 |
0 Diseases |  |
25 Trials |
|
25 Trials |  |
2418 News |  |
| «12...30313233343536373839404142» |
- || albendazole / Generic mfg.
Clinical, Journal: Efficacy of albendazole ointment on cutaneous larva migrans in a 2 years child. (Pubmed Central) - Jan 4, 2020
No abstract available
- | Decadron (dexamethasone) / Merck (MSD), Trileptal (oxcarbazepine) / Novartis
Journal: Abdominal epilepsia partialis continua in neurocysticercosis. (Pubmed Central) - Jan 4, 2020
The involvement of the primary motor cortex during ictal propagation may account for this curious phenomenon. This is the first report of abdominal EPC in a patient with inflammatory granuloma as a result of neurocysticercosis.
- ||||| albendazole / Generic mfg.
Clinical: 3/ EGD was ordered. Duodenal fluid was taken for diagnosis. Diagnosis: Strongyloides stercoralis 📸📽️ Ivermectin and albendazole 💊💊 were started. Patient regained weight progressively and eosinophilia resolved. (Twitter) - Jan 2, 2020
- || albendazole / Generic mfg.
Clinical, Journal: An Imported Case of Disseminated Echinococcosis in Korea. (Pubmed Central) - Jan 2, 2020
He is now on prolonged albendazole treatment (400 mg twice a day) with gradual clinical and radiological improvement. A high index of suspicion is warranted to early diagnose echinococcosis in a patient with a travel history to endemic areas of echinococcosis.
- | albendazole / Generic mfg., Thelmox (mebendazole) / Remedica
Journal: Sustained preventive chemotherapy for soil-transmitted helminthiases leads to reduction in prevalence and anthelminthic tablets required. (Pubmed Central) - Jan 2, 2020
In this study, the data show that nine countries should adapt their PC strategies and the frequency of PC rounds to yield a 36% reduction in drug needs. The study also highlights the importance of impact assessment surveys to adapt control strategies according to STH prevalence.
- || Decadron (dexamethasone) / Merck (MSD)
Clinical, Journal: A curious case of disseminated cysticercosis in an immunocompetent adult. (Pubmed Central) - Jan 1, 2020
Mandatory reporting of diagnosis would enable complete understanding of epidemiology of the disease. In this case we have emphasized the importance of early diagnosis of a systemic condition that could have caused serious implications if left untreated.
- | albendazole / Generic mfg.
Journal: Formulation development of chewable albendazole tablets with improved dissolution rate. (Pubmed Central) - Jan 1, 2020
The formulation was comparable to the reference product on the market with similarity factor (f2) 62 and difference factor (f1) of 6 at pH1.2. A new generic albendazole tablet with improved dissolution rate was formulated, developed and optimized by using a wet granulation method.
- || albendazole / Generic mfg.
Clinical, Observational data, Journal: Persistent eosinophilia in rheumatoid arthritis: a prospective observational study. (Pubmed Central) - Jan 1, 2020
Patients with a definite parasitic infestation received targeted therapy, and the rest were treated with albendazole empirically...Eosinophilia is due to secondary causes in the majority of RA patients, and the most common cause in our setting is an intestinal helminthic infection. Persistent eosinophilia in our cohort of RA did not indicate a more severe disease phenotype.
- || albendazole / Generic mfg.
Review, Journal: Diffuse unilateral subacute neuroretinitis: review article. (Pubmed Central) - Dec 30, 2019
Due to the possibility of this disease being, in part, autoimmune nematode retinopathy, corticosteroids associated with both albendazole or laser therapy, could be in any way beneficial. Thus, further comparative studies are necessary to elucidate the best treatment for this potentially blinding disease.
- || albendazole / Generic mfg.
Clinical, Journal: Co-infection with Strongyloides stercoralis hyperinfection syndrome and Klebsiella in a nephrotic syndrome patient: A case report. (Pubmed Central) - Dec 27, 2019
It is essential to consider the possibility of S stercoralis infection in immunosuppressed patients with nephrotic syndrome. Given the lack of classic manifestations and high mortality rate of advanced disease, continuous monitoring, early diagnosis, and proper treatment are imperative.
