 |
13 Diseases |  |
1 Trial |
|
1 Trial |  |
39 News |  |
- | levodopa/carbidopa CR / Generic mfg.
Trial completion: Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease (clinicaltrials.gov) - Mar 13, 2024
P4, N=36, Completed, Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Recruiting --> Completed
- ||| levodopa/carbidopa CR / Generic mfg.
In my experience SInemet CR worsen dyskinesia (Twitter) - Apr 20, 2023
- || carbidopa/levodopa / Generic mfg., levodopa/carbidopa CR / Generic mfg.
PK/PD data, Journal: Pharmaceutical and pharmacokinetic evaluation of a newly formulated multiparticulate matrix of levodopa and carbidopa. (Pubmed Central) - Feb 13, 2023
Recruiting --> Completed The AUC for levodopa/carbidopa multiparticulate matrix (Formulation 3: 484.98
- | levodopa/carbidopa CR / Generic mfg.
Trial completion date, Trial primary completion date: Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease (clinicaltrials.gov) - Aug 24, 2022
P4, N=42, Recruiting, Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
The AUC for levodopa/carbidopa multiparticulate matrix (Formulation 3: 484.98 Trial completion date: Mar 2022 --> Mar 2023 | Trial primary completion date: Feb 2022 --> Dec 2022
- | Duodopa (levodopa/carbidopa intraduodenal gel infusion) / AbbVie
Journal: European Academy of Neurology/Movement Disorder Society-European Section Guideline on the Treatment of Parkinson's Disease: I. Invasive Therapies. (Pubmed Central) - Jul 24, 2022
Only some of these therapies have a strong scientific basis. They differ in their profile of effects and have been tested only for specific patient groups.
- | levodopa/carbidopa CR / Generic mfg.
Enrollment open: TESDR: Treating Early Stage Diabetic Retinopathy (clinicaltrials.gov) - Jul 18, 2022
P1, N=244, Enrolling by invitation, Sponsor: VA Office of Research and Development
They differ in their profile of effects and have been tested only for specific patient groups. Not yet recruiting --> Enrolling by invitation
- | levodopa/carbidopa CR / Generic mfg.
Trial initiation date: TESDR: Treating Early Stage Diabetic Retinopathy (clinicaltrials.gov) - Apr 8, 2022
P1, N=244, Not yet recruiting, Sponsor: VA Office of Research and Development
Not yet recruiting --> Enrolling by invitation Initiation date: Apr 2022 --> Jul 2022
- | Duodopa (levodopa/carbidopa intraduodenal gel infusion) / AbbVie
Journal: Per-oral image guided gastrojejunostomy insertion for levodopa-carbidopa intestinal gel in Parkinson's disease is safe and may be advantageous. (Pubmed Central) - Feb 5, 2022
In summary, PIG-J insertion is safe with a similar complication rate to traditional PEG-J, well tolerated and effective for use in LCIG administration. This may widen access to LCIG for PD patients who may not be suitable or unable to tolerate PEG-J.
- || levodopa/carbidopa CR / Generic mfg.
Question: How much time between the last dosage of Sinemet and Sinemet CR ? (Twitter) - Jan 8, 2022
- | levodopa/carbidopa CR / Generic mfg.
New P1 trial: TESDR: Treating Early Stage Diabetic Retinopathy (clinicaltrials.gov) - Nov 23, 2021
P1, N=244, Not yet recruiting, Sponsor: VA Office of Research and Development
- | levodopa/carbidopa CR / Generic mfg.
Trial completion date, Trial primary completion date: Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease (clinicaltrials.gov) - Aug 31, 2021
P4, N=42, Recruiting, Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
This may widen access to LCIG for PD patients who may not be suitable or unable to tolerate PEG-J. Trial completion date: Dec 2021 --> Mar 2022 | Trial primary completion date: Jul 2021 --> Feb 2022
- || levodopa/carbidopa CR / Generic mfg.
