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25 Trials |  |
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- | albendazole / Generic mfg.
Journal: Secretion into Milk of the Main Metabolites of the Anthelmintic Albendazole Is Mediated by the ABCG2/BCRP Transporter. (Pubmed Central) - Jul 23, 2022
Milk concentrations and milk-to-plasma ratio were higher in wild-type compared to Abcg2 mice for all the metabolites tested. We conclude that ABZ metabolites are undoubtedly in vitro substrates of ABCG2 and actively secreted into milk by ABCG2.
- | albendazole / Generic mfg.
Preclinical, Journal: Ultrastructural tegumental changes of Trichinella spiralis adult and larval stages after in vitro exposure to Allium sativum. (Pubmed Central) - Jul 23, 2022
Albendazole (ALB) is the most used therapeutic drug for trichinellosis treatment, but it has many drawbacks...Adult worms and muscular larvae of T. spiralis incubated with 100 μg/mL of Tomex displayed loss of normal annulations and creases of the cuticle, multiple vesicles, widening of longitudinal furrow space, and multiple minor loss blebs. Our results suggested that Tomex can be a therapeutic agent against adults and larvae stages of T. spiralis.
- ceftriaxone / Generic mfg., albendazole / Generic mfg., paracetamol / Generic mfg.
RARE CASE OF ISOLATED PERITONEAL CYSTIC ECHINOCOCCOSIS IN A 33-YEAR-OLD MALE PATIENT (Science Lounge) - Jul 20, 2022 - Abstract #UEGW2022UEGW_2702;
1).Under the hypothesis of subsided appendicitis, the patient recovered quickly under treatment with ceftriaxone and paracetamol...Serum ELISA and Westernblot showed positive results forEchinococcus granulosus.After surgery, antihelminthic treatment with albendazole 400 mg orally twice daily was initiated...The diagnosis of peritoneal cystic echinococcosis corresponds well with the patient's history, who originated from a farm in Kosovo, and with the imaging findings. However, peritoneal cystic echinococcosis without liver manifestation is a rare condition and may complicate diagnosis.
- | albendazole / Generic mfg., tetracycline / Generic mfg.
Journal: Potential effects and relevant lead compounds of Vigna mungo (L.) Hepper seeds against bacterial infection, helminthiasis, thrombosis and neuropharmacological disorders. (Pubmed Central) - Jul 20, 2022
The MESVM exhibited remarkable anthelmintic activity at 50 mg/mL concentration with 35.4 min paralysis time, 75.2 min death time and were closer to the durations of standard drug albendazole...In docking, 2'-hydroxygenistein, cyclokievitone hydrate, and aureol displayed maximum affinity to the target proteins for anthelmintic, antibacterial, and thrombolytic activity, respectively. This research revealed that the MESVM demonstrated potential anthelmintic, antibacterial and thrombolytic effects that confirmed the folkloric uses of VM and the found relevant lead compounds might be further optimized in future drug development.
- | albendazole / Generic mfg.
Observational data, Journal: Is ignorance of the weekly iron and folic acid scheme among adolescents the deciding factor for its suboptimal utilization and ineffectiveness? A cross-sectional study. (Pubmed Central) - Jul 20, 2022
There is a hint of the fact that effective execution of the program among its beneficiaries leads to an automatic increased knowledge of the program, at least among the beneficiaries. Thus, an indirect but significant indirect finding is that the nationwide WIFS program needs to be put to greater focus among the adolescent boys, apart from its major focus on the female gender among most age groups.
- levamisole / Generic mfg.
Levamisole as a major cause of acute disseminated encephalomyelitis: russian single-center experience (B1) - Jul 18, 2022 - Abstract #EAN2022EAN_2418;
LAMIE is a very important diagnostic consideration in the first demyelinating episode in Russia. LEV is the most frequent cause of ADEM at the South of Moscow.
- | albendazole / Generic mfg.
