- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Cytovene (ganciclovir) / Roche
Journal: Long-term outcomes of congenital cytomegalovirus infection in children early identified by extended hearing-targeted screening. (Pubmed Central) - Sep 5, 2024
With a significant proportion of cCMV children developing sensorineural hearing loss, ophthalmological and neurodevelopmental issues, the results emphasize the importance of continuous, multidisciplinary follow-up. Early identification and tailored interventions are crucial for improving the long-term health and quality of life of children affected by cCMV.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe
Retrospective data, Journal: Ocular involvement in highly treatment-experienced patients with HIV. (Pubmed Central) - Jul 15, 2024
The study highlighted the importance of constant monitoring even after viral suppression. Abbreviations: HIV = Human immunodeficiency virus, ART = antiretroviral therapy, CMV = cytomegalovirus, IRU = immune recovery uveitis, ELISA = enzyme-linked immunosorbent assay, WB = Western Blot, VL = viral load, CD4 = CD4+ T cells.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe
Journal: CMV neuroretinitis in an immunocompetent patient: a unique case report. (Pubmed Central) - Jul 15, 2024
This case underscores the importance of considering rare infectious agents in immunocompetent patients when encountering neuroretinitis, particularly in the absence of typical symptoms or signs of the disease. Abbreviations: CMV = Cytomegalovirus, BE = Both eyes, RE = Right eye, LE = Left eye, CBC = Complete Blood Count, ESR = Erythrocyte Sedimentation Rate, VDRL = Venereal Disease Research Laboratory, FTA-ABS = Fluorescent Treponemal Antibody Absorption, PPD = Purified Protein Derivative, ANA = Anti-Nuclear Antibodies, RF = Rheumatoid Factor, ACE = Anti Converting Enzyme, Ig G = Immunoglobulin G, HSV = Herpes simplex virus.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Journal, Surgery: Herpes Simplex Keratitis as a Complication of Pterygium Surgery. (Pubmed Central) - Feb 28, 2024
Timely diagnosis and treatment are crucial to prevent unfavorable outcomes. Consequently, routine corneal fluorescein staining, tear sIgA examination, and corneal scraping for polymerase chain reaction or next-generation sequencing of metagenomics should be performed in any suspected cases.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
Journal: What happens when salinization meets eutrophication? A test using stream microcosms. (Pubmed Central) - Nov 30, 2023
Finally, both structural equation models and biotic-abiotic interaction networks showed that complex biological interactions could be modulating the response of the biological communities to our treatments. Thus, our study calls for species-level assessments of salt and nutrient effects on river ecosystems and advocates for better management of co-occurring pollutants.
- |||||||||| Ozurdex (dexamethasone intravitreal implant) / AbbVie
Journal: Dexamethasone intravitreal implant for macular edema and some other rare indications in uveitis. (Pubmed Central) - Aug 10, 2023
Retinal detachment occurred in one eye (0.9%), endophthalmitis in one eye (0.9%), and transient intravitreal hemorrhage occurred in three eyes (2.7%) after the IDI injections. On the whole, the present study demonstrates that although IDI is mostly employed in non-infectious uveitic eyes with macular edema, it can also be administered in cases with systemic therapy intolerance, pseudophakic macular edema prophylaxis, and with great caution, in selected cases involving infectious uveitis and macular edema.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Neonatal Herpes Simplex Virus (HSV)-Associated Ocular Manifestations: The Hidden Disease () - Mar 14, 2023 - Abstract #PAS2023PAS_4108;
Overall, 23% (15/65) of infants had HSV-associated ocular abnormalities on initial or follow-up exams: SEM (39%; 7/18), CNS (15%; 3/20), and DIS (25%; 5/20). No eye abnormalities were observed in infants with HSV+ surface only.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche, Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) / Gilead
A Case of Bilateral Cytomegalovirus Retinitis in a Patient with a CD4+ count of > 200 cells/ (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3617;
Objective N/A Design/Methods N/A Results A 54-year-old HIV+ male on Biktarvy presented to an outside hospital for binocular vision loss...Infectious workup was positive for serum CMV and IV ganciclovir was started for presumed CMV retinitis...While extensive antiretroviral usage has significantly decreased the incidence of CMV end-organ disease, viral reactivation can still occur in patients with relatively elevated CD4+ counts. Thus, physicians must still consider CMV retinitis in any HIV-positive patient who presents with vision loss.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
From (Cat) Scratch: A Unique Presentation of CNS Bartonella Infection (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1459;
Two months before presenting to ED, her ophthalmologist increased her prednisone regimen to 80 mg daily due to concern for lupus retinitis...She was started on empiric therapy with ceftriaxone, ganciclovir, voriconazole, pyrimethamine, and sulfadiazine...She was started on doxycycline and rifampin and discharged home...We encourage evaluation for Bartonella infection if standard infectious workup is negative and there is no improvement with empiric treatment. Prompt diagnosis is important as treatment can improve morbidity and mortality.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche, inactivated SARS-CoV-2 Vaccine / Chinese Academy of Medical Sciences
Retrospective data, Journal: Posner-Schlossman syndrome relapse following inactivated COVID-19 vaccination in China. (Pubmed Central) - Jan 31, 2023
