- |||||||||| Kineret (anakinra) / SOBI
A Case of Hemophagocytic Lymphohistiocytosis (HLH) Triggered by Dengue Fever in a 26-Year-Old Woman Returning from Bali: Diagnostic Challenges and Multidisciplinary Management () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_22;
Her past medical history includes migraines and endometriosis, and her regular medications are Naproxen, OCP, Fexofenadine, and a calcium supplement...Expanded dengue syndromes encompass atypical and unusual manifestations.Treatment for our patient included pulse intravenous Methylprednisolone followed by oral prednisolone and Anakinra, with antimicrobial prophylaxis...Regular follow-up appointments allow for adjustments in therapy, ensuring optimal disease management and patient outcomes.These key learning points underscore the importance of early recognition, multidisciplinary collaboration, and comprehensive management strategies in improving outcomes for patients with HLH. By adopting a structured approach to diagnosis, treatment, and follow-up, clinicians can effectively address the complexities of this rare but potentially life-threatening condition, particularly in the context of travel-related infections
- |||||||||| fexofenadine / Generic mfg.
Journal: Demonstration of a kHz-repetition-rate extreme ultraviolet laser at 41.8?nm. (Pubmed Central) - Nov 1, 2024
The 41.8?nm laser pulses were generated in a Xe plasma created by optical-field ionization by the L1 Allegra laser at ELI Beamlines. The output power of the XUV laser lies in the few microwatt range, and the energy efficiency of this pumping scheme opens the way for further scaling in repetition rate and average power.
- |||||||||| Retrospective data, Review, Journal: Towards sustainable water reuse: A critical review and meta-analysis of emerging chemical contaminants with risk-based evaluation, health hazard prediction and prioritization for assessment of effluent water quality. (Pubmed Central) - Oct 27, 2024
The 10 highest-priority chemicals (final score 2.3-3.0 out of 4.0) were venlafaxine, bicalutamide, desvenlafaxine, diclofenac, amoxicillin, clarithromycin, diethyltoluamide, genistein, azithromycin, and fexofenadine. Potential crop exposure to selected chemicals following one year of wastewater reuse for agricultural irrigation was also estimated, resulting in a range of 0.04
- |||||||||| fexofenadine / Generic mfg., bilastine / Generic mfg.
Journal: Comparison of the Efficacy and Safety of Bilastine 20 (Pubmed Central) - Oct 8, 2024
Bilastine was found to be more effective in overall as well as sneezing and rhinorrhoea noted two weeks after therapy. The online version contains supplementary material available at 10.1007/s12070-024-04770-0.
- |||||||||| fentanyl citrate / Generic mfg., fexofenadine / Generic mfg., morphine sulphate / Generic mfg.
AN ITCHY ISSUE: OPIOIDS ACTIVATE MAST CELLS IN AUTOLOGOUS SKIN GRAFTS (Monitor 1; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1104;
He reported localized pruritis and erythema over bilateral grafts 30-60 minutes after using multiple oral morphine-based medications...Fexofenadine 360mg twice daily was initiated to suppress symptoms and oral oxycodone and fentanyl transdermal patches were resumed...Indeed, increased mast cell numbers have been found in both burn scars and tolerant grafts in mouse models. Antihistaminergic agents may provide relief in patients with similar presentations, especially when opioid therapy cannot be discontinued.
- |||||||||| pregabalin / Generic mfg.
PREGABALIN ANAPHYLAXIS RELATED TO DOSING INCREASE (Monitor 3; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1001;
The anaphylaxis likely triggered CHF exacerbation. Pregabalin should be considered as a dose dependent trigger for immediate drug reactions.
- |||||||||| Xolair (omalizumab) / Roche, Novartis
AN OVERLAPPING CASE OF CHRONIC SPONTANEOUS URTICARIA AND NORMOCOMPLEMENTEMIC URITCARIAL VASCULITIS (Monitor 6; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_803;
She failed management with mycophenolate, fexofenadine, famotidine, doxepin and oral ketotifen...However, several months later her chronic urticaria became refractory to omalizumab and only responded to oral prednisone...Due to the refractory nature of the urticaria, the second skin biopsy was revisited, and the patient was treated for NUV with azathioprine and dapsone. This case highlights that although CSU and NUV are two different disease entities, a patient may transition between them, as both these conditions may fall on the same disease spectrum.
- |||||||||| fexofenadine / Generic mfg.
Clinical, Review, Journal: Twenty-five years: The fexofenadine clinical experience. (Pubmed Central) - Sep 10, 2024
An ideal anti-allergic formulation should provide fast relief of symptoms and long-lasting effect without drowsiness. Data from randomized clinical trials show that FEX meets these criteria and is an effective treatment option with a favourable safety profile, improving the quality of life of patients suffering from AR and urticaria.
- |||||||||| fexofenadine / Generic mfg.
