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28 Diseases |  |
17 Trials |
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17 Trials |  |
1171 News |  |
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- ||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
? New formula for rectal TNT from RAPIDO + PRODIGE 23 data—> short course RT+ 6-8 cycles of mFOLFIRINOX—> TME, ? Wait and watch. Please comment. @agrothey @GIcancerDoc @pashtoonkasi @anup_kasi @OncoThor @SalemGIOncDoc @helops79 @WasifSaifMD (Twitter) - May 14, 2020
- |||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
🔥GI studies at #ASCO20 OPRA -Rectal cancer organ preservation -RT➡️chemo better than chemo➡️RT? RAPIDO -5 fxn RT➡️chemo➡️TME Sx -⬇️distant mets & ⬆️pCR than standard tx ESPAC-5F -Neoadj Tx ⬆️ OS borderline resectable pancreatic cancer #crcsm #pancsm #radonc @ashiq_masood (Twitter) - May 13, 2020
- |||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
Clinical: With higher path CR and decreased distant metastases, RAPIDO and PRODIGE 23 establish TNT as the optimal treatment for clinical stage II/III rectal cancer. Thrilled to see these positive results! (Twitter) - May 13, 2020
- ||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
How do one reconcile PRODIGE 23 vs OPRA vs RAPIDO - Rectal Ca mgmt getting confusing - @GIcancerDoc @agrothey @aakonc (Twitter) - May 13, 2020
- || fexofenadine / Generic mfg., piroxicam / Generic mfg.
Chemo first if doing chemoRT (based on OPRA) or SCRT first if not doing chemoRT (based on RAPIDO) (preliminarily, need full ms/presentation) (Twitter) - May 13, 2020
- ||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
Clinical: Both approaches seem to work well but RAPIDO approach seems cheaper and more convenient for patients. (Twitter) - May 13, 2020
- ||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
RAPIDO shows improved pCR and lower disease related failure for preop short course + chemo compared to CRT. PRODIGE23 shows improved pCR and DFS for preop FOLFIRINOX+ CRT compared to CRT. Different ways to do TNT #ASCO20 @ACKoongMDPhD @ColonCancerDoc (Twitter) - May 13, 2020
- ||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
RAPIDO is here! Short course better than long course chemoRT for rectal as part of TNT! Between these 2 TNT RCTs, I think #rectalcancer practice can change dramatically w #ASCO20. @smitha42 @SAmarnathMD https://t.co/xpAVt35UH1 (Twitter) - May 13, 2020
- ||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
L'@EMA_News ha predisposto un percorso di approvazione rapido per #vaccini e #farmaci contro #covid19, se supportati da solide evidenze scientifiche. Qui il comunicato: https://t.co/D1slHYte6W (Twitter) - May 12, 2020
- | fexofenadine / Generic mfg.
Preclinical, Journal: Quality by Design for the Development and Analysis of Enhanced In-Situ Forming Vesicles for the Improvement of the Bioavailability of Fexofenadine HCl in Vitro and in Vivo. (Pubmed Central) - May 6, 2020
The pharmacokinetic study and the pharmacological effect of the fexofenadine-loaded optimized formulation showed a significant increase in blood concentration and significantly higher activity against compound 48/80 induced systemic anaphylaxis-like reactions in mice. Therefore, enhanced in situ forming vesicles were effective nanocarriers for the entrapment and delivery of Fexofenadine HCl.
- | carbamazepine / Generic mfg.
Journal: Spatial and seasonal trends of organic micropollutants in Sweden's most important drinking water reservoir. (Pubmed Central) - May 2, 2020
Two industrial chemicals, tolyltriazole and tris(2-butoxylethyl)phosphate were detected frequently and it is recommended to incorporate these compounds more regularly in future analysis. To the best of our knowledge, this study is the first one to report the occurrence and distribution of OMPs representing such wide physico-chemical properties, including industrial chemicals, in a Swedish lake.
- || fexofenadine / Generic mfg., piroxicam / Generic mfg.
Lees rapido todo el articulo (Twitter) - May 2, 2020
- || Omeprazole RBX (omeprazole) / Generic mfg., bupropion / Generic mfg.