Journal: Selection of benzimidazole resistance in Ancylostoma ceylanicum in hamsters shows that the E198A substitution in the beta-tubulin isotype-1 gene is correlated with the resistance phenotype and also identifies a new F200L substitution: Moving beyond the state of the art of understanding resistance mechanisms in hookworms: confirming old and suggesting new associated SNPs. (Pubmed Central) - Jul 15, 2022
Through bioassay and in vivo analysis, we successfully isolated an albendazole-resistant A. ceylanicum strain by drug selective pressure...The results presented here are important for updating the current knowledge about anthelmintic resistance in hookworms. The answers and the new questions raised may provide a basis for the establishment of more effective control strategies.
- | albendazole / Generic mfg.
Journal: Cystic lesions of the brain: Think of the hydatid cyst. (Pubmed Central) - Jul 14, 2022
The answers and the new questions raised may provide a basis for the establishment of more effective control strategies. Hydatid cyst of the brain is characterized by the severity of the neurological signs, the mandatory use of surgery because of life threatening and the excellent outcomes.
- | Enrollment closed: MALHELMIN: Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children (clinicaltrials.gov) - Jul 14, 2022
P=N/A, N=600, Active, not recruiting, Sponsor: London School of Hygiene and Tropical Medicine
Hydatid cyst of the brain is characterized by the severity of the neurological signs, the mandatory use of surgery because of life threatening and the excellent outcomes. Not yet recruiting --> Active, not recruiting
- | albendazole / Generic mfg.
New trial: Pharmacokinetics and Excretion of Albendazole and Its Metabolites in Saliva (clinicaltrials.gov) - Jul 12, 2022
P=N/A, N=12, Not yet recruiting, Sponsor: Universidad Nacional de Salta
- || albendazole / Generic mfg.
Clinical, Journal: Semiannual Treatment of Albendazole Alone is Efficacious for Treatment of Lymphatic Filariasis: A Randomized Open-label Trial in Cote d'Ivoire. (Pubmed Central) - Jul 10, 2022
P=N/A
Repeated semiannual treatment with ALB is macrofilaricidal for W. bancrofti and leads to sustained reductions in Mf counts. This is a safe and effective regimen that could be used as MDA to eliminate LF in areas where ivermectin cannot be used.
- | albendazole / Generic mfg.
Preclinical, Journal: In Vitro Anthelmintic Activity and Phytochemical Screening of Crude Extracts of Three Medicinal Plants against Haemonchus Contortus in Sheep at Haramaya Municipal Abattoir, Eastern Hararghe. (Pubmed Central) - Jul 10, 2022
Albendazole (1.25 mg/ml) and distilled water were used as the positive and negative controls, respectively...Concentrations of all the extracts had showed a comparable and strong nematocidal effect on H. contortus having no significant difference with that of the positive control (P > 0.05) at 8 hr posttreatment period. Hence, the current study revealed that the extracts from three plants have potential anthelmintic effect, and we recommend further study on fractionating each component separately and validating the materials using other parasite developmental stages are warranted.
- | moxidectin / Generic mfg., albendazole / Generic mfg., levamisole / Generic mfg.
Journal: Susceptibility of Angiostrongylus cantonensis Larvae to Anthelmintic Drugs. (Pubmed Central) - Jul 10, 2022
Collectively, our study revealed that macrocyclic lactones, levamisole, pyrantel pamoate, and albendazole are important anthelmintic agents against A. cantonensis. The results of this in vitro study also suggest that A. cantonensis L1 may be a particularly sensitive and useful model for anthelmintic studies.
- | albendazole / Generic mfg.
Biomarker, Journal: Application of multiplex amplicon deep-sequencing (MAD-seq) to screen for putative drug resistance markers in the Necator americanus isotype-1 β-tubulin gene. (Pubmed Central) - Jul 9, 2022
In Ghana, previous studies have demonstrated significant variability in albendazole effectiveness among people infected with the hookworm Necator americanus, although the mechanisms underlying deworming response have not been defined...This MAD-seq method provides a highly sensitive tool to monitor the three putative benzimidazole resistance markers at individual and community levels. Further work is required to understand the association of these polymorphisms to treatment response.
- | Trial completion date: Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge Infection (clinicaltrials.gov) - Jul 8, 2022
P2, N=39, Active, not recruiting, Sponsor: Baylor College of Medicine
Further work is required to understand the association of these polymorphisms to treatment response. Trial completion date: Aug 2022 --> Dec 2022
- | ivermectin oral / Generic mfg., albendazole / Generic mfg.
