- |||||||||| prednisolone / Generic mfg., cyclopentolate hydrochloride / Generic mfg.
[VIRTUAL] Traumatic Iritis: Practical Considerations During a Global Pandemic (Track 1 - Academy at Home) - Oct 14, 2020 - Abstract #AAOPT2020AAOPT_280;
Education on proper mask application/removal and the associated potential trauma risks should be discussed. As routine office visits are limited during the COVID-19 pandemic, flexibility should be maintained on what constitutes as critical care to ensure patients are not overlooked during appointment bookings and virtual triage processes.
- |||||||||| prednisolone / Generic mfg.
[VIRTUAL] Multidermatomal Herpes Zoster as Presenting Manifestation of Human Immunodeficiency Virus (Track 1 - Academy at Home) - Oct 14, 2020 - Abstract #AAOPT2020AAOPT_123;
Screening for coinfections like syphilis, which affects up to 25% of HIV patients, should also be conducted.This case highlights the crucial role of optometry in an integrated, hospital-based healthcare system, allowing for interdisciplinary co-management with emergency medicine, inpatient medicine, and infectious disease. Treatment, Management The patient was admitted for a 10-day course of IV acyclovir, prophylactic topical prednisolone acetate, and close monitoring...A careful exam for hidden vesicles can confirm multidermatomal presentation and elevate concern for immunodeficiency, ensuring proper, timely treatment. Suspicion for immunodeficiency is reasonable justification for aggressive treatment with IV antivirals or extended oral regimens to avoid a prolonged course and poor outcomes.
- |||||||||| latanoprost / Generic mfg., prednisolone / Generic mfg., dorzolamide / Generic mfg.
[VIRTUAL] Recurrent Choroidal Effusion in a Patient with Previous Trabeculectomy (Track 1 - Academy at Home) - Oct 14, 2020 - Abstract #AAOPT2020AAOPT_88;
The patient is on max medical therapy for POAG OD with good compliance to Latanoprost QHS, Dorzolamide BID, and Pilocarpine 1% BID. Pertinent Findings Best corrected visual acuities were stable at 20/70 OD and 20/300 OS...Patients with choroidal detachments may also present with decreased vision, eye pain, a shallow anterior chamber, hypotonous maculopathy, and a visual field defect. Treatment, Management Treatment was initiated with prednisolone acetate 1% QID and atropine 1% BID...In many cases, the choroid begins to settle within 7-10 days with conservative therapy, if not, oral steroids can be initiated. In severe cases such as large hemorrhagic detachments, surgical drainage may be required. Conclusion Fundus exam with auxiliary testing such as a B-scan can be utilized by optometrists to not only detect the presence of choroidal effusion and identify its etiology but to initiate appropriate treatment as well.
- |||||||||| prednisolone / Generic mfg., cyclopentolate hydrochloride / Generic mfg.
[VIRTUAL] Triage of an Acute Red Eye after Bungee Cord Injury (Track 1 - Academy at Home) - Oct 14, 2020 - Abstract #AAOPT2020AAOPT_80;
For this patient, the presence of cells and flare in the anterior chamber, as well as the presence of redness, pain, photophobia, and a mid-dilated pupil, made this patient pathognomonic for traumatic uveitis. Treatment, Management Began prednisolone acetate 1% suspension one drop every four hours while awake...Patient also prescribed cyclopentolate 1% one drop up to three times daily for cycloplegia with follow up in 1 week to assess progress...It is important to educate the patient on short and long term ramifications of the original injury. However, when treated promptly, traumatic uveitis patients have an excellent visual recovery, with most patients returning to their baseline best corrected visual acuity2.
- |||||||||| Tobradex (tobramycin/dexamethasone) / Alcon
[VIRTUAL] Viral Conjunctivitis With Probable Association With The Novel Coronavirus Disease 2019 (Track 1 - Academy at Home) - Oct 14, 2020 - Abstract #AAOPT2020AAOPT_47;
Still, the SEIs remained stable and scarring ensured.SEI’s may last for months to years even after the infection subsides and can scar and affect vision.1 At this point, we are managing the corneal scars and refractive error. Conclusion Given the COVID-19 pandemic, there has been reports in the literature regarding conjunctivitis associated with COVID-19 with a similar presentation to our patient. 2 This case report emphasizes and agrees that we should not dismiss that viral conjunctivitis can arise from COVID-19.
