albendazole / Generic mfg. 
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  • ||||||||||  albendazole / Generic mfg.
    Clinical, Journal:  Effect of anthelmintic treatment on serum free IGF-1 and IGFBP-3: a cluster-randomized-controlled trial in Indonesia. (Pubmed Central) -  Mar 11, 2021   
    In the whole study population, albendazole treatment significantly increased serum free IGF-1 level [estimate and 95% CI 0.031 (0.004; - 0.057), P = 0.024] whereas no effect was found on the IGFBP-3 level. Our study showed that helminth infection in adults is associated with lower free IGF-1 levels but not with IGFBP-3 and albendazole treatment significantly increases free IGF-1 levels in the study population.Clinical Trial Registration: https://www.isrctn.com/ISRCTN75636394 .
  • ||||||||||  Enrollment closed, Trial completion date, Trial primary completion date:  Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection (clinicaltrials.gov) -  Mar 11, 2021   
    P2,  N=48, Active, not recruiting, 
    So, our results suggest that mefloquine might be a superior treatment for chronic trichinellosis. Recruiting --> Active, not recruiting | Trial completion date: Aug 2021 --> Jun 2022 | Trial primary completion date: Feb 2021 --> Dec 2021
  • ||||||||||  Journal:  Anthelmintic resistance and common worm control practices in sheep farms in Flanders, Belgium. (Pubmed Central) -  Mar 10, 2021   
    Results indicated widespread resistance against benzimidazoles (albendazole, fenbendazole and mebendazole), with treatment failure on all 8 farms investigated...Resistance against macrocyclic lactones (ivermectin, doramectin and moxidectin) was recorded on 7 out of 20 flocks, mainly in H. contortus and T. circumcincta...Only few sheep farmers (9%) regularly used faecal egg counts to monitor worm infections. Despite the FECRT showing otherwise, most of the farmers perceived the efficacy of anthelmintics as very good (30%) or good (54%).
  • ||||||||||  albendazole / Generic mfg.
    Journal:  The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity. (Pubmed Central) -  Mar 9, 2021   
    Since chromosomal aberrations promote both cancer development and cell death, we determined if besides its general cytotoxicity, ABZ could predispose to tumor development. As measured by loss of heterozygosity (LOH) in vitro and in vivo ABZ was found as a potent inducer of LOH and accelerator of chromosomal missegregation.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Anaphylaxis due to a ruptured hydatid cyst (Pubmed Central) -  Mar 6, 2021   
     Obscure clinical symptoms alongside signs of shock, should always considered to be an allergic reaction in absence of sepsis or hemorrhage. In anaphylaxis, echinococcosis should always be included in the differential diagnosis.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Transcriptome assembly dataset of anthelmintic response in Fasciola hepatica. (Pubmed Central) -  Mar 5, 2021   
    The average genome-mapping rate is 81.29% and the average gene-mapping rate is 62.81%. 30,105 genes were identified in which 28,669 of them are known genes and 1,237 of them are novel genes from novel coding transcripts without any known features, 20,743 novel RNA transcripts were identified of which 14,293 of them are previously unknown splicing event for known genes but no alternative splicing was detected, the remaining 5,213 transcripts were found to be long noncoding RNA.
  • ||||||||||  albendazole / Generic mfg.
    Review, Journal:  Toxocariasis of the Nervous System. (Pubmed Central) -  Mar 4, 2021   
    Neurotoxocariasis should always be suspected in patients with neurologic symptoms accompanied by eosinophilia in blood and/or CSF. Early diagnosis and treatment could prevent long-term neurologic impairment.
  • ||||||||||  albendazole / Generic mfg.
    Review, Journal:  The Story of Lymphatic Filariasis Elimination as a public health problem from Yemen. (Pubmed Central) -  Mar 3, 2021   
    LF mapping was started in 2000, followed by five annual rounds of mass drug administration (MDA) with ivermectin and albendazole in 8 implementation units (IUs) during 2002-2006...Thus, after almost two decades of sustained effort, Yemen met the WHO criteria for successful elimination of LF as a public health problem. In 2019, WHO validated Yemen as the second country in the WHO' Eastern Mediterranean Region to successfully eliminate LF as a public health problem.
  • ||||||||||  albendazole / Generic mfg.