Biomarker, Journal: Lymphatic filarial serum proteome profiling for identification and characterization of diagnostic biomarkers. (Pubmed Central) - Jul 7, 2022
A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF)...Furthermore, the differentiation between different stages of LF cases and biomarkers identified in this study clearly demonstrates the potential of the human serum profiling approach for LF detection. To our knowledge, this is the first report of comparative human serum profiling in different categories of LF patients.
- | albendazole / Generic mfg.
Retrospective data, Journal: PRELIMINARY DATA ON LIVER TRANSPLANTATION IN HYDATIDOSIS DISEASE. (Pubmed Central) - Jul 7, 2022
To our knowledge, this is the first report of comparative human serum profiling in different categories of LF patients. The patients benefited from the procedure and have a good prognosis due to the absence of metastasis, early reintroduction of antiparasitic drugs, and continuous follow-up.
- | albendazole / Generic mfg.
Journal: Clinical and epidemiological characteristics of cystic echinococcosis in children from a tertiary center in Peru. (Pubmed Central) - Jul 7, 2022
Albendazole was prescribed in 100% of hepatic cases, in 73.7% of pulmonary cases, and in 75% of those with both conditions. Mortality was not reported.
- | albendazole / Generic mfg.
Journal: Microsporidial myositis, keratitis and hypercalcaemia in a cystic fibrosis lung transplant recipient. (Pubmed Central) - Jul 5, 2022
Albendazole was commenced and after a 1 week systemic inflammatory response syndrome, the patient made a significant recovery and was discharged home...A tissue sample yielded highly beneficial and unexpected results. A multispecialty approach was essential given the varied infection manifestations, which included myositis, keratitis and possible central nervous system, vocal cord, parapharyngeal and renal involvement.
- | ivermectin oral / Generic mfg.
Journal: Impact of preventive chemotherapy on transmission of soil-transmitted helminth infections in Pemba Island, United Republic of Tanzania, 1994-2021. (Pubmed Central) - Jul 5, 2022
Improvement of sanitation coverage remains a key measure to permanently reduce the prevalence and intensity of STH. Possible changes to the present PC approaches to better control STH in Pemba would be (i) to assure high coverage in all schools, (ii) to use mebendazole instead of albendazole given its better activity on T. trichiura and (iii) to use a combination of ivermectin and mebendazole to further increase anthelminthic efficacy on T. trichiura.
- | albendazole / Generic mfg.
Journal: Diethylcarbamazine citrate-fortified salt for lymphatic filariasis elimination in India. (Pubmed Central) - Jul 2, 2022
The Government of India (GOI) prioritized the elimination of LF through the annual mass drug administration (MDA) programme in 2004 and continued with a single dose of diethylcarbamazine citrate (DEC), 6 mg/kg of body weight, plus albendazole annually over a period of 5-6 years...If implemented appropriately, this strategy will ensure the complete cessation of LF transmission within two years from its introduction. If the said strategy is implemented in 2022, it is expected that India will be able to achieve the LF elimination by 2024, much before the global target of 2030.
- | albendazole / Generic mfg.
Journal: Spectrophotometric determination of Zr(IV), Hg(II) and U(VI) in solution with their analytical applications: Structural characterization and molecular docking of the solid complexes. (Pubmed Central) - Jun 28, 2022
The band gap values indicated that these complexes were semi-conductors and belong to the same class of extremely effective solar materials. The albendazole ligand and its complexes have been biologically tested against a variety of bacterial and fungal strains, and molecular docking studies have been conducted to evaluate the optimal binding site and its inhibitory action.
- | albendazole / Generic mfg.
Journal: Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway. (Pubmed Central) - Jun 25, 2022
Currently, only one drug, albendazole is efficient to treat hookworm infection and the scientific community fears the rise of resistant strains...A first screen of a library of 2654 natural compounds identified four that caused decreased worm viability in a blood-feeding-dependent manner. This new screening assay has significant potential to accelerate the discovery of new drugs against hookworms.
