- |||||||||| Gazyva (obinutuzumab) / Roche, Biogen
[VIRTUAL] A Case of Strongyloides Hyperinfection Syndrome in an Immunocompromised Patient () - Sep 15, 2020 - Abstract #ACG2020ACG_1235;
Case Description/ A 67-year-old male with leukemia on ibrutinib and obinutuzumab presented with persistent non-productive cough and dyspnea unresponsive to methylprednisolone...He was treated for pneumonia, yet had worsening hypoxia with suspicion for Pneumocystis pneumonia, and was started on trimethoprim-sulfamethoxazole and prednisone with paradoxical worsening respiratory failure requiring intubation...He was treated with subcutaneous ivermectin and albendazole with persistent shock...This case highlights classic features of SHS including eosinophilia, cough with progressive respiratory failure, thumb-print purpuric rash, and gastrointestinal symptoms. Due to significant mortality, it is critical to maintain a high index of suspicion and carefully consider steroid use in immunocompromised patients with this constellation of symptoms.
- |||||||||| albendazole / Generic mfg.
[VIRTUAL] Hydatic pulmonary embolism: A rare complication of hepatic hydatid cyst : a case report. () - Sep 12, 2020 - Abstract #EUSEM2020EUSEM_625;
She presented a hepatic and splenic recurrence treated with oral albendazole for 2 years...the most useful imaging technique in the investigation of an Echinococcus-related pulmonary embolism is CT-based angiography, which may not only reveal the embolism but also indicate its parasitic cause (from the cystic appearance of the filling defect) and reveal other cysts. in conclusion, Pulmonary embolism caused by a Cystic echinococcosis should be considered in patients who have undergone surgery for CE hepatic and/or cardiac cysts, especially in regions where CE is endemic
- |||||||||| albendazole / Generic mfg., Avastin (bevacizumab) / Roche
Journal: Antiangiogenesis Effect of Albendazole on the Cornea. (Pubmed Central) - Sep 11, 2020
Albendazole significantly decreased NV and LY in the cornea. This beneficial effect is additively enhanced when combined with bevacizumab treatment.
- |||||||||| albendazole / Generic mfg.
Review, Journal: The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. (Pubmed Central) - Sep 9, 2020
The present review summarizes central literature regarding the anticancer effects of benzimidazole anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, and flubendazole in cancer cell lines, animal tumor models, and clinical trials. This review provides valuable information on how to improve the quality of life in patients with cancers by increasing the treatment options and decreasing side effects from conventional therapy.
- |||||||||| albendazole / Generic mfg.
Journal: A boy with thoracic pain (Pubmed Central) - Sep 2, 2020
Imaging revealed multiple large cystic lesions in the right lung and liver, highly suggestive of echinococcosis, which was serologically confirmed. He was treated with albendazole and underwent lung surgery successfully.
- |||||||||| ivermectin / Generic mfg., albendazole / Generic mfg.
Review, Journal: Anthelmintic drugs for treating ascariasis. (Pubmed Central) - Sep 1, 2020
The drugs appear to be safe to treat children and adults with confirmed Ascaris infection. There is little to choose between drugs and regimens in terms of cure or adverse events.
- |||||||||| albendazole / Generic mfg.
Preclinical, Journal: Subcutaneous Hydatid Cyst in Laboratory Mice: Is it a Suitable Method for Evaluating Therapeutic Agents against Hydatid Cyst? (Pubmed Central) - Sep 1, 2020
Consequently, in this study, the impact of the nanoemulsion of Z. multiflora essential oil on subcutaneous hydatid cysts was compared with albendazole (ABZ)...Overall, the number, weight, and size of cysts were not significantly different between the groups in this investigation. The lack of satisfactory therapeutic results in this study might be due to the location of hydatid cysts in the subcutaneous space.
- |||||||||| albendazole / Generic mfg.
Journal: A Large Cohort of Neurocysticercosis in Shandong Province, Eastern China, 1997-2015. (Pubmed Central) - Aug 29, 2020
After antiparasitic therapy, the positive rates of the IHA, ELISA, and CAg tests were 74.77%, 84.70%, and 3.75%, respectively, showing no significant difference in antibody levels (p > 0.05), but a significant difference in CAg levels (p < 0.01). The clinical antiparasitic treatment of NCC with three to four courses of a combination of albendazole and praziquantel achieved satisfactory therapeutic efficacy.
- |||||||||| albendazole / Generic mfg.
Journal: Surgical excision of an epicardial ventricular hydatid cyst. (Pubmed Central) - Aug 29, 2020
It warrants early surgical repair because cyst rupture is potentially fatal. We report the case of a 32-year-old lady with an epicardial ventricular hydatid cyst, which was managed successfully by complete cyst excision.
