- |||||||||| prednisolone / Generic mfg., tacrolimus topical / Generic mfg., cyclosporine / Generic mfg.
Journal: Treatment Considerations for Pyoderma Gangrenosum After Reduction Mammoplasty in an Unsuspecting Patient Demographic. (Pubmed Central) - Jan 13, 2025
Transition to oral cyclosporine with continued daily topical tacrolimus ultimately led to complete healing. This case underscores the need for a high clinical suspicion for PG in nonhealing ulcerative lesions after breast surgery, in addition to the importance of timely initiation of immunomodulatory agents and modification of the regimen if incomplete resolution is encountered.
- |||||||||| hydroxychloroquine / Generic mfg., prednisolone / Generic mfg., methotrexate / Generic mfg.
Journal: Normal tension glaucoma as initial manifestation of Takayasu arteritis- an unknown entity. (Pubmed Central) - Jan 13, 2025
This case underscores the need for a high clinical suspicion for PG in nonhealing ulcerative lesions after breast surgery, in addition to the importance of timely initiation of immunomodulatory agents and modification of the regimen if incomplete resolution is encountered. This case highlights the importance of comprehensive ophthalmic evaluation in patients with NTG and the need to consider systemic conditions, such as TA, as potential underlying cause in young female patients presenting with NTG.
- |||||||||| Budenofalk granules (budesonide gastro-resistant granules) / Dr Falk
Journal: Novel desensitization therapy of mesalamine intolerance in patients with ulcerative colitis. (Pubmed Central) - Jan 12, 2025
This case highlights the importance of comprehensive ophthalmic evaluation in patients with NTG and the need to consider systemic conditions, such as TA, as potential underlying cause in young female patients presenting with NTG. This retrospective study reports a successful and safe desensitization method for UC patients with mesalamine intolerance.
- |||||||||| prednisolone / Generic mfg., ebastine / Generic mfg.
Journal: Prednisolone versus antihistamine for allergic rhinitis: No significant difference found in randomized trial. (Pubmed Central) - Jan 12, 2025
Prednisolone tablets did not show superior efficacy over antihistamine tablets in reducing symptoms or medication usage in tree pollen-induced AR. These results suggest that systemic corticosteroids may not provide additional benefits over antihistamines, and clinicians should prioritize individualized treatment based on patient preferences and tolerability.
- |||||||||| prednisolone / Generic mfg., Rituxan (rituximab) / Roche
Journal: Clinical and immunological predictors of post-rituximab paradoxical pemphigus flare: A prospective cohort study. (Pubmed Central) - Jan 8, 2025
Though these unexpected pemphigus flares are likely to be associated with rituximab infusion, the possibility of spontaneous disease exacerbation cannot be entirely excluded. Conclusions Patients with more severe pemphigus or high serum anti-Dsg1 are at risk of post-rituximab paradoxical flare, and may benefit from rituximab administration under close monitoring.
- |||||||||| Kineret (anakinra) / SOBI
Review, Journal: Anakinra in relapsing polychondritis: a case report and review of the literature. (Pubmed Central) - Dec 20, 2024
In one of these patients, there was co-administration of methotrexate. In summary, anakinra may remain as an option, only for those subsets of patients in whom many of the other more efficacious treatments have been tried to provide sustained disease control.
- |||||||||| prednisolone / Generic mfg.
Journal: Retraction of cystoid macular edema from the fovea after intravitreal anti-VEGF therapy for birdshot chorioretinopathy. (Pubmed Central) - Dec 18, 2024
Lower response to treatment among corticosteroid-treated COP patients may suggest secondary causes of organizing pneumonia. Here, we report for the first time the long-term outcomes of anti-vascular endothelial growth factor injections on fovea-involving cystoid macular edema in Birdshot chorioretinopathy to keep steroid at the minimal possible doses and preserve a satisfying visual acuity level.
- |||||||||| prednisolone / Generic mfg., azithromycin / Generic mfg.
Journal: A case of Mycoplasma pneumoniae-induced rash and mucositis with recent influenza vaccination. (Pubmed Central) - Dec 3, 2024
Secondly, our case highlights the clinical challenge in differentiating MIRM from EMM or Stevens-Johnson syndrome, particularly if there is a potential drug trigger (in our case the influenza vaccine), as all these conditions can feature a severe mucositis with often indistinguishable histological findings. Correct diagnosis of MIRM is important for appropriate and timely administration of anti-MP antibiotic therapy to facilitate recovery and minimise complications.
- |||||||||| prednisolone / Generic mfg., lorazepam / Generic mfg., quetiapine / Generic mfg.