Clinical, PK/PD data, Journal: Evaluating the effect of type 2 diabetes mellitus on CYP450 enzymes and P-gp activities, before and after glycemic control: A protocol for a case-control pharmacokinetic study. (Pubmed Central) - Apr 28, 2020
Furthermore, the influence of variables such as glycemia, genetic polymorphisms, and inflammation on the metabolism process will be evaluated. The first patient has entered the study in Dec 2018.
- ||||| fexofenadine / Generic mfg., piroxicam / Generic mfg.
Clinical: To answer your question other than the @SWOG survey being created to capture the "real life" setting...At @VUMC_Cancer @VUMCradiology we do it selectively. @nrg TNT was created while @ALLIANCE_org #PROSPECT + #rapido was open. All pending #clinicaltrials #NewEra #CancerResearch (Twitter) - Apr 27, 2020
- fexofenadine / Generic mfg.
Intra-trabecular Endocardial Structures Of The RVOT Exhibit Prominent Action Potential Notches Capable Of Generating Phase 2 Reentrant Extrasystoles And VT/VF In The Setting Of Brugada Syndrome (Poster Hall) - Apr 22, 2020 - Abstract #RHYTHM2020RHYTHM_2676;
Our findings suggest that the deep intra-trabecular structures of RVOT Endo, in addition to those of RVOT Epi, can be the source of phase 2 reentrant extrasystoles that trigger VT/VF. Our data may explain the effectiveness of Endo RVOT ablation in some patients with BrS.
- || fexofenadine / Generic mfg.
Clinical, Journal: Effects of a Novel Barley-based Formulation on Allergic Rhinitis: A Randomized Controlled Trial. (Pubmed Central) - Apr 22, 2020
MS formulation based on H. vulgare may be an effective treatment for AR. Further studies are needed to confirm the effect of MS as an alternative treatment in AR.
- || fexofenadine / Generic mfg., rosuvastatin / Generic mfg., AstraZeneca
PK/PD data, Preclinical, Journal: Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1. (Pubmed Central) - Apr 22, 2020
Rosuvastatin oral and intravenous pharmacokinetics were not dependent on OATP2B1. These findings support the utility of the Slco2b1 knockout mice model for defining mechanisms of drug disposition at the intersection of in vitro and clinical pharmacology.
- | fexofenadine / Generic mfg., dofetilide / Generic mfg.
Journal: Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds. (Pubmed Central) - Apr 22, 2020
These data represent, to our knowledge, the first pharmacological characterization of isolated zkcnh6a channels and the first assessment of hERG enhancing therapeutics in zebrafish. Our findings suggest that the zebrafish ex vivo whole heart model serves as a valuable tool in the screening of hKCNH2a blocker and activator compounds.
- | fexofenadine / Generic mfg., piroxicam / Generic mfg.
Lei rapido Boeing y mucho sentido no tenia :P (Twitter) - Apr 21, 2020
- | fexofenadine / Generic mfg.
Journal: Successful oral delivery of fexofenadine hydrochloride by improving permeability via phospholipid complexation. (Pubmed Central) - Apr 14, 2020
The in vivo evaluation in Wistar rats presented 3.38 fold increment in oral bioavailability of FEX-PLC as compared to FEX. In summary, the phospholipid complexation demonstrated as a simple and promising approach to tackle oral bioavailability hurdles of BCS class III drugs and convert them to BCS class I drugs.
- | fexofenadine / Generic mfg.
Journal: Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis. (Pubmed Central) - Apr 12, 2020
In summary, the phospholipid complexation demonstrated as a simple and promising approach to tackle oral bioavailability hurdles of BCS class III drugs and convert them to BCS class I drugs. Collectively, these findings not only provide new insights into the understanding of fexofenadine action and underlying mechanisms but also provide new therapeutic interventions for various TNF-α and cPLA2-associated pathologies and conditions, particularly inflammatory rheumatic diseases.