- |||||||||| albendazole / Generic mfg.
Clinical, Journal: Encephalopathy in a patient with loiasis treated with albendazole: A case report. (Pubmed Central) - Aug 23, 2020
The clinical and electroencephalographic similarities between Loa loa albendazole-related encephalopathy and immune-mediated encephalitis suggest the possibility of an underlying inflammation-based pathogenesis. Although corticosteroid administration is not recommended in Loa loa ivermectin-induced encephalopathy, in this case of Loa loa albendazole-induced encephalopathy it may have played a therapeutic role.
- |||||||||| albendazole / Generic mfg., praziquantel / Generic mfg.
Clinical, Journal: The data are inadequate to assess safety and efficacy of mass chemotherapy for Taenia solium taeniasis. (Pubmed Central) - Aug 20, 2020
These neurologic side effects, due the inadvertent killing of viable brain cysts, have been noted after mass therapy with praziquantel and albendazole. We wholeheartedly agree with the authors' statement in their discussion that control programs applying chemotherapy using mass drug administration "need to be informed by evidence of the best drug and dose in terms of efficacy and side-effects." Unfortunately, the flawed analysis that was published is contrary to that goal.
- |||||||||| albendazole / Generic mfg.
Clinical, Journal: Primary cardiac hydatid cyst presenting with massive pericardial effusion: a case report. (Pubmed Central) - Aug 18, 2020
We wholeheartedly agree with the authors' statement in their discussion that control programs applying chemotherapy using mass drug administration "need to be informed by evidence of the best drug and dose in terms of efficacy and side-effects." Unfortunately, the flawed analysis that was published is contrary to that goal. The aims of this article are to consider the diagnosis of cardiac hydatid cysts in the presence of pericardial effusion, especially if there is a prior history of hydatid disease, a contact with animals, or when it occurs in an endemic country, and to be able to make a differential diagnosis with cardiac imaging in order to avoid its complications and to guide the management.
- |||||||||| albendazole / Generic mfg., praziquantel / Generic mfg.
[VIRTUAL] Neurocysticercosis – Gender Differences in Clinical Presentations. () - Aug 14, 2020 - Abstract #IDWeek2020IDWEEK_1738;
This study suggests that men either present early in the disease phase or have different immune responses than women and require anti-parasitic therapy more frequently. More research in this aspect is needed.
- |||||||||| ceftriaxone / Generic mfg.
[VIRTUAL] Case Series of Echinococcus Infections at Mayo Clinic Florida () - Aug 14, 2020 - Abstract #IDWeek2020IDWEEK_987;
History and clinical presentation are key to diagnosis, but histopathology remains the gold standard. Hydatid bone infection progresses insidiously and frequently recurs, depending upon excision and debridement.
- |||||||||| albendazole / Generic mfg.
Trial completion, Trial primary completion date: Albendazole Plus High Dose Ivermectin for Trichuriasis in Pediatric Patients (clinicaltrials.gov) - Aug 7, 2020
P2, N=176, Completed,
Trial completion date: Aug 2021 --> Jan 2022 | Trial primary completion date: Aug 2021 --> Jan 2022 Not yet recruiting --> Completed | Trial primary completion date: Nov 2019 --> Mar 2020
- |||||||||| Journal: Comparison of induction methods for supersaturation: pH shift versus solvent shift. (Pubmed Central) - Jul 31, 2020
For the induction time, precipitation rate and the solid form of the precipitate, no systematic differences between the induction methods were detected, however individual drugs did show differences. The study shows that, if a drug is sufficiently soluble at low pH, the solvent shift and pH shift induction methods of supersaturation yield comparable results.
- |||||||||| albendazole / Generic mfg.
Clinical, Journal: Enhanced Oral Bioavailability and Anti-Echinococcosis Efficacy of Albendazole Achieved by Optimizing the "Spring" and "Parachute". (Pubmed Central) - Jul 29, 2020
More significantly, the anti-echinococcosis efficacy of the improved formulation was 2.4 times higher than that of Albenda® in a secondary hepatic alveolar echinococcosis Sprague Dawley rat model. The strategy of simultaneously improving the "spring" and "parachute" of an oral formulation of ABZ, by using a highly soluble salt and an effective polymeric crystallization inhibitor, was once again proved to be a viable and readily translatable approach to optimize the unsatisfactory oral medicines due to solubility and bioavailability limitations.
- |||||||||| albendazole / Generic mfg.