Journal: Steroid-Induced Psychosis in a Child With Nephrotic Syndrome Secondary to Focal Segmental Glomerulosclerosis: A Case Report. (Pubmed Central) - Dec 2, 2024
He was initiated on oral prednisolone 3?weeks ago after being diagnosed with nephrotic syndrome...He was then initiated on tacrolimus, quetiapine, and lorazepam and was discharged after a week...Similarly, atypical antipsychotics (like quetiapine) are preferred for psychosis because of their lesser risk for extrapyramidal side effects compared to typicals. Parental counseling and informed consent are utmost for children on steroids or tacrolimus.
- |||||||||| prednisolone / Generic mfg.
Journal: Case report: Acute macular neuroretinopathy post-COVID-19 infection. (Pubmed Central) - Nov 27, 2024
This case illustrates a clear temporal and possible causal relationship of COVID-19 infection with AMN. Further studies and data are required to justify its association, but the rising cases of AMN shall be anticipated as COVID-19 infections have become endemic worldwide.
- |||||||||| Tagrisso (osimertinib) / AstraZeneca
Journal: Bilateral Hemorrhagic Occlusive Retinal Vasculitis Induced by Osimertinib in a Patient with Non-Small Cell Lung Cancer. (Pubmed Central) - Nov 26, 2024
Eighteen months before symptom onset, the treatment was changed from afatinib (20?mg/day) to osimertinib (80?mg/day) because of tumor progression...Osimertinib was reduced to 40?mg/day, and oral prednisolone was started at 30?mg/day...Osimertinib, a third-generation tyrosine kinase inhibitor, can be used to treat advanced non-small cell lung cancer with epidermal growth factor receptor mutation-induced bilateral HORV. This adverse effect can be managed with systemic and local steroid treatment and continued osimertinib administration.
- |||||||||| prednisolone / Generic mfg.
Assessing the Utility of High Dose Prednisolone Compared to ACTH for the Treatment of Infantile Spasms (South Hall H - Level 1 - LACC) - Nov 26, 2024 - Abstract #AES2024AES_1489;
ACTH costs continue to rise with a 14 day course of treatment costing $100,457 in 2020, compared to oral prednisolone costing about $89 in 2020... Our study portrays a benefit to starting treatment with high dose prednisolone as it is associated with earlier initiation of treatment, and significantly lower rates of relapse with similar treatment response rate when compared to ACTH while being more cost-effective.
- |||||||||| Rituxan (rituximab) / Roche
Retrospective data, Journal: Retrospective Analysis of Rituximab Therapy for Myasthenia Gravis: A Case Series. (Pubmed Central) - Nov 26, 2024
In the three cases included in this analysis, rituximab led to notable improvements in quality of life, general clinical condition, and muscle weakness. Further studies with larger patient populations and longer follow-up periods are needed to validate these results and provide a more comprehensive understanding of rituximab's role in MG treatment.
- |||||||||| prednisolone / Generic mfg.
Journal: Efficacy and safety of 10 (Pubmed Central) - Nov 21, 2024
Key Points The 10- and 30-mg daily doses of prednisolone were equally effective in treating acute symptoms of CPP crystal arthritis, with no significant differences in resolution time, recurrence rates, or safety outcomes.
- |||||||||| prednisolone / Generic mfg.
Journal: Intravitreal AAV2 gene delivery to feline retinal ganglion cells. (Pubmed Central) - Nov 18, 2024
The 10- and 30-mg daily doses of prednisolone were equally effective in treating acute symptoms of CPP crystal arthritis, with no significant differences in resolution time, recurrence rates, or safety outcomes. Immunosuppressive oral prednisolone was administered perioperatively and gradually tapered over 6-10wks post-injection...Peak transduction in RGCs (up to
- |||||||||| prednisolone / Generic mfg.
Journal: Focal segmental glomerulosclerosis (FSGS) in pregnancy: The case of a 27-year-old woman with nephrotic syndrome at 22 weeks of gestation. (Pubmed Central) - Nov 17, 2024
Six weeks after commencing empirical treatment with high-dose oral prednisolone, there was no response; hence, tacrolimus was initiated...A live male infant was delivered weighing 1625 g. Renal biopsy at 4 weeks post-partum was consistent with primary FSGS. This case highlights the strategies we utilised to manage a gravid patient presenting with nephrotic syndrome at 22 weeks gestation, where diagnosis could only be confirmed on renal biopsy in the postpartum period.
- |||||||||| prednisolone / Generic mfg., benidipine / Generic mfg.
Journal: Refractory vasospastic angina in a patient with autoimmune hepatitis managed by using combined non-invasive provocation tests: A case report. (Pubmed Central) - Nov 14, 2024
To assess the effectiveness of the pharmacotherapy following a Ca2+ antagonist (benidipine) administration, we adopted non-invasive and non-pharmacological coronary vasospasm provocation tests (cold-pressor stress, isometric handgrip exercise, and hyperventilation)...Discontinuation of corticosteroids is often difficult, and long-term administration may be inevitable. Evaluation of the fluctuated spasmogenicity during long-term observation of autoimmune hepatitis may be crucial.
- |||||||||| prednisolone / Generic mfg.
