- |||||||||| Livalo (pitavastatin) / Kowa, Eli Lilly
Review, Journal: Protective Effects of Different Classes, Intensity, Cumulative Dose-Dependent of Statins Against Primary Ischemic Stroke in Patients with Type 2 Diabetes Mellitus. (Pubmed Central) - Jul 29, 2023
Corresponding aHRs (95% CI) were 0.09 to 0.79 for pitavastatin, rosuvastatin, atorvastatin, pravastatin, simvastatin, fluvastatin, and lovastatin...Persistent statin use reduces the risk of primary ischemic stroke in T2DM patients. Higher cDDD-year values are associated with higher reductions in primary ischemic stroke risk in T2DM patients.
- |||||||||| cyclosporine / Generic mfg.
Journal: Tacrolimus and Cyclosporin Pharmacotherapy, Detection Methods, Cytochrome P450 Enzymes after Heart Transplantation. (Pubmed Central) - Jul 27, 2023
Polypharmacy based on tacrolimus or cyclosporine needs vigilant therapeutic drug monitoring due to the cytochrome P450 enzymes associated with biochemical variables in metabolic pathways. Further attention to polypharmacy should be given to circulate drugs that could hide pharmacokinetics interactions associated with infections, malignancies, chronic kidney disease, and rejection after organ transplantation.
- |||||||||| Biomarker, Journal, Real-world evidence, Real-world: Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2, and CYP2C9 variants. (Pubmed Central) - Jul 25, 2023
Further attention to polypharmacy should be given to circulate drugs that could hide pharmacokinetics interactions associated with infections, malignancies, chronic kidney disease, and rejection after organ transplantation. The current results can inform pharmacogenetic statin prescribing guidelines and show feasibility for the methodology to be used in larger future studies.
- |||||||||| fluvastatin / Generic mfg.
Journal: Acidity-Responsive Nanoreactors Destructed "Warburg Effect" for Toxic-Acidosis and Starvation Synergistic Therapy. (Pubmed Central) - Jul 21, 2023
In the nanoreactor, the fluvastatin (Flu) could reduce lactate efflux by inhibiting the lactate-proton transporter (monocarboxylate transporters, MCT4), resulting in intracellular lactate accumulation...Cellular dysfunction under pHi acidification and impaired Adenosine Triphosphate (ATP) synthesis under starvation synergistically promote tumor cell apoptosis. Both in vitro and in vivo studies demonstrate that this combinational approach of toxic-acidosis/starvation therapy could effectively destruct the "Warburg Effect" to inhibit tumor growth and anti-metastatic effects.
- |||||||||| lovastatin / Generic mfg., fluvastatin / Generic mfg.
Preclinical, Journal: Statins protect mice from high-decibel noise-induced hearing loss. (Pubmed Central) - Jul 16, 2023
Direct delivery of fluvastatin to the cochlea and oral delivery of lovastatin were evaluated...Lovastatin delivered by gavage showed lower threshold shifts than with carrier alone. These data show that direct and oral statin delivery protects mice against NIHL.
- |||||||||| fluvastatin / Generic mfg.
Journal: Fluvastatin: a choice for COVID-19 associated mucormycosis management. (Pubmed Central) - Jul 7, 2023
Thus, fluvastatin could be considered a potential antifungal agent when no other option is available. Furthermore, in comparison with other statins, fluvastatin exhibits the fewest drug/drug interactions with anti-Mucorales azoles (e.g., isavuconazole and posaconazole), as well as with medicines that are used in solid organ transplant recipients (e.g., cyclosporine) and HIV-positive individuals (e.g., ritonavir); two groups of patients that have a higher risk of infection with Mucorales fungi following a SARS-CoV-2 infection.
- |||||||||| atorvastatin / Generic mfg., fluvastatin / Generic mfg.
Journal: Atorvastatin and Fluvastatin Potentiate Blood Pressure Lowering Effect of Amlodipine through Vasorelaxant Phenomenon. (Pubmed Central) - Jul 2, 2023
A positive relaxing effect on 80 mM KCl induced contractions were further confirmed in the absence and presence of atorvastatin and fluvastatin by constructing calcium concentration response curves (CCRCs) while using verapamil as a standard calcium channel blocker...These statins also inhibit the effects of NE induced contractions. The study also confirms that atorvastatin and fluvastatin potentiate blood pressure lowering effects in hypertensive rats.
