central) - Feb 26, 2022
Previous drug use disorder was an important confounding variable in the gender outcomes analyses. Future studies should try to replicate these positive smoking cessation effects of CBT-based group therapy plus pharmacotherapy in women.
- ||||| gabapentin / Generic mfg., nortriptyline / Generic mfg.
Reimbursement: I saw Northwestern Neuro post Covid clinic. They wanted me to try nortriptyline and when didn’t work they said there’s no other recommendations. I saw OHSU post Covid clinic they wanted me to go on high doses of gabapentin and work with a speech pathologist. Covered insurance (Twitter) - Feb 14, 2022
- || doxepin / Generic mfg., amitriptyline / Generic mfg.
Review, Journal: The effect of smoking on the plasma concentration of tricyclic antidepressants - a systematic review. (Pubmed Central) - Feb 12, 2022
The effect of smoking on the plasma concentration of TCAs is still not entirely clear. There is a possibility that smoking affects the distribution of TCA metabolites, but this is probably not of clinical importance.
- || nortriptyline / Generic mfg.
Nor have I ever spelled Nortriptyline correctly. (Twitter) - Feb 11, 2022
- | amitriptyline / Generic mfg.
Journal: Role of serum amitriptyline concentration and CYP2C19 polymorphism in predicting the response to low-dose amitriptyline in irritable bowel syndrome. (Pubmed Central) - Feb 8, 2022
There is a possibility that smoking affects the distribution of TCA metabolites, but this is probably not of clinical importance. NT serum concentration but not CYP2C19 polymorphism may be correlated with the clinical efficacy of AMT for treating IBS-D, and such a response may occur at the upper NT threshold of 2.91 ng/ml.
- || Fycompa (perampanel) / Eisai
Clinical, Journal: Effectiveness of perampanel in managing chronic pain caused by the complex regional pain syndrome: A case report. (Pubmed Central) - Feb 2, 2022
NT serum concentration but not CYP2C19 polymorphism may be correlated with the clinical efficacy of AMT for treating IBS-D, and such a response may occur at the upper NT threshold of 2.91 ng/ml. These results suggest that perampanel may potentially be used to treat centralized pain.
- | Journal: Determination of psychoactive drugs in serum using conductive vial electromembrane extraction combined with UHPLC-MS/MS. (Pubmed Central) - Feb 1, 2022
EME was combined with UHPLC-MS/MS, and a method to determine selected psychoactive drugs (alimemazine, amitriptyline, atomoxetine, clomipramine, doxepin, duloxetine, fluvoxamine, levomepromazine, nortriptyline and trimipramine) and metabolites (desmethyl clomipramine and desmethyl doxepin) in serum was developed, optimized, and validated...These results thus serve as motivation for further advancing the EME technology. Until now, EME has been carried out with laboratory-build equipment, and the introduction of commercially available standardized equipment is expected to have a positive impact on future research activity.
- | nortriptyline / Generic mfg.
Preclinical, Journal: Dose-dependent opposite effects of nortriptyline on affective-like behavior in adolescent rats: Comparison with adult rats. (Pubmed Central) - Jan 29, 2022
In conclusion, clear behavioral and neurochemical differences were observed between adolescent and adult rats in response to nortriptyline treatment. Interestingly, while nortriptyline displayed an antidepressant-like potential at the lowest dose examined in adolescence, a higher dose shifted these results towards a negative outcome, thus reinforcing the need to extreme caution when considering this treatment for our younger population.
- nortriptyline / Generic mfg.
EXERCISE INDUCED UNMASKING OF BRUGADA SYNDROME (Poster Hall_Hall C) - Jan 28, 2022 - Abstract #ACC2022ACC_2741;
However, there is insufficient evidence regarding BrS precipitated by exercise. This is a unique case of BrS unmasked during an exercise session while being on sodium channel blockade medications.
- duloxetine / Generic mfg.
Identification of drug metabolites of tricyclic antidepressant medications in rat liver microsome using compact mass spectrometry (In-Person Room (Virtual Room)) - Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_5116;
The future goal is to repeat these experiments using HPLC/CMS to further separate the metabolites. Using different drugs would also explain the outcome of metabolism a little further, such as if a drug can be both demethylated and hydroxylated.
