- |||||||||| bleomycin / Generic mfg., cyclosporin A microemulsion / Generic mfg.
Journal: Double Braking Effects of Nanomedicine on Mitochondrial Permeability Transition Pore for Treating Idiopathic Pulmonary Fibrosis. (Pubmed Central) - Oct 30, 2024 Herein, a "double braking" strategy on mPTP by cyclosporin A (CsA) derived ionizable lipid with 3D structure (3D-lipid) binding cyclophilin D (CypD) and siRNA downregulating mitochondrial calcium uniporter (MCU) expression is proposed for treating IPF...In vitro results demonstrated that these NPs effectively inhibit mPTP opening by 3D-lipid binding with CypD and siRNA downregulating MCU expression, thereby decreasing damage-associated molecular patterns (DAMPs) release and suppressing epithelial-to-mesenchymal transition (EMT) process in bleomycin-induced A549 cells...Moreover, compared to the commercial MC3-based formulation, optimized Opt-MC3/siRNA NPs with incorporating 3D-lipid as the fifth component, showed superior therapeutic efficacy against PF due to their enhanced stability and higher gene silencing efficiency. Overall, the nanomedicine containing 3D-lipid and siMCU will be a promising and potential approach for IPF treatment.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Review, Journal: Managing Ocular Surface Disease in Glaucoma Treatment: A Systematic Review. (Pubmed Central) - Oct 25, 2024 In particular, the use of adjunct cyclosporine A, through its anti-inflammatory and enhanced tear film stability actions, was shown to be very beneficial to the ocular surface. Therefore, the most effective management of OSD is multi-factorial, consisting of switching to PF or less cytotoxic medications, adjunct use of cyclosporine A, and early incorporation of glaucoma surgical treatments such as laser trabeculoplasty, trabeculectomy, glaucoma drainage devices, or minimally invasive glaucoma surgery (MIGS).
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Journal: Cyclophilin D plays a critical role in the survival of senescent cells. (Pubmed Central) - Oct 25, 2024 Genetic or pharmacological inhibition of NCLX, another mitochondrial calcium efflux channel, also leads to senolysis, while inhibition of the main Ca2+ influx channel, MCU, prevents senolysis induced by CypD inhibition. We conclude that senescent cells are highly vulnerable to elevated mitochondrial Ca2+ ions, and that
- |||||||||| tofacitinib / Generic mfg.
Retrospective data, Journal: Tofacitinib for child-onset systemic lupus erythematosus. (Pubmed Central) - Oct 23, 2024 Tofacitinib may provide clinical benefits for some patients with refractory cSLE, and can also allow reduction in the glucocorticoid dosage. Tofacitinib has the potential as an adjunctive treatment for some patients with cSLE.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Preclinical, Journal: Modelling the maternal-fetal interface: An in (Pubmed Central) - Oct 18, 2024 NP65 modulates the level of GABAAR-?2 through the CaN-NFATc4 signaling pathway, which may serve as the underlying mechanism of NP. The latter relies on the adequate localization and function of the amino-acid transporter LAT1 and the drug transporter P-glycoprotein (P-gp) which were studied by immunofluorescence microscopy and application of respective inhibitors (2-Amino-2-norbornanecarboxylic acid (BCH) for LAT1; cyclosporine-A for P-gp)...Our in
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Journal: Drug Survival of Dupilumab, Methotrexate, and Cyclosporine A in Children With Atopic Dermatitis. (Pubmed Central) - Oct 16, 2024 This study also identified characteristics associated with discontinuation. These results provide insight into drug survival resulting from the effectiveness, safety, and tolerability of these systemic treatments in pediatric patients with AD and contribute to the optimization of patient outcomes.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Journal: Bioinformatics Analysis of the Panax ginseng Cyclophilin Gene and Its Anti-Phytophthora cactorum Activity. (Pubmed Central) - Oct 16, 2024 The protein encoded by the PgCyP gene contains the active site of PPIase (R62, F67, and H133) and a binding site for cyclosporine A (W128)...Further experiments on the roots of susceptible Arabidopsis thaliana showed that the PgCyP protein could improve the resistance of arabidopsis to Phytophthora cactorum. The findings of this study provide a basis for the use of the PgCyP protein as a new type of green biopesticide.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Journal: Ionic Liquid-Mediated Transdermal Delivery of Organogel Containing Cyclosporine A for the Effective Treatment of Psoriasis. (Pubmed Central) - Oct 14, 2024 The topical application of CsA-CAGE-P gel (10 mg/kg) on an imiquimod-induced plaque psoriatic model reduced the area of the psoriasis and severity index (PASI) score significantly for erythema and scaling, reversing the changes to skin thickness, blood flow rate, and transepidermal water loss. Together, CAGE-Pluronic F127 organogel was developed as an effective topical formulation for the local and systemic delivery of CsA for the treatment of psoriasis.