- || fexofenadine / Generic mfg., piroxicam / Generic mfg.
dale, si lo hacen rapido lo sacamos rapido Estemos en contacto. Abrazo (Twitter) - Apr 10, 2020
- || fexofenadine / Generic mfg.
Clinical, Journal: International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients with AR: Current knowledge and future strategies. (Pubmed Central) - Apr 9, 2020
Fexofenadine a non-sedating oral antihistamine improves AR symptoms aggravated by air pollution. However, more efficacy studies on other pharmacological therapy of coexisting AR and air pollution are currently lacking.
- || fexofenadine / Generic mfg., naproxen / Generic mfg.
Clinical, Journal: The Effects of SJP-001 on Alcohol Hangover Severity: A Pilot Study. (Pubmed Central) - Apr 6, 2020
Compared to placebo, SJP-001 significantly reduced overall hangover severity. The effects of SJP-001 should be further examined in a double-blind, placebo-controlled trial with a larger sample size and controlled administration of sufficient amounts of alcohol to provoke a more substantial alcohol hangover.
- | fexofenadine / Generic mfg.
Preclinical, Journal: Bergamottin can be used to assess CYP3A-mediated intestinal first-pass metabolism without affecting P-glycoprotein-mediated efflux in rats. (Pubmed Central) - Apr 1, 2020
5. These profiles of bergamottin enable the convenient assessment of CYP3A-mediated intestinal metabolism.
- || fexofenadine / Generic mfg., piroxicam / Generic mfg.
Asi que como sokn drenajes en agudo con rapido proresion a taponamiento, con aguja y pgitail me lleva masomenos 2 minutos estar en posicion y drenar primer cn jeringa de 20 y luego presion negativa. Llevo haciendo lo msimo con exito por casi 30 anios... (Twitter) - Apr 1, 2020
- | fexofenadine / Generic mfg., piroxicam / Generic mfg.
Ahora entiendo por que la Junta dice lo de las farmaceuticas en PR, esas 2 lineas de produccion estan aqui y levantan rapido. La medicina es buena, las fabricas son buenas pero el TAX HEAVEN es malo. (Twitter) - Mar 19, 2020
- | fexofenadine / Generic mfg., piroxicam / Generic mfg.
Forniremo l'accesso a tutte le nostre competenze scientifiche con la piattaforma https://t.co/obG0JsYop5, per raccogliere subito le evidenze scientifiche disponibili sul #coranavirus e garantire un rapido aggiornamento ai medici #novartisperlitalia https://t.co/E5Hr6wNZaV (Twitter) - Mar 19, 2020
- || fexofenadine / Generic mfg., piroxicam / Generic mfg.
@novonordisk @novonordiskus @novonordiskfond @NovoNordiskLive LES INICIE CAUSA PENAL FEDERAL POR PRIDUCTOS Q FALLAN Y MANDAN.MUESTRAS GRATIS EN VTO RAPIDO. RESPINDABLE SRA SONIA ARGENTINA. FRAUDE MY PRESÍDENT @realDonaldTrump in ARGENTINE (Twitter) - Mar 18, 2020
- | Omeprazole RBX (omeprazole) / Generic mfg.
Journal: Limited Sampling Modeling for Estimation of Phenotypic Metrics for CYP Enzymes and the ABCB1 Transporter Using a Cocktail Approach. (Pubmed Central) - Mar 17, 2020
Increasing the number of sampling points to three led to minor increases in R and/or the bias or prediction of the estimates. In conclusion, the LSS models provided accurate prediction of phenotypic indices for CYP1A2, CYP2C19, CYP2D6, CYP3A, and ABCB1, when using subtherapeutic doses of selective probes for these enzymes and transporter.
- | irinotecan / Generic mfg.
Preclinical, Journal: MitoToxy assay: A novel cell-based method for the assessment of metabolic toxicity in a multiwell plate format using a lactate FRET nanosensor, Laconic. (Pubmed Central) - Mar 14, 2020
A pilot screening allowed sensitive detection of commercial drugs that were previously withdrawn from the market due to liver/cardiac toxicity issues, such as camptothecin, ciglitazone, troglitazone, rosiglitazone, and terfenadine, in ten minutes. We envisage that the availability of this technology, based on a fluorescent genetically encoded indicator, will allow direct assessment of mitochondrial metabolism, and will make the early detection of mitochondrial toxicity in the drug development process possible, saving time and resources.