- |||||||||| Livalo (pitavastatin) / Kowa, Eli Lilly
Clinical, Retrospective data: Association between Statins Types with Incidence of Liver Cancer: An Updated Meta-analysis. (Pubmed Central) - Jul 2, 2023
Moreover, atorvastatin (OR=0.55, p<0.001), simvastatin (OR=0.59, p<0.001), lovastatin (OR=0.51, p<0.001), pitavastatin (OR=0.36, p=0.008) and rosuvastatin (OR=0.60, p=0.027) could effectively reduce the incidence of liver cancer, unlike fluvastatin, cerivastatin and pravastatin Both lipophilic and hydrophilic statins contribute to the prevention of liver cancer. Moreover, the efficacy was influenced by the region and the specific type of statins used.
- |||||||||| fluvastatin / Generic mfg.
PK/PD data, Retrospective data, Journal: Associations between SLCO1B1, APOE and (Pubmed Central) - Jun 16, 2023
These findings provide insights into the inhibitory mechanism of statins against hMCT1, hMCT2, and hMCT4 and may aid in the development of novel anticancer agents. Patients carrying 521CC or total cholesterol had a significantly higher area under the curve than those carrying
- |||||||||| Journal, PD(L)-1 Biomarker, IO biomarker: Statins exert anti-growth effects by suppressing YAP/TAZ expressions via JNK signal activation and eliminate the immune suppression by downregulating PD-L1 expression in pancreatic cancer. (Pubmed Central) - Jun 9, 2023
Simvastatin had an anti-proliferative effect on pancreatic cancer cells with decreased the yes-associated protein (YAP)/PDZ-binding motif (TAZ) expression by activating the JNK pathway, and simvastatin treatment with oxaliplatin revealed additive anti-growth effects...Simvastatin treatment with an anti-PD-1 drug (BP0273) provided immediate anti-growth effects compared to controls, such as anti-PD-1 only and simvastatin only, and suppressed progressive disease during the early period of anti-PD-1 treatment in vivo. In conclusion, Statins display two distinct anti-cancer effects (direct anti-growth effect and elimination of immune suppression by downregulating PD-L1 expression) by targeting YAP/TAZ expression.
- |||||||||| Preclinical, Journal, IO biomarker: Investigating potential anti-proliferative activity of different statins against five cancer cell lines. (Pubmed Central) - May 14, 2023
Simvastatin and atorvastatin may inhibit cellular proliferation via BCL-2/p53, Bax/Bak, and PI3K/Akt/mTOR signalling pathways. This is the first research to evaluate the anti-cancer effects of simvastatin, rosuvastatin, fluvastatin, atorvastatin, and pravastatin against five different cell lines from distinct origins and provided a relevant comparison of their efficacies for their anti-proliferative activity.
- |||||||||| fluvastatin / Generic mfg.
Preclinical, Journal: Lycium barbarum Oligosaccharides Alleviate Hepatic Steatosis by Modulating Gut Microbiota in C57BL/6J Mice Fed a High-Fat Diet. (Pubmed Central) - Apr 28, 2023
Significantly different metabolites between LBO and the HFD, such as taurochenodeoxycholate, taurocholate, fluvastatin, and kynurenic acid, were related to the cholesterol metabolism, bile acid metabolism, and tryptophan metabolic pathways. In light of the above, LBO can alleviate HFD-induced NAFLD by modulating the components of the intestinal flora and fecal metabolites.
- |||||||||| Livalo (pitavastatin) / Kowa, Eli Lilly
Journal: Optimal statin use for prevention of sepsis in type 2 diabetes mellitus. (Pubmed Central) - Apr 19, 2023
In light of the above, LBO can alleviate HFD-induced NAFLD by modulating the components of the intestinal flora and fecal metabolites. Our real-world evidence demonstrated that the persistent use of statins reduced sepsis and septic shock risk in patients with T2DM and a higher cDDD-year of statin use was associated with an increased reduction of sepsis and septic shock risk in these patients.