- |||||||||| Jakafi (ruxolitinib) / Incyte
Targetome of miRNA-Mimic identifies GvHD- and GvL-specific transcripts (Singapore; In-Person) - Oct 13, 2024 - Abstract #DGHO2024DGHO_1024; We use RNAseq to (1) define the targetome of fully chemically modified miRNA mimics in T cells, (2) to define the miRNA targets driving GvHD and GvL inhibiting effects. To summarize, we develop fully chemically modified miRNA mimics that can potentially be used for graft engineering to prevent GvHD while sparing or even increasing GvL.
- |||||||||| Promacta (eltrombopag) / Novartis
Feasibility and efficacy of immunosuppressive treatment with hATG, cyclosporin A (Cairo) - Oct 13, 2024 - Abstract #DGHO2024DGHO_601; Conclusion : Based on retrospective real-life data, IST with hATG is feasible in selected older patients with AA resulting in promising survival and response. Older AA patients might benefit from the addition of Eltrombopag to hATG and CSA in first-line.
- |||||||||| latanoprost / Generic mfg., cyclosporin A microemulsion / Generic mfg., timolol maleate ophthalmic solution / Generic mfg.
Review, Journal: Elucidating acceptance and clinical indications to support the rational design of drug-eluting contact lenses. (Pubmed Central) - Oct 9, 2024 It is hoped that this review will facilitate a deeper understanding of DECLs acceptance and indications, thereby supporting the rational design of DECLs. At the same time, this review provides a reference for the design of other drug-device combination products.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Journal: PPP3CB overexpression mediates EGFR TKI resistance in lung tumors via calcineurin/MEK/ERK signaling. (Pubmed Central) - Oct 3, 2024 Neutralization of PPP3CB by siRNA or inactivation of calcineurin by cyclosporin A induces apoptosis in resistant cells treated with EGFR TKIs...Combining EGFR, calcineurin, and MEK inhibitors overcomes resistance to EGFR TKI in both in vitro and in vivo models. Our results identify PPP3CB overexpression as a new mechanism of acquired resistance to EGFR TKIs, and provide a promising therapeutic approach for NSCLC patients that progress under TKI treatment.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Journal: Challenges in acute cyclosporine toxicity in a child with steroid-dependent nephrotic syndrome. (Pubmed Central) - Sep 30, 2024 Our results identify PPP3CB overexpression as a new mechanism of acquired resistance to EGFR TKIs, and provide a promising therapeutic approach for NSCLC patients that progress under TKI treatment. Despite its widespread use in patients undergoing organ transplantation or managing nephrotic syndrome, there is a lack of literature on the acute toxicity of cyclosporine A (CsA)...Remarkably, despite a tenfold overdose and elevated trough levels, the patient remained asymptomatic, and the CsA trough level normalized within 48
- |||||||||| Review, Journal: Cutting edge of immune response and immunosuppressants in allogeneic and xenogeneic islet transplantation. (Pubmed Central) - Sep 30, 2024
Additionally, the current availability of islet organ donations fails to meet the demand for organ transplants, making xenotransplantation a crucial method for addressing organ shortages. This review will cover the following three aspects: 1) the immune responses occurring during allogeneic islet transplantation, including three stages: inflammation and IBMIR, allogeneic immune response, and autoimmune recurrence; 2) commonly used immunosuppressants in allogeneic islet transplantation, including calcineurin inhibitors (Cyclosporine A, Tacrolimus), mycophenolate mofetil, glucocorticoids, and Bortezomib; and 3) early and late immune responses in xenogeneic islet transplantation and the immune effects of triple therapy (ECDI-fixed donor spleen cells (ECDI-SP) + anti-CD20 + Sirolimus) on xenotransplantation.
