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153 Diseases |  |
74 Trials |
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74 Trials |  |
10107 News |  |
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- prednisolone / Generic mfg.
[VIRTUAL] Recovery of Adrenal Function After Secondary Iatrogenic Adrenal Failure in Severe Asthma Patients (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1513;
Three-quarters of patients were able to recover adrenal function within one year. Routine asthma care for OCS-dependent patients must now include monitoring of the HPA axis, allowing secure down-titration of OCS for disease control and safe, observed recovery of the HPA axis, thereby avoiding unnecessary OCS treatment or replacement.
- Nucala (mepolizumab) / GSK, Fasenra (benralizumab) / AstraZeneca
[VIRTUAL] The Response to Benralizumab at 1 Year After A Sub-Optimal Response to Mepolizumab in Severe Eosinophilic Asthma (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1287;
We report real world clinical effectiveness of benralizumab at 1 year following a poor response to mepolizumab in SEA with reductions in exacerbation frequency and OCS exposure, alongside improvements in patient reported outcome measures. Research into the mechanisms of this differential response is required as are randomised head-to-head trials to aid clinicians choosing between mAbs in SEA.
- ||| prednisolone / Generic mfg.
Clinical: The patient relapsed while on prednisolone 15mg plus vedo. would think that he is probably not responding to vedo. Why not try Tofa alone. (Twitter) - Jul 6, 2020
- | prednisolone / Generic mfg.
Clinical, Journal: Efficacy of g-csf in the management of steroid-nonresponsive severe alcoholic hepatitis: a double-blind randomized controlled trial. (Pubmed Central) - Jul 5, 2020
P=N/A
Approximately one quarter of patients with SAH do not respond to corticosteroid therapy. Administration of G-CSF is safe and helps to reduce the disease severity and 90-day mortality in these patients.
- || prednisolone / Generic mfg., hydrocortisone / Generic mfg.
Clinical, Journal: Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK. (Pubmed Central) - Jul 5, 2020
Anaesthetists must be familiar with the symptoms and signs of acute adrenal insufficiency so that inadequate supplementation or undiagnosed adrenal insufficiency can be detected and treated promptly. Delays may prove fatal.
- | prednisolone / Generic mfg., prednisone / Generic mfg.
Journal: Challenges in managing graft-versus-host disease in developing countries: a perspective. (Pubmed Central) - Jul 4, 2020
For optimal management, HCT programs should develop systems in place for long-term follow-up of HCT survivors and have a low threshold to initiate treatments for GVHD early. Awareness and health policy programs must be initiated at the grass-root level for long-term management of these survivors in developing countries.
- | prednisolone / Generic mfg.
Journal: Canine sterile steroid-responsive lymphadenitis in 49 dogs. (Pubmed Central) - Jul 4, 2020
Awareness and health policy programs must be initiated at the grass-root level for long-term management of these survivors in developing countries. Sterile steroid-responsive lymphadenitis should be considered in dogs with pyrexia of unknown origin with inflammatory lymphadenopathy if no underlying cause can be found and often responds well to immunosuppressive corticosteroid therapy.
- | prednisolone / Generic mfg.
Journal: Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs. (Pubmed Central) - Jul 4, 2020
Sterile steroid-responsive lymphadenitis should be considered in dogs with pyrexia of unknown origin with inflammatory lymphadenopathy if no underlying cause can be found and often responds well to immunosuppressive corticosteroid therapy. In dogs with acute pancreatitis, initial treatment with prednisolone resulted in earlier reductions in C-reactive protein concentration and earlier improvement of clinical signs.
- || prednisolone / Generic mfg.
Clinical, Journal: Results of oral prednisolone administration or ventriculoperitoneal shunt placement in dogs with congenital hydrocephalus: 40 cases (2005-2016). (Pubmed Central) - Jul 4, 2020
Approximately half of the dogs treated with prednisolone in this population had neurologic improvement at last follow-up; results of surgical treatment were comparable to those in previous studies. Further research is needed to assess factors associated with acceptable outcomes for dogs with congenital hydrocephalus.