Journal: Ratiometric Molecularly Imprinted Particle Probes for Reliable Fluorescence Signaling of Carboxylate-Containing Molecules. (Pubmed Central) - Sep 4, 2024
The dual-fluorescent MIP probe detects fexofenadine as the model analyte with a change in green emission signal referenced against a stable red signal, achieving a detection limit of 0.13 ?M and a broad dynamic range from 0.16 ?M to 1.2 mM, with good discrimination against other antibiotics in acetonitrile. By selecting a versatile dye scaffold and recognition element, this approach can be extended to other carboxylate-containing analytes and/or wavelength combinations, potentially serving as a robust multiplexing platform.
- |||||||||| fexofenadine / Generic mfg.
Systemic Mastocytosis and the Pivotal Role of the Gastroenterologist (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4256;
The patient was treated with a low histamine diet and fexofenadine to which he initially responded with symptom improvement...There are currently no formal guidelines regarding increased colon cancer screening for patients with systemic mastocytosis. Based on our case, we recommend increased vigilance and attention to detail with regard to screening for colon cancer in patients with systemic mastocytosis particularly if disease remains poorly controlled.
- |||||||||| fexofenadine / Generic mfg., gabapentin / Generic mfg.
Enrollment closed: Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis (clinicaltrials.gov) - Aug 20, 2024
P4, N=60, Active, not recruiting,
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024. Not yet recruiting --> Active, not recruiting
- |||||||||| Journal: Pharmaceutical Pollution of the English National Parks. (Pubmed Central) - Aug 14, 2024
Not yet recruiting --> Active, not recruiting Thirty-one APIs were detected, with metformin, caffeine, and paracetamol showing the highest mean concentrations and cetirizine, metformin, and fexofenadine being the most frequently detected...Fourteen locations had concentrations of either amitriptyline, carbamazepine, clarithromycin, diltiazem, metformin, paracetamol, or propranolol above levels of concern for fish, invertebrates, and algae or for selection for antimicrobial resistance..
- |||||||||| fexofenadine / Generic mfg., montelukast / Generic mfg.
Journal: Green micellar UPLC and complementary eco-friendly spectroscopic techniques for simultaneous analysis of anti-COVID drugs: a comprehensive evaluation of greenness, blueness, and whiteness. (Pubmed Central) - Aug 10, 2024
Moreover, we embraced the innovative notions of 'blueness' and 'whiteness' assessment by harnessing the recently formulated BAGI and RGB12 algorithms. The higher BAGI score (90, 82.5) than reported (72.5, 70, 70, 67.5, 67.5, 67.5, and 72.5), confirmed the excellent real-world applicability of the proposed methods, while the notable RGB12 indices (89.8, 88.1) than reported (67.8, 72.8, 71.5, 67.1, 73.7, 70.3, and 73.2), validated their cost-effectiveness and overall sustainability, contributing to an eco-friendly future for quality control processes.
- |||||||||| fexofenadine / Generic mfg.
Review, Journal: Why fexofenadine is considered as a truly non-sedating antihistamine with no brain penetration: a systematic review. (Pubmed Central) - Aug 7, 2024
Clinical trials in adults and children showed fexofenadine to be well tolerated without sedative effect or impairment of cognitive/psychomotor function even at higher than recommended doses. Published literature based on various parameters and clinical trials conducted for evaluating the effect of fexofenadine on sedation and central nervous system shows fexofenadine is both clinically effective and non-sedating.
- |||||||||| fexofenadine / Generic mfg., pregabalin / Generic mfg., doxycycline / Generic mfg.
Paraneoplastic pruritus in lymphoid malignancies (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4731;
It is essential to evaluate such patients thoroughly. Clinical findings like fever, weight loss and lymphadenopathy are important clues to detect a lymphoproliferative neoplasm.
- |||||||||| doxycycline / Generic mfg.
Doxycycline induced generalized morbilliform rash simulating viral exanthem. (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1939;
To differentiate between its two most common causes (drug-induced and viral) , most often remains a diagnostic challenge. History, clinical, and histopathological findings may help to arrive at the correct diagnosis but are usually inadequate in distinguishing between these two.
- |||||||||| fluconazole oral / Generic mfg.
Fluconazole induced fixed drug eruption: An exceedingly rare presentation (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_1938;
Caution needs to be exercised as cross-reaction may occur with structurally related drug (itraconazole) . This case emphasizes to create awareness among dermatologists about the various adverse effects due to commonly prescribed medications like fluconazole.
- |||||||||| fexofenadine / Generic mfg.
