albendazole / Generic mfg. 
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  • ||||||||||  albendazole / Generic mfg.
    Journal:  Microsporidiosis in Humans. (Pubmed Central) -  Feb 3, 2022   
    In addition, immune restoration can lead to resolution of infection. While the prevalence rate of microsporidiosis in patients with AIDS has fallen in the United States, due to the widespread use of combination antiretroviral therapy (cART), infection continues to occur throughout the world and is still seen in the United States in the setting of cART if a low CD4 count persists.
  • ||||||||||  peloruside A (RTA404) / Reata
    Preclinical, Journal:  In silico to In vivo development of a polyherbal against Haemonchus contortus. (Pubmed Central) -  Feb 3, 2022   
    In silico molecular docking and pharmacokinetic prediction studies were conducted with known bioactive molecules of these plants (palasonin, vinblastine, vincristine, betulinic acid and ursolic acid) against Glutamate Dehydrogenase (GDH) and tubulin molecules of the parasite...Albendazole bound to α-tubulin next to colchicine site whereas vinblastine is bound at the nearby laulimalide/peloruside site of the dimer...The in vitro studies demonstrated good dose dependent anthelmintic potential. Both the prototypes were quite efficacious in clearing the infection, keeping it to a minimal for more than 5 months, probably, through direct anthelmintic effect through GDH, tubulin depolymerization and uncoupling as well as indirectly through immunomodulation along with antioxidant and anti-inflammatory properties.
  • ||||||||||  albendazole / Generic mfg., praziquantel / Generic mfg.
    Pericardial and Pulmonary Hydatid cysts with embolic spread () -  Feb 3, 2022 - Abstract #IWLH2022IWLH_106;    
    A combination therapy with albendazole and praziquantel had offered a symptom free interval with regression of the cysts. The need for prolonged course of medical therapy needs to be studied in such patients with non resectable pulmonary hydatid cysts.
  • ||||||||||  ivermectin oral / Generic mfg., albendazole / Generic mfg.
    Retrospective data, Journal:  Is strongyloidiasis currently autochthonous in Croatia? A retrospective study. (Pubmed Central) -  Feb 1, 2022   
    Strongyloidiasis is currently endemic in Croatia and immunosuppressed travellers to this region should be advised to take precautions. Patients undergoing immunosuppression and organ donors from Croatia should be screened.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Angiostrongylosis meningomyelitis without blood eosinophilia. (Pubmed Central) -  Feb 1, 2022   
    Immediate treatment with intravenous pulse methylprednisolone and oral albendazole resulted in complete recovery. Despite an unremarkable differential leucocytes count, absence a history of parasitic hosts consumption, and a less common presentation with meningomyelitis, A. cantonensis should be considered when cerebrospinal fluid eosinophilia presents.
  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administration (clinicaltrials.gov) -  Feb 1, 2022   
    P2/3,  N=536, Completed, 
    Despite an unremarkable differential leucocytes count, absence a history of parasitic hosts consumption, and a less common presentation with meningomyelitis, A. cantonensis should be considered when cerebrospinal fluid eosinophilia presents. Not yet recruiting --> Completed | Trial completion date: Apr 2022 --> Sep 2021 | Trial primary completion date: Mar 2022 --> Aug 2021
  • ||||||||||  albendazole / Generic mfg.
    Retrospective data, Journal:  Retrospective Evaluation of Hydatid Cyst Cases During Pregnancy. (Pubmed Central) -  Jan 29, 2022   
    Albendazole was started as medical therapy in six patients, and percutaneous drainage was applied to one patient...We would also like to underscore that echinococcal disease of the liver should be kept in mind in the differential diagnosis of abdominal pain, jaundice, and/or fever, especially in endemic regions. We think that when we increase awareness about this disease, we can improve fetal and maternal outcomes by making an early diagnosis and management.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  EgGLUT1 Is Crucial for the Viability of Echinococcus granulosus sensu stricto Metacestode: A New Therapeutic Target? (Pubmed Central) -  Jan 28, 2022   
    In addition, WZB117 showed significant therapeutic activity in E. granulosus s.s.-infected mice: a 10 mg/kg dose of WZB117 significantly reduced the number and weight of parasite cysts (P < 0.05) as efficiently as the reference drug, albendazole. Our results demonstrate that EgGLUT1-ss is crucial for glucose uptake by the protoscoleces of E. granulosus s.s., and its inhibitor WZB117 has a therapeutic effect on CE.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Anthelmintic Drug Resistance of Gastrointestinal Nematodes of Naturally Infected Goats in Haramaya, Ethiopia. (Pubmed Central) -  Jan 28, 2022   
    FECRT% and lower 95% confidence limit were 69.9% and 36.9 for albendazole, 84.3% and 66.1 for tetraclozan, 95.7% and 87.4 for tetramisole, and 71.1% and 38.2 for ivermectin, respectively...Therefore, this study demonstrated the presence of multidrug resistant nematodes that may limit the productivity of goats. Moreover, further studies covering wider areas of Ethiopia and mechanisms of nematode resistance need to be studied in the future.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Trichinella spiralis-associated myocarditis mimicking acute myocardial infarction. (Pubmed Central) -  Jan 27, 2022   
    A diagnosis of Trichinella spiralis associated-myocarditis was made.The patient was treated with albendazole-prednisolone dual therapy with favorable clinical and biological outcomes...Chest pain, increase in troponins, and electrocardiographic abnormalities are all elements that can mimic a myocardial infarction and mislead clinicians. Abbreviations ANCA: Anti-Neutrophil Cytoplasmic Antibodies; ANA: Anti-Nuclear Antibodies; ECDC: European Centre for Disease Prevention and Control; ECG: Electrocardiogram; ELISA: Enzyme-Linked ImmunoSorbent Assay; EMF: Endomyocardial Fibrosis; ES: Excretory-Secretory; ICT: International Commission on Trichinellosis; MRI: Magnetic Resonance Imaging.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Veterinary sanitary assessment of mutton after application of antihelminth feed additive with albendazole. (Pubmed Central) -  Jan 26, 2022   