- | albendazole / Generic mfg.
Clinical, Journal: A Case of Toxocariasis Suspected of having Infiltrated Directly from the Liver to the Lung through the Diaphragm. (Pubmed Central) - Dec 26, 2019
After treatment with albendazole, the liver and lung nodules disappeared. We suspect that larvae had directly invaded the lung from the liver, through the diaphragm.
- || albendazole / Generic mfg.
Clinical, Journal: Efficacy of High-Dose Albendazole with Ivermectin for Treating Imported Loiasis, Italy. (Pubmed Central) - Dec 25, 2019
Patients had microfilaremia <20,000/mL and were treated with high-dose albendazole for 28 days and a single dose of ivermectin. This combination might be an effective treatment option in nonendemic areas, when diethylcarbamazine, the drug of choice, is not available.
- | Alinia (nitazoxanide) / Lupin, Romark Lab
Preclinical, Journal: IN VITRO NITAZOXANIDE EXPOSURE AFFECTS ENERGETIC METABOLISM OF TAENIA CRASSICEPS. (Pubmed Central) - Dec 25, 2019
In conclusion, NTZ induced a significant metabolic stress in the parasite indicating that it may be used as an alternative therapeutic choice for cysticercosis treatment. The use of metabolic approaches to establish comparisons between anti parasitic drugs mode of actions is proposed.
- | Decadron (dexamethasone) / Merck (MSD), albendazole / Generic mfg.
Preclinical, Journal: Effect of dexamethasone on albendazole cysticidal activity in experimental cysticercosis by Taenia crassiceps in BALB/c mice: In vitro and in vivo evaluation. (Pubmed Central) - Dec 25, 2019
Corticosteroids are generally used for this purpose and the results of this study demonstrate the need to find other therapeutic strategies. Further studies are needed to better understand the mechanisms involved.
- | albendazole / Generic mfg.
Journal: Non-mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-α upregulation. (Pubmed Central) - Dec 23, 2019
Taken together, our data indicate that ABZ-induced SIRT3 downregulation promotes its microtubule-destabilizing effect, and that the non-mitotic effect of ABZ largely triggers apoptosis of U937 cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-α upregulation. Notably, the same pathway is involved in the ABZ-induced death of HL-60 cells.
- | Preclinical, Journal: In Vitro and in Vivo Effect of MAPK Signal Transduction Pathway Inhibitors on Echinococcus multilocularis. (Pubmed Central) - Dec 23, 2019
All the inhibitors had low toxicity on L02 cells. Inhibitors of the MAPK signal transduction pathway showed significant inhibitory effects on E. multilocularis, suggesting these may be potential candidates for the treatment of alveolar echinococcosis.
- || albendazole / Generic mfg.
Clinical, Journal: DNA Barcoding as a Diagnostic Tool of a Rare Human Parasitosis: The First Case of Lagochilascaris minor in Quintana Roo, Mexico. (Pubmed Central) - Dec 23, 2019
After a radical mastoidectomy and a treatment with 200 mg oral albendazole for 63 days, the patient completely recovered...Future diagnosis of larval and adult stages of L. minor using DNA barcoding will allow the recognition of its infection parameters, transmission, and precise epidemiology. Reports of lagochilascarosis in the Yucatán Peninsula have been occurred over the last decade, suggesting it is an emerging zoonotic disease in the region.
- || albendazole / Generic mfg.
Clinical, Journal: Evaluation of the effect of mass drug administration against lymphatic filariasis in three health districts and public health implications: study of 12 epidemiological surveillance sites in Burkina Faso. (Pubmed Central) - Dec 23, 2019
The implementation of mass drug administration (MDA) campaigns of albendazole (400 mg) and ivermectin (150-200 μm/kg) since 2001 has helped to change the epidemiological profile of lymphatic filariasis (LF) in many health districts in Burkina Faso...The MDA strategy has helped to reduce the prevalence of LF significantly in Burkina Faso, but some outbreaks still have microfilarial prevalence greater than 1%. Continuation of the additional 2-year strategy with improved adherence to treatment and vector control would help break LF transmission.
