- |||||||||| fluvastatin / Generic mfg.
Journal, Immunomodulating: Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration. (Pubmed Central) - Oct 27, 2024
Here, we demonstrate synergistic effects of the combination of an HMG-CoA reductase inhibitor, statin/fluvastatin and critical components of the extracellular matrix, Matrix-Bound Nanovesicles (MBV) to enhance axon regeneration and neuroprotection after mouse optic nerve injury...Finally, this therapy can be further combined with AAV-based gene therapy blocking anti-regenerative pathways in RGCs to extend regenerated axons. These data highlight novel molecular insights into the development of immunomodulatory regenerative therapy.
- |||||||||| fluvastatin / Generic mfg.
Journal: Preparation of chiral metal organic framework modified silica monolithic capillary column and its application in enantioseparations of chiral drugs (Pubmed Central) - Oct 25, 2024
Under the conditions of an applied voltage of -20 kV and a mobile phase consisting of acetonitrile and 20 mmol/L disodium hydrogen phosphate (80?20, v/v), six chiral drugs were separated within 3 min, with baseline separation achieved for amlodipine, fluvastatin, and tryptophan...In conclusion, this study demonstrates that chiral MOFs can be effectively used as chiral functional monomers to prepare chiral monolithic capillary columns, highlighting their significant potential for the separation and analysis of chiral compounds. The comprehensive exploration of the synthesis, characterization, and applications of these MOFs will help provide valuable insights into the development of advanced separation technologies.
- |||||||||| MK-2206 / Merck (MSD)
Journal: Effects of Lipophilic Statins on Cell Viability and Tissue Factor Expression in Canine Haemangiosarcoma Cells. (Pubmed Central) - Sep 25, 2024
Further investigation using cell viability assays and flow cytometry revealed that simvastatin decreased Akt phosphorylation, and MK-2206, a specific Akt inhibitor, mirrored the effect of simvastatin on cell viability and cell cycle arrest...Overall, this study provides insights into the potential therapeutic use of statins in targeting tumour growth and coagulation abnormalities in canine HSA. Further research is warranted to fully elucidate the underlying mechanisms and clinical applications of statins in canine HSA treatment.
- |||||||||| Impact of Statin Use on Post-ERCP Complications: A U.S. Cohort Propensity-Matched Study (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4969;
After PSM, we had 37,826 patients in both groups. Patients who were on statins and underwent ERCP had a lower risk of intubation (HR 0.77, 95% CI [0.67-0.88]), PEP (0.48, [0.42-0.55]), GI bleeding (0.75, [0.66-0.85]), GI perforation (0.57, [0.42-0.78]), systemic complications (0.84, [0.77-0.91]), and all-cause mortality (0.51, [0.47-0.54]) within 30 days of the ERCP.
- |||||||||| Real-World Statin Use and 10-Year Atherosclerotic Cardiovascular Disease Risk in Patients With Biopsy-Confirmed Metabolic Dysfunction Associated Steatohepatitis in an Integrated Delivery Network (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3374;
Patients who were on statins and underwent ERCP had a lower risk of intubation (HR 0.77, 95% CI [0.67-0.88]), PEP (0.48, [0.42-0.55]), GI bleeding (0.75, [0.66-0.85]), GI perforation (0.57, [0.42-0.78]), systemic complications (0.84, [0.77-0.91]), and all-cause mortality (0.51, [0.47-0.54]) within 30 days of the ERCP. 3,442 MASH patients had data available to calculate ASCVD risk
- |||||||||| colchicine / Generic mfg.
Journal, Adverse events, Real-world evidence, Real-world: Muscular toxicity of colchicine combined with statins: a real-world study based on the FDA adverse event reporting system database from 2004-2023. (Pubmed Central) - Aug 12, 2024
Similar ADRs can occur when colchicine and statins are used individually or in combination; however, the strength of these reactions may differ. To minimize the risk of drug interactions, statins with less potential interactions, such as lovastatin, pitavastatin, and pravastatin, should be chosen, and myopathy-related indices and symptoms should be closely monitored during use.
- |||||||||| SP600125 / BMS
Review, Journal: Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches. (Pubmed Central) - Jul 22, 2024
This review describes the molecular mechanisms of programmed death and the impact of cardiomyocyte death on cardiovascular disease development. Emphasis is placed on a summary of drugs and potential therapeutic approaches that can be used to treat cardiovascular disease by targeting and blocking programmed cell death in cardiomyocytes.
- |||||||||| fluvastatin / Generic mfg.
Journal, Metabolomic study: Material Composition Characteristics of Aspergillus cristatus under High Salt Stress through LC-MS Metabolomics. (Pubmed Central) - Jun 19, 2024
The biosynthesis of energy-related pantothenol and pantothenic acid and antagonism-related fluvastatin, aflatoxin, and alternariol significantly increased at high NaCl concentrations...The aforementioned results indicate that A. cristatus adapts to changes in salt concentration by adjusting their metabolite synthesis. At the same time, a unique set of strategies was developed to cope with high salt stress, including growth restriction, osmotic pressure balance, oxidative stress response, antioxidant defense, and survival competition.
