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- albendazole / Generic mfg.
SYNERGISTIC DRUG INSIGHTS: LEVERAGING KNOWLEDGE GRAPHS IN ALZHEIMER DRUG REPURPOSING () - Mar 10, 2025 - Abstract #ADPD2025ADPD_1613;
We provide researchers with a powerful resource for repurposing clinically approved drugs for AD. Utilizing more specialized knowledge graphs and diverse drug combination datasets will aid in repurposing more drugs for the better management of AD.
- || ivermectin oral / Generic mfg., albendazole / Generic mfg.
Clinical, Journal: Impact of mass drug administration with ivermectin, diethylcarbamazine, and albendazole for lymphatic filariasis on hookworm and Strongyloides stercoralis infections in Papua New Guinea. (Pubmed Central) - Mar 10, 2025
Utilizing more specialized knowledge graphs and diverse drug combination datasets will aid in repurposing more drugs for the better management of AD. MDA with IDA was more effective than DA for reducing hookworm and Strongyloides infections in PNG, extending the benefit of MDA with IDA beyond its effect on LF.
- | ceftriaxone / Generic mfg., albendazole / Generic mfg.
Journal: Treatment of a rare and severe infection of central nervous system by Angiostrongylus cantonensis: A case report. (Pubmed Central) - Mar 10, 2025
MDA with IDA was more effective than DA for reducing hookworm and Strongyloides infections in PNG, extending the benefit of MDA with IDA beyond its effect on LF. This case highlights the diagnostic challenges of Angiostrongylus cantonensis infection and the importance of advanced sequencing techniques in identifying rare pathogens.
- | albendazole / Generic mfg.
Journal: Environment-like exposure of free-living stages of Haemonchus contortus to albendazole: The intra- and intergeneration stability of altered expression of UDP-glycosyl transferases and ABC-transporters. (Pubmed Central) - Mar 9, 2025
Interestingly, ABZs-induced changes in the expression of some genes became apparent only in the second generation of L3. Taking together, contact of free-living stages of H. contortus with traces of ABZs in the environment evokes changes in the expression of certain UGTs and Pgps, with some of these changes being intra- and inter-generation stable.
- | albendazole / Generic mfg.
Journal: Orbital and medial rectus muscle involvement as initial presentations of hydatid disease. (Pubmed Central) - Mar 7, 2025
Orbital hydatid cysts may present as inflammatory proptosis and should be considered in populations from endemic areas of human echinococcosis. Early diagnosis using orbital MRI, systemic investigations such as liver sonography, timely surgery for definitive diagnosis and treatment, and appropriate adjuvant antiparasitic medication are crucial for effective management.
- | albendazole / Generic mfg.
Biomarker, Journal: Comparative analysis of anthelmintic treatments: impact on liver biomarkers and clinical recovery in sheep with fasciolosis. (Pubmed Central) - Mar 7, 2025
Despite the widely use of Triclabendazole (TCBZ), Tetraclozan (TETRA), and Albendazole (ALBE) for treating fasciolosis, their effectiveness remains a significant concern...TCBZ and TETRA were highly effective against ovine fasciolosis, with TETRA recommended if TCBZ is unavailable. Biochemical parameters are key biomarkers for liver damage and selecting effective anthelmintic drugs.
- | dexamethasone / Generic mfg., albendazole / Generic mfg., praziquantel / Generic mfg.
Journal: Racemose Neurocysticercosis Presenting As Vasculitic Infarct and Obstructive Hydrocephalus: A Rare Presentation. (Pubmed Central) - Mar 6, 2025
Prompt treatment using antiparasitic agents and steroids can play a pivotal role in facilitating recovery and minimizing complications. Recognizing racemose NCC as a potential cause of stroke and hydrocephalus in endemic areas is vital for early intervention and enhanced patient outcomes.
- | albendazole / Generic mfg.