- albendazole / Generic mfg.
[VIRTUAL] CYSTIC MASS IN THE RIGHT VENTRICLE (eAbstract Virtual Hall) - Dec 22, 2019 - Abstract #ACC2020ACC_6443;
DDX includes infectious, oncogenic, vascular or myocardial origin. The right ventricular cyst location is very rare (10%) compared to left ventricular cyst (60%) with potential risks for complications including pulmonary embolism, anaphylactic shock and dissemination.
- | albendazole / Generic mfg.
Journal: Comparison of the Impact of Annual and Semiannual Mass Drug Administration on Lymphatic Filariasis Prevalence in Flores Island, Indonesia. (Pubmed Central) - Dec 21, 2019
Two villages (Paga, B. timori only; Lewomada, co-endemic) received annual MDA with diethylcarbamazine/albendazole and a larger village (Pruda, co-endemic) received semiannual MDA...We conclude that in this setting, annual MDA was sufficient to reduce Mf prevalence to less than 1% in areas with low to moderate baseline prevalence. Semiannual MDA was useful for rapidly reducing Mf prevalence in an area with higher baseline endemicity.
- | albendazole / Generic mfg.
Journal: Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana. (Pubmed Central) - Dec 20, 2019
A previously unreported association between F200Y and a third resistance-associated SNP, E198A, was identified by sequencing of F200Y amplicons. These data confirm that markers of benzimidazole resistance are circulating among hookworms in central Ghana, with unknown potential to impact the effectiveness and sustainability of chemotherapeutic approaches to disease transmission and control.
- || albendazole / Generic mfg.
Clinical, Journal: Toxocara related peritonitis: A case report and review of literature. (Pubmed Central) - Dec 19, 2019
Here, we present a T. canis related gastroenteritis and peritonitis case successfully treated with albendazole...To our knowledge, this is the first review about non-disseminated toxocariasis that restricted to the intestine and presented as eosinophilic ascites due to peritoneal inflammation. The most common abdominal symptoms were abdominal pain and nausea, and the most common findings were eosinophilic infiltrations on endoscopic biopsy specimens and eosinophilia in the peripheric blood samples.
- | albendazole / Generic mfg.
Journal: Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells. (Pubmed Central) - Dec 19, 2019
In addition, albendazole decreased the colony-forming ability of SCC cells, together with inhibition of Wnt/β-catenin signaling. These results indicate that albendazole shows an antitumor effect via regulation of ER stress and cancer stemness, suggesting that albendazole could be repositioned for cutaneous SCC treatment.
- | albendazole / Generic mfg.
Preclinical, Journal: Bone marrow-derived mesenchymal stem cell (BM-MSC): A tool of cell therapy in hydatid experimentally infected rats. (Pubmed Central) - Dec 19, 2019
This study aimed to clarify the potentiality of bone marrow mesenchymal stem cells (BM-MSC) transplantation with albendazole (ABZ) on the modulation of immune responses against hydatid cyst antigens and the regeneration of injured livers in experimentally infected rats...In addition, it can modulate host protective humeral and cell mediated immune responses against hydatid cyst antigens. Therefore, the current study encourages to move to the step of performing clinical trials in humans.
- || albendazole / Generic mfg.
Clinical, Journal: A case of hydatid cyst in biceps femoris. (Pubmed Central) - Dec 13, 2019
Therefore, the current study encourages to move to the step of performing clinical trials in humans. Hydatid cyst should be considered as differential diagnosis of any growing mass or cyst in the body in the endemic areas.
- | albendazole / Generic mfg.
Journal: Insights from quantitative analysis and mathematical modelling on the proposed WHO 2030 goals for soil-transmitted helminths. (Pubmed Central) - Dec 12, 2019
For T. trichiura, dual therapy with albendazole and ivermectin is required...Moreover, the link between morbidity and infection intensity has not been fully elucidated. By providing more insights on all the above, we aim to inform discussions on the goals and treatment guidelines for STHs.