    Clinical, Journal:  Toxocariasis Presenting with Hypereosinophilia and Lymphadenopathy: A Case Report. (Pubmed Central) -  Feb 27, 2021   
    Albendazole is used for the treatment of toxocariasis diagnosed by serologic and immunological methods. Herein, we report two cases of toxocariasis that were investigated due to hypereosinophilia and lymphadenopathy for a long time.
  • ||||||||||  albendazole / Generic mfg., azithromycin / Generic mfg.
    Trial completion date, Trial primary completion date:  Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin (clinicaltrials.gov) -  Feb 25, 2021   
    P4,  N=16000, Not yet recruiting, 
    The present study demonstrates for the first time that contact of H. contortus with sub-lethal doses of ABZ (e.g. during underdose treatment) improves the ability of H. contortus adults to deactivate ABZ in consequent therapy. Trial completion date: Dec 2021 --> Jul 2022 | Trial primary completion date: Dec 2020 --> Dec 2021
  • ||||||||||  albendazole / Generic mfg.
    Clinical, Journal:  Esophageal Scab Mimicking a Parasite: A Case Report. (Pubmed Central) -  Feb 23, 2021   
    Administration of albendazole did not expel any helminths...CONCLUSIONS The scab formed by the esophageal ulcer was identified based on clinical manifestations, anti-helminth and stool examinations, parasite morphology, and molecular biology. Our experience with this case suggests that the universal barcoding technique can be used for identification of foreign bodies suspected to be parasites.
  • ||||||||||  albendazole / Generic mfg.
    Clinical, Journal:  Cutaneous larva migrans in a young child following circumrotation as a cultural ritual. (Pubmed Central) -  Feb 23, 2021   
    The forearm is an unusual site for this infestation, and most reported cases had lesions on the feet, thighs and buttocks following either sitting or playing on contaminated soil. The child made complete recovery following treatment with albendazole for 1 week.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes. (Pubmed Central) -  Feb 20, 2021   
    These results demonstrate that terpenes are broad-acting anthelmintics. Terpenes are predicted to be extremely difficult for parasites to resist, and YP encapsulation provides water-suspendable terpene materials without surfactants and sustained terpene release that could lead to the development of formulations for oral delivery that overcome fast absorption in the stomach, thus reducing dosage and toxic side effects.
  • ||||||||||  leucovorin calcium / Generic mfg., prednisone / Generic mfg., albendazole / Generic mfg.
    [VIRTUAL] ADDING SALT PORK TO THE WOUND (eAbstract site) -  Feb 17, 2021 - Abstract #ACC2021ACC_2184;    
    We should consider cardiac cysticercosis if there is epidemiologic exposure associated with typical intramyocardial cystic or calcified lesions, especially when the scolex can be identified. The treatment with albendazole and prednisone was well-tolerated and curative.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  The Identification of Metabolites and Effects of Albendazole in Alfalfa (Medicago sativa). (Pubmed Central) -  Feb 17, 2021   
    UHPLC-MS/MS analysis revealed three new ABZ metabolites that have not been described yet. The discovery of the parent compound ABZ together with the anthelmintically active and instable metabolites in alfalfa leaves shows that the contact of fodder plants with ABZ-containing manure might represent not only a danger for herbivorous invertebrates, but also may cause the development of ABZ resistance in helminths.
  • ||||||||||  albendazole / Generic mfg.
    Clinical, Journal:  Concomitant Pulmonary Cystic Echinococcosis and Aspergillosis in a Male Child. (Pubmed Central) -  Feb 16, 2021   
    Medical therapy with albendazole was started for the patient with the initial clinical impression of cystic echinococcosis...Thus, the diagnosis of a cystic echinococcosis and aspergillosis co-infection was established. Surgery is the mainstay of treatment along with anthelminthic and anti-fungal therapy, especially in immunocompromised patients.
