albendazole / Generic mfg. 
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  • ||||||||||  albendazole / Generic mfg.
    Trial completion, Trial completion date, Combination therapy:  DOLF IDA/Oncho: Safety and Efficacy of IDA for Onchocerciasis (clinicaltrials.gov) -  Dec 14, 2022   
    P2,  N=154, Completed, 
    Active, not recruiting --> Completed | Trial completion date: Jan 2023 --> Jun 2022
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Benzimidazole fungicide biotransformation by comammox Nitrospira bacteria: Transformation pathways and associated proteomic responses. (Pubmed Central) -  Dec 12, 2022   
    Interestingly, the exposure to albendazole enhanced the expression of the antibiotic resistance gene acrB of Nitrospira inopinata, suggesting that some benzimidazole fungicides could act as environmental stressors that trigger cellular defense mechanisms. Altogether, this study demonstrated the distinct substrate specificity of comammox bacteria towards benzimidazole fungicides and implies their significant roles in the biotransformation of these fungicides in nitrifying environments.
  • ||||||||||  albendazole / Generic mfg.
    Biomarker, Journal, Next-generation sequencing:  Diagnostic value of metagenomics next-generation sequencing technology in disseminated strongyloidiasis. (Pubmed Central) -  Dec 10, 2022   
    In recent years, mNGS has been increasingly used in clinical practice, and is becoming the main means of detecting strongyloides stercoralis in non-endemic areas. Especially during the corona virus disease 2019 pandemic, mNGS technology has irreplaceable value in identifying the source of infection.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Development of Hydrogel-Forming Microneedles for Transdermal Delivery of Albendazole from Liquid Reservoir. (Pubmed Central) -  Dec 10, 2022   
    Incorporated with the liquid reservoir, the ex vivo permeation test showed that the cumulative amount of ABZ permeated through the skin was about 971.23 ± 11.77 µg/cm. In conclusion, this innovation has a huge potential to overcome the limitations of ABZ in oral preparations and potentially enhance its therapeutic effect through the transdermal route.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Gut microbiome of helminth-infected indigenous Malaysians is context dependent. (Pubmed Central) -  Dec 9, 2022   
    Furthermore, a substantial quantity of the microbiome remains unannotated, and this large dataset from an indigenous population associated with helminth infections is a valuable resource for future studies. Video Abstract.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Cough, bloody sputum, eosinophil elevation and lung shadow (Pubmed Central) -  Dec 9, 2022   
    It was recommended that the patient should be treated by surgery combined with albendazole. His symptoms relieved and lung nodules were shrinking without treatment after 5 years follow-up.
  • ||||||||||  albendazole / Generic mfg.
    Journal, HEOR:  Cost-benefit ratio of anthelmintic treatment and its comparative efficacy in commercial dairy farms. (Pubmed Central) -  Dec 6, 2022   
    In the current study, the efficacy and impact of benzimidazole (albendazole) were assessed in a total of 400 (100 each) on the performance of buffaloes, buffalo-heifer, cattle, and cattle-heifers at two commercial dairy farms in the Province of Punjab, Pakistan...Cumulative cost-benefit analysis indicated a positive correlation between treated and non-treated animals. These findings reiterate the importance of anthelmintic drugs in reducing the impacts of parasites on the productivity, health, and well-being of an animal under high infection challenges.
  • ||||||||||  ivermectin oral / Generic mfg., albendazole / Generic mfg., levamisole / Generic mfg.
    Journal:  Efficacy of clinically used anthelmintics against toxocariasis of buffalo calves in Bangladesh. (Pubmed Central) -  Dec 3, 2022   
    Thirty-two buffalo calves below 3 months of age with clinical Toxocara infection had been selected and treated with albendazole (ABZ), levamisole (LVM) and ivermectin (IVM)...This is a novel information on anthelmintics efficacy in buffalo calves in Bangladesh. Details study is recommended on the efficacy of anthelmintics in different buffalo management systems by in vitro egg hatch assay (EHA) test.
  • ||||||||||  dexamethasone / Generic mfg., albendazole / Generic mfg.