More frequent relapses and harder control of IOP were found in PSS relapse following COVID-19 vaccination. Ophthalmologists need to be aware of the group vulnerability and take precautions, though the pathogenesis is still under investigation.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche, TPOXX (tecovirimat) / SIGA Technologies
Journal: Corneal Ulcer due to Monkeypox Infection. (Pubmed Central) - Dec 13, 2022
Oral tecovirimat 600 mg was administered during 14 days...This is an uncommon case report of epithelial keratitis due to human monkeypox. PCR positivity for monkeypox in the corneal epithelium confirmed the presence of viral material in the cornea.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Journal: Presumed cytomegalovirus retinitis late after kidney transplant. (Pubmed Central) - Sep 30, 2022
CMV retinitis is one of the most serious ocular complications in immune-suppressed individuals and can lead to irreversible blindness, and because of that, early diagnosis and treatment remains crucial in obtaining the best visual prognosis in affected patients. Secondary prophylaxis with ganciclovir is not consensual, neither is the safety of reintroducing the antimetabolite in these cases.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Journal: COVID-19 infection with keratitis as the first clinical manifestation. (Pubmed Central) - Sep 22, 2022
A new type of keratitis, atypical keratitis, is a clinical manifestation of COVID-19, and this clinical manifestation could appear 3d earlier than fever and cough. The earlier a COVID-19 clinical manifestation is identified, the earlier can a patient be directed to stay at home, and significantly fewer people would be infected.
- |||||||||| A RARE CASE OF PNEUMONIA BY CONCURRENT PNEUMOCYSTIS JIROVECI AND CYTOMEGALOVIRUS INFECTIONS (Convention Center Exhibit Hall: Rapid Area 4D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4196;
Patients with underlying immuncompromise conditions are at risk of many infections with grave morbidity and mortality risks. Though it is a rare to have a concurrent CMV and PCP lung infection, a patient treated with immunomodulating medications including methotrexate, prednisone and rituximab was a culprit for severe infection.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Journal: Clinical Features of Glaucoma Associated with Cytomegalovirus Corneal Endotheliitis. (Pubmed Central) - Aug 27, 2022
Although medical therapy, including 0.5% topical GCV, had efficacy in lowering the intraocular pressure, one-half of the cases required glaucoma surgery. Therefore, ophthalmologists should strive to make an earlier diagnosis of CMV corneal endotheliitis by utilizing PCR testing of aqueous humor samples to prevent sight-threatening glaucomatous damage.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
Journal: Coin-shaped corneal endothelial scar in herpes zoster ophthalmicus: a case report. (Pubmed Central) - Mar 24, 2022
www.chictr.org.cn, identifier: ChiCTR1900022340, Date: 2019/04/06. In patients with a history of facial herpes zoster with coin-shaped corneal endothelial scar accompanying recurrent anterior uveitis, suspicion for active varicella-zoster virus is warranted, and prolonged intake of oral antiviral agents is required despite varicella-zoster virus DNA not being detected in aqueous humor.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
Journal: Genetic diversity of healthcare-associated methicillin-resistant Staphylococcus aureus isolates from Southern Iran. (Pubmed Central) - Mar 8, 2022
The MRSA isolates had the highest resistance to penicillin (100%), tetracycline (88%), levofloxacin (86%), ciprofloxacin (84%), erythromycin (82%), gentamicin (80%), and clindamycin (78%)...The rapid and timely detection of MRSA and the administration of appropriate antibiotics according to the published antibiotic resistance patterns are essential. Furthermore, the continuous and nationwide MRSA surveillance studies are necessary to investigate clonal distribution and spreading of MRSA from community to hospitals.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe
Journal: Bilateral cytomegalovirus retinitis as the presenting feature of Dyskeratosis Congenita. (Pubmed Central) - Mar 5, 2022
CMVR in non-HIV individuals should be considered as a harbinger of systemic immunosuppressive conditions. Ophthalmologists may be the first ones to suspect and diagnose congenital immunosuppressive disorders like Dyskeratosis Congenita in these patients.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Clinical, Journal: The Treatment Models for Adenoviral Keratoconjunctivitis in the Childhood Population. (Pubmed Central) - Feb 26, 2022
Conjunctival irrigation with 2.5% PVP-I is very effective for the treatment of adenoviral conjunctivitis in childhood. Ganciclovir ophthalmic gel 0.15% increases the effect of 2.5% PVP-I on AK, but this was not statistically significant.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
Journal: Haemophilus Influenzae Endogenous Endophthalmitis in an Immunocompetent Host. (Pubmed Central) - Feb 26, 2022
Pediatric endogenous bacterial endophthalmitis is a rare but potentially devastating infection which is often misdiagnosed. Moreover, we want to highlight the importance of an adequate clinical suspicion in cases of H. influenzae to prevent the serious complications seen in this report.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
A Case of Necrotizing Sarcoid Granulomatosis (Area I, Hall F (North Building, Exhibition Level), Moscone Center) - Feb 19, 2022 - Abstract #ATS2022ATS_2555;
NSG’s definite diagnosis requires excluding a malignant, infectious, or autoimmune process that may also present with granuloma. NSG holds a favorable prognosis with a good response to steroid treatment
- |||||||||| thioguanine / Generic mfg.