- | mebendazole / Generic mfg.
Preclinical, Journal: HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo. (Pubmed Central) - Jun 25, 2022
P-MBZ also demonstrated considerable antitumour activity in EL-4 tumour-bearing mice when administered intraperitoneal (i.p.), either as a single dose or using 3 intermittent doses. The combination of P-MBZ with immunotherapy based on complexes of IL-2 and anti-IL-2 mAb S4B6, potently stimulating activated and memory CD8 T cells, as well as NK cells, further improved the therapeutic effect.
- | albendazole / Generic mfg.
Journal: Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens. (Pubmed Central) - Jun 24, 2022
Treatment with single dose of albendazole led to reduction in naturally acquired immune response against hookworm infection. Thus, P. falciparum infection may have a boosting effect on hookworm vaccine effectiveness.
- | albendazole / Generic mfg.
Journal: Brain lesions associated with eosinophilia. A useful clue for neurotoxocariasis. Report of one case. (Pubmed Central) - Jun 24, 2022
Serological studies found specific IgG antibodies by ELISA against antigens of the genus Toxocara, which were confirmed by a positive IgG Western Blot. The patient was treated with albendazole (800 mg/d) for 14 days associated with parenteral and then oral corticosteroids with a favorable response and gradual complete recovery.
- | albendazole / Generic mfg.
Journal: Hookworm re-infection rate and efficacy of single-dose albendazole among pregnant women in Debre Elias District, Northwest Ethiopia: A single-arm trial. (Pubmed Central) - Jun 23, 2022
Though the cure rate of single-dose albendazole was 81.7%, with an overall egg reduction rate of 92.5%, the re-infection rate of hookworm 18-24 weeks post-treatment was substantial at 21.4%. More effective intervention measures are thus needed.
- ||| albendazole / Generic mfg.
@GSK extends its albendazole donation @WHO to include treatment of echinococcosis in addition to LF and STH. @RMinghui #beatNTDs #NTDs #NTDroadmap (Twitter) - Jun 23, 2022
- | albendazole / Generic mfg.
Journal: Successful use of albendazole and fenbendazole therapy in a cat with persistent diarrhea due Enterocytozoon bieneusi. (Pubmed Central) - Jun 22, 2022
The treatment with albendazole (10 days) followed by fenbendazole (5 days) proved to be effective and safe after diagnosis. This description highlights the need to investigate these pathogens in cases of diarrhea due to their importance in public health since they are zoonotic agents.
- | nitazoxanide / Generic mfg.
Preclinical, Journal: In vitro metabolic stress induced by nitazoxanide and flubendazole combination in Taenia crassiceps cysticerci. (Pubmed Central) - Jun 22, 2022
While the NTZ isolated exposure induced metabolic acidosis and protein catabolism and the FLB isolate exposure induced gluconeogenesis and protein catabolism. These results show that the combination of drugs with different modes of action increase the antiparasitic effect and may be indicated as alternative cysticercosis treatments.
- || albendazole / Generic mfg.
Clinical, Journal: Defining optimal implementation packages for delivering community-wide mass drug administration for soil-transmitted helminths with high coverage. (Pubmed Central) - Jun 22, 2022
Efficient duration of MDA delivery uniquely stood out as a highly influential implementation activity for producing high coverage of community-wide MDA for STH. Effective MDA delivery can be achieved with flexible implementation strategies that include various combinations of influential intervention components.
- albendazole / Generic mfg.
Pulmonary hydatid disease: clinical and radiographic features (TP-20 in thematic poster area) - Jun 22, 2022 - Abstract #ERS2022ERS_1234;
We referred 17 patients to thoracic surgery, while one patient refused surgery and was put under albendazole...In adults, the lungs are the second-most common organ to be involved, after the liver. Complicated cysts often present with atypical radiological features.
- | albendazole / Generic mfg.
Journal: Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites: Binary Longitudinal Models with Temporal Structure in a Four-Arm Randomized Trial. (Pubmed Central) - Jun 19, 2022
Results showed a decreased chance of having anemia and diarrhea over time, although with no significant differences between arms. Data from longitudinal studies are essential to study the direct and indirect effects of interventions, such as deworming, and to explore additional approaches aiming at better understanding the temporal structure of nutrition and health outcomes in children.