- || prednisolone / Generic mfg.
Clinical, Journal: Clinical and serologic remission of acquired myasthenia gravis in a domestic ferret (Mustela putorius furo). (Pubmed Central) - Jul 4, 2020
Findings indicated that clinical and serologic remission can be achieved in ferrets with myasthenia gravis. However, owner willingness to provide extensive supportive care was vital to the outcome for this patient, as was the owner's decision to not euthanize the ferret despite an initial lack of response to treatment.
- || prednisolone / Generic mfg., methylprednisolone oral / Generic mfg.
Biomarker, Clinical, Journal, Head-to-Head: Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial. (Pubmed Central) - Jul 4, 2020
P4
Eosinophil-guided therapy was non-inferior compared with standard care for the number of days alive and out of hospital, and reduced the duration of systemic corticosteroid exposure, although we could not entirely exclude harm on some secondary outcome measures. Larger studies will help to determine the full safety profile of this strategy and its role in the management of COPD exacerbations.
- | prednisolone / Generic mfg., vinblastine / Generic mfg.
Retrospective data, Journal: Haematologic toxicity in dogs with mast cell tumours treated with vinblastine/prednisolone chemotherapy with/without radiotherapy. (Pubmed Central) - Jul 4, 2020
Larger studies will help to determine the full safety profile of this strategy and its role in the management of COPD exacerbations. Radiation and vinblastine chemotherapy can be safely combined in dogs with mast cell tumours without increasing the risk of clinically important myelosuppression.
- | prednisolone / Generic mfg.
Journal: Characterisation and outcome of idiopathic pyogranulomatous lymphadenitis in 64 English springer spaniel dogs. (Pubmed Central) - Jul 4, 2020
Idiopathic pyogranulomatous lymphadenitis should be considered as a differential diagnosis for lymphadenopathy and pyrexia in English springer spaniels. The characteristics of the disease, absence of identifiable infectious aetiology and response to glucocorticoid therapy suggest an immune-mediated aetiology.
- || prednisolone / Generic mfg., Leukeran (chlorambucil) / GSK
Clinical, Journal: Rapid clinical progression of B-cell chronic lymphocytic leukemia in a horse. (Pubmed Central) - Jul 4, 2020
This report was the first to describe the use of chemotherapy, albeit unsuccessful, for the treatment of B-cell CLL in a horse. This information should be useful for guiding expectations for prognosis and management of other horses affected with the disease.
- | prednisolone / Generic mfg.
Journal: Prednisolone therapy in prolonged cerebral edema due to diabetic ketoacidosis. (Pubmed Central) - Jul 4, 2020
This information should be useful for guiding expectations for prognosis and management of other horses affected with the disease. No abstract available
- | cytarabine / Generic mfg., cyclophosphamide intravenous / Generic mfg.
Journal: Toxicity of cytarabine constant rate infusion in dogs with high-grade non-Hodgkin lymphoma with bone marrow or central nervous system involvement. (Pubmed Central) - Jul 4, 2020
No abstract available Our findings suggest that gastrointestinal toxicity should be expected in lymphoma patients undergoing cytarabine CRI.
- || prednisolone / Generic mfg., prednisone / Generic mfg.
Retrospective data, Review, Journal: Prednisolone/prednisone as adrenocorticotropic hormone alternative for infantile spasms: a meta-analysis of randomized controlled trials. (Pubmed Central) - Jul 3, 2020
Our findings suggest that gastrointestinal toxicity should be expected in lymphoma patients undergoing cytarabine CRI. Prednisolone/prednisone elicits a similar electroclinical response as ACTH for infantile spasms, which indicates that it can be an alternative to ACTH for treating infantile spasms.
- | doxycycline / Generic mfg., Pierre Fabre
Journal: Progressive cutaneous angiomatosis in the metatarsal region of a cat. (Pubmed Central) - Jul 3, 2020
Prednisolone/prednisone elicits a similar electroclinical response as ACTH for infantile spasms, which indicates that it can be an alternative to ACTH for treating infantile spasms. Findings in the cat of the present report highlighted that cutaneous angiomatosis could recur in a short period of time and that amputation of the affected limb was a viable treatment option when surgical resection was not successful.
