- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
[VIRTUAL] The benefits of rituximab for the treatment of immunobullous diseases: real clinic data for remission induction and side‐effect profile () - Sep 9, 2020 - Abstract #BAD2020BAD_133;
Fourteen per cent (n = 4) experienced side‐effects after the infusion (one patient had a community‐acquired bronchopneumonia; one patient had ophthalmic shingles with a corneal ulcer; and another felt nonspecifically feverish 2 days after the second infusion; the final patient had multiple comorbidities and complex social problems and died a few months later). In our experience, rituximab has been well tolerated and highly effective in a cohort of patients with resistant autoimmune blistering conditions, allowing for significant reduction in long‐term immunosuppression and, in nearly a third of cases, complete remission. Our experience suggests that the current NHS England guidelines for rituximab in immunobullous diseases needs to be reviewed and that rituximab should be considered as a first‐line treatment owing to its ability to induce complete remission.
- |||||||||| prednisolone / Generic mfg., mycophenolate mofetil / Generic mfg.
[VIRTUAL] Immunotherapy‐induced bullous pemphigoid: a multicentre observational study () - Sep 9, 2020 - Abstract #BAD2020BAD_131;
The pathogenesis is hypothesized to be a shared target antigen with both T‐ and B‐cell‐mediated responses. Bullous skin toxicity frequently requires discontinuation of immunotherapy and early referral to dermatology for optimal diagnosis and management is essential.
- |||||||||| doxycycline / Generic mfg., Pierre Fabre
[VIRTUAL] The role of tetracycline–nicotinamide in management of bullous pemphigoid: a systematic review of the literature () - Sep 9, 2020 - Abstract #BAD2020BAD_127;
Oral prednisolone was used at a dose of 40–80 mg daily and topical steroids at a dose of 0.5 mg kg–1 daily...Nevertheless, tetracycline–nicotinamide is a useful alternative in treatment of mild‐to‐moderate BP in adults, especially in patients with medical conditions which preclude the use of corticosteroids. Current guidelines by the British Association of Dermatologists recommends use of systemic/topical steroids, but this evidence could strengthen future recommendations on this topic.
- |||||||||| [VIRTUAL] An annular vesicobullous presentation of Sweet syndrome () - Sep 9, 2020 - Abstract #BAD2020BAD_56;
Dapsone was contraindicated because its use alongside glyceryl‐trinitrate can result in methaemoglobinaemia, and colchicine contraindicated because use with atorvastatin can result in rhabdomyolysis...Therefore, the patient was started on a trial of indomethacin, but despite this the patient continued to develop new skin lesions...This is an atypical presentation of SS, presenting as an annular vesicobullous eruption, and clinicopathological correlation was key to making the diagnosis. It also demonstrates how the management of SS requires careful consideration of a patient's comorbidities and medications.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie, cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] ‘Otofacial’ granulomatosis () - Sep 9, 2020 - Abstract #BAD2020BAD_42;
In January 2018, she developed vertigo, tinnitus and preauricular pain, which was responsive to moderate‐dose steroids and antiemetics but unsustained on attempts to wean with methotrexate, cyclophosphamide and azathioprine...She commenced adalimumab in July 2019, with initial improvement reported in both erythema and swelling; in particular, she has managed to reduce her prednisolone dose to 5 mg daily...We propose that this patient is afflicted by an analogous condition that we term ‘otofacial’ granulomatosis. A proportion of those affected by orofacial granulomatosis have positive reactions to patch allergy tests; interestingly, our patient's initial clinical photographs show scaly inflammation around a silver earring, with positive patch tests to nickel and palladium.
- |||||||||| meropenem / Generic mfg., Daewon Pharmaceutical
[VIRTUAL] Drug reaction with eosinophilia and systemic symptoms complicated by haemophagocytic lymphohistiocytosis: is screening required? () - Sep 9, 2020 - Abstract #BAD2020BAD_39;
The admission was complicated by pneumonia, requiring vancomycin and piperacillin with tazobactam, later switching to meropenem...Prednisolone 60 mg daily was initiated, but, despite this, the patient continued to deteriorate, with persistent high fevers and the development of multiorgan failure...A joint decision to treat the patient with dexamethasone and anakinra was made, following which gradual clinical and biochemical improvement was observed, and the patient was able to leave the ICU after a further 3 weeks...Distinguishing findings in HLH include hyperferritinaemia, hypertriglyceridaemia, hypofibrinogenaemia and the presence of haemophagocytosis on biopsy of lymphoid organs. We propose using these features as the basis for screening for HLH in all critically ill patients with DRESS.
- |||||||||| prednisolone / Generic mfg., methylprednisolone oral / Generic mfg.
