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Clinical, Journal: Three cases of non-Hodgkin's lymphoma in HIV-infected Bulgarian patients. (Pubmed Central) - Apr 11, 2019 The first patient received antiretroviral therapy (ART) and EPOCH (etoposide, pharmarubicin, vincristin, endoxane, uromitexan) plus radiotherapy, while the second received ART and CHOEP (endoxan, epirubicin, vincristin, etoposide, prednisolone). The third patient died a few days after beginning antiretroviral therapy.
- |||||||||| prednisolone / generics, vigabatrin / generics
Review, Journal: Infantile Spasms-Have We Made Progress? (Pubmed Central) - Apr 11, 2019 Additionally, the use of appropriate medications as well as an early diagnosis has the most impact on short-term outcomes. Children with infantile spasms benefit most from early diagnosis and early treatment with appropriate standard medications such as hormonal therapy (ACTH or prednisolone) or vigabatrin.
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Preclinical, Journal: Prednisolone treatment reduces the osteogenic effects of loading in mice. (Pubmed Central) - Apr 9, 2019 In conclusion, high-dose prednisolone treatment strongly inhibits the loading-induced increase in trabecular BMD, and abolishes the loading-induced increase in cortical bone mass. This phenomenon could be due to prednisolone inhibition of osteoblast differentiation and function.
- |||||||||| Orencia (abatacept) / BMS, Stelara (ustekinumab) / J&J, Actemra IV (tocilizumab) / Roche, JW Pharma
Journal: Current and emerging diagnosis tools and therapeutics for giant cell arteritis. (Pubmed Central) - Apr 9, 2019 ...Expert commentary: Prednisone/prednisolone of 40-60 mg/day is the mainstay in GCA therapy...Methotrexate is the most common conventional immunosuppressive drug used as a glucocorticoid sparing agent...Anti-tumor necrosis factor-α therapy is not useful in GCA. Experience with other biologic agents, such as abatacept or ustekinumab, looks promising but it is still scarce.
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Clinical, Journal: Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue. (Pubmed Central) - Apr 9, 2019 Here, we describe the use of these 3 injury models and their combined use with systemic glucocorticoid treatment, which exerts bone inhibitory and immunosuppressive effects. We provide a workflow on how to prepare for immunosuppressive treatment in adult zebrafish, illustrate how to perform fin amputation, trepanation of calvarial bones, and fin fractures, and describe how the use of glucocorticoids affects both bone forming osteoblasts and cells of the monocyte/macrophage lineage as part of innate immunity in bone tissue.
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Clinical, Journal: Growth of children with biliary atresia living with native livers: impact of corticoid therapy after portoenterostomy. (Pubmed Central) - Apr 9, 2019 As high postoperative corticosteroid dosage has a short-term negative effect on height, very high dosages should be avoided. What Is Known: • Growth of biliary atresia patients has mostly been shown to be within normal limits • Corticosteroids may decrease growth rate What Is New: • Biliary atresia patients surviving with their native livers are shorter than general population and their mid-parental target height at birth • A high (> 50 mg/kg) cumulative prednisolone dosage has a negative transitory impact on height gain after portoenterostomy.
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Clinical, Journal: Malignancy in Systemic Lupus Erythematosus (SLE) Patients (Pubmed Central) - Apr 9, 2019 ...steroid sparing agent like mycophenolate mofetil (15.4%), azathioprine (36.8%) or ciclosporin (15.4%)...and all patients a median dose of prednisolone 10 (2.5, 10) mg with 10 (4-24) years of steroids...cyclophosphamide prior to the development of cancer for their SLE compared to overall cohort of 160... We found a loweroccurrence of cancer in our SLE patients as compared with the reported literature.
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Clinical, Journal: Glucocorticoid-induced diabetes and risk factors during high-dose therapy (Pubmed Central) - Apr 7, 2019 This review describes the cumulative incidence (CI) and risk factors of glucocorticoid (GC)-induced diabetes in patients commencing high-dose GC therapy: ≥ 30 mg prednisolone/day...Risk factors may include high age and high levels of BMI and glycated haemoglobin, respectively, before GC therapy. It is important to acknowledge, that hyperglycaemia in GC therapy is more prevalent postprandially, and screening should be planned accordingly.
- |||||||||| methylprednisolone / generics, mycophenolate mofetil / generics
Journal: Recurrent arterial ischemic stroke with good response to mycophenolate mofetil. (Pubmed Central) - Apr 7, 2019 A guideline for current treatment of relapsing central nervous system angiitis in childhood is missing in the literature. We describe a subject with multiple relapses despite treatment with corticosteroids and immunosuppressive agents, and stabilization of his clinical condition and of the radiological signs under mycophenolate mofetil treatment.
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Clinical, Journal: Current epidemiology and clinical characteristics of autoimmune liver diseases in South Korea. (Pubmed Central) - Apr 5, 2019 However, scarce data, low awareness, delayed diagnosis and non-availability of 2nd line therapeutics are important issues to be solved. Therefore, governmental support for research and drug development and nationwide cooperative studies are warranted.
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Clinical, Journal: Ciclosporin and the cat: Current understanding and review of clinical use. (Pubmed Central) - Apr 5, 2019 Information presented has been summarised from the existing literature on CsA, with specific interest in studies carried out in cats. For its licensed indication, chronic allergic dermatitis, evidence provided includes randomised, placebo or prednisolone-controlled studies (EBM grade I) and prospective or retrospective open trials.
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Clinical, Review, Journal, Adverse events: Side effects of medications used to treat childhood interstitial lung disease. (Pubmed Central) - Apr 5, 2019 The European Respiratory Society chILD guidelines recommend the use of systemic glucocorticosteroids, hydroxychloroquine and azithromycin. Side effects of these drugs will be discussed followed by consideration of other drugs used for the treatment of chILD.
- |||||||||| Azulfidine (sulfasalazine) / Pfizer
Clinical, Journal: A case of ankylosing spondylitis with concurrent Takayasu arteritis. (Pubmed Central) - Apr 5, 2019 ...Ankylosing spondylitis (AS) was diagnosed at 41 years of age, and treatment with sulfasalazine was initiated...Intraoperative aortic biopsy revealed findings pathologically consistent with TA. Although AS with concurrent AR is well described, AS with concurrent TA, as in the present case, is rare.
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Clinical, Journal: Clinical and pathological characteristics and outcome of 46 children with autoimmune hepatitis (Pubmed Central) - Apr 3, 2019 Most cases have progressive liver inflammation and fibrosis when diagnosed. Prednisolone monotherapy or combined with azathioprine could achieve both biochemical and pathological improvement, but relapse is inevitable during drug tapering, hence long-term treatment is essential.
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