- |||||||||| Tagrisso (osimertinib) / AstraZeneca, Gilotrif (afatinib) / Boehringer Ingelheim, allitinib (AST1306) / Allist
The implication of RKIP loss in primary resistance to EGFR inhibitors in NSCLC: a novel predictive biomarker? (Poster Area) - Jun 28, 2022 - Abstract #EACR2022EACR_865;
When assessing the activation levels of EGFR related signaling pathways upon treatment, AKT pathway was overactivated in RKIP KO cells, thus shedding light on the possible mechanism of resistance behind RKIP’s loss. Conclusion To sum up, these results show the potential of RKIP as a negative predictive biomarker to EGFR targeted therapy response in NSCLC.
- |||||||||| Gilotrif (afatinib) / Boehringer Ingelheim, allitinib (AST1306) / Allist
[VIRTUAL] RKIP protein as a diagnostic, prognostic and therapeutic marker in HPV-related cancers. () - May 30, 2021 - Abstract #EACR2021EACR_575;
These results give us new insights about through which players RKIP could be modulating cellular processes, such as apoptosis and signal transduction. Conclusion In conclusion, we demonstrated for the first time that besides its role as a prognostic marker, RKIP loss is associated with higher aggressiveness in vitro and in vivo , being a potential predictor to anti-EGFR therapy response in HNSCC patients.
- |||||||||| Gilotrif (afatinib) / Boehringer Ingelheim, allitinib (AST1306) / Allist
[VIRTUAL] RKIP protein as a diagnostic, prognostic and therapeutic marker in HPV-related cancers. () - May 30, 2021 - Abstract #EACR2021EACR_574;
These results give us new insights about through which players RKIP could be modulating cellular processes, such as apoptosis and signal transduction. Conclusion In conclusion, we demonstrated for the first time that besides its role as a prognostic marker, RKIP loss is associated with higher aggressiveness in vitro and in vivo , being a potential predictor to anti-EGFR therapy response in HNSCC patients.
- |||||||||| Gilotrif (afatinib) / Boehringer Ingelheim, allitinib (AST1306) / Allist
[VIRTUAL] RKIP protein as a diagnostic, prognostic and therapeutic marker in HPV-related cancers. () - May 30, 2021 - Abstract #EACR2021EACR_573;
These results give us new insights about through which players RKIP could be modulating cellular processes, such as apoptosis and signal transduction. Conclusion In conclusion, we demonstrated for the first time that besides its role as a prognostic marker, RKIP loss is associated with higher aggressiveness in vitro and in vivo , being a potential predictor to anti-EGFR therapy response in HNSCC patients.
- |||||||||| Gilotrif (afatinib) / Boehringer Ingelheim, allitinib (AST1306) / Allist
[VIRTUAL] RKIP protein as a diagnostic, prognostic and therapeutic marker in HPV-related cancers. () - May 30, 2021 - Abstract #EACR2021EACR_572;
These results give us new insights about through which players RKIP could be modulating cellular processes, such as apoptosis and signal transduction. Conclusion In conclusion, we demonstrated for the first time that besides its role as a prognostic marker, RKIP loss is associated with higher aggressiveness in vitro and in vivo , being a potential predictor to anti-EGFR therapy response in HNSCC patients.
- |||||||||| AST6 / Allist, allitinib (AST1306) / Allist
Journal: Induction of Phlorotannins and Gene Expression in the Brown Macroalga Fucus vesiculosus in Response to the Herbivore Littorina littorea. (Pubmed Central) - May 27, 2021
Soluble phlorotannin levels remained stable during the kinetics and increased significantly only after 12 h in the presence of grazers, compared to the control, before decreasing to the initial steady state for the rest of the kinetics. Under grazing conditions, the expression of vbpo, cyp450 and ast6 genes was upregulated, respectively, at 6 h, 12 h and 24 h, and cyp450 gene was downregulated after 72 h. Interestingly, the pksIII gene involved in the synthesis of phloroglucinol was overexpressed under grazing conditions after 24 h and 72 h. This study supports the hypothesis that phlorotannins are able to provide an inducible chemical defense under grazing activity, which is regulated at different stages of the stress response.
- |||||||||| AST6 / Allist, allitinib (AST1306) / Allist
Journal: A hidden human proteome encoded by 'non-coding' genes. (Pubmed Central) - Dec 19, 2019
As the new protein UBAP1-AST6 is localized in the nucleoli and is preferentially expressed by lung cancer cell lines, we biologically verified that it has a function associated with cell proliferation. In sum, we experimentally evidenced a hidden human functional proteome encoded by purported lncRNAs, suggesting a resource for annotating new human proteins.
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