Journal: Combined morphological and molecular approaches to the clinical diagnosis of Necator americanus infection: a case report. (Pubmed Central) - Mar 6, 2025
In this study, a combination of morphological and molecular approaches were used to make a definite diagnosis of severe iron deficiency anemia caused by Necator americanus infection in a patient. The results presented here provide suitable guidance for the clinical diagnosis of hookworm infection and a powerful tool for the identification of hookworms.
- | albendazole / Generic mfg.
Journal: Primary hydatid cyst of skeletal muscle: A rare clinical entity. (Pubmed Central) - Mar 6, 2025
Although rare, muscular hydatid cysts should be considered in the differential diagnosis of soft tissue swellings, particularly in endemic regions. Early recognition and appropriate management prevent complications and improve patient outcomes.
- | albendazole / Generic mfg.
Journal: Uncommon Presentation of a Pulmonary Hydatid Cyst: A Case Report. (Pubmed Central) - Mar 5, 2025
The patient was discharged in stable condition with four and a half months of albendazole therapy and a pulmonologist follow-up plan. This report highlights the diagnostic challenges, clinical course, and surgical management of a ruptured pulmonary hydatid cyst.
- | ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: Recurrence of microfilaraemia after triple-drug therapy for lymphatic filariasis in Samoa: recrudescence or reinfection? (Pubmed Central) - Mar 3, 2025
One or two doses of directly observed IDA was not sufficient for sustained clearance of Wuchereria bancrofti Mf in Samoa. The high Mf prevalence in treated individuals compared to household members suggests recrudescence rather than reinfection.
- | albendazole / Generic mfg.
Preclinical, Journal: The Nematocidal Effect of Leiurus quinquestratus Scorpion Venom on Toxocara canis in Mice Model. (Pubmed Central) - Mar 3, 2025
Also, improved the liver transaminases activity, and ameliorated liver and brain architecture. Collectively, LQV may be a promising treatment for T. canis infection and albendazole alternative.
- | albendazole / Generic mfg.
Journal: Quercetin-loaded solid lipid nanoparticles for enhanced anti-helminthic activity. (Pubmed Central) - Mar 2, 2025
Liver histology and biochemical analysis of blood plasma and liver homogenate showed no toxic effects of quercetin and SLN-Qt. Therefore, SLN-Qt presents a promising strategy for delivering poorly soluble drugs and could be a valuable tool in controlling parasitic infections and diseases.
- | niclosamide / Generic mfg., albendazole / Generic mfg.
Journal: Efficacy of Anthelmintics Against Canine Hookworm Infections in the Bono East Region of Ghana. (Pubmed Central) - Feb 28, 2025
The findings emphasize the importance of regular monitoring and treatment of hookworm infections to improve the overall health and well-being of dogs in the region. Herein, we report for the first time on reduced efficacy of albendazole and pyrantel against dog-related hookworms in Ghana.
- | albendazole / Generic mfg.
Journal: Optimisation of albendazole delivery and assessment of anticancer potential in hepatocellular carcinoma (HepG2 cells) using surface modified nanostructured lipid carriers. (Pubmed Central) - Feb 27, 2025
The cytotoxicity assays revealed that ABZ-CS-NLCs were more effective than uncoated NLCs and free ABZ, with an IC50 value of 8.89??M in HepG2 cells. Overall, ABZ-CS-NLCs demonstrate a promising and effective delivery platform for targeted hepatic cancer therapy.
- | albendazole / Generic mfg.
Journal: A comparative analysis of ultrasound and serology for the diagnosis and post-treatment monitoring of cystic echinococcosis in experimentally infected sheep. (Pubmed Central) - Feb 25, 2025
Seropositivity was detected in a sheep with PPHCFA and another sheep with rEgPmy5 from the seventh day of experimental infection and remained detectable till death. In conclusion, albendazole can induce deformation in hydatid cysts as early as the first week of treatment and PPHCF antigen can be used for serological monitoring of the sheep population.
- | albendazole / Generic mfg.