- | albendazole / Generic mfg.
Clinical protocol, Retrospective data, Journal: Resistance to single dose albendazole and reinfection with intestinal helminths among children ages 2 to 11 years from the Peruvian Amazon region: a study protocol. (Pubmed Central) - Jun 15, 2022
Trial registration https://www.researchregistry.com/ . Identification number: researchregistry7736; Registered retrospectively March 13, 2022; https://www.researchregistry.com/browse-the-registry#home/registrationdetails/622e024cf06132001e3327bf/.
- | ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: Integrated transmission assessment surveys (iTAS) of lymphatic filariasis and onchocerciasis in Cross River, Taraba and Yobe States, Nigeria. (Pubmed Central) - Jun 15, 2022
The study identifies that LF-MDA can be safely stopped in all four of the IUs studied, but that MDA for onchocerciasis needs to continue, even though this may pose a challenge for LF surveillance. Based on the preliminary results from all four sites, this study has fulfilled the primary objective of determining the programmatic feasibility of an iTAS as a tool to simultaneously assess onchocerciasis and LF prevalence in areas co-endemic for the two infections that have completed the recommended treatment for one or both infections, and to make decisions on how to proceed.
- | albendazole / Generic mfg.
Journal: The potentials of Calotropis procera against filarial elephantiasis: an in-silico approach. (Pubmed Central) - Jun 14, 2022
Drugs such as Albendazole, Ivermectin and diethylcarbamazine are administered either individually or in combination to overcome the progress of the lymphatic filariasis...N-octanoate was the phytocompound obtained based on molecular docking, subjected to molecular dynamics. These results require further in vitro and in vivo validation to consider n-octanoate as a potential drug candidate for lymphatic filariasis treatment.
- albendazole / Generic mfg., clarithromycin / Generic mfg.
An unwanted guest - Cutaneous larva migrans (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_382;
Although the rash was not typical, the history is an important element. Advising not walking barefoot and laying on the ground in unknown places are crucial advice in the prevention of occurrence of this disease.
- | albendazole / Generic mfg.
Journal: Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells. (Pubmed Central) - Jun 9, 2022
However, ABZ could even recover suppression of apoptosis and autophagy caused by NAC in colon cancer cells. Therefore, ABZ can potentially up-regulate both the apoptosis and autophagy to significantly suppress tumorigenesis in colorectal cancer cell lines.
- | albendazole / Generic mfg., praziquantel / Generic mfg.
Journal, HEOR: Cost-effectiveness evaluation of different control strategies for Clonorchis sinensis infection in a high endemic area of China: A modelling study. (Pubmed Central) - Jun 9, 2022
The findings may help to develop control policies for C. sinensis infection in high endemic areas. Moreover, the method adopted is applicable for assessment of optimal strategies in other endemic areas.
- | albendazole / Generic mfg.
Journal: Lentinula edodes extract increases goblet cell number and Muc2 expression in an intestinal inflammatory model of Trichinella spiralis infection. (Pubmed Central) - Jun 8, 2022
Standard treatment with albendazole (ABZ) was used as control in the assessment of parasite burden...In addition, AHCC® diminished the number of adults of T. spiralis in treated animals. AHCC® treatment anticipates T. spiralis expulsion and increases goblet cell number and Muc2 gene expression.
- | albendazole / Generic mfg.
Journal: Haycocknema perplexum myositis: the first description of subclinical disease and a proposed distinctive triad to evoke clinical suspicion. (Pubmed Central) - Jun 8, 2022
This report aimed to raise awareness of H. perplexum myositis and the possibility of subclinical infection, which suggests a protracted disease course. Further research is required to identify a non-invasive diagnostic test, given that early diagnosis and timely initiation of albendazole treatment may drastically limit patient disability.
- | albendazole / Generic mfg.