The results are indeed surprising. I wonder how this associated is modulated by presence of bladder dysfunction. Sinemet CR may improve noctiuria (commonly seen) and associated QoL too. https://t.co/o1hy7YMERK (Twitter) - Feb 6, 2021
- | carbidopa/levodopa / Generic mfg., levodopa/carbidopa CR / Generic mfg.
Preclinical, Journal: Chitosan-Coated Hydroxypropylmethyl Cellulose Microparticles of Levodopa (and Carbidopa): In Vitro and Rat Model Kinetic Characteristics. (Pubmed Central) - Dec 10, 2020
(Curr Ther Res Clin Exp. 2020; 81:XXX-XXX
- || levodopa/carbidopa CR / Generic mfg., amantadine / Generic mfg.
Dr Okin,57yr old male y.o.p.d. Do 10/31/2005. Sinemet cr 50/200 1q 3h - Sinemet 25/100 1.5 q3. Amantadine q6 Doing fairly well but eye trouble is problematic. Convergence issues inc double visionHave a prism in my eyeglasses but it’s a struggle. One neuro-opthamologist ,in town (Twitter) - Nov 11, 2020
- | levodopa/carbidopa CR / Generic mfg.
Trial completion date, Trial primary completion date: Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease (clinicaltrials.gov) - Aug 8, 2020
P4, N=42, Recruiting, Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
2020; 81:XXX-XXX Trial completion date: Sep 2021 --> Dec 2021 | Trial primary completion date: Jan 2021 --> Jul 2021
- || levodopa/carbidopa CR / Generic mfg.
@Merck is sinemet cr is discontinued? (Twitter) - Dec 22, 2019
- | NN1213 / Novo Nordisk
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: The Effect of Dopamine on Diabetic Retinopathy (clinicaltrials.gov) - Oct 9, 2019
P1, N=60, Completed, Sponsor: Emory University
Trial completion date: Sep 2021 --> Dec 2021 | Trial primary completion date: Jan 2021 --> Jul 2021 Enrolling by invitation --> Completed | N=45 --> 60 | Trial completion date: Dec 2019 --> Aug 2019 | Trial primary completion date: Dec 2019 --> Aug 2019
- Duodopa (levodopa/carbidopa intraduodenal gel infusion) / AbbVie
Per-oral image guided gastrojejunostomy insertion for levodopa-carbidopa intestinal gel in Parkinson’s disease is safe and may be advantageous (Agora 3 West, Level 3) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_1099;
The size of this cohort precludes any firm conclusions being drawn as to the potential advantages of this technique. However, based on this preliminary data, we propose that this promising technique warrants further investigation as it has the potential to reduce procedure related complications and may also allow access to LCIG therapy for patients in which PEG-J is unsuitable or not tolerated.
- | NN1213 / Novo Nordisk
Trial completion date, Trial primary completion date: The Effect of Dopamine on Diabetic Retinopathy (clinicaltrials.gov) - Jan 23, 2019
P1, N=45, Enrolling by invitation, Sponsor: Emory University
However, based on this preliminary data, we propose that this promising technique warrants further investigation as it has the potential to reduce procedure related complications and may also allow access to LCIG therapy for patients in which PEG-J is unsuitable or not tolerated. Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019
- | levodopa/carbidopa CR / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease (clinicaltrials.gov) - Sep 11, 2018
P4, N=42, Recruiting, Sponsor: McGill University Health Center
Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Dec 2018 --> Dec 2019 Trial completion date: Apr 2020 --> Sep 2021 | Initiation date: Dec 2016 --> May 2017 | Trial primary completion date: Apr 2020 --> Jan 2021
- || Accordion Pill carbidopa/levodopa CR (carbidopa/levodopa CR) / Jazz, Indaptus Therap
New P2 trial: Study to Assess Pharmacokinetics of Accordion Pill Carbidopa-Levodopa Compared to Immediate Release Carbidopa-Levodopa in Parkinson's Disease Patients (clinicaltrials.gov) - Jul 2, 2018
P2, N=12, Not yet recruiting, Sponsor: Intec Pharma Ltd.