Journal: Eosinophilia and IgE Elevation: An Uncommon Toxocara Infection. (Pubmed Central) - Feb 25, 2025
In conclusion, albendazole can induce deformation in hydatid cysts as early as the first week of treatment and PPHCF antigen can be used for serological monitoring of the sheep population. After initiating antiparasitic treatment with albendazole, the patient showed a gradual normalization of eosinophil counts and IgE levels...In this case, the patient had no symptoms
- | albendazole / Generic mfg.
Journal: Safety and effectiveness of triple-drug therapy with ivermectin, diethylcarbamazine, and albendazole in reducing lymphatic filariasis prevalence and clearing circulating filarial antigens in Mombasa, Kenya. (Pubmed Central) - Feb 25, 2025
The high incidence of AEs highlights the need for safety monitoring during MDA. The significant reductions in LF antigenemia prevalence and high CFA clearance rates underscore IDA's effectiveness in reducing LF transmission, positioning it as a key strategy for eliminating LF as a public health problem by 2030.
- | albendazole / Generic mfg.
Journal: Inverse Duane's retraction syndrome: rare presentation of orbital myocysticercosis. (Pubmed Central) - Feb 24, 2025
All 3 patients were treated with oral albendazole with resolution of the cyst on follow up imaging and improvement in clinical findings...Diagnosis relies on high clinical suspicion and imaging such as ultrasound B scan, MRI, or CT, which can reveal the cyst and scolex within the muscle. Relative rarity of this presentation of myocysticercosis as inverse Duane's retraction syndrome makes it imperative for clinicians to be aware of this entity to clinch the diagnosis early and initiate prompt treatment.
- | albendazole / Generic mfg.
Journal: Impact of albendazole treatment on the symptom profile of neurocysticercosis patients 14-16 years following diagnosis. (Pubmed Central) - Feb 24, 2025
Relative rarity of this presentation of myocysticercosis as inverse Duane's retraction syndrome makes it imperative for clinicians to be aware of this entity to clinch the diagnosis early and initiate prompt treatment. No abstract available
- | albendazole / Generic mfg., praziquantel / Generic mfg.
Journal: Bibliometric analysis of neurocysticercosis case reports and evaluation of presented cases. (Pubmed Central) - Feb 23, 2025
No abstract available Albendazole was used in 174 (54.5
- || mebendazole / Generic mfg., albendazole / Generic mfg.
Review, Journal: Rare presentation of Echinococcal Disease: A Systematic Review on Arterial Hydatid Cyst. (Pubmed Central) - Feb 23, 2025
Arterial echinococcosis is an extremely rare condition that may potentially be lethal. The current review showed favorable outcomes following complete surgical excision and antiparasitic drug that currently remain the only definitive treatment.
- | albendazole / Generic mfg.
Journal: Neurosurgical Approach to Neurocysticercosis in Adults: A Comprehensive Systematic Review of Clinical and Imaging Insights. (Pubmed Central) - Feb 21, 2025
Limitations of this study include its retrospective nature and low sample sizes of individual studies. The prominence of corticosteroids, albendazole, and surgical procedures highlights their central role in NCC management, as well as the indispensable role of neurosurgeons.
- || ivermectin topical / Generic mfg.
Review, Journal: Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions. (Pubmed Central) - Feb 20, 2025
The prominence of corticosteroids, albendazole, and surgical procedures highlights their central role in NCC management, as well as the indispensable role of neurosurgeons. Despite low bioavailability, many benzimidazoles
- | albendazole / Generic mfg.
Journal: Alveolar echinococcosis in the canton of Geneva between 2010 and 2021: a descriptive analysis. (Pubmed Central) - Feb 20, 2025
The establishment of mandatory reporting of this disease in Switzerland would allow monitoring of its epidemiological evolution. Primary and secondary prevention measures, currently non-existent, could potentially lower the incidence and severity of the disease.