- |||||||||| hydroxychloroquine / Generic mfg., cyclosporin A microemulsion / Generic mfg.
Journal: Hyperuricemia Facilitates Uric Acid-Mediated Vascular Endothelial Cell Damage by Inhibiting Mitophagy. (Pubmed Central) - Sep 29, 2024 This study elucidates the role of hydroxychloroquine (HCQ) in the context of uric acid (UA)-induced vascular endothelial cell damage...The mechanistic exploration revealed that HCQ, in conjunction with the mitochondrial autophagy inhibitor Cyclosporine A (CsA), exacerbated the inhibitory effects of UA on HUVEC autophagy...This intervention led to increased expression of PINK1, Parkin, Bnip3, and Nix, along with enhanced fluorescence of LC3-II/LC3-I and Parkin, effectively inhibiting cell senescence and apoptosis while promoting cell proliferation. In conclusion, our findings underscore the pivotal role of HCQ in modulating UA-mediated vascular endothelial cell damage through the inhibition of mitophagy, providing novel insights into the therapeutic potential of targeting HCQ in the management of hyperuricemia-associated vascular complications.
- |||||||||| cyclosporin A microemulsion / Generic mfg., mycophenolate mofetil / Generic mfg., sirolimus / Generic mfg.
Preclinical, Journal, IO biomarker: The Effect of Chronic Immunosuppressive Regimen Treatment on Apoptosis in the Heart of Rats. (Pubmed Central) - Sep 29, 2024 The TRG (rats treated with rapamycin, tacrolimus and glucocorticosteroids) group showed the lowest percentage of apoptotic cells. The internal apoptosis pathway was confirmed only in the TMG group; in the remaining groups, the results indicate programmed cell death via the receptor pathway.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Journal: Anterior Segment Optical Coherence Tomography for the Tailored Treatment of Mooren's Ulcer: A Case Report. (Pubmed Central) - Sep 29, 2024 The AS-OCT imaging modality allowed for the accurate evaluation of corneal ulcer characteristics, facilitating informed decision-making regarding the use of systemic immunosuppression, surgical interventions, and local immunomodulation and providing detailed and precise assessment of disease progression. This approach enabled a tailored and effective treatment strategy for the patient and played a critical role in guiding the therapeutic approach.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Journal: Cadmium exposure induces skeletal muscle insulin resistance through the reactive oxygen species-mediated PINK1/Parkin pathway. (Pubmed Central) - Sep 28, 2024 N-acetyl-cysteine (NAC), a scavenger of reactive oxygen species (ROS), and mitophagy inhibitor Cyclosporin A (CsA) were used to confirm the role of oxidative stress in mitophagy and mitochondrial dysfunction caused by Cd...Strikingly, NAC ameliorated oxidative stress, excessive mitophagy, and the associated reduction in myotube insulin sensitivity, while inhibition of mitophagy by CsA alleviated skeletal muscle IR. In conclusion, this study reveals a previously unrecognized mechanism that chronic low-level Cd exposure may induce mitophagy by activating the PINK1/Parkin signal pathway by increasing ROS, thus causing skeletal muscle IR and elevated blood glucose.