- || prednisolone / Generic mfg., Durezol (difluprednate ophthalmic emulsion) / Senju, Novartis
Clinical, Journal: Comparison of topically administered 0.05% difluprednate and 1% prednisolone acetate for inhibition of aqueocentesis-induced breakdown of the blood-aqueous barrier in healthy dogs. (Pubmed Central) - Jul 3, 2020
All 4 treatments were effective for reducing aqueocentesis-induced anterior uveitis in healthy dogs regardless of the drug or frequency of administration. Topical ophthalmic administration of 0.05% difluprednate may be a viable treatment option for dogs with anterior uveitis and warrants further study.
- || clarithromycin / Generic mfg.
Clinical, Journal: Asymptomatic sinusitis as an origin of infection-related glomerulonephritis manifesting steroid-resistant nephrotic syndrome: A case report. (Pubmed Central) - Jul 3, 2020
A gold standard therapy for idiopathic GN, corticosteroid could be damaging in uncontrolled or underdiagnosed infection. In asymptomatic patients, a thorough screening of infectious diseases, including sinusitis, together with a renal histological evaluation of glomerular nephritis-associated plasmin receptor deposition is also essential in treating a wide spectrum of GN.
- || prednisolone / Generic mfg., Durezol (difluprednate ophthalmic emulsion) / Senju, Novartis
Clinical, Journal: Difluprednate 0.05% versus Prednisolone Acetate Post-Phacoemulsification for Inflammation and Pain: An Efficacy and Safety Clinical Trial. (Pubmed Central) - Jul 3, 2020
P3
The results of this study suggest that PRO-145 is as effective and safe as prednisolone acetate in treating postoperative inflammation and pain in patients undergoing phacoemulsification. The study was registered at ClinicalTrials.gov as NCT03693989.
- Flagyl (metronidazole) / SLA, tacrolimus / Generic mfg.
[VIRTUAL] PNEUMATOSIS INTESTINALIS AS A RARE POST-TRANSPLANT COMPLICATION IN PEDIATRIC PATIENTS (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5544;
Both cases confirm the previously described association of PI with GvHD and intense immunosuppression. While conservative management was successful in one asymptomatic patient, an emergency diagnostic laparotomy could not be avoided in the other patient due to acute abdominal pain.
- Flagyl (metronidazole) / SLA, tacrolimus / Generic mfg.
[VIRTUAL] PNEUMATOSIS INTESTINALIS AS A RARE POST-TRANSPLANT COMPLICATION IN PEDIATRIC PATIENTS (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5543;
Both cases confirm the previously described association of PI with GvHD and intense immunosuppression. While conservative management was successful in one asymptomatic patient, an emergency diagnostic laparotomy could not be avoided in the other patient due to acute abdominal pain.
- Flagyl (metronidazole) / SLA, tacrolimus / Generic mfg.
[VIRTUAL] PNEUMATOSIS INTESTINALIS AS A RARE POST-TRANSPLANT COMPLICATION IN PEDIATRIC PATIENTS (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5542;
Both cases confirm the previously described association of PI with GvHD and intense immunosuppression. While conservative management was successful in one asymptomatic patient, an emergency diagnostic laparotomy could not be avoided in the other patient due to acute abdominal pain.
- [VIRTUAL] IDIOPATHIC PNEUMONIA SYNDROME (IPS) AFTER PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FROM UNRELATED DONOR FOR HURLER SYNDROME (MUCOPOLYSACCHARIDOSIS TYPE 1) SUCCESSFULLY TREATED WITH ETANERCEPT AND STEROIDS (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5514;
TNF-α is crucially involved in inflammation and immune responses in the lungs post-HSCT. Etanercept, a TNF-α inhibitor, has been postulated to improve the Overall survival in IPS patients.