    Journal:  A Histopathologically Diagnosed Neurocysticercosis Case from Türkiye (Pubmed Central) -  Dec 3, 2022   
    The patient received an antiparasitic treatment with albendazole 1000 mg/d in combination with dexamethasone. The patient was successfully treated and is still being followed up by calling for controls.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Clostridia isolated from helminth-colonized humans promote the life cycle of Trichuris species. (Pubmed Central) -  Dec 1, 2022   
    Remarkably, Peptostreptococcaceae isolated from the Orang Asli display superior capacity to promote the life cycle of whipworm species, including hatching of eggs from Trichuris muris and Trichuris trichiura. These findings support a model in which helminths select for gut colonization of microbes that support their life cycle.
  • ||||||||||  moxidectin / Generic mfg., albendazole / Generic mfg., levamisole / Generic mfg.
    Journal:  Signs of multiple anthelmintic resistance in sheep gastrointestinal nematodes in Sweden. (Pubmed Central) -  Nov 28, 2022   
    Thus, there is a need for a truly randomized study to get an update on the extent of the situation of anthelmintic resistance at a national level, as well as to identify risk factors involved in the resistance selection. Research is also required to establish the optimal intervals for sampling post-treatment.
  • ||||||||||  albendazole / Generic mfg.
    Journal, Combination therapy:  Experimental treatment of cystic echinococcosis: Combination therapy with carvacrol and thymol versus albendazole. (Pubmed Central) -  Nov 27, 2022   
    Moreover, the combination of two drugs with different modes of action would cause a reduction in the doses and treatment times. Based on the promising results obtained in vitro, in the future, different doses of the combined drugs will be assayed in vivo to determine the potential of these compounds for the treatment of cystic echinococcosis.
  • ||||||||||  albendazole / Generic mfg., praziquantel / Generic mfg.
    Enrollment change, Trial termination:  Sub Arachnoid Neurocysticercosis Treatment Outcome (SANTO) (clinicaltrials.gov) -  Nov 16, 2022   
    P3,  N=107, Terminated, 
    N=164 --> 107 | Recruiting --> Terminated; Albendazole and albendazole placebo are not available in our local suppliers or in the international market. Consequently, it is no possible to re-initiate the enrollment to complete the original sample size.
  • ||||||||||  albendazole / Generic mfg.
    Trial completion date, Trial primary completion date:  Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) (clinicaltrials.gov) -  Nov 14, 2022   
    P3,  N=380000, Recruiting, 
    In summary, ABZ could suppress the proliferation and migration of HCC cells by regulating WWOX-dependent signaling pathway. Trial completion date: Dec 2023 --> Apr 2024 | Trial primary completion date: Dec 2023 --> Apr 2024
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Unusual migration of cutaneous larva migrans. (Pubmed Central) -  Nov 9, 2022   
    The question remains as to whether albendazole is a drug that can induce autoimmune hepatitis in the paediatric population. No abstract available
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Hydatid disease of the ribs: An exceptional location. (Pubmed Central) -  Nov 8, 2022   
    All of our patients underwent a rib excision accompanied by medical treatment of albendazole 24 hours after the surgery...The diagnosis was based on radiology and intraoperative exploration. The treatment remained essentially surgical by rib excision with anthelmintic drugs to prevent recurrence.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Clinical Reasoning: A 12-Month-Old Male With Staring Episodes, Ataxia, and Right-Sided Weakness. (Pubmed Central) -  Nov 3, 2022   
    Notably, this child had a remarkably positive outcome with near complete recovery of neurologic function after treatment with albendazole and steroids. While eosinophilic meningoencephalitis is rare, accounting for less than 3% of all lumbar punctures with pleocytosis, this case illustrates: A) the importance of early disease recognition and treatment to improve patient outcomes and B) the fact that automated cell differentials may misidentify eosinophils as monocytes.
  • ||||||||||  ivermectin oral / Generic mfg., albendazole / Generic mfg.
    Review, Journal:  Ivermectin and albendazole coadministration: opportunities for strongyloidiasis control. (Pubmed Central) -  Nov 2, 2022   
    Finally, the evolution of ivermectin resistance represents a credible risk to control S stercoralis; we argue that genome-wide approaches, together with improved genome resources, are needed to characterise and prevent the emergence of resistance. Overcoming these challenges will help to reduce strongyloidiasis burden and enhance the feasibility of controlling it worldwide.