- | zosuquidar (LY335979) / Kanisa Pharma, monepantel (NUZ-001) / Neurizon Therapeutics
Preclinical, Journal: In vitro analysis of the activities of commercial anthelmintics in the presence of inhibitors of xenobiotic detoxification pathways in Haemonchus contortus exsheathed L3 stage. (Pubmed Central) - Feb 20, 2025
The inhibitors used were piperonyl butoxide (PBO) for phase I metabolism, 5-nitrouracil (5-NU) for phase II metabolism, and zosuquidar (ZOS) inhibiting efflux transport proteins...The use of inhibitors of xenobiotic detoxification pathways led to significant changes in the in vitro activity of the anthelmintics evaluated in H. contortus xL3 stage. Further studies, as ex vivo parasite diffusion assays in the xL3 stage, should be conducted to directly assess the impact on detoxification pathways.
- | albendazole / Generic mfg.
Journal: A potential therapeutic effect of sea cucumber Holothuria polii extract during the intestinal phase of experimental trichinellosis. (Pubmed Central) - Feb 20, 2025
Albendazole (ABZ) is the main clinical treatment for trichinellosis but has some adverse effects and drug resistance...The ameliorating effect of HPE could be due to its total antioxidant capacity content and the presence of natural anti-inflammatory and antioxidant agents like saponins, phenolics, alkaloids, and flavonoids. In conclusion, HPE has a multifaceted, effective impact on trichinellosis and can be considered an ABZ-promising complementary treatment.
- | albendazole / Generic mfg.
Journal: Albendazole resistance evidence in Teladorsagia circumcincta in Iranian sheep by allele-specific PCR. (Pubmed Central) - Feb 20, 2025
Molecularly, the frequency of resistant alleles to Alb in examined T. circumcincta was 48.3%, i.e. 51.7% homozygous susceptible (SS), 6.9% homozygous resistant (rr) and 41.4% heterozygous susceptible (Sr). It was concluded that Alb-resistance alleles were increasingly widespread in examined T. circumcincta, therefore prevention and control program should be lunched in the region.
- | albendazole / Generic mfg.
Journal: Investigating therapeutic efficacy of silymarin on intestinal and muscular phases of trichinellosis: an experimental study. (Pubmed Central) - Feb 20, 2025
Also, vascular endothelial growth factor immunoreactivity was significantly reduced in both silymarin, and albendazole-treated groups compared to the diseased model. Silymarin recorded antiparasitic, anti-inflammatory, and antiangiogenic effects on experimental trichinellosis.
- || emodepside (BAY 44-4400) / Bayer
Clinical, Journal, Polymerase Chain Reaction: Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials. (Pubmed Central) - Feb 18, 2025
Our study confirmed that qPCR is a sensitive diagnostic method for diagnosing STH infections compared to Kato-Katz and serves as a valuable tool for determining treatment efficacy in clinical trials. Furthermore, qPCR confirmed the better treatment efficacy of emodepside compared to albendazole, despite indicating lower cure rates than Kato-Katz.
- | albendazole / Generic mfg.
Journal: Case Report: Hymenolepis diminuta in an asymptomatic Ecuadorian child. (Pubmed Central) - Feb 14, 2025
After receiving treatment with Albendazole suspension 400mg/20mL, on the 10th day post-treatment, he showed no H. diminuta eggs in his fecal matter. Detailed morphological review of Hymenolepis nana-like eggs is recommended to distinguish them from H. diminuta eggs.
- || albendazole / Generic mfg.
Review, Journal: Cystic Echinococcus of the Liver. (Pubmed Central) - Feb 13, 2025
Detailed morphological review of Hymenolepis nana-like eggs is recommended to distinguish them from H. diminuta eggs. Hepatic echinococcal cysts, which are relatively rare in North America, should be considered in the differential diagnosis of hepatic cysts, especially in individuals with risk factors.
- | albendazole / Generic mfg., praziquantel / Generic mfg.
Journal: A new human opisthorchiasis outbreak in central Italy: a never-ending story. (Pubmed Central) - Feb 13, 2025
Albendazole may lead to treatment failure. Control measures in known endemic areas should be implemented.
- | albendazole / Generic mfg.