    The drug had a significant effect on the biological value of meat in the experimental group, where there is a higher content of essential amino acids (P = 0.06), nonessential (P = 0.05) concentrations in comparison with the CON groups. The results obtained show that the meat of the experimental groups of sheep, when using the anthelminthic feed additive albendazole, did not have a significant effect on organoleptic parameters, but significantly positively influenced the metabolism, live weight gain and biological value of meat.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Coordination compounds with heterocyclic ester derivatives. Structural characterization and anti-proliferative activity. (Pubmed Central) -  Jan 18, 2022   
    A series of new coordination compounds of cobalt(II), copper(II) and zinc(II) with heterocyclic ester derivatives (ethyl 4-methyl-5-imidazole-carboxylate (emizco), 1-(2-(phenylsulphonyl)ethyl)-4-imidazole carboxylate (semizco)) and methyl 5-(propylthio)-2-benzimidazolecarbamate (albendazole, abz) were synthesized...A cytotoxic study was carried out with the free ligands and their copper(II) and zinc(II) halide coordination compounds on HeLa (cervix-uterine), MCF-7 (breast), HCT-15 (colon), PC3 (prostate) human carcinoma cell lines and L929 mouse fibroblast (healthy cells). A TUNEL assay (terminal deoxynucleotidyl transferase dUTP nick end labeling) was performed with the most active copper(II) compounds to determine if cell death was by apoptosis.
  • ||||||||||  albendazole / Generic mfg.
    Clinical, Journal:  "The Magic Glasses Philippines": a cluster randomised controlled trial of a health education package for the prevention of intestinal worm infections in schoolchildren. (Pubmed Central) -  Jan 14, 2022   
    The primary trial outcomes were the proportion of STH infected schoolchildren and their knowledge, attitude and behaviour of STH assessed in both groups at baseline and through two follow-up surveys undertaken immediately prior to the semi-annual national mass administration of albendazole...The health-education package demonstrated a modest but statistically significant impact on the students' overall STH knowledge and changes in their behaviour but was only effective in preventing STH infections in intervention schools where the baseline prevalence was ≤15%. National Health and Medical Research Council, Australia, and the UBS-Optimus Foundation, Switzerland.
  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg.
    Journal:  Multiple drug resistance in hookworms infecting greyhound dogs in the USA. (Pubmed Central) -  Jan 7, 2022   
    For samples collected TAC) resistance polymorphism in 99% of these samples. These clinical, in vitro, and genetic data provide strong evidence that greyhound dogs in the USA are infected with MDR A. caninum at very high levels in prevalence and infection intensity.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma, Lamprene (clofazimine) / Novartis
    Clinical, Review, Journal:  Treatment of human intestinal cryptosporidiosis: A review of published clinical trials. (Pubmed Central) -  Jan 7, 2022   
    Other trials of therapeutic modalities were terminated due to futility. Currently, available data is intended to aid the development of strategies for improving access to treatments in different clinical settings, as well as to help guide further studies on treatments of human intestinal cryptosporidiosis.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles. (Pubmed Central) -  Jan 7, 2022   
    We introduced these four new alleles into the sensitive C. elegans laboratory-adapted N2 strain and exposed these genome-edited strains to both albendazole and fenbendazole...Because it is unknown if previously validated alleles confer a dominant or recessive BZ resistance phenotype, we tested the phenotypes caused by five of these alleles and found that none of them conferred a dominant BZ resistance phenotype. Accurate measurements of resistance, fitness effects, and dominance caused by the resistance alleles allow for the generation of better models of population dynamics and facilitate control practices that maximize the efficacy of this critical anthelmintic drug class.
  • ||||||||||  albendazole / Generic mfg., praziquantel / Generic mfg.
    Journal:  Hydatid brain cyst: A delayed diagnosis in a rural setting during COVID-19. (Pubmed Central) -  Jan 5, 2022   
    Hydatid protoscolices and hooklets were seen on microscopy of cyst fluid, and treatment with albendazole and praziquantel was initiated. While her infection was treated successfully, long-term sequelae including permanent blindness and hemiparesis could potentially have been prevented with early neuroimaging and surgical intervention.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Failure of Repeated MDA with Albendazole for Trichuriasis Control in Schoolchildren of the Yangon Region, Myanmar. (Pubmed Central) -  Jan 4, 2022   
    The results indicated that repeated MDAs (2-4 times a year for 3 years) using albendazole on schoolchildren in Myanmar failed to control T. trichiura infection. For a successful control of trichuriasis in Myanmar, new MDA strategies, using a modified albendazole regimen (multiple daily doses for 2 or 3 days) or an alternative anthelmintic drug, such as oxantel pamoate, is strongly recommended.
  • ||||||||||  albendazole / Generic mfg.
    Review, Journal:  Neurocysticercosis and HIV/AIDS Co-infection: A Scoping Review. (Pubmed Central) -  Dec 29, 2021   
    There is a paucity of evidence to guide treatment of PLWH/A and NCC co-infection. There is a pressing need for high-quality studies in this patient group to appropriately inform diagnostic and management guidelines for HIV-positive patients with NCC.