- |||||||||| Rituxan (rituximab) / Roche
Results of Haploidentical Transplant in Wiskott-Aldrich Syndrome Patients with Donor Specific Antibodies: A Case Report (Exhibition Hall (3F)) - Sep 24, 2024 - Abstract #ICBMT2024ICBMT_319; He received a combination therapy of five consecutive therapeutic plasma exchanges, IVIG and rituximab, due to the antibodies against donor HLA class I and II...Haploidentical HSCT with T-cell depletion (CD3/CD45RA depletion) and myeloablative conditioning (busulfan, fludarabine, ATG, and thiotepa) had been done using his father as the donor...We used cyclosporine A for the prevention of graft-vs-host disease...Suppose you have to do haplo-HSCT from donors with HLA antigens corresponding to high levels of DSA. In that case, recipients should be treated with appropriate therapy to improve donor stem cell engraftment.
- |||||||||| Lupkynis (voclosporin) / Aurinia Pharma
Integrative Systems Analyses Reveal Calcineurin Inhibitor-Mediated Control of Human Podocyte Biophysics and Physiology (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_4036; Funding: Commercial Support - Aurinia Pharmaceuticals Background: Calcineurin inhibitors (CNIs), such as cyclosporine A (CsA), tacrolimus (TAC), and voclosporin (VCS), have been used to regulate the immune response in a number of conditions, including kidney transplantation, lupus nephritis and other autoimmune disorders. Based on these findings, our study contributes significantly to the understanding of the role of CNIs in podocyte function, independently from other cell biological impacts, and it represents an integrative cellular and molecular atlas to guide the discovery of novel drug-induced modulators of glomerulopathies and evaluate the effect of new CNIs on podocyte biophysical and biomechanical features.
- |||||||||| cyclosporin A microemulsion / Generic mfg., telmisartan / Generic mfg.
A Cost-Effective, High-Throughput, Three-Dimensional Coculture Model of Kidney Fibrosis for Drug Discovery (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3587; The 3D coculture was treated with Transforming Growth Factor beta (TGFb) and Cyclosporin A (CsA) simultaneously to induce AKI and fibrosis. In conclusion, We have successfully developed a 3D coculture model of tubulointerstitial fibrosis to be used as a low-cost, high throughput fibrotic assay for studying intercellular interaction and drug effects.
- |||||||||| cyclosporin A microemulsion / Generic mfg.
Kidney and Patients Outcomes of Pure Lupus Nephritis: A Nationwide Analysis in Japan (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1702; During a median 5-year observation period, some patients with pure MLN experienced a decline in renal function or death. An eGFR <45 at the time of renal biopsy was identified as a risk factor for both poor renal outcomes and decreased patient survival.
- |||||||||| Clinical, Journal: Comparison table: Some drugs for plaque psoriasis. (Pubmed Central) - Sep 21, 2024
To our knowledge, this is the first study to show that CNIs disrupt energy metabolism by inactivating PDH in PTCs and that activating PDH ameliorates dysregulated energy metabolism as well as kidney fibrosis. No abstract available
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Observational data, Retrospective data, Journal: CYSTOID MACULAR EDEMA IN BIRDSHOT RETINOCHORO (Pubmed Central) - Sep 20, 2024 Registered on 20 July 2021, with the registration number ChiCTR2100049059. The classical uveitic cystoid macular edema therapeutic algorithm could be adapted to birdshot retinochoro
- |||||||||| cyclosporin A microemulsion / Generic mfg., voriconazole / Generic mfg.
Journal: Synergistic antifungal activity against Candida albicans between voriconazole and cyclosporine a loaded in polymeric nanoparticles. (Pubmed Central) - Sep 15, 2024 Therefore, the enhancement of the biofilm inhibition found for the three tested treatments (CsA alone, VRZ alone, and VRZ+CsA) when comparing free and encapsulated drugs, within the therapeutic window, can be attributed to the drug encapsulation approach. Indeed, polymeric PLGA NPs loaded with CsA, VRZ, or VRZ+CsA are more effective at inhibiting the C. albicans biofilm growth than their free counterparts.
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