[VIRTUAL] Two cases of necrotizing neutrophilic dermatoses disguised as necrotizing fasciitis () - Sep 9, 2020 - Abstract #BAD2020BAD_32;
He was diagnosed with NND and treated with high‐dose intravenous methylprednisolone...Dapsone was initiated as a steroid sparing agent at 25 mg daily increasing slowly to 75 mg daily as the prednisolone was slowly reduced. The second patient was a 61‐year‐old man with known myelodysplasia...These cases highlight the importance of recognizing acute presentations of NND. They also emphasize the role of dermatologists in ensuring early diagnosis, with consequent avoidance of both unnecessary surgical procedures and the significant morbidity associated with misdiagnosis of NF.
- |||||||||| prednisolone / Generic mfg., Yervoy (ipilimumab) / Ono Pharma, BMS
[VIRTUAL] Cutaneous toxicities occurring in patients with melanoma receiving immunotherapy: the experience of a single large specialist institution () - Sep 9, 2020 - Abstract #BAD2020BAD_30;
These effects may target any organ; however, the skin is most commonly affected, occurring in 50% of those on ipilimumab and 40% on anti‐programmed cell death 1 inhibitors...Treatment when required included topical steroid in 75 of 168 (44.6%) and oral prednisolone in 14 of 168 (8.3%), and discontinuation of therapy was required secondary to skin toxicity in 4.8%...This is the single largest study to date of dermatological toxicity occurring secondary to immunotherapy in melanoma. Prompt recognition and management of these cutaneous adverse events managed under the care of a dermatologist can limit the impact that these toxicities have on quality of life and allow oncology treatment to continue where possible.
- |||||||||| JNJ-1887 / J&J
Trial completion date: AAVCAGsCD59 for the Treatment of Wet AMD (clinicaltrials.gov) - Sep 7, 2020
P1, N=25, Active, not recruiting,
Prompt recognition and management of these cutaneous adverse events managed under the care of a dermatologist can limit the impact that these toxicities have on quality of life and allow oncology treatment to continue where possible. Trial completion date: Feb 2021 --> Jan 2022
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, prednisolone / Generic mfg.
Journal: Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia. (Pubmed Central) - Sep 5, 2020
Manipulation of CELSR2 recapitulated glucocorticoid resistance in human leukemia cell lines and revealed a synergistic drug combination (prednisolone and venetoclax) that mitigated resistance in mouse xenograft models. These findings illustrate the power of an integrative genomic strategy for elucidating genes and pathways conferring drug resistance in cancer cells.
- |||||||||| prednisolone / Generic mfg., melphalan / Generic mfg.
Review, Journal: Fibrogenesis Imperfecta Ossium. (Pubmed Central) - Sep 5, 2020
Recently, a trial of recombinant growth hormone therapy was found to be effective. Further research focused on the pathogenetic mechanisms of FIO is needed to identify and develop targeted therapeutic options.
- |||||||||| cyclophosphamide intravenous / Generic mfg.
Preclinical, Journal: Resistance of t(17;19)-acute lymphoblastic leukemia cell lines to multiagents in induction therapy. (Pubmed Central) - Sep 4, 2020
Sensitivities to three (Pred, VCR, and l-asparaginase [l-Asp]), four (Pred, VCR, l-Asp, and DNR) and five (Pred, VCR, l-Asp, DNR, and cyclophosphamide) agents, widely used in induction therapy, were significantly poorer for t(17;19)-ALL cell lines than for t(1;19)-ALL cell lines...A combination of cyclosporine A with DNR prolonged survival of NSG mice inoculated with P-gp-positive t(17;19)-ALL cell line...In all four t(17;19)-ALL cell lines, RAS pathway mutation was detected. Furthermore, among 16 t(1;19)-ALL cell lines, multiagent resistance was usually observed in the cell lines with RAS pathway mutation in comparison to those without it, suggesting at least a partial involvement of RAS pathway mutation in multiagent resistance of t(17;19)-ALL.
- |||||||||| prednisolone / Generic mfg., prednisone / Generic mfg., methotrexate / Generic mfg.
Trial completion date, Trial primary completion date: CHASM-CS-RCT: Cardiac Sarcoidosis Randomized Trial (clinicaltrials.gov) - Aug 30, 2020
P3, N=194, Recruiting,
Intraocular inflammation improved with maintained visual acuity, systemic corticosteroid dose decreased and there was a low frequency of adverse events. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Clinical, Journal: Long-term outcomes in elderly patients with ANCA-associated vasculitis. (Pubmed Central) - Aug 30, 2020
Baseline frailty associates with disease outcomes including mortality. A low-dose glucocorticoid regimen (avoiding intravenous methylprednisolone) can be used to treat AAV effectively in elderly patients.