- |||||||||| Maxitrol (dexamethasone/neomycin/polymyxin B) / Novartis
[VIRTUAL] Unusual Manifestation of Bilateral Dendritiform Keratitis (Track 1 - Academy at Home) - Oct 14, 2020 - Abstract #AAOPT2020AAOPT_11;
After the condition worsened at the one day follow up, prednisolone acetate was discontinued, and the patient was prescribed 1 gram valacyclovir PO TID for 14 days. Conclusion Viral keratoconjunctivitis can be difficult to differentiate when the signs do not fit the typical disease characteristics. Best practice requires applying the treatment most likely to improve the situation, and to follow up appropriately.
- |||||||||| doxorubicin hydrochloride / Generic mfg., cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] WHERE ARE THE EFFUSIONS? () - Oct 12, 2020 - Abstract #CHEST2020CHEST_2321;
The treatment of PEL involves multi-drug chemotherapy, including use of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) and methotrexate. The prevalence of PEL is low; but should be considered in in patients with long standing HIV infection and Kaposi sarcoma.
- |||||||||| Remicade (infliximab) / Mitsubishi Tanabe, J&J
[VIRTUAL] IMMUNE CHECK POINT INHIBITOR-INDUCED ORGANIZING PNEUMONIA IN A LUNG TRANSPLANT PATIENT () - Oct 12, 2020 - Abstract #CHEST2020CHEST_1674;
Our patient presented with ICI related organizing pneumonia in transplanted lungs, which has been reported in few case reports with favorable response to high dose steroids. Awareness of potential complications of ICI especially in transplant population facilitates early recognition and prompt treatment with improved outcomes.
- |||||||||| Vocozo (voriconazole) / Orchid
[VIRTUAL] CO-OCCURENCE OF ORGANIZING PNEUMONIA WITH ASPERGILLUS LUNG INFECTION () - Oct 12, 2020 - Abstract #CHEST2020CHEST_1164;
He was started on voriconazole 200mg every 12 hourly along with oral prednisolone 60mg per day. Co-occurrence of OP with aspergillus lung infection is rare and has not been reported from South Asia to the best of our knowledge.
- |||||||||| Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Loniten (minoxidil) / Pfizer
[VIRTUAL] Minoxidil-Induced Chylous Ascites in a Renal Transplant Recipient (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_3215;
Discussion Minoxidil causes vasodilatation like calcium channel blockers though by a different mechanism so the mechanisim of chylous ascites formation could be the same that it is also a lipophilic drug allowing it to pass rapidly into the lymphatic system and causes relaxation of smooth muscles of lymphatic vessels,interferes with lymphatic drainage, increases the hydrostatic pressure in lymph vessels and causing it to leak in the peritoneum. Minoxidil must be considered as a probable cause of atraumatic drug induced chylous ascites.
- |||||||||| prednisolone / Generic mfg., mycophenolate mofetil / Generic mfg.
[VIRTUAL] Nephrotic Syndrome Relapse due to Bee Sting in Steroid-Resistant Nephrotic Syndrome (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2868;
Mycophenolate mofetil (MMF) treatment was then initiated, which resulted in rapid remission...While not a common trigger, the prevalent exposure to bee and insect stings, in both the general and pediatric populations, argues for clinical awareness of this etiology for nephrotic syndrome presentation and relapse. This report also provides clinical insight into the management of nephrotic syndrome relapses caused by bee stings, and suggests the possibility that glucocorticoid use may be generally effective, irrespective of underlying nephrotic syndrome classifcation.
- |||||||||| cyclophosphamide intravenous / Generic mfg.
[VIRTUAL] Glucocorticoid Toxicity in the Ponticelli Regimen (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2283;
The results at 0,6 and 12 months post completion of the Ponticelli regime for individual patients is shown on the graph. At completion 12/15 patients demonstrated GC toxicity, 7 at 6 months improving to 6/15 at 12 months.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS
[VIRTUAL] A Case of Membranous Nephropathy After Nivolumab Administration (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2266;
Discussion There are several reports of interstitial nephritis by Nivolumab, however, the report of nephrotic syndrome is rare. Particularly, no case of membranous nephropathy by Nivolumab has ever been reported and this case is considered to be valuable.
- |||||||||| Benlysta (belimumab) / GSK
[VIRTUAL] Therapeutic Effect of Belimumab in Lupus Nephritis with Impaired Renal Function (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2193;
The doses of prednisolone (mg/day) decreased in both groups. BEL may improve SLE activities and also renal function in patients with renal insufficiency as effectively as in those with normal renal function, although hypogammaglobulinemia comparably develops in both groups.