- [VIRTUAL] IDIOPATHIC PNEUMONIA SYNDROME (IPS) AFTER PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FROM UNRELATED DONOR FOR HURLER SYNDROME (MUCOPOLYSACCHARIDOSIS TYPE 1) SUCCESSFULLY TREATED WITH ETANERCEPT AND STEROIDS (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5513;
TNF-α is crucially involved in inflammation and immune responses in the lungs post-HSCT. Etanercept, a TNF-α inhibitor, has been postulated to improve the Overall survival in IPS patients.
- [VIRTUAL] IDIOPATHIC PNEUMONIA SYNDROME (IPS) AFTER PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FROM UNRELATED DONOR FOR HURLER SYNDROME (MUCOPOLYSACCHARIDOSIS TYPE 1) SUCCESSFULLY TREATED WITH ETANERCEPT AND STEROIDS (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5512;
TNF-α is crucially involved in inflammation and immune responses in the lungs post-HSCT. Etanercept, a TNF-α inhibitor, has been postulated to improve the Overall survival in IPS patients.
- tacrolimus / Generic mfg.
[VIRTUAL] T-CELL-RICH HAPLOIDENTICAL STEM CELL TRANSPLANTATION IMPROVES SURVIVAL IN CHILDREN WITH ACUTE LEUKEMIA RELAPSED AFTER ALLOGENEIC TRANSPLANTATION (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5457;
Our analysis suggests that TCR-haplo-HSCT with low-dose ATG (2.5 mg/kg) hold promise to improve outcome in children relapsed after allo-HSCT. We propose TCR-haplo-SCT as a new immune cell therapy for improving survival rate in patients with relapsed/refractory acute leukemia, for which no effective treatment is currently available.
- tacrolimus / Generic mfg.
[VIRTUAL] T-CELL-RICH HAPLOIDENTICAL STEM CELL TRANSPLANTATION IMPROVES SURVIVAL IN CHILDREN WITH ACUTE LEUKEMIA RELAPSED AFTER ALLOGENEIC TRANSPLANTATION (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5456;
Our analysis suggests that TCR-haplo-HSCT with low-dose ATG (2.5 mg/kg) hold promise to improve outcome in children relapsed after allo-HSCT. We propose TCR-haplo-SCT as a new immune cell therapy for improving survival rate in patients with relapsed/refractory acute leukemia, for which no effective treatment is currently available.
- tacrolimus / Generic mfg.
[VIRTUAL] T-CELL-RICH HAPLOIDENTICAL STEM CELL TRANSPLANTATION IMPROVES SURVIVAL IN CHILDREN WITH ACUTE LEUKEMIA RELAPSED AFTER ALLOGENEIC TRANSPLANTATION (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_5455;
Our analysis suggests that TCR-haplo-HSCT with low-dose ATG (2.5 mg/kg) hold promise to improve outcome in children relapsed after allo-HSCT. We propose TCR-haplo-SCT as a new immune cell therapy for improving survival rate in patients with relapsed/refractory acute leukemia, for which no effective treatment is currently available.
- Jakafi oral (ruxolitinib) / Novartis, Incyte, sirolimus / Generic mfg.
[VIRTUAL] RUXOLITINIB FOR STEROID-REFRACTORY GVHD ABOLISHES ANTIVIRAL IMMUNE RESPONSE FOLLOWING T-CELL TRANSFER FOR REFRACTORY ADENOVIRUS INFECTION AFTER HAPLOIDENTICAL STEM CELL TRANSPLANTATION (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4024;
Administration of ruxolitinib in this patient after haploidentical SCT ameliorated intestinal GvHD, but completely abrogated virus-specific T-cell function. After cessation of ruxolitinib adotively transferred HAdV.specific T cells against hexon and penton could be detected and led to decrease in HAdV viral load.
- Jakafi oral (ruxolitinib) / Novartis, Incyte, sirolimus / Generic mfg.