Journal: Novel techniques for drug loading quantification in mesoporous SBA-15 using chemometric-assisted UV and FT-IR data. (Pubmed Central) - May 31, 2022
Albendazole is a crystalline drug that is poorly soluble in water, thus the dissolution rate in gastrointestinal fluids is limited...It is important to highlight that the prediction adjustment of the FT-IR model (root-mean-square error of prediction=2.196%) presented lower error than the UV model (root-mean-square error of prediction=3.553%). Therefore, this development contributes to improve the overall time and cost of drug loading determination into mesoporous materials.
- | ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: Using quantitative PCR to identify opportunities to strengthen soil-transmitted helminth control in Solomon Islands: A cross-sectional epidemiological survey. (Pubmed Central) - May 31, 2022
Furthermore, One Health strategies are needed for improved A. ceylanicum and Strongyloides spp. control, WASH access and use should be improved to complement deworming programmes, and control efforts should ideally be expanded to entire communities.
- | albendazole / Generic mfg.
Journal: Filariasis presenting as pancytopenia in a child. (Pubmed Central) - May 31, 2022
Subsequent haemograms showed improved cell counts. This along with a previous handful of case reports emphasises filariasis as one of the differentials of pancytopenia and should be kept in mind while evaluating for the same, especially in the endemic areas.
- | albendazole / Generic mfg.
Journal: Safety and Tolerability of Ivermectin and Albendazole Mass Drug Administration in Lymphatic Filariasis Endemic Communities of Tanzania: A Cohort Event Monitoring Study. (Pubmed Central) - May 30, 2022
IA combination preventive chemotherapy is safe and tolerable, and associated AEs are mild-to-moderate and transient, with few severe AEs. Safety monitoring during MDA campaigns in individuals with underlying clinical conditions is recommended for timely detection and management of AEs.
- | albendazole / Generic mfg.
Journal: Pulmonary Infection Caused by Strongyloides stercoralis. (Pubmed Central) - May 29, 2022
Safety monitoring during MDA campaigns in individuals with underlying clinical conditions is recommended for timely detection and management of AEs. In this case report, combination of microscopic examination of sputum and alveolar lavage fluid and CT scan were used to quickly identify the cause of the patient, it provides a diagnostic basis and method for clinical treatment.
- | ivermectin oral / Generic mfg., albendazole / Generic mfg., praziquantel / Generic mfg.
Journal: Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia. (Pubmed Central) - May 27, 2022
In contrast, MDA with praziquantel had little impact on hyperendemic Schistosoma mansoni in the study area. Results from a long-term follow-up survey showed that improvements in infection parameters were sustained by routine annual MDA provided by the Liberian Ministry of Health after our study endpoint.
- | Journal: Molecular Modelling and Virtual Screening to Identify New Piperazine Derivatives as Potent Human 5-HT1A Antagonists and Reuptake Inhibitors. (Pubmed Central) - May 26, 2022
Results from a long-term follow-up survey showed that improvements in infection parameters were sustained by routine annual MDA provided by the Liberian Ministry of Health after our study endpoint. The study represents a cost-effective, faster and environmentally friendly approach to the discovery of promising SARI antidepressants for further translational study.
- | albendazole / Generic mfg.
Preclinical, Journal: Dissolution/permeation of albendazole in the presence of cyclodextrin and bile salts: a mechanistic in-vitro study into factors governing oral bioavailability. (Pubmed Central) - May 26, 2022
These results indicate that the interplay between bile salts and cyclodextrins can enhance the free (molecularly dissolved) fraction of drug in solution to a greater extent than could be obtained with one of the solubilizing components alone. In conclusion, at carefully selected cyclodextrin-concentrations in combination with biomimetic media, obviously, a transient supersaturation is induced, which is made responsible for the observed major permeation enhancement.
- | albendazole / Generic mfg.
Preclinical, Journal: Effects of Echinococcus multilocularis metacestodes infection and drug treatment on the activities of biotransformation enzymes in mouse liver. (Pubmed Central) - May 26, 2022
In addition, after six weeks treatment of albendazole in E...Moreover, albendazole and 3-bromopyruvate, the promising potential drug against Echinococcus, affected different hepatic biotransformation enzymes and may affect their metabolism. The findings will help to develop rational treatments with less side effects and promote the development of more efficient treatments against E. multilocularis.