- |||||||||| fluvastatin / Generic mfg.
Preclinical, Journal: Screening approach by a combination of computational and in vitro experiments: identification of fluvastatin sodium as a potential SIRT2 inhibitor. (Pubmed Central) - May 27, 2024
Next, molecular docking, molecular dynamics (MD) simulations, and binding free energy calculations were performed, revealing the binding mode of fluvastatin sodium at the SIRT2 active site, further validating the stability and interaction of the ligand-protein complex under physiological conditions. Overall, this study provides a systematic virtual screening workflow for the discovery of SIRT2 activity inhibitors, identifies the potential inhibitory effect of fluvastatin sodium as a lead compound on SIRT2, and opens up a new direction for developing highly active and selectively targeted SIRT2 inhibitors.
- |||||||||| tetracycline / Generic mfg., fluvastatin / Generic mfg.
Journal: Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B1. (Pubmed Central) - May 23, 2024
Overall, this study provides a systematic virtual screening workflow for the discovery of SIRT2 activity inhibitors, identifies the potential inhibitory effect of fluvastatin sodium as a lead compound on SIRT2, and opens up a new direction for developing highly active and selectively targeted SIRT2 inhibitors. Olmesartan-MX is a substrate for OATP2B1, and the naringin-sensitive transport system contributes to the improved intestinal absorption of olmesartan-MX compared with its parent drug, olmesartan.
- |||||||||| Nulojix (belatacept) / BMS
Safety of High-Intensity Statin Use in Liver and Kidney Transplant Recipients Taking Tacrolimus (Poster Hall, Exhibit Hall A, Level 2) - May 6, 2024 - Abstract #ATC2024ATC_2331;
In liver and kidney transplant recipients receiving tacrolimus, the use of HI statins was not associated with an increased risk of myalgia, rhabdomyolysis, or elevated creatinine kinase when compared with low-moderate intensity statin use. This is an important consideration when determining statin use and dose post-abdominal transplant, especially in patients with an indication for a HI statin.
- |||||||||| Natural Statins as Inhibitors of Alpha-synuclein Fibril Formation (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3608;
Virtual hepatic/plasma exposures in subjects harboring the impaired CYP2C9*3 allele estimated using pharmacokinetic modeling indicate that such exposure could be a causal factor for hepatic disorders induced by fluvastatin prescribed alone in a manner similar to that for interactions with a variety of co-administered drugs. Of these, lovastatin (IC50 = 19
- |||||||||| pravastatin / Generic mfg., fluvastatin / Generic mfg.
Journal: Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia. (Pubmed Central) - Feb 16, 2024
Chemerin is a biomarker for preeclampsia, and statins both prevent its placental upregulation and effects, in an NO and low-density lipoprotein receptor-dependent manner. Combined with their capacity to improve the sFlt-1/PlGF ratio, this offers an attractive mechanism by which statins may prevent or treat preeclampsia.
- |||||||||| fluvastatin / Generic mfg., rosuvastatin / Generic mfg.
Biomarker, Journal: Utilizing Pharmacogenomic Data for a Safer Use of Statins among the Emirati Population. (Pubmed Central) - Jan 29, 2024
Among the sparse studies available, the present one demonstrates all SLCO1B1 and CYP2C9 function-impairing alleles among Emiratis. We highlighted how population-specific pharmacogenomic data can predict safer choices of statins, especially in understudied populations.
- |||||||||| Journal: Genetic Determinants of Response to Statins in Cardiovascular Diseases. (Pubmed Central) - Jan 11, 2024
There is a growing body of data evaluating drug-gene interactions in recent years, some of which have led to FDA recommendations and detection of markers to predict drug responses (e.g., genetic variant in VKORC1 and CYP2C9 genes for prediction of drug response in warfarin treatment)...Atorvastatin, fluvastatin, rosuvastatin, simvastatin, and lovastatin are the most common statins used to manage dyslipidemia. This review provides an overview of the current knowledge on the pharmacogenetics of statins, which are being used to treat cardiovascular diseases.
- |||||||||| fluvastatin / Generic mfg., ibuprofen / Generic mfg., rosuvastatin / Generic mfg.
Journal: Uptake of Fluorescein via a pH-Dependent Monocarboxylate Transporter by Human Kidney 2 (HK-2) Cells. (Pubmed Central) - Jan 8, 2024
pH-dependent FLS uptake was trans-stimulated by the inhibitable monocarboxylates. Collectively, the present data indicate that the pH-dependent transporters expressed in HK-2 cells are involved in the reabsorption of monocarboxylates from the urinary fluid into the tubular epithelia.