- | fexofenadine / Generic mfg., dofetilide / Generic mfg., sotalol / Generic mfg.
Journal: Evaluation of possible proarrhythmic potency: comparison of the effect of dofetilide, cisapride, sotalol, terfenadine and verapamil on hERG and native IKr currents and on cardiac action potential. (Pubmed Central) - Mar 14, 2020
Action potential studies are also required to analyze complex multichannel effects. Therefore, manual patch-clamp and action potential experiments should be a part of preclinical safety tests.
- ||| fexofenadine / Generic mfg., loratadine / Sedico, Remedica, Generic mfg., Merck (MSD), Bayer
At present, your best bet is reading up yourself and approaching your friendly GP with the #EDSToolkit https://t.co/y8tX8PaZRK. Certainly few risks in a trial of fexofenadine or loratadine. Some improvement is further evidence towards the diagnosis of #MCAS. (Twitter) - Mar 10, 2020
- ||| fexofenadine / Generic mfg.
Even Chlorphenamine? It's routinely prescribed by the UK NHS so that surprises me (It really helps me control my hayfever at night, combined with fexofenadine during the day - and I swear it helps me sleep better too 😅) (Twitter) - Mar 2, 2020
- fexofenadine / Generic mfg., piroxicam / Generic mfg.
[VIRTUAL] Short-course radiotherapy followed by chemotherapy before TME in locally advanced rectal cancer: The randomized RAPIDO trial. () - Feb 27, 2020 - Abstract #ASCO2020ASCO_250;
P3
In addition, the high pCR rate, achieved with the experimental treatment regimen can contribute to organ preservation. This treatment can be considered as a new standard of care.
- | fexofenadine / Generic mfg.
I now have to take Daily fexofenadine , terrible itching ,scratching,rashes and Fibro type symptoms if I don't (Twitter) - Feb 25, 2020
- | Omeprazole RBX (omeprazole) / Generic mfg.
Preclinical, Journal: Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach. (Pubmed Central) - Feb 21, 2020
In conclusion, our study shows that EPP-AF® does not clinically change CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A activities, once, despite statistical significant, the magnitude of the changes in AUC values after EPP-AF® were all below 20% and therefore may be considered safe regarding potential interactions involving these enzymes. Besides, to the best of our knowledge this is the first study to assess potential HDIs with propolis.
- | fexofenadine / Generic mfg., piroxicam / Generic mfg.
si supiera me hubiera postulado, ahora dejen de defender a estos ineficientes que nos dejaron en default, yo no la puedo creer. Igual hubiera arrancado por un shock en el 2016 Y no le hubiera bajado al campo las retenciones tan rapido, ni levantado el cepo asi (Twitter) - Feb 18, 2020
- | fexofenadine / Generic mfg., methadone / Generic mfg.
Journal: Summary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative Chlorobutanol. (Pubmed Central) - Feb 14, 2020
Besides, to the best of our knowledge this is the first study to assess potential HDIs with propolis. The pharmacologic profile of chlorobutanol (synergistic I block) and its association with reports of TdP and QT prolongation suggest the need for a full evaluation of its cardiac safety when used as a preservative in IV drug and vitamin formulations.
- || fexofenadine / Generic mfg., piroxicam / Generic mfg.
La clorhexidina es . Menos citotoxica y su efecto bactericida es más RAPIDO AL COLOCARSE SOBRE LA.PIEL. (Twitter) - Feb 8, 2020
- | Tagrisso (osimertinib) / AstraZeneca
Trial completion date, Metastases: Study to Assess the Effect of Osimertinib (TAGRISSO (clinicaltrials.gov) - Feb 5, 2020
P1, N=24, Active, not recruiting, Sponsor: AstraZeneca
The pharmacologic profile of chlorobutanol (synergistic I block) and its association with reports of TdP and QT prolongation suggest the need for a full evaluation of its cardiac safety when used as a preservative in IV drug and vitamin formulations. Trial completion date: Dec 2019 --> Mar 2021
- ||| levocetirizine / Generic mfg.