- | levodopa/carbidopa CR / Generic mfg.
Trial primary completion date: The Effect of Dopamine on Diabetic Retinopathy (clinicaltrials.gov) - Jan 8, 2018
P1, N=45, Enrolling by invitation, Sponsor: Emory University
Trial completion date: Apr 2020 --> Sep 2021 | Initiation date: Dec 2016 --> May 2017 | Trial primary completion date: Apr 2020 --> Jan 2021 Trial primary completion date: Dec 2017 --> Dec 2018
- | levodopa/carbidopa CR / Generic mfg.
New P4 trial: Effect of Long-acting Levodopa on Obstructive Sleep Apnea in Parkinson's Disease (clinicaltrials.gov) - Apr 12, 2017
P4, N=42, Recruiting, Sponsor: McGill University Health Center
- levodopa/carbidopa CR / Generic mfg.
Trial primary completion date: The Effect of Dopamine on Diabetic Retinopathy (clinicaltrials.gov) - Feb 1, 2017
P1, N=45, Enrolling by invitation, Sponsor: Emory University
Trial primary completion date: Dec 2017 --> Dec 2018 Trial primary completion date: Dec 2016 --> Dec 2017
- levodopa/carbidopa CR / Generic mfg.
Enrollment status: The Effect of Dopamine on Diabetic Retinopathy (clinicaltrials.gov) - Oct 11, 2016
P1, N=45, Enrolling by invitation, Sponsor: Emory University
Trial primary completion date: Dec 2016 --> Dec 2017 Recruiting --> Enrolling by invitation
- levodopa/carbidopa CR / Generic mfg.
Trial primary completion date: The Effect of Dopamine on Diabetic Retinopathy (clinicaltrials.gov) - Aug 12, 2016
P1, N=45, Recruiting, Sponsor: Emory University
Recruiting --> Enrolling by invitation Trial primary completion date: Jul 2016 --> Dec 2016
- levodopa/carbidopa CR / Generic mfg.
New P1 trial: The Effect of Dopamine on Diabetic Retinopathy (clinicaltrials.gov) - Mar 11, 2016
P1, N=45, Recruiting, Sponsor: Emory University
- | pramipexole IR / Generic mfg.
Trial completion: The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease (clinicaltrials.gov) - Aug 26, 2014
P=N/A, N=30, Completed, Sponsor: Huashan Hospital
Trial primary completion date: Jul 2016 --> Dec 2016 Active, not recruiting --> Completed
- ||| Apokyn (apomorphine bolus injection) / Stada, Supernus Pharma, Aguettant
Enrollment change: Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT) (clinicaltrials.gov) - Apr 24, 2014
P4, N=129, Completed, Sponsor: US WorldMeds LLC
Active, not recruiting --> Completed N=100 --> 129
- |||| Apokyn (apomorphine bolus injection) / Stada, Supernus Pharma, Aguettant
Trial completion: Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT) (clinicaltrials.gov) - Apr 24, 2014
P4, N=129, Completed, Sponsor: US WorldMeds LLC
N=100 --> 129 Active, not recruiting --> Completed
- pramipexole IR / Generic mfg.
Enrollment closed: The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease (clinicaltrials.gov) - Aug 25, 2013
P=N/A, N=30, Active, not recruiting, Sponsor: Huashan Hospital
Active, not recruiting --> Completed Recruiting --> Active, not recruiting
- ||||| Apokyn (apomorphine bolus injection) / Stada, Supernus Pharma, Aguettant
New P4 trial: Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT) (clinicaltrials.gov) - Jan 15, 2013
P4, N=129, Completed, Sponsor: US WorldMeds LLC