Trial completion: Effect of Antihistamines on Ureteral Stent-Related Symptoms (clinicaltrials.gov) - Aug 1, 2024
P2, N=78, Completed,
This case emphasizes to create awareness among dermatologists about the various adverse effects due to commonly prescribed medications like fluconazole. Recruiting --> Completed
- |||||||||| Xolair (omalizumab) / Roche, Novartis
SERUM SICKNESS-LIKE REACTION SECONDARY TO OMALIZUMAB (Convention Center Exhibit Hall: Poster Area 1) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1083;
Serum-sickness like reactions are hypersensitivity reactions which can be seen with biologic therapies. Physicians should have a high index of suspicion when patients have arthralgias and constitutional symptoms temporally associated with exposure to these medications.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
PK/PD data, Journal: Bioanalytical HPLC method with fluorescence detector for determination of Entresto (Pubmed Central) - Jun 17, 2024
In conclusion, our study underscores the importance of cautious administration and appropriate dose spacing of IBU and FEX in patients treated with LCZ696 to prevent elevated serum concentrations and potential toxicity. The novelty of this work lies in its dual contribution: developing a highly sensitive HPLC-FLD method and comprehensively elucidating significant pharmacokinetic interactions between LCZ696 and common OTC drugs.
- |||||||||| fexofenadine / Generic mfg.
Trial completion: Bioavailability Study of Fexofenadine HCl New Formulation Tablet (clinicaltrials.gov) - Jun 10, 2024
P1, N=25, Completed,
The novelty of this work lies in its dual contribution: developing a highly sensitive HPLC-FLD method and comprehensively elucidating significant pharmacokinetic interactions between LCZ696 and common OTC drugs. Recruiting --> Completed
- |||||||||| fexofenadine / Generic mfg.
Trial completion date, Trial primary completion date: Excipient Effect on Drug Absorption in Humans (clinicaltrials.gov) - Jun 7, 2024
P1, N=12, Recruiting,
Recruiting --> Completed Trial completion date: Aug 2024 --> Aug 2025 | Trial primary completion date: Aug 2024 --> Aug 2025
- |||||||||| Journal: Identifying organic micropollutants (Pubmed Central) - Jun 1, 2024
Micropollutant recoveries from freeze-dried soils were 60-120%, with the exception of atorvastatin, fexofenadine, and telmisartan, which had reduced recoveries (40-66%)...We identified TPs of five compounds (venlafaxine, telmisartan, valsartan, atorvastatin, and sertraline) by applying suspect and non-targeted data analyses...We estimated the stability and presence of the identified TPs based on the constructed time trends and the ratio between TP formation and degradation rates. We demonstrated how valuable a non-targeted approach can be for complex evaluation of the fate and effect of soil pollutants.
- |||||||||| CoAprovel (irbesartan hydrochlorothiazide) / Sanofi, Prezista (darunavir) / J&J
Journal: Comparing the adsorption of micropollutants on activated carbon from anaerobically stored, organics-depleted, and nitrified urine. (Pubmed Central) - May 27, 2024
In addition, we showed that the relative pharmaceutical removal in all solutions was independent of the initial pharmaceutical concentration unless the background organics matrix changed considerably. We conclude that removal of micropollutants in GAC columns from organics-depleted urine can be performed without clogging, but with the drawback of a higher carbon usage compared to removal from nitrified urine.
- |||||||||| Ocrevus (ocrelizumab) / Roche
Enrollment closed, Trial completion date, Trial primary completion date, Head-to-Head: DanNORMS: Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis (clinicaltrials.gov) - May 15, 2024
P3, N=600, Active, not recruiting,
Trial completion date: Mar 2026 --> Dec 2025 | Trial primary completion date: Jul 2025 --> Oct 2025 Recruiting --> Active, not recruiting | Trial completion date: Dec 2028 --> May 2028 | Trial primary completion date: Dec 2025 --> May 2026
- |||||||||| Xolair (omalizumab) / Roche, Novartis
Successful Treatment of Post-Orgasmic Illness Syndrome with Omalizumab: A Report on Two Case (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_2348;
Cetirizine 10 mg BID and montelukast 10 mg were administered, and due to partial benefit observed, omalizumab 300 mg every 28 days was initiated...Despite daily intake of ibuprofen 400 mg and fexofenadine 120 mg BID , due to the inability to control the symptoms, omalizumab was initiated at a dose of 300 mg every 28 days...Conclusion POIS is a rare condition that severely impairs quality of life. Omalizumab therapy appears to be an effective treatment option for the management of POIS patients.
- |||||||||| imatinib / Generic mfg.
A Case of Strongyloides Infection Presenting As Imatinib Sensitivity (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_2335;
In patients with malignancies a misdiagnosis of the reaction and the subsequent unnecessary treatment cessation can affect prognosis. Moreover, immunosuppressed patients who are at risk of developing strongyloides hyperinfection syndrome, a life threatening complication leading to systemic sepsis and multiorgan failure.
- |||||||||| Xolair (omalizumab) / Roche, Novartis
Treatment of Chronic Spontaneous Urticaria with Omalizumab Complicated by Onychodystrophy? (E-TPS Display Only Digital section) - Apr 21, 2024 - Abstract #EAACI2024EAACI_1589;
Although onychodystrophy is not a typical side effect of omalizumab, individual clinical cases cannot be completely ruled out where onychodystrophy may develop or worsen due to its use. Currently, this issue remains unresolved due to the complexity of establishing a possible cause-effect relationship
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