- | albendazole / Generic mfg., sulfadoxine/pyrimethamine / Generic mfg., azithromycin / Generic mfg.
Trial completion date: Nutritional and Anti-infective Interventions for Malnutrition in Pregnancy (Beleuman Welbodi) (clinicaltrials.gov) - Dec 9, 2019
P=N/A, N=1507, Active, not recruiting, Sponsor: Washington University School of Medicine
By providing more insights on all the above, we aim to inform discussions on the goals and treatment guidelines for STHs. Trial completion date: Dec 2019 --> Mar 2020
- | albendazole / Generic Mfg.
Journal: The Maverick Disease: Cystic Echinococcosis in Unusual Locations: A Ten Year Experience from an Endemic Region. (Pubmed Central) - Dec 8, 2019
The treatment courses employed were a) medical, consisting of oral albendazole use(400 mg twice daily), b) surgical c) combined (medical plus surgical) therapy...Conclusions CE can be challenging to diagnose especially when it occurs in unusual locations. CE must be included in the differential diagnosis of a cystic lesion in any organ of the body, especially in endemic areas, to ensure timely diagnosis and treatment, to prevent morbidity and mortality associated with chronicity of the disease.
- || albendazole / Generic Mfg.
Clinical, Journal: The safety of double- and triple-drug community mass drug administration for lymphatic filariasis: A multicenter, open-label, cluster-randomized study. (Pubmed Central) - Dec 6, 2019
P=N/A
Posttreatment AE rates and severity did not differ significantly after IDA or DA treatment. Thus, results of this study suggest that IDA should be as safe as DA for use as a MDA regimen for LF elimination in areas that currently receive DA.
- | albendazole / Generic Mfg.
Journal: Ultrastructure changes induced by the phloroglucinol derivative agrimol G isolated from Leucosidea sericea in Haemonchus contortus. (Pubmed Central) - Dec 6, 2019
Based on the structural changes induced by AG, together with the absence of an effect in combination with ivermectin and albendazole would suggest a disrupted microtubular network. The latter does however require biochemical confirmation.
- | albendazole / Generic Mfg.
Preclinical, Journal: In vitro ovicidal and larvicidal activity of Carica papaya seed hexane extract against Strongyloides venezuelensis. (Pubmed Central) - Dec 5, 2019
The crude extract at the concentrations of 566 - 0.0566 mg/mL or the control with albendazole (0.025 mg/mL) and negative controls (water and PBS) were incubated with an equal volume of egg suspension (± 50 specimens) followed by counting of the specimens after 48 h. The same extract and dilutions were added to L3 larvae suspensions (±50 specimens) followed by analysis of larvae viability after 24, 48, and 72 h. The extract inhibited egg hatching with high efficiency at concentrations of 56.6 mg/mL (95.74%) and 5.66 mg/mL (92.16%)...The larvicidal effect depended on the extract concentration, but not on the treatment period. Therefore, C. papaya seed hexane extract has anthelmintic potential against S. venezuelensis and is a promising compound for the development of phytotherapies to treat strongyloidiasis.
- | albendazole / Generic mfg.
New P2 trial, Combination therapy: DOLF IDA/Oncho: Safety and Efficacy of IDA for Onchocerciasis (clinicaltrials.gov) - Dec 4, 2019
P2, N=201, Recruiting, Sponsor: Washington University School of Medicine
- | albendazole / Generic Mfg.
Journal: The Effect of Gut Microbiome Composition on Human Immune Responses: An Exploration of Interference by Helminth Infections. (Pubmed Central) - Dec 1, 2019
For 66 subjects from a randomized placebo-controlled trial, stool and blood samples were available at both baseline and 21 months after starting three-monthly albendazole treatment...Trial Registration: ISRCTN, ISRCTN83830814. Registered 27 February 2008 - Retrospectively registered, http://www.isrctn.com/ISRCTN83830814.
- | albendazole / Generic Mfg.