- |||||||||| prednisolone / Generic mfg., cyclophosphamide oral / Generic mfg.
[VIRTUAL] A Case of C-ANCA Associated Retroperitoneal Fibrosis and Periaortitis (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2150;
Moreover it has been suggested that retro peritoneal fibrosis may be an early clinical manifestation of ANCA associated vasculitis. Consequently, ANCA associated vasculitis should be considered in the differential diagnosis of any patient who has Retroperitoneal fibrosis and an active urinary sediment
- |||||||||| tacrolimus / Generic mfg., enoxaparin sodium / Generic mfg.
[VIRTUAL] A New Approach to De Novo Minimal Change Disease in Pregnancy (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2106;
We achieved partial remission in this heavily nephrotic patient with use of tacrolimus alone allowing us to avoid steroid adverse effects, which was especially important after her GI bleed. We believe tacrolimus is a valuable option for treatment of MCD in pregnancy.
- |||||||||| prednisolone / Generic mfg., cyclosporin A microemulsion / Generic mfg., cyclosporine / Generic mfg.
[VIRTUAL] A Rare Case of Nephrotic Syndrome Associated with Dent Disease (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_1980;
(Right) Von Kossa staining showed renal medulla with calcifications (arrows) was observed in the medullary interstitium. Figure 2 The patient treatment course
- |||||||||| omeprazole / Generic mfg., azathioprine orodispersible / Generic mfg.
[VIRTUAL] Use of Azathioprine in Treating Severe Corticosteroid-Resistant Acute Interstitial Nephritis (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_691;
She had been taking omeprazole for 2 weeks prior to presentation...She was discharged on 60 mg of prednisolone daily...As it has lesser side effects and better compliance than steroids, it is suggested that azathioprine may be considered in future as an adjuvant or alternative first line of treatment for AIN. Larger, randomized clinical trials need to be conducted in order to establish optimal dosing and long term effectiveness of azathioprine in treating AIN.
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis
Journal: Vogt-Koyanagi-Harada: treatment of recurrence after administration of 3 intravenous bolus of 1g of corticosteroids and mycophenolate mofetil. (Pubmed Central) - Oct 11, 2020
She was diagnosed with incomplete Vogt-Koyanagi-Harada syndrome, and treated early with a combination of intravenous therapy with 1g of prednisolone per day for 3 days, as recommended by published evidence, as well as mycophenolate mofetil (2g per day). During the corticosteroids tapering, there was a recurrence of exudative retinal detachments, and megadoses of 1g of intravenous corticosteroids per day were reintroduced for 6 days until the complete resolution of the fluid of the exudative RD, and cyclosporine (100mg per day), subtenon triamcinolone (40mg/mL), and intravitreal ranibizumab once a month in the both eyes were added to the treatment, with a great control of choroidal inflammation that resulted in the remission of symptoms and signs.
- |||||||||| prednisolone / Generic mfg., azathioprine orodispersible / Generic mfg.
[VIRTUAL] THE IMPACT OF PREGNANCY IN PATIENTS WITH AUTOIMMUNE HEPATITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1274;
However, the changes of liver function indicator such as AST need to be follow-up closely in both puerperium and postpartum period. With the help of carefully selected medications and the joint efforts of obstetrician and hepatologists, most patients and fetuses should be able to pass the puerperium safely.
- |||||||||| tacrolimus / Generic mfg.
[VIRTUAL] EFFECT OF TREATMENT REGIMENS ON RELAPSE IN ALASKA NATIVE AUTOIMMUNE HEPATITIS PATIENTS. () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1236;
Since the 1950s, prednisolone and azathioprine have been used for induction and remission of the disease and remain the mainstay of treatment...In the crude analysis odds of having relapse were 1.7 (CI 1.29-2.30) times higher among patients receiving prednisone monotherapy, and 2.3 (1.58-3.55) times higher among patients receiving mycophenolic acid or tacrolimus compared to azathioprine treatment regimen. Among AIH patients, those on azathioprine maintenance treatment regimens had the lowest the odds of having relapses compared to those on other drugs.