- |||||||||| Noxafil (posaconazole) / Merck (MSD), Cresemba (isavuconazonium sulfate) / Astellas, Basilea, Pfizer, Laboratoire Riva, Asahi Kasei
Journal: Exploring synergy between azole antifungal drugs and statins for Candida auris. (Pubmed Central) - Dec 4, 2023
A prognostic signature may contribute to the personalized treatment and prognostic determination. Our results provide a rationale for pursuing in vivo synergy tests as well as clinical studies to explore tolerability, treatment outcomes, optimal dose and exposure targets.
- |||||||||| fluvastatin / Generic mfg.
Journal: CaaX-motif-adjacent residues influence G protein gamma (G?) prenylation under suboptimal conditions. (Pubmed Central) - Nov 27, 2023
subtypes, our findings indicate a plausible mechanism allowing for statins to differentially perturb heterotrimeric G protein signaling in cells depending on their G?-subtype composition. Our results may also provide molecular reasoning for repurposing statins as Ras oncogene inhibitors and the failure of using prenyltransferase inhibitors in cancer treatment.
- |||||||||| fluvastatin / Generic mfg.
Journal: SLC3A2 N-glycosylation and Golgi remodeling regulate SLC7A amino acid exchangers and stress mitigation. (Pubmed Central) - Nov 5, 2023
In replete conditions, SLC3A2 interactions require Golgi-modified N-glycans at N365D and N381D, whereas reducing N-glycosylation in the endoplasmic reticulum by fluvastatin treatment promoted the recruitment of CD44 and transporters needed to mitigate stress. Thus, SLC3A2 N-glycosylation and Golgi remodeling of the N-glycans have distinct roles in amino acids import for growth, maintenance, and metabolic stresses.
- |||||||||| ubenimex (DFP-14323) - Delta / Fly Pharma
Journal: Statins markedly potentiate aminopeptidase inhibitor activity against (drug-resistant) human acute myeloid leukemia cells. (Pubmed Central) - Oct 16, 2023
Consistently, statin potentiation of CHR2863 activity was abrogated by co-administration of mevalonate and/or farnesyl pyrophosphate, suggesting the involvement of protein prenylation; this was experimentally confirmed by impaired Rheb prenylation by simvastatin. These novel findings suggest that the combined inhibitory effect of impaired Rheb prenylation and CHR2863-dependent mTOR inhibition instigates a potent synergistic inhibition of statins and APis on human AML cells.
- |||||||||| fluvastatin / Generic mfg.
Journal: Wolbachia interferes with Zika virus replication by hijacking cholesterol metabolism in mosquito cells. (Pubmed Central) - Oct 9, 2023
Inhibition of the MVA pathway using fluvastatin decreased total cholesterol and viral titers, mimicking the effects of Wolbachia on the virus in Wolbachia-free cells...Here, we describe how intracellular bacteria redirect resources within their host cells and suppress Zika virus replication at the cellular level. Understanding the mechanism behind Wolbachia-induced interference of arbovirus replication could help advance strategies to control arbovirus pathogens in insect vectors and human populations.
- |||||||||| pravastatin / Generic mfg.
Review, Journal: Pravastatin for lowering lipids. (Pubmed Central) - Sep 22, 2023
Pravastatin lowers blood total cholesterol, LDL cholesterol and triglyceride in a dose-dependent linear fashion. This review did not provide a good estimate of the incidence of harms associated with pravastatin because of the lack of reporting of adverse effects in 48.4% of the randomized placebo-controlled trials.
- |||||||||| fluvastatin / Generic mfg.
Journal: Neutrophils for Revascularization Require Activation of CCR6 and CCL20 by TNF?. (Pubmed Central) - Aug 29, 2023
recruits proangiogenic VEGFA-expressing neutrophils to sites of ischemic injury for initiation of muscle tissue revascularization. The findings provide an attractive option for tissue revascularization, particularly under diabetic conditions.
- |||||||||| fluvastatin / Generic mfg.
Journal: Statin Action Targets Lipid Rafts of Cell Membranes: GIXD/PM-IRRAS Investigation of Langmuir Monolayers. (Pubmed Central) - Aug 8, 2023
Two representatives of these drugs, fluvastatin (FLU) and cerivastatin (CER), of different hydrophobicity were chosen, while cholesterol (Chol) and sphingomyelin (SM), and their 1:1 mixture were selected to form condensed monolayers of lipid rafts...In this case, the less hydrophobic FLU was not able to penetrate the binary layer at all, while exposure to the hydrophobic CER resulted in the phase separation and formation of ordered assemblies. The changes in the membrane properties were visualized by BAM images and GIXD patterns and confirmed by thermodynamic parameters of hysteresis in the Langmuir monolayer compression-decompression experiments.
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