- | nortriptyline / Generic mfg., tramadol hydrochloride / Generic mfg.
Journal: Effects of different pharmaceutical residues on embryos of fish species native to Central Europe. (Pubmed Central) - Jan 27, 2022
Specifically, we applied concentration ranges of tramadol, enrofloxacin and nortriptylined on a common toxicological model organism, the zebrafish (Danio rerio), and other species native to Central European freshwaters, i.e. common carp (Cyprinus carpio), catfish (Silurus glanis) and tench (Tinca tinca). Our results show that, though malformation and negative impacts on hatching and mortality were only observed at the highest test concentrations, gene expression indicated that even low environmentally relevant concentrations (0.1 μg/L) can cause significant changes in early development of embryo.
- | amitriptyline / Generic mfg., nortriptyline / Generic mfg.
Journal: Electrochemical sensor for tricyclic antidepressants with low nanomolar detection limit: Quantitative Determination of Amitriptyline and Nortriptyline in blood. (Pubmed Central) - Jan 19, 2022
In this work, the concentrations of Amitriptyline and Nortriptyline were determined in whole blood using the sensor and the results of our analysis were compared to the results of the standard HPLC-MS method. Based on our experience, the one-step voltammetric methods with the membrane-coated sensor may become a real alternative to the significantly more complex HPLC-MS analysis.
- || risperidone / Generic mfg., amitriptyline / Generic mfg., sertraline / Generic mfg.
Retrospective data, Review, Journal: Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis. (Pubmed Central) - Jan 18, 2022
Exposure differences were also observed for clozapine, quetiapine fumarate, amitriptyline hydrochloride, mirtazapine, nortriptyline hydrochloride, fluoxetine hydrochloride, fluvoxamine maleate, paroxetine hydrochloride, and venlafaxine hydrochloride; however, these differences were marginal, ambiguous, or based on less than 3 independent studies. In this systematic review and meta-analysis, the association between CYP2C19/CYP2D6 genotype and drug levels of several psychiatric drugs was quantified with sufficient precision as to be useful as a scientific foundation for CYP2D6/CYP2C19 genotype-based dosing recommendations.
- || Review, Journal: Antidepressant transfer into amniotic fluid, umbilical cord blood & breast milk: A systematic review & combined analysis. (Pubmed Central) - Jan 15, 2022
We observed considerable variability across antidepressants regarding their ability to enter fetal, newborn and infant fluids. Measuring antidepressant concentrations in a maternal blood sample can provide a reliable estimate of fetal/infant exposure, although further evidence for concentration-dependent effects is required.
- ||| amitriptyline / Generic mfg., nortriptyline / Generic mfg.
Yes agree- its one of the effects of anticholinergics Amitriptyline 10 MG dose causes Long QT as dose Nortriptyline (Twitter) - Jan 1, 2022
- || citalopram / Generic mfg., nortriptyline / Generic mfg., fluoxetine / Generic mfg.
Not in the USA where Celexa, Pamelor Prozac was over-scripted and not checked against other drugs.. The USA rely's on these SSRI's more than any other country.. (Twitter) - Dec 30, 2021
- | nortriptyline / Generic mfg.
Journal: RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11. (Pubmed Central) - Dec 21, 2021
Importantly, RBMS1 depletion or inhibition by nortriptyline hydrochloride sensitized radioresistant lung cancer cells to radiotherapy. Our findings established RBMS1 as a translational regulator of ferroptosis and a prognostic factor with therapeutic potentials and clinical values.
- | amitriptyline / Generic mfg., sertraline / Generic mfg.
Journal: Efficient dispersive micro solid-phase extraction of antidepressant drugs by a robust molybdenum-based coordination polymer. (Pubmed Central) - Dec 16, 2021
Finally, the D-μSPE-HPLC-UV method was applied for the determination of antidepressant drugs in human plasma samples with recoveries of the analytes in the range 94.9 to 102%. The article describes the synthesis of a robust molybdenum-based coordination polymer, and its application as sorbent for dispersive micro solid-phase extraction of antidepressant drugs from human plasma samples.