- |||||||||| Bredinin (mizoribine) / Asahi Kasei
Clinical, Journal: Mizoribine treatment in an elderly diabetic patient with antisynthetase-associated interstitial lung disease. (Pubmed Central) - Oct 10, 2020
The patient's clinical symptoms and daily life activities have been well persevered as an outpatient and well maintained with 200 mg of MZB and 10 mg of prednisolone for several months without obvious clinical recurrence and without any remarkable steroid- and MZB-related side effects. The use of MZB appeared to suppress the pathophysiology of anti-ARS antibody-associated ILD.
- |||||||||| hydroxychloroquine / Generic mfg., prednisolone / Generic mfg.
Journal: A rare form of dermatomyositis associated with muscle weakness and normal creatine kinase level. (Pubmed Central) - Oct 9, 2020
She received standard treatment for DM, including oral prednisolone, hydroxychloroquine, mycopheonlate and topical betamethasone. The treatment successfully reversed skin changes; however, the patient remained generally weak and unable to carry out her activities of daily living.
- |||||||||| Zolgensma (onasemnogene abeparvovec-xioi) / Novartis
Clinical, Journal: Gene Therapy for Spinal Muscular Atrophy: Safety and Early Outcomes. (Pubmed Central) - Oct 8, 2020
This is the first report of a non-hematologic solid organ tumor responding to the discontinuation of immunosuppressants. In this population, with thorough screening and careful post-gene transfer management, replacement therapy with onasemnogene abeparvovec-xioi is safe and shows promise for early efficacy.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
[VIRTUAL] Pembrolizumab (pembro) or placebo added to docetaxel and prednisone/prednisolone for metastatic castration-resistant prostate cancer (mCRPC) previously treated with next-generation hormonal agents (NHAs): KEYNOTE-921 phase III study (On-Demand e-Poster Display) - Oct 8, 2020 - Abstract #ESMOAsia2020ESMO_Asia_1273;
P1, P3
Trial design Eligibility criteria include histologically or cytologically confirmed adenocarcinoma of the prostate without small cell histology; evidence of metastatic disease or PSA (PCWG3), soft tissue (RECIST v1.1), or bone (PCWG3) progression; prior treatment with 1 (but not more than 1) NHA (abiraterone acetate, enzalutamide, apalutamide, or darolutamide) for metastatic hormone-sensitive prostate cancer or CRPC (nonmetastatic or metastatic); ongoing androgen deprivation; and Eastern Cooperative Oncology Group performance status 0 or 1...Funding: Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. Clinical trial identification: NCT03834506, February 8, 2019.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
[VIRTUAL] Pembrolizumab (pembro) or placebo added to docetaxel and prednisone/prednisolone for metastatic castrationresistant prostate cancer (mCRPC) previously treated with nextgeneration hormonal agents (NHAs): KEYNOTE921 phase III study (On-Demand e-Poster Display) - Oct 8, 2020 - Abstract #ESMOAsia2020ESMO_Asia_908;
P1, P3
The coprimary end points are OS and rPFS; additional details are in the table Table: 233TiP End points in KEYNOTE-921 Primary Secondary OS TFST rPFS per PCWG3-modified RECIST v1.1, as assessed by BICR Confirmed PSA response ratea ORR and DOR per PCWG3-modified RECIST v1.1, assessed by BICRTime to PSA progressionTime to first symptomatic skeletal-related eventTime to pain progression based on BPI (SF) item 3 and on opioid analgesic use based on the analgesic quantification algorithm scoreSafety and tolerability aDecrease of ≥50% from baseline, measured twice ≥3 weeks apart. . Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
[VIRTUAL] Pembrolizumab (pembro) or placebo added to docetaxel and prednisone/prednisolone for metastatic castrationresistant prostate cancer (mCRPC) previously treated with nextgeneration hormonal agents (NHAs): KEYNOTE921 phase III study (On-Demand e-Poster Display) - Oct 8, 2020 - Abstract #ESMOAsia2020ESMO_Asia_540;
P1, P3
The coprimary end points are OS and rPFS; additional details are in the table Table: 233TiP End points in KEYNOTE-921 Primary Secondary OS TFST rPFS per PCWG3-modified RECIST v1.1, as assessed by BICR Confirmed PSA response ratea ORR and DOR per PCWG3-modified RECIST v1.1, assessed by BICRTime to PSA progressionTime to first symptomatic skeletal-related eventTime to pain progression based on BPI (SF) item 3 and on opioid analgesic use based on the analgesic quantification algorithm scoreSafety and tolerability aDecrease of ≥50% from baseline, measured twice ≥3 weeks apart. . Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.
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