[VIRTUAL] RUXOLITINIB FOR STEROID-REFRACTORY GVHD ABOLISHES ANTIVIRAL IMMUNE RESPONSE FOLLOWING T-CELL TRANSFER FOR REFRACTORY ADENOVIRUS INFECTION AFTER HAPLOIDENTICAL STEM CELL TRANSPLANTATION (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4023;
Administration of ruxolitinib in this patient after haploidentical SCT ameliorated intestinal GvHD, but completely abrogated virus-specific T-cell function. After cessation of ruxolitinib adotively transferred HAdV.specific T cells against hexon and penton could be detected and led to decrease in HAdV viral load.
- Jakafi oral (ruxolitinib) / Novartis, Incyte, sirolimus / Generic mfg.
[VIRTUAL] RUXOLITINIB FOR STEROID-REFRACTORY GVHD ABOLISHES ANTIVIRAL IMMUNE RESPONSE FOLLOWING T-CELL TRANSFER FOR REFRACTORY ADENOVIRUS INFECTION AFTER HAPLOIDENTICAL STEM CELL TRANSPLANTATION (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_4022;
Administration of ruxolitinib in this patient after haploidentical SCT ameliorated intestinal GvHD, but completely abrogated virus-specific T-cell function. After cessation of ruxolitinib adotively transferred HAdV.specific T cells against hexon and penton could be detected and led to decrease in HAdV viral load.
- [VIRTUAL] IS PREEMPTIVE STRATEGY ENOUGH? RELATIONSHIP BETWEEN CMV REACTIVATION AND STEROID THERAPY FOR GHVD IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS: 97 PATIENTS FROM TURKEY (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3940;
We concluded that steroid treatment increases CMV reactivation risk in allogeneic stem cell transplantation. In conclusion, increasing risk implies the need to discuss prophylaxis instead of preemptive therapy in steroid users due to GVHD after AlloHSCT.
- [VIRTUAL] IS PREEMPTIVE STRATEGY ENOUGH? RELATIONSHIP BETWEEN CMV REACTIVATION AND STEROID THERAPY FOR GHVD IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS: 97 PATIENTS FROM TURKEY (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3939;
We concluded that steroid treatment increases CMV reactivation risk in allogeneic stem cell transplantation. In conclusion, increasing risk implies the need to discuss prophylaxis instead of preemptive therapy in steroid users due to GVHD after AlloHSCT.
- [VIRTUAL] IS PREEMPTIVE STRATEGY ENOUGH? RELATIONSHIP BETWEEN CMV REACTIVATION AND STEROID THERAPY FOR GHVD IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS: 97 PATIENTS FROM TURKEY (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3938;
We concluded that steroid treatment increases CMV reactivation risk in allogeneic stem cell transplantation. In conclusion, increasing risk implies the need to discuss prophylaxis instead of preemptive therapy in steroid users due to GVHD after AlloHSCT.
- [VIRTUAL] IMPROVING THE RESULT OF HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR PRIMARY IMMUNODEFICIENCY WITH SERIOUS INFECTION IN DEVELOPING COUNTRIES USING RIC REGIMENT (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3778;
Although there are concerns about ability of RIC regimen to achieve engraftment and higher incidence of engraftment failure or mix chimerism following RIC-HSCTs, It has created an opportunity for patients who are not eligible for myeloablative conditioning regimen. Use of RIC in developing countries where BCG vaccination are mandatory at birth can improve survival rates and mixed donor chimerism appears to be sufficient to control the disease in PIDs.
- [VIRTUAL] IMPROVING THE RESULT OF HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR PRIMARY IMMUNODEFICIENCY WITH SERIOUS INFECTION IN DEVELOPING COUNTRIES USING RIC REGIMENT (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3777;
Although there are concerns about ability of RIC regimen to achieve engraftment and higher incidence of engraftment failure or mix chimerism following RIC-HSCTs, It has created an opportunity for patients who are not eligible for myeloablative conditioning regimen. Use of RIC in developing countries where BCG vaccination are mandatory at birth can improve survival rates and mixed donor chimerism appears to be sufficient to control the disease in PIDs.