Journal: 6-Thioguanine Inhibits Herpes Simplex Virus 1 Infection of Eyes. (Pubmed Central) - Feb 9, 2022
In addition, we also documented that Rac1 is highly expressed in corneal tissues from HSK patients, indicating that Rac1 is associated with HSK pathogenesis. In view of the high potency of 6-TG, low cytotoxicity, targeting a distinct therapeutic target, we suggest that 6-TG is a potential candidate for development as a therapeutic agent for HSK therapy.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
UNUSUAL HERPES: A DIFFERENT KIND OF PRESENTATION () - Feb 8, 2022 - Abstract #ESCRSWM2022ESCRS_WM_563;
HSV infections are very prevalent, and, as Ophthalmologists, we must all be aware of ocular manifestations, as there are many (to periocular vesicles to dendritic epithelial keratitis). Sometimes, some unusual forms may appear (as the one we described), and we must stay alert to this, so we can treat the patients on time, and in the best possible way.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories
Clinical, Journal: ENDOGENOUS ASPERGILLUS ENDOPHTHALMITIS IN AN IMMUNOCOMPETENT PATIENT WITH A REMOTE HISTORY OF PULMONARY TUBERCULOSIS. (Pubmed Central) - Dec 29, 2021
Sometimes, some unusual forms may appear (as the one we described), and we must stay alert to this, so we can treat the patients on time, and in the best possible way. To the best of our knowledge, this is the first reported case of Aspergillus endogenous endophthalmitis in an immunocompetent patient secondary to pulmonary changes that occurred from previously treated tuberculosis.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Clinical, Journal: Acute retinal necrosis with exudative retinal detachment in a child. (Pubmed Central) - Dec 17, 2021
In addition, she also received intravitreal ganciclovir 4 mg/0.1 mL three times under general anaesthesia. At her last follow-up, 3 years from her presentation, her right eye examination was within normal limits, and left eye showed thick vitreous bands with a posterior vitreous detachment, and left inferotemporal retinal scarring.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Pancytopenia with multiple opportunistic infections in a lupus patient () - Nov 7, 2021 - Abstract #APLAR2021APLAR_766;
She received pulse intravenous (IV) methylprednisolone for presumed haematological flare followed by prednisolone 40 mg daily...She was treated with multiple antibiotics (Levofloxacin, Azithromycin, IV Imipenem and Amikacin for atypical Mycobacterium), anti-tuberculous medications (ethambutol, isoniazid, rifampicin and pyrazinamide), antifungal (amphotericin B, followed by itraconazole and later fluconazole) and anti-viral (ganciclovir) agents...Her prednisolone dose was tapered to 5 mg daily and subsequently converted to replacement hydrocortisone. Opportunistic infections should be considered as a potential cause of pancytopenia especially in lupus patients.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Cytovene (ganciclovir) / Roche
Journal: Reactivation of herpes simplex keratitis following vaccination for COVID-19. (Pubmed Central) - Sep 9, 2021
A diagnosis of herpetic stromal keratitis was made, requiring systemic aciclovir, topical prednisolone, moxifloxacin and atropine, and oral doxycycline...Clearly, public and personal health benefits from vaccination are hugely important and we would not suggest avoiding vaccination in such patients. It is, however, important for ophthalmic providers to be aware of the rare potential for reactivation of herpetic eye disease following vaccination to enable prompt diagnosis and treatment.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
Central Retinal Vein Occlusion in the Setting of Severe Ulcerative Colitis (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1204;
He completed a four-week course of oral valganciclovir with negative viral load and was initiated on infliximab...Given the worsening retina exam he was started on therapeutic anticoagulation with rivaroxaban per hematology...However, in our case the patient responded well to systemic steroids and anticoagulation. When concerning findings arise, being aware of the extent of ophthalmologic manifestations of IBD is important to ensure a prompt evaluation.
- |||||||||| Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe
Journal: Cytomegalovirus Endotheliitis After Penetrating Keratoplasty. (Pubmed Central) - Sep 3, 2021
It should be kept in mind that local or systemic immunosuppressants used after keratoplasty may trigger CMV reactivation. Anti-CMV treatment should be initiated immediately in patients with coin-shaped keratic precipitates.
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