Journal: Giardiasis: Report of a Case Refractory to Treatment. (Pubmed Central) - Feb 11, 2025
A 32-year-old male presented with chronic symptoms of watery diarrhea, abdominal pain, and significant weight loss, despite multiple rounds of standard therapies, including metronidazole and albendazole...This case emphasizes the need for ongoing monitoring of treatment-refractory giardiasis and calls for further study of resistant strains. It also provides an effective approach for managing cases of treatment-resistant giardiasis.
- | Journal: Spatial occurrence of emerging contaminants in rivers and wastewater. Analysis of environmental and human risks. (Pubmed Central) - Feb 7, 2025
This work underscores the critical need for monitoring and regulating ECs in aquatic environments. Further studies are necessary to fully understand their impact and to develop effective strategies for mitigating their presence in water systems.
- || albendazole / Generic mfg.
Clinical, Retrospective data, Journal: Correlation between imaging features and rEm18 antibodies in alveolar echinococcosis: results from a multicenter study in France. (Pubmed Central) - Feb 7, 2025
P=N/A
Maximum lesion size, percentage of microcysts within the lesion, and maximum lesion SUV are significant imaging features of AE correlated with the rEm18AB index. Serologic response at 2
- || albendazole / Generic mfg.
Review, Journal: Presentation and management of pancreatic hydatid cyst: A comprehensive systematic review of the literature with meta-data. (Pubmed Central) - Feb 6, 2025
Although pancreatic hydatid cysts are rare and can be challenging to diagnose, their prognosis is generally favorable when appropriate therapeutic measures are employed. Surgical intervention, often combined with Albendazole, remains the mainstay of treatment.
- | ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: Alternative approaches for monitoring and evaluation of lymphatic filariasis following mass drug treatment with ivermectin, diethylcarbamazine and albendazole in East New Britain Province, Papua New Guinea. (Pubmed Central) - Feb 5, 2025
P
A single round of high-coverage MDA with IDA achieved elimination targets in low-prevalence villages in PNG. Higher-prevalence areas will need additional MDA rounds, which could be targeted to smaller evaluation units to cut costs.
- | mebendazole / Generic mfg., albendazole / Generic mfg.
Journal: Diversity and Prevalence of Helminths and Protozoa Among Pregnant Women in Tropical Ecuador: Implications for Chemotherapy. (Pubmed Central) - Feb 5, 2025
Six protozoan pathogens were detected, including Entamoeba histolytica/dispar (23%), Giardia intestinalis (5%), and Balantidium coli, along with nine protozoa that are nonpathogenic or of debated pathogenicity. The high infection burden and diversity of intestinal parasites found in this study highlight a need to revise strategies for preventing and treating intestinal parasitic infections in pregnant women.
- | albendazole / Generic mfg.
Journal: Hepatotoxicity due to albendazole: safe alternatives for echinococcosis therapy (Pubmed Central) - Feb 5, 2025
In these cases, albendazole therapy is the first-choice treatment. We present a
- | albendazole / Generic mfg.
Journal: Acute peritonitis secondary to spontaneous rupture of hepatic hydatid cyst: A case report and literature review. (Pubmed Central) - Feb 5, 2025
Postoperatively, the patient developed a transient biliary fistula but recovered well with albendazole therapy to prevent recurrence...The case underscores the importance of considering hydatid disease in acute abdomen diagnoses in endemic regions and highlights the critical role of imaging and timely surgical intervention. The literature review indicates variability in the prevalence of cyst rupture and emphasizes the need for a comprehensive approach combining surgery and antiparasitic treatment for effective management and recurrence prevention.
- | albendazole / Generic mfg.
Journal: Changes in circulating filarial antigen status in previously positive individuals: Lessons for treatment monitoring and pre-transmission assessment surveys. (Pubmed Central) - Feb 4, 2025
The FTS is a more sensitive diagnostic tool that plausibly detects residual CFA in blood. The impact and influence of time as compared to additional ivermectin/Albendazole intake, on CFA seroreversion in this study was significant (p < 0.001).
- | albendazole / Generic mfg.