- |||||||||| Livalo (pitavastatin) / Kowa, Eli Lilly
Journal: Long-term outcomes of statin dose, class, and use intensity on primary prevention of cardiovascular mortality: a national T2DM cohort study. (Pubmed Central) - Apr 19, 2023
The optimal statin dose daily was 0.86 DDD. The priority of protective effects on mortality are pitavastatin, rosuvastatin, pravastatin, simvastatin, atorvastatin, fluvastatin, and lovastatin for the statin users compared with non-statin users.
- |||||||||| CRT0066101 / Cancer Research UK
Preclinical, Journal: Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids. (Pubmed Central) - Mar 24, 2023
Other lipophilic statins, including simvastatin, atorvastatin, and fluvastatin also prevented PKD activation in a dose-dependent manner...Using enteroids generated from intestinal crypt-derived epithelial cells from PKD1 transgenic mice as a model of intestinal regeneration, we show that statins oppose PKD1-mediated increase in enteroid area, complexity (number of crypt-like buds) and DNA synthesis. Our results revealed a previously unappreciated inhibitory effect of statins on receptor-mediated PKD activation and in opposing the growth-promoting effects of PKD1 on intestinal epithelial cells.
- |||||||||| Journal, Adverse drug reaction: Adverse drug reactions of statin therapy in China from 1989 to 2019: a national database analysis. (Pubmed Central) - Mar 24, 2023
Our results revealed a previously unappreciated inhibitory effect of statins on receptor-mediated PKD activation and in opposing the growth-promoting effects of PKD1 on intestinal epithelial cells. In Chinese clinical trials, gastrointestinal symptoms were the most common ADR of statin use for hyperlipidaemia and other cardiovascular diseases.
- |||||||||| IMPACT OF STATINS AND NON-SELECTIVE BETA-BLOCKERS IN HEPATIC ENCEPHALOPATHY AND ASCITES EVENTS IN PATIENTS WITH DECOMPENSATED CIRRHOSIS: A NATIONWIDE ANALYSIS (South Hall A, Poster Hall - McCormick Place) - Mar 23, 2023 - Abstract #DDW2023DDW_3368;
Patients with decompensated cirrhosis were divided into 2 different cohorts; first cohort was patients who received NSBB (propranolol or nadolol) and statins (simvastatin, lovastatin, rosuvastatin, atorvastatin, pravastatin or fluvastatin), compared to a second cohort of patients who only received NSBB... In a large nationwide study, the adjunctive therapy of statins to NSBB in decompensated cirrhotic patients had a significantly lower rate of hepatic encephalopathy, ascites, and all-cause mortality.
- |||||||||| Journal, Adverse events: Statin associated Muscular Adverse Effects. (Pubmed Central) - Feb 27, 2023
Early recognition of muscle symptoms is required to prevent rhabdomyolysis. Further researchare needed to completely elucidate the pathophysiology of statin-induced muscular adverse effects.
- |||||||||| simvastatin / Generic mfg., lovastatin / Generic mfg., fluvastatin / Generic mfg.
Journal: High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing. (Pubmed Central) - Feb 3, 2023
In the secondary screen, we indeed verified that four out of the five statins (mevastatin, lovastatin, simvastatin and fluvastatin) increased CFTR function when combined with CFTR modulators...Future studies should focus on elucidating genotype specificity and mode-of-action of statins in more detail. This study exemplifies proof of principle of large-scale compound screening in a functional assay using patient-derived organoids.
- |||||||||| simvastatin / Generic mfg., atorvastatin / Generic mfg., fluvastatin / Generic mfg.
Journal: Effects of Statin Combinations on Zika Virus Infection in Vero Cells. (Pubmed Central) - Jan 22, 2023
Overall, certain combinations of ATO or FLU with SIM or MEV may be synergistic. More exhaustive combinatorial assays in vitro and in vivo could help define whether combining lipophilic statins would be beneficial and safe for treating ZIKV infections.
- |||||||||| Livalo (pitavastatin) / Kowa, Eli Lilly
Retrospective data, Journal: Statins improve asthma symptoms by suppressing inflammation: a meta-analysis based on RCTs. (Pubmed Central) - Dec 3, 2022
Together, these results suggest that hiBMEC can be used to model cerebral vascular glucose metabolism, which expands their use beyond barrier models. Although statins did not change the lung function in patients with asthma, they improved asthma symptoms and reduced the serum hsCRP, sputum eosinophil ratio, and IL6 levels.