Journal: Autochthonous and persistent cutaneous larva migrans in an infant successfully treated by topic albendazole ointment. (Pubmed Central) - Nov 30, 2019
Herein we report a case of CLM contracted in France by a 10-month-old infant, successfully treated by albendazole ointment after 6 months of evolution. This case emphasizes the fact that Western physicians do not have sufficient knowledge of this dermatitis.
- | albendazole / Generic Mfg., praziquantel (MSC2499550A) / Merck (MSD)
Journal: Analysis of Schistosomiasis and soil-transmitted helminths mixed infections among pupils in Enugu State, Nigeria: Implications for control. (Pubmed Central) - Nov 29, 2019
This case emphasizes the fact that Western physicians do not have sufficient knowledge of this dermatitis. The results from the present study revealed an evident need for the systematic and sustained administration of school-based chemotherapy program targeting the control of STH infection and Schistosomiasis using Albendazole and Praziquantel respectively in the community, instead of a one-off approach that was carried out.
- | albendazole / Generic Mfg.
Journal: Disseminated strongyloidiasis complicated by alveolar hemorrhage, meningitis, and septic shock treated with albendazole and subcutaneous ivermectin. (Pubmed Central) - Nov 29, 2019
The results from the present study revealed an evident need for the systematic and sustained administration of school-based chemotherapy program targeting the control of STH infection and Schistosomiasis using Albendazole and Praziquantel respectively in the community, instead of a one-off approach that was carried out. We presented a patient with disseminated strongyloidiasis post chemotherapy for lymphoblastic lymphoma.
- | albendazole / Generic Mfg.
Clinical, Journal: A cluster-randomised controlled trial comparing school and community-based deworming for soil transmitted helminth control in school-age children: the CoDe-STH trial protocol. (Pubmed Central) - Nov 29, 2019
We presented a patient with disseminated strongyloidiasis post chemotherapy for lymphoblastic lymphoma. The first large-scale trial comparing mass and targeted deworming for STH control in South East Asia will provide key information for policy makers regarding the optimal design of STH control programs.
- | albendazole / Generic Mfg.
Journal: Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells. (Pubmed Central) - Nov 27, 2019
Albendazole and fenbendazole, two approved and commonly used benzimidazole anthelmintics, stimulated p53 activity and were selected for further studies...The drugs promoted the stability and transcriptional activity of wild-type p53 via downregulation of its negative regulators Mdm2 and MdmX in cells overexpressing these proteins. The results indicate the potential for repurposing the benzimidazole anthelmintics for the treatment of cancers overexpressing p53 negative regulators.
- | mebendazole / Generic mfg., albendazole / Generic mfg.
New trial: StarwormsWP2: Monitoring Drug Efficacy and Anthelmintic Resistance in Soil-transmitted Helminth Programs (clinicaltrials.gov) - Nov 25, 2019
P, N=8000, Recruiting, Sponsor: University Ghent
- | albendazole / Generic Mfg.
Preclinical, Journal: A preventive effect of the combination of albendazole and pomegranate peel aqueous extract treatment in cystic echinococcosis mice model: an alternative approach. (Pubmed Central) - Nov 24, 2019
PGE treatment indicates a significant beneficial additive antihydatic effect with a reduction of the liver side effects. The combination of albendazole and PGE treatment is more efficient and suggests its potential preventive value against Echinococcus granulosus infection.
- albendazole / Generic Mfg., praziquantel (MSC2499550A) / Merck (MSD)
A rare cause of eosinophilic liver abscess: Fascioliasis () - Nov 24, 2019 - Abstract #APDW2019APDW_1414;
Diagnosis can be made based on eggs on stool examination, worms on biliary aspirate and serology. Triclabendazole is the only recommended treatment option, with good response.
- albendazole / Generic Mfg.
Disseminated Abdominal Hydatidosis: A rare presentation of common zoonosis. () - Nov 24, 2019 - Abstract #APDW2019APDW_1324;
Disseminated abdominal hydatidosis is a rare entity, results from rupture of hepatic, splenic or mersentric hydatid cyst. It can cause chronic non-specific symptoms like pain, fullness, anorexia and vomiting.
- lamivudine / Generic Mfg.