Journal: Ascaris lumbricoides Emerging from a PleurX Draining Catheter: An Unexpected Diagnosis. (Pubmed Central) - Jan 30, 2025
She received 400?mg of albendazole. Our case describes a rare clinical situation of pleural ascariasis, emphasizing the importance of remaining aware of this rare complication of ascariasis.
- | ivermectin oral / Generic mfg.
Journal: A combined treatment regimen for Trichuris rhinopiptheroxella infection in Rhinopithecus roxellana in southern China. (Pubmed Central) - Jan 27, 2025
The initial administration of albendazole to 15 monkeys resulted in a reduction of fecal eggs per gram (EPG) by 7.8%-73.2%...Additionally, 2 monkeys demonstrated a negative EPG after one month. This study provides evidence for the control of Trichuris infection in R. roxellana and offers a guideline for the treatment of trichuriasis in animals.
- | albendazole / Generic mfg.
Journal: Outcome Assessment of the implementation of Mass Drug Administration against Lymphatic Filariasis, in Kalaburagi (Gulbarga) District of Karnataka state: A Cross Sectional Survey. (Pubmed Central) - Jan 14, 2025
Mass Drug Administration (MDA) of Di-Ethyl Carbamazine and Albendazole is an effective strategy recommended by the World Health Organization to prevent transmission and eliminate lymphatic filariasis...The coverage of MDA varied from 90.33% in Heerapur in Kalaburagi Urban to 97.87% in Mogala thanda (Chittapur Taluk). MDA Coverage against Lymphatic Filariasis has improved when compared to previous reported studies carried out and it has also exceeded the coverage threshold as determined by programme for elimination of Lymphatic Filariasis.
- | albendazole / Generic mfg., tetracycline / Generic mfg.
Journal: Investigating drug residues in Mongolian milk using a newly developed method with high performance liquid chromatography and a photo diode array. (Pubmed Central) - Jan 13, 2025
To the best of our knowledge, this is the first report about drug residues in milk published in an international journal by a Mongolian domestic institution. Further investigations of drug residue in Mongolia are urgently needed.
- | albendazole / Generic mfg.
Journal: Prevalence, intensity and risk factors of soil-transmitted helminthiasis after five effective rounds of preventive chemotherapy across three implementation units in Ondo State, Nigeria. (Pubmed Central) - Jan 12, 2025
These findings demonstrate significant progress in reducing STH prevalence across the three IUs following PC interventions. However, the data underscores the need for enhanced efforts to improve access to and use of WASH facilities to achieve STH elimination.
- | albendazole / Generic mfg.
Journal: Microsporidiosis in Patients with Autoimmune Diseases Undergoing Monoclonal Antibody Associated Therapy. (Pubmed Central) - Jan 12, 2025
In conclusion, microsporidia infection occurs in patients with autoimmune diseases undergoing prolonged monoclonal antibody therapies. Diagnosis should be carefully assessed in this population and a thorough benefit-risk analysis is essential prior to initiating therapeutic interventions.
- | albendazole / Generic mfg.
Journal: Tea Saponins: a Novel Stabilizer for Enhancing the Oral Bioavailability of Albendazole Nanocrystals. (Pubmed Central) - Jan 12, 2025
Furthermore, pharmacokinetic studies revealed that the nanocrystals significantly enhanced oral bioavailability, resulting in a 4.65-fold increase in plasma AUC0-t value of albendazole sulfoxide (the primary active metabolite of albendazole) compared to the albendazole group. The present data indicates that tea saponins are potential natural stabilizers for preparing nanocrystals with enhanced oral bioavailability for insoluble drugs.
- | albendazole / Generic mfg.
Journal: The first case of alveolar echinococcosis from southern Croatia: progressive course of the disease in an immunocompromised patient. (Pubmed Central) - Jan 12, 2025
Therefore, conservative treatment with albendazole was started and the existing immunosuppressive therapy was modulated...Clinicians should be aware of this emerging parasitic disease, especially in immunocompromised patients, because every delay in reaching the diagnosis seriously hampers therapeutic efficacy. Better therapeutic options and standardized guidelines on the modulation of immunosuppressive therapy in these patients are highly needed.