Clinical, Journal: The impact of intensive versus standard anthelminthic treatment on allergy-related outcomes, helminth infection intensity and helminth-related morbidity in Lake Victoria fishing communities, Uganda: results from the LaVIISWA cluster randomised trial. (Pubmed Central) - Jul 25, 2020
In an open, cluster-randomized trial (ISRCTN47196031), we randomized 26 high-schistosomiasis-transmission fishing villages in Lake Victoria, Uganda, in a 1:1 ratio to receive community-wide intensive (quarterly single-dose praziquantel plus albendazole daily for 3 days) or standard (annual praziquantel plus 6 monthly single-dose albendazole) MDA...This could be due to sustained low-intensity infections, thus a causal link between helminths and allergy outcomes cannot be discounted. Intensive community-based MDA has limited impact in high-schistosomiasis-transmission fishing communities, in the absence of other interventions.
- |||||||||| Flagyl (metronidazole) / SLA, Omeprazole RBX (omeprazole) / Generic mfg.
Journal: Drug resistance in Giardia: Mechanisms and alternative treatments for Giardiasis. (Pubmed Central) - Jul 22, 2020
Other promising agents derived from higher organisms including phytochemicals, lactoferrin and propolis as well as probiotic bacteria/fungi have also demonstrated significant potential for therapeutic and prophylactic purposes in giardiasis. In this context the present chapter offers a comprehensive review of the current knowledge, including commonly prescribed drugs, causes of therapeutic failures, drug resistance mechanisms, strategies for the discovery of new agents and alternative drug therapies.
- |||||||||| Trial completion date, Trial primary completion date: Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection (clinicaltrials.gov) - Jul 22, 2020
P2, N=48, Recruiting,
In this context the present chapter offers a comprehensive review of the current knowledge, including commonly prescribed drugs, causes of therapeutic failures, drug resistance mechanisms, strategies for the discovery of new agents and alternative drug therapies. Trial completion date: Aug 2020 --> Aug 2021 | Trial primary completion date: Apr 2020 --> Feb 2021
- |||||||||| albendazole / Generic mfg.
Journal: Albendazole negatively regulates keratinocyte proliferation. (Pubmed Central) - Jul 21, 2020
Trial completion date: Aug 2020 --> Aug 2021 | Trial primary completion date: Apr 2020 --> Feb 2021 Data show that albendazole inhibits keratinocyte proliferation and exerts therapeutic effect in a murine model of psoriasis.
- |||||||||| albendazole / Generic mfg.
[VIRTUAL] ALVEOLAR ECHINOCOCCOSIS: ONE PATIENT PRESENTING THE WHOLE PANORAMA OF POTENTIAL BILIARY COMPLICATIONS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_5653;
Albendazole 800mg daily was initiated...These include cholangitis lesions (biliary duct stenosis and dilations on imaging) evocating sclerosing cholangitis, common bile duct stenosis, biliary fistulae and eventually secondary biliary cirrhosis. This case report illustrates the whole spectrum of biliary complications that potentially characterize the course of alveolar echinococcosis.
- |||||||||| albendazole / Generic mfg.
[VIRTUAL] ALVEOLAR ECHINOCOCCOSIS: ONE PATIENT PRESENTING THE WHOLE PANORAMA OF POTENTIAL BILIARY COMPLICATIONS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_3677;
Albendazole 800mg daily was initiated...These include cholangitis lesions (biliary duct stenosis and dilations on imaging) evocating sclerosing cholangitis, common bile duct stenosis, biliary fistulae and eventually secondary biliary cirrhosis. This case report illustrates the whole spectrum of biliary complications that potentially characterize the course of alveolar echinococcosis.
- |||||||||| albendazole / Generic mfg.
[VIRTUAL] ALVEOLAR ECHINOCOCCOSIS: ONE PATIENT PRESENTING THE WHOLE PANORAMA OF POTENTIAL BILIARY COMPLICATIONS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_1693;
Albendazole 800mg daily was initiated...These include cholangitis lesions (biliary duct stenosis and dilations on imaging) evocating sclerosing cholangitis, common bile duct stenosis, biliary fistulae and eventually secondary biliary cirrhosis. This case report illustrates the whole spectrum of biliary complications that potentially characterize the course of alveolar echinococcosis.
- |||||||||| albendazole / Generic mfg.
[VIRTUAL] Treatment of relapsed hydatid disease of lungs. (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_2305;
170 (89,5%) patients were performed organsaving operation, 20 (10,5%) patients underwent resections [figure 2]. In the postoperative period albendazole was administered in a doze 10-12 mg/kg/day, quantity of courses depended on the form of a defeat.
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