Recurrent Disseminated Abdominal Hydatid Cyst in an Immunocomprimised Individual () - Nov 24, 2019 - Abstract #APDW2019APDW_1321;
Patient was treated with tenofovir, lamivudine, emtricitabine regimen with albendazole 10-15 mg/kg for 3 months. Disseminated abdominal hydatidosis is rare and uncommon presentation of a common endemic zoonosis.
- albendazole / Generic Mfg.
Radical surgery is preferable to conservative surgery in hepatic hydatid cyst (P8) - Nov 24, 2019 - Abstract #APDW2019APDW_708;
Patients received 4-26 weeks of albendazole therapy prior to surgery... Whenever feasible, radical surgery should be preferred treatment of hepatic hydatid cyst.
- albendazole / Generic Mfg.
Atypical presentation of eosinophilic lung disease () - Nov 24, 2019 - Abstract #NAPCON2019NAPCON_140;
This is atypical presentation of Loeffler syndrome. Lung diseasesassociated with marked peripheral blood eosinophilia is unusual and nearly always clinicallysignificant.
- || albendazole / Generic Mfg.
Clinical, Journal: Frequency and clinical presentation of alveolar and cystic echinococcosis in a tertiary medical center in Germany 2004-2018: lessons from a low-prevalence area. (Pubmed Central) - Nov 24, 2019
Due to favorable factors such as the escalation of migration, a further increase is expected. Diagnosis and therapy are challenging and should be supported by specialists (experienced infectiologists, imaging experts and skilled hepatobiliary surgeons) who should be integrated in a German network.
- | albendazole / Generic Mfg.
Journal: Evaluation of the curative effect of Balanites aegyptiaca fruits ethanolic extract on Haemonchosis experimentally induced in Egyptian Baladi goats: phytoanalytical, parasitological and hematological studies. (Pubmed Central) - Nov 23, 2019
Twelve male goats were randomly divided into four groups (n = 3) as: G1 (infected-untreated) which served as control positive, G2 (infected-BAF-EE treated), G3 (infected-albendazole treated) and G4 (uninfected-BAF-EE treated) that served as control negative...After treatments, WBCs and previously mentioned cells tended to decease. This study demonstrated that BAF-EE has anthelmintic effect against H. contortus and can improve hemogram and health condition of infected goats.
- | albendazole / Generic Mfg.
Preclinical, Journal: Evaluation of the therapeutic efficacy of albendazole-loaded silver nanoparticles against Echinococcus granulosus infection in experimental mice. (Pubmed Central) - Nov 23, 2019
Moreover, Ag NPs had reduced the toxic effects of ABZ such as necrosis, steatosis and the elevated serum liver enzymes. Therefore, loading ABZ on Ag NPs could be a potential method to improve ABZ efficacy against hydatid disease.
- | albendazole / Generic Mfg.
Journal: Enhancement of the Therapeutic Effect of Albendazole on Cystic Echinococcosis using a Herbal Product. (Pubmed Central) - Nov 21, 2019
The results of this study revealed the superiority of co-administration of albendazole and Z. multiflora AW to albendazole alone in the treatment of CE in laboratory mice. Since Z. multiflora AW is a safe and useful drink, it may be used successfully to enhance the therapeutic effect of albendazole in the patients infected with hydatid disease.
- || albendazole / Generic Mfg., Thelmox (mebendazole) / Remedica
Clinical, Review, Journal: Therapeutic efficacy of nanocompounds in the treatment of cystic and alveolar echinococcoses: challenges and future prospects. (Pubmed Central) - Nov 18, 2019
Moreover, BMZ-loaded polymeric NPs show a tendency to increase mortality rate against protoscoleces and microcysts compared with metallic formulations, nanoemulsions, lipid nanocapsules, solid lipid NPs, liposomes, and nanocrystals. In the future, the use of the newly structured entities, attained by bridging ligands to the modified surface of NPs, as well as the electromagnetically produced nanodrugs could be helpful for developing fine-tuned formulations as an alternative to the already existing drugs against these neglected parasitic infections.