- [VIRTUAL] IMPROVING THE RESULT OF HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR PRIMARY IMMUNODEFICIENCY WITH SERIOUS INFECTION IN DEVELOPING COUNTRIES USING RIC REGIMENT (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3776;
Although there are concerns about ability of RIC regimen to achieve engraftment and higher incidence of engraftment failure or mix chimerism following RIC-HSCTs, It has created an opportunity for patients who are not eligible for myeloablative conditioning regimen. Use of RIC in developing countries where BCG vaccination are mandatory at birth can improve survival rates and mixed donor chimerism appears to be sufficient to control the disease in PIDs.
- doxorubicin hydrochloride / Generic mfg., cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] A COMPARISON OF ALLOGENEIC STEM CELL TRANSPLANTATION AND BFM 95 CHEMOTHERAPY PROTOCOL IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3607;
Of 84 transplanted patients, 40 received The Hyper - Cyclophosphamide - Vincristin - Adriamycin - Dexamethasone (Hyper-CVAD) chemotherapy, 21 received Cancer and Leukemia Group B (cyclophosphamide, daunorubicine, vincristine, prednisolon and L-asparaginase) chemotherapy and 23 received Berlin -Frankfurt - Munster 95 (BFM 95) (prednisolone, vincristine, daunorubicine and L-asparaginase) chemotherapy and AHSCT was performedearly after obtaining a complete remission. These results suggest that whether if there exist any advantage of AHSCT over BFM-95 chemotherapy regimen for adults with ALL in first remission large prospective randomized studies are needed before reaching a definitive conclusion.
- doxorubicin hydrochloride / Generic mfg., cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] A COMPARISON OF ALLOGENEIC STEM CELL TRANSPLANTATION AND BFM 95 CHEMOTHERAPY PROTOCOL IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3606;
Of 84 transplanted patients, 40 received The Hyper - Cyclophosphamide - Vincristin - Adriamycin - Dexamethasone (Hyper-CVAD) chemotherapy, 21 received Cancer and Leukemia Group B (cyclophosphamide, daunorubicine, vincristine, prednisolon and L-asparaginase) chemotherapy and 23 received Berlin -Frankfurt - Munster 95 (BFM 95) (prednisolone, vincristine, daunorubicine and L-asparaginase) chemotherapy and AHSCT was performedearly after obtaining a complete remission. These results suggest that whether if there exist any advantage of AHSCT over BFM-95 chemotherapy regimen for adults with ALL in first remission large prospective randomized studies are needed before reaching a definitive conclusion.
- doxorubicin hydrochloride / Generic mfg., cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] A COMPARISON OF ALLOGENEIC STEM CELL TRANSPLANTATION AND BFM 95 CHEMOTHERAPY PROTOCOL IN ADULT PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3605;
Of 84 transplanted patients, 40 received The Hyper - Cyclophosphamide - Vincristin - Adriamycin - Dexamethasone (Hyper-CVAD) chemotherapy, 21 received Cancer and Leukemia Group B (cyclophosphamide, daunorubicine, vincristine, prednisolon and L-asparaginase) chemotherapy and 23 received Berlin -Frankfurt - Munster 95 (BFM 95) (prednisolone, vincristine, daunorubicine and L-asparaginase) chemotherapy and AHSCT was performedearly after obtaining a complete remission. These results suggest that whether if there exist any advantage of AHSCT over BFM-95 chemotherapy regimen for adults with ALL in first remission large prospective randomized studies are needed before reaching a definitive conclusion.
- Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] AUTOIMMUNE MYOSITIS AS PARANEOPLASTIC COMPLICATION OF A SQUAMOUS CELL CARCINOMA OF THE TONGUE AFTER SEVERE CHRONIC GRAFT VERSUS HOST DISEASE (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3424;
To our knowledge this is a very rare event and this long term follow up of a patient with secondary malignancy following chronic GVHD is an example for the successful multidisciplinary approach in taking care of long-term survivors. Clinical Trial Registry: -
- Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] AUTOIMMUNE MYOSITIS AS PARANEOPLASTIC COMPLICATION OF A SQUAMOUS CELL CARCINOMA OF THE TONGUE AFTER SEVERE CHRONIC GRAFT VERSUS HOST DISEASE (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3423;
To our knowledge this is a very rare event and this long term follow up of a patient with secondary malignancy following chronic GVHD is an example for the successful multidisciplinary approach in taking care of long-term survivors. Clinical Trial Registry: -
- Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] AUTOIMMUNE MYOSITIS AS PARANEOPLASTIC COMPLICATION OF A SQUAMOUS CELL CARCINOMA OF THE TONGUE AFTER SEVERE CHRONIC GRAFT VERSUS HOST DISEASE (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3422;
To our knowledge this is a very rare event and this long term follow up of a patient with secondary malignancy following chronic GVHD is an example for the successful multidisciplinary approach in taking care of long-term survivors. Clinical Trial Registry: -
- prednisolone / Generic mfg., cyclosporine / Generic mfg.
[VIRTUAL] EFFECT OF EXTRACORPOREAL PHOTOPHERESIS ON PRODUCTION OF SERUM SOLUBLE CD163: RELATIONSHIP TO IMMUNOSUPPRESSION AND DISEASE ACTIVITY IN CHRONIC GRAFT VERSUS HOST DISEASE (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3178;
We confirm that sCD163 is significantly raised in a subset of cGVHD patients compared to healthy controls, which is reduced by ECP. Further, the data suggest that ECP therapy reduces hepatocellular injury as indicated by serum ALT and AST liver enzyme levels in sCD163hi patients.
- prednisolone / Generic mfg., cyclosporine / Generic mfg.
[VIRTUAL] EFFECT OF EXTRACORPOREAL PHOTOPHERESIS ON PRODUCTION OF SERUM SOLUBLE CD163: RELATIONSHIP TO IMMUNOSUPPRESSION AND DISEASE ACTIVITY IN CHRONIC GRAFT VERSUS HOST DISEASE (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3177;
We confirm that sCD163 is significantly raised in a subset of cGVHD patients compared to healthy controls, which is reduced by ECP. Further, the data suggest that ECP therapy reduces hepatocellular injury as indicated by serum ALT and AST liver enzyme levels in sCD163hi patients.
- prednisolone / Generic mfg., cyclosporine / Generic mfg.
[VIRTUAL] EFFECT OF EXTRACORPOREAL PHOTOPHERESIS ON PRODUCTION OF SERUM SOLUBLE CD163: RELATIONSHIP TO IMMUNOSUPPRESSION AND DISEASE ACTIVITY IN CHRONIC GRAFT VERSUS HOST DISEASE (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3176;
We confirm that sCD163 is significantly raised in a subset of cGVHD patients compared to healthy controls, which is reduced by ECP. Further, the data suggest that ECP therapy reduces hepatocellular injury as indicated by serum ALT and AST liver enzyme levels in sCD163hi patients.
- dexamethasone / Generic mfg., prednisolone / Generic mfg.
[VIRTUAL] REDUCED INFLAMMATORY TISSUE INFILTRATION DURING INTESTINAL STEROID-REFRACTORY GVHD (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3166;
In the context of disappointing clinical results of SR-GVHD treatment by immunosuppressive agents, our current results provide a rationale for non-immunosuppressive therapies, e.g. tissue protection or regenerative approaches. Clinical Trial Registry: not applicable
- dexamethasone / Generic mfg., prednisolone / Generic mfg.
[VIRTUAL] REDUCED INFLAMMATORY TISSUE INFILTRATION DURING INTESTINAL STEROID-REFRACTORY GVHD (ePoster Area) - Jul 3, 2020 - Abstract #EBMT2020EBMT_3165;
In the context of disappointing clinical results of SR-GVHD treatment by immunosuppressive agents, our current results provide a rationale for non-immunosuppressive therapies, e.g. tissue protection or regenerative approaches. Clinical Trial Registry: not applicable