- |||||||||| doxorubicin hydrochloride / Generic mfg.
Clinical, Review, Journal: Role of microRNA dysregulation in childhood acute leukemias: Diagnostics, monitoring and therapeutics: A comprehensive review. (Pubmed Central) - Aug 30, 2020
Specific miRNA patterns have also been described for commonly used AL therapy drugs (e.g., miR-125b and miR-223 for doxorubicin, miR-335 and miR-1208 for prednisolone, and miR-203 for imatinib), uncovering miRNAs that are associated with treatment response. In the current review, the role of miRNAs in the development, progression, and therapy monitoring of pediatric ALs will be presented and discussed.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
The effect of low-dose rituximab on immunosuppressive drugs dependent minimal change nephrotic syndrome (Room4 (G316+G317, North 3F, PACIFICO YOKOHAMA)) - Aug 30, 2020 - Abstract #JSN2020JSN_918;
Subjects and methods 17 patients with MCNS (9 males, 8 females, age 16-65 years, average treatment period: 13 years) who are undergoing treatment with prednisolone (PSL) and cyclosporine (CyA) in complete remission (CR) And RTX 200 mg/body was administered once every 6 months, and PSL and CyA were gradually reduced and discontinued. Low-dose RTX therapy is suggested to be useful for maintaining remission of treatment-dependent MCNS and reducing the dose of immunosuppressants.
- |||||||||| prednisolone / Generic mfg., cyclosporine / Generic mfg.
Ten cases of steroid-resistant nephrotic syndrome undergoing transient remission during initial treatment () - Aug 30, 2020 - Abstract #JSN2020JSN_916;
The mean age of onset in these 10 cases was 3.4 years (median 2.0 years), and the average Selectivity Index = 0.028, and complete remission was achieved by cyclosporine ± steroid pulse additional administration in all cases. All patients in the transient remission group had minimal changes, 5 of 13 were significantly less than the FSGS typical group (p = 0.046), and no end-stage renal failure occurred during the observation period.
- |||||||||| prednisolone / Generic mfg., methylprednisolone oral / Generic mfg.
Steroid therapy for renal disease Early continuous blood glucose monitoring () - Aug 30, 2020 - Abstract #JSN2020JSN_840;
During pulse therapy, all patients had postprandial hyperglycemia (defined as a postprandial blood glucose level of 200 mg/dL or more). Eight patients with post-prandial postprandial hyperglycemia were taken daily, and five of them had come on the first day of oral administration.
- |||||||||| prednisolone / Generic mfg., methylprednisolone oral / Generic mfg.
Long-term clinical evaluation of renal prognostic factors in anti-GBM antibody nephritis () - Aug 30, 2020 - Abstract #JSN2020JSN_596;
Laboratory findings at the first visit were urinary protein 1.6 [1.3,5.1] (median [interquartile range]) g/g Cr, serum Cr 3.8 [1.7,8.0] mg/dL, CRP 8.3 [1.0,14.7] mg /dL, anti-GBM antibody 124 [83,260] mg/dL. Nine cases underwent renal biopsy and the crescent formation rate was 87[66,90]%.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Efficacy and safety of rituximab for frequent recurrent minimal change nephrotic syndrome () - Aug 30, 2020 - Abstract #JSN2020JSN_332;
As an adverse event, there was no infusion reaction, and transient neutropenia was observed in 1 case, but it resolved spontaneously. [Discussion] RTX 500 mg/week once x 4 weeks + RTX 500 mg/6 months administration was considered to be an extremely effective therapeutic means because it was possible to safely suppress recurrence and reduce the amount of immunosuppressant.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Efficacy and safety of repeated administration of rituximab for adult nephrotic syndrome () - Aug 30, 2020 - Abstract #JSN2020JSN_331;
The number of CD19-positive cells was less than 5 cells/mm3 at 3 to 6 months after RTX administration, and the cells remained depleted for 12 months after completion. The frequency of recurrence was 0.93/patient/year before the introduction, 0.11/patient/year during the treatment period, and 0.06/patient/year after the treatment was significantly suppressed.
- |||||||||| prednisolone / Generic mfg.
Clinicopathological study of 56 cases of pediatric IgA nephropathy () - Aug 30, 2020 - Abstract #JSN2020JSN_195;
The motives for discovery were 43 cases of school and garden urinalysis, 10 cases of gross hematuria, 2 cases of edema with gross hematuria, and 1 case of edema. At the first visit, 3 cases of nephrosis, 2 cases of hypertension, and 2 cases of renal dysfunction were observed.
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