Retrospective data, Journal, Adverse events: Chlorpheniramine-induced anaphylaxis: Two case reports and a retrospective review of pharmacovigilance database. (Pubmed Central) - Feb 1, 2020
Physicians should be aware chlorpheniramine could be a cause for allergic reaction. In addition, we suggest that serum tryptase level, skin prick test, and intradermal test could be considered as a supplementary test for diagnosing chlorpheniramine anaphylaxis and cross-reactivity should also be considered.
- | fexofenadine / Generic mfg., Noxafil (posaconazole) / Merck (MSD)
Preclinical, Journal: Synergistic combinations of azoles and antihistamines against Candida species in vitro. (Pubmed Central) - Jan 29, 2020
Terfenadine (TERF) and ebastine (EBA) are second-generation antihistamines, with EBA being used in many countries...Finally, we tested the specificity of the combinations towards fungal cells by mammalian cytotoxicity assays. These findings suggest a potential new strategy for targeting drug-resistant Candida infections.
- || fexofenadine / Generic mfg.
But I already take fexofenadine daily, should I consider taking one of the other two instead of diphenhydramine anyway? (Twitter) - Jan 16, 2020
- | fexofenadine / Generic mfg.
New P4 trial: Role of Fexofenadine in Diabetic Kidney Disease (clinicaltrials.gov) - Jan 13, 2020
P4, N=60, Recruiting, Sponsor: Tanta University
- || praziquantel (MSC2499550A) / Merck (MSD)
Clinical, Journal: Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel. (Pubmed Central) - Jan 10, 2020
He was diagnosed with AGEP caused by praziquantel. Physicians need to be aware that praziquantel could cause AGEP, although it is generally considered a safe drug.
- | fexofenadine / Generic mfg.
Journal: Nasal Symptoms Reduction and Decreased Neutrophilia in Japanese Cedar Pollinosis With Prophylactic Treatment With a Combination of Montelukast, Fexofenadine, and Fluticasone Nasal Spray. (Pubmed Central) - Jan 8, 2020
In PreSyP and PreAsP subjects, treatments with Mo-Fex-Flu were more effective than Cet-Flu to reduce nasal symptom scores. These effects were associated with reduction in the number of neutrophils and mast cells in nasal swabs.
- | fexofenadine / Generic mfg., Neforex (nefopam) / Incepta, warfarin / Generic mfg.
Journal: Synergistic Enantioseparation Systems with either Cyclodextrins or Cyclofructans and L-Alanine Tert Butyl Ester Lactate. (Pubmed Central) - Dec 23, 2019
In other cases, the synergistic effect enabled baseline separation of analyte enantiomers, at a much lower concentration of the CS. Finally, after optimization of separation conditions, baseline separations (R >1.5) of all four analytes were achieved in less than 5 minutes.
- | fexofenadine / Generic mfg.
Journal: The exploration of effect of terfenadine on Ca signaling in renal tubular cells. (Pubmed Central) - Dec 23, 2019
Together, in MDCK cells, terfenadine induced [Ca] rises by evoking PLC-dependent Ca release from the endoplasmic reticulum and Ca entry via PKC-sensitive store-operated Ca entry. Furthermore, terfenadine caused cell death that was not triggered by preceding [Ca] rises.
- fexofenadine / Generic mfg., atorvastatin / Generic mfg.
Organic Anion Transporting Polypeptide (Oatp)-Mediated Transport is Required for Statin-Induced Neuroprotection: A Role for Blood-Brain Barrier Transporters in Stroke Treatment (Hall H) - Dec 21, 2019 - Abstract #ISC2020ISC_1881;
Our data indicate that pharmacological inhibition of Oatp-mediated transport at the BBB prevents ATV from exerting neuroprotective effects in rats following tMCAO. Our results also suggest that i.v. ATV administered at an early time point following reperfusion (i.e., 2 h) can provide effective neuroprotection in male and female rats subjected to tMCAO.