  • ||||||||||  albendazole / Generic mfg., doxycycline / Generic mfg., Pierre Fabre
    Journal:  Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections. (Pubmed Central) -  Feb 12, 2021   
    In summary, CorA is a preclinical candidate for filariasis, which significantly reduces treatment times required to achieve sustained Wolbachia depletion, clearance of microfilariae, and inhibition of embryogenesis. In combination with albendazole, CorA is robustly macrofilaricidal after 7 days of treatment and fulfills the Target Product Profile for a macrofilaricidal drug.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions. (Pubmed Central) -  Feb 11, 2021   
    The oral absorption of ALZ in rats administered as ASD suspensions was not explained by dissolution study but was predicted using liquid-liquid phase separation concentration, which suggested that the absorption of ALZ was solubility-limited. The oral administration study in dogs performed using solid capsules demonstrated the low efficacy of ASDs because the absorption was likely to be limited by dissolution rate, which indicated the importance of designing the final dosage form of the ASDs.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  BEED: The Bangladesh Environmental Enteric Dysfunction Study (clinicaltrials.gov) -  Feb 9, 2021   
    P=N/A,  N=1575, Recruiting, 
    Thus, a call for action is demanding to eliminate STH among PSAC in Ethiopia by 2030. Trial completion date: Oct 2020 --> Jun 2021 | Trial primary completion date: Oct 2020 --> Jun 2021
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Detection of Ascaris lumbricoides infection by ABA-1 coproantigen ELISA. (Pubmed Central) -  Feb 9, 2021   
    Furthermore, the levels of ABA-1 in stool were shown to rapidly and strongly decrease upon administration of a standard anthelminthic treatment (single oral dose of 400 mg albendazole)...This report demonstrates that ABA-1 can be considered an Ascaris -specific coproantigen marker that can be used to monitor infection intensity. It also opens the path for development of point-of-care immunoassay-based tests to determine A. lumbricoides infection in stool at the sample collection site.
  • ||||||||||  metronidazole oral / Generic mfg., albendazole / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  Parasitic Infection in Anemic Pregnant Women (clinicaltrials.gov) -  Feb 9, 2021   
    P4,  N=200, Recruiting, 
    The vector-parasite MX, can be used to evaluate interventions in this area after further standardization of the protocol. Not yet recruiting --> Recruiting | Trial completion date: Sep 2020 --> Sep 2021 | Trial primary completion date: Aug 2020 --> Aug 2021
  • ||||||||||  albendazole / Generic mfg., tadalafil / Generic mfg.
    Journal:  Comparison of induction methods for supersaturation: amorphous dissolution versus solvent shift. (Pubmed Central) -  Feb 7, 2021   
    For tadalafil with HPMC, the precipitate was amorphous following solvent shift, but crystalline after amorphous dissolution. Overall, this study shows that the maximum concentration achievable through amorphous dissolution can be estimated when performing solvent shift and the precipitation inhibition of excipients assessed via solvent shift can be used to predict the effect on precipitation using amorphous dissolution.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Combined use of chemical and biological compounds to control hookworm. (Pubmed Central) -  Feb 7, 2021   
    The aim of this study was to evaluate the combined use of different chemical (albendazole, ivermectin, glycerine and Vaseline) and biological (Monacrosporium thaumasium) compounds in the control of Ancylostoma caninum...The groups (G1 to G15) that contained any chemical or biological compound (NF34) and/or their combined use (chemical + biological) showed a difference in relation to the control group, except G5 - Vaseline 100% without combinations. It was concluded that, even on an experimental basis, the combined use of anthelmintic drugs with biological control was efficient; however, more studies must be carried out in order to elucidate the synergistic action between chemical and biological compounds to be used in the effective control of hookworms in the future.
  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg.
    New P3 trial:  Efficacy and Safety of MOX/ALB Co-administration (clinicaltrials.gov) -  Jan 26, 2021   
    P3,  N=282, Not yet recruiting, 
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Baseline patterns of infection in regions of Benin, Malawi and India seeking to interrupt transmission of soil transmitted helminths (STH) in the DeWorm3 trial. (Pubmed Central) -  Jan 26, 2021   
    P3
    Clusters were randomized to receive twice yearly community-wide MDA with albendazole (GSK) targeting eligible individuals of all ages (20 clusters), or to receive the standard-of-care deworming program targeting children provided in each country...In addition, the baseline prevalence and intensity data from DeWorm3 suggest that each site has unique epidemiologic characteristics that will be critical in determining correlates of achieving STH transmission interruption in the DeWorm3 trial. Trial registration: The trial was registered at ClinicalTrials.gov (NCT03014167).