  • ||||||||||  albendazole / Generic mfg.
    Review, Journal:  Review of Cysticercosis of Maxillofacial Region and Report of Two Cases. (Pubmed Central) -  Nov 2, 2022   
    Excision of cystic lesion was the treatment modality in majority of published reports. It is emphasised that cysticercosis should be considered in differential diagnosis of solitary painless swellings of oral and maxillofacial region, especially in patients from an endemic region.
  • ||||||||||  Review, Journal:  Anthelmintic intoxication in goats and sheep: A systematic review. (Pubmed Central) -  Nov 2, 2022   
    The most prevalent symptoms of anthelmintic intoxication reported were showed involvement of the nervous, locomotor, and renal systems, as well as teratogenic influences. Data from this review underscore the need of the care required in the control of parasitic infections through the safe use of antiparasitic drugs to avoid cases of intoxication.
  • ||||||||||  albendazole / Generic mfg.
    Journal:  Potential New Therapeutic Approaches Based on Punica granatum Fruits Compared to Synthetic Anthelmintics for the Sustainable Control of Gastrointestinal Nematodes in Sheep. (Pubmed Central) -  Oct 28, 2022   
    The aim of this study was to evaluate the anthelmintic efficacy of aqueous pomegranate (Punica granatum L.) macerate compared to the treatment with Ivermectin and Albendazole in sheep naturally infected with GINs...This in vivo study demonstrated the unequivocal efficacy of plant macerate in easily reducing 50% of the number of GIN eggs in sheep faeces. These results, obtained without the use of synthetic anthelmintics, indicate the use of green veterinary pharmacology as a sustainable alternative to the use of synthetic drugs to reduce the increase in drug resistance phenomena and the environmental impact.
  • ||||||||||  albendazole / Generic mfg., praziquantel / Generic mfg.
    Review, Journal:  Human Neurocysticercosis: An Overview. (Pubmed Central) -  Oct 28, 2022   
    These drugs have been shown to reduce the burden of infection and to improve the clinical course of the disease in many patients. Efforts should be directed to eradicate the disease through the implementation of control programs against all the steps in the life cycle of T. solium, including carriers of the adult tapeworm, infected pigs, and eggs in the environment.
  • ||||||||||  moxidectin / Generic mfg., ivermectin oral / Generic mfg., albendazole / Generic mfg.
    Journal:  Current pharmacotherapeutic strategies for Strongyloidiasis and the complications in its treatment. (Pubmed Central) -  Oct 28, 2022   
    Moxidectin might be a valid alternative to ivermectin, with the advantage of being a dose-independent formulation...In pregnant or lactating women, studies have not identified increased risk with ivermectin use. However, with limited available data, a risk-benefit assessment should be considered for each case.
  • ||||||||||  Preclinical evaluation of novel repurposed drug combinations in Hodgkin lymphoma (Great Hall) -  Oct 27, 2022 - Abstract #ISHL2022ISHL_46;    
    On the contrary Eprosartan (Epro) Metformin (Met) Clofibrate (Clof) and Ornidazole (Orni) increased antibody dependent cellular phagocytosis (ADCP) in in-vitro assays.This project shows that combinations of repurposed non-oncological drugs at safe doses have a direct cytotoxic effect against HL and a potentially beneficial impact on key immune response mechanisms. Taken together our results justify further evaluation of combinations of these clinically known drugs with chemotherapy or checkpoint blockade in cases of HL without other treatment options.
  • ||||||||||  albendazole / Generic mfg.
    Preclinical, Journal:  Evaluation of the mechanism of action of albendazole on adult rat lungworm (Angiostrongyluscantonensis). (Pubmed Central) -  Oct 27, 2022   
    Similarly, our MTT assay showed a dose-dependent decrease in formazan intensity (proportional to cell viability), suggesting that the rate of nematocidal activity of albendazole is also proportional to its concentration. In compiling the results from both these experiments, a correlation between the microtubule assembly and worm viability is evident.