An acutely unwell and rare presentation of systemic lupus erythematosus; a case report () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_99;
She was commenced on high dose oral prednisolone (40 mg/day) and antibiotics...Normal value . Haemoglobin109106130-180 g/LWhite cell count21114-11 x 10 ^9/LLymphocytes0.91.11.0-4.0 x 10^9/lNeutrophils19.59.91.8-7.5 x 10^9/LPlatelet105244150-450 x 10^9/LESR120390-27 mm/hrCRP192348.08.08.08.08.08.090
- |||||||||| Rituxan (rituximab) / Roche
Decoding short stature in a child with lupus nephritis: an unusual association with de la Chapelle syndrome () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_96;
However, persistence of proteinuria after 3-months necessitated addition of mycophenolate mofetil (1200 mg/m2/day) following which his SLE-disease activity went into remission.Notwithstanding the control of SLE-disease activity, there was no improvement in his height after 1-year of follow-up...Chagnon et al reported using corticosteroids, hydroxychloroquine, methotrexate, intravenous pulse cyclophosphamide, azathioprine, and plasmapheresis...The need for escalation of therapy or primary therapy with rituximab in such patients needs further exploration. Another point of concern is using cyclophosphamide, a known drug to have adverse effect on testes, in these patients since it may further compromise testicular function.
- |||||||||| Humira (adalimumab) / AbbVie
TB or not TB... That is the question! () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_87;
Unfortunately he could not tolerate high doses of sulfasalazine and hydroxychloroquine was introduced, which again he could not tolerate...Incidentally, it picked up tree-in-bud changes in the lower lungs in keeping with possible chest infection, treated with two weeks of levofloxacin...He was on 17.5 mg of oral prednisolone, which was incrementally increased to 80 mg in light of rifampicin effect...Lastly, this case report represents a case of GCA occurring in a patient already on adalimumab and methotrexate (a steroid-sparing agent for GCA)...This case is complex, demonstrating an unusual presentation of GCA in the context of a patient already on immunosuppression, who subsequently developed military TB despite a negative pre-immunosuppression screen and no risk factors for TB. It contributes to the ongoing discussion about the need for TB screening in all DMARD-naive patients.
- |||||||||| Olumiant (baricitinib) / Eli Lilly, Actemra IV (tocilizumab) / Roche, JW Pharma, Kineret (anakinra) / SOBI
The role of JAK inhibitors in difficult-to-treat adult-onset Still's disease: a case series () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_57;
Initial treatment with 60 mg oral prednisolone showed some response, but polyarthritis necessitated further intervention...Colchicine was tried next...The successful outcomes with JAK inhibitors highlight their ability to achieve disease control where other treatments failed, demonstrating their efficacy in reducing systemic inflammation and disease activity.Further research is warranted to establish optimal dosing, duration of therapy, and long-term safety profiles of JAK inhibitors in this patient population. These preliminary results are encouraging and suggest a new avenue for treating AOSD.Key learning points:
- |||||||||| Sarcoidosis, Steroids and Saprophytes () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_25;
Risks of continuous immunosuppressive treatment need to be balanced with more definitive hematopoietic stem cell transplantation (HSCT) previously used to achieved complete remission in LRBA deficiency. He was treated empirically for sarcoidosis with oral methotrexate and high dose oral prednisolone.Two months later, he travelled to London...Ceftriaxone was substituted to co-trimoxazole to cover Nocardia and Toxoplasma.Blood cultures, HIV test, urinary legionella, pneumococcal, histoplasma and serum cryptococcal antigens were negative...In keeping with our case report, Nocardia is more common in Australia with one case series describing 484 cases in seven major Queensland Hospitals over a 15-year time period.
- |||||||||| prednisolone / Generic mfg.
Review, Journal: IgG4-Related Dacryoadenitis With Fibrous Mass in a 19-Month-Old Child: Case Report and Literature Review. (Pubmed Central) - Nov 4, 2024
The patient received oral prednisolone for 4 months postoperatively and remained relapse-free for 27 months...IgG4-related dacryoadenitis with a fibrous mass may occur in very young children, responding well to surgical excision and steroids. Although pediatric IgG4-related orbital disease is not well-characterized yet, it may manifest differently from its adult variant.
- |||||||||| prednisolone / Generic mfg.
Journal: Purtscher-like retinopathy and paracentral acute middle maculopathy associated with improper antihypertensive drug use: a case report. (Pubmed Central) - Nov 4, 2024
The patient was recommended to stop his antihypertensive medication, and prescribed other systemic medicines, including oral prednisolone (40?mg q.d. with gradual tapering), oral cobalamin (0.5?mg?t.i.d.), and subcutaneous injections of compound anisodine (2.0?mL q.d.) beside the superficial temporal artery...Our report expands our understanding of the etiology and pathophysiology of PLR and PAMM. We also stress the importance of proper application of medications in clinical practice.
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