- |||||||||| fluvastatin / Generic mfg.
Journal: Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins. (Pubmed Central) - Nov 18, 2022
The activities of the HMG-CoA reductase films were preserved over time, and the two lipid raft systems, nanoparticles and films, were exposed to solutions of fluvastatin, a HMG-CoA reductase inhibitor commonly used in the treatment of hypercholesterolemia. Both lipid raft systems constructed were useful membrane models for the determination of reductase activity and for monitoring the statin inhibitory effects and may be used for investigating other integral membrane proteins during exposure to inhibitors/activators considered to be potential drugs.
- |||||||||| fluvastatin / Generic mfg.
Journal, IO biomarker: Hybrid nanoparticulate system of Fluvastatin loaded phospholipid, alpha lipoic acid and melittin for the management of colon cancer. (Pubmed Central) - Nov 17, 2022
According to studies analyzing cell cycle, optimized FLV PL ALA MEL was found to inhibit Caco2 colon cancer cells more significantly than other therapeutic treatments, wherein a higher number of cells were found to accumulate over G2/M and pre-G1 phases, whereas G0/G1/S phases witnessed the accumulation of a lower number of cells. The optimized formulation may pave the way for a novel and more efficacious treatment for colon cancer.
- |||||||||| fluvastatin / Generic mfg.
Journal: Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy. (Pubmed Central) - Nov 15, 2022
To address these issues, an inhalable nanoreactor was proposed by spontaneously adsorbing biomimetic protein corona (PC) composed of matrix metalloproteinase 2 responsive gelatin and glutamate (Glu) on the surface of cationic nanostructured lipid carriers (NLC) core loaded with ferrocene (Fc) and fluvastatin...The enhanced antitumor effects by combination of tumor acidosis and antioxidant system collapse were confirmed in an orthotopic lung ADC tumor model. Overall, the proposed nanoreactor highlights the pulmonary delivery approach for local lung ADC treatment and underscores the great potential of ferroptosis therapy.
- |||||||||| Preclinical evaluation of novel repurposed drug combinations in Hodgkin lymphoma (Great Hall) - Oct 27, 2022 - Abstract #ISHL2022ISHL_46;
On the contrary Eprosartan (Epro) Metformin (Met) Clofibrate (Clof) and Ornidazole (Orni) increased antibody dependent cellular phagocytosis (ADCP) in in-vitro assays.This project shows that combinations of repurposed non-oncological drugs at safe doses have a direct cytotoxic effect against HL and a potentially beneficial impact on key immune response mechanisms. Taken together our results justify further evaluation of combinations of these clinically known drugs with chemotherapy or checkpoint blockade in cases of HL without other treatment options.
- |||||||||| Review, Journal: Statins and Male Fertility: Is There a Cause for Concern? (Pubmed Central) - Oct 27, 2022
These contradictory findings are in part due to the different age of users, concentrations of statins, the type and duration of treatment, and the underlying disease and/or comorbidities. Therefore, the current study aims to analyze the literature and gather evidence as to the effects of statin on male sexual health and reproductive parameters, and subsequently give recommendations for the direction of future studies.
- |||||||||| IMPACT OF STATINS AND NON-SELECTIVE BETA-BLOCKERS ON ESOPHAGEAL VARICEAL BLEEDING AND MORTALITY IN PATIENTS WITH DECOMPENSATED CIRRHOSIS: A NATIONWIDE ANALYSIS (Room 202) - Oct 23, 2022 - Abstract #AASLD2022AASLD_354;
Eligible patients were divided into two different cohorts; first cohort received NSBB (propranolol or nadolol) and statins (simvastatin, lovastatin, rosuvastatin, atorvastatin, pravastatin or fluvastatin), compared to a second cohort of patients on NSBB alone... In a large nationwide study, patients with decompensated cirrhosis on NSBB and a statin had a significant lower rate of esophageal bleeding, mortality, ICU-length of stay, length of hospital stay when compared with patients only receiving NSBB.
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