diclofenac sodium topical / Generic mfg. 
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  • ||||||||||  Trial completion date, Trial initiation date, Trial primary completion date:  DITCH: Diclofenac Gel in the Treatment of Cervicogenic Headache (clinicaltrials.gov) -  Nov 29, 2022   
    P3,  N=50, Not yet recruiting, 
    These results highlight the potential of HP-β-CD-stabilized nanocrystals as a promising approach to enhance drug solubility, dissolution rate, and anti-inflammatory properties. Trial completion date: Jul 2024 --> Jan 2025 | Initiation date: Jul 2022 --> Jan 2023 | Trial primary completion date: Jul 2024 --> Jan 2025
  • ||||||||||  eflornithine topical / Generic mfg.
    Trial completion date, Trial primary completion date:  Topical Diclofenac and Topical DFMO Chemoprevention Trial in Subjects With a History of Skin Cancer (clinicaltrials.gov) -  Nov 15, 2022   
    P2,  N=138, Recruiting, 
    This trial is expected to develop capacity to scientifically evaluate various STM that are claimed to have efficacy in treatment of various disease conditions. Trial completion date: Mar 2023 --> Dec 2024 | Trial primary completion date: Jan 2023 --> Nov 2023
  • ||||||||||  diclofenac sodium topical / Generic mfg.
    Journal:  Formulation and Evaluation of Diclofenac Potassium Gel in Sports Injuries with and without Phonophoresis. (Pubmed Central) -  Oct 27, 2022   
    In addition, DK gel with phonophoresis was well tolerated. Thus, in this personalized clinical setting, according to the degree of inflammation or injured-induced pain, disability, and stiffness, DK gel 6% with phonophoresis appeared more effective and thus more recommendable than DS gel 6% alone or DS gel 6% combined to phonophoresis.
  • ||||||||||  diclofenac sodium topical / Generic mfg.
    Journal:  Direct photolysis of diclofenac under simulated sunlight: Transformation pathway and biological concerns. (Pubmed Central) -  Sep 29, 2022   
    Topical diclofenac gels are frequently applied on human skin and, consequently are exposed to sunlight during outdoor activities...Modest cytotoxicity to the human skin epidermis cell line was observed and attributed to the formation of intermediate species. This outcome highlighted the biological concerns of diclofenac to human health when exposed to sunlight.
  • ||||||||||  tirbanibulin oral (KX2-391 oral) / Hanmi, Athenex
    Cost-Effectiveness Analysis of Tirbanibulin for the Treatment of Actinic Keratosis from a Scottish NHS Perspective (In-person; Virtual) -  Sep 1, 2022 - Abstract #ISPOREU2022ISPOR_EU_1941;    
    A one-year decision tree model was developed to compare tirbanibulin with diclofenac sodium gel 3%, imiquimod cream 5%, and fluorouracil cream 5%. Tirbanibulin is cost-saving and cost-effective for the treatment of actinic keratosis in Scotland when compared with the most commonly used topical therapies.
  • ||||||||||  diclofenac sodium topical solution 2% / Generic mfg.
    Trial completion:  Evaluate the Ability of dOFM for BE Testing of Topically Applied Diclofenac Sodium Products in Healthy Subjects (clinicaltrials.gov) -  Aug 26, 2022   
    P=N/A,  N=22, Completed, 
    However, more studies are needed to further understand the effectiveness of combination therapy in clinical practice and to investigate the role of acitretin, methotrexate, vitamin D, thermomechanical fractional injury, and microdermabrasion in humans. Recruiting --> Completed
  • ||||||||||  fluorouracil topical / Generic mfg.
    Short sharp shock or slow burn: immunocompromised patient perspectives on treatment of actinic keratoses with 5-fluorouracil 5% cream monotherapy versus 5-fluorouracil/calcipotriol ointment combination therapy (Alsh 1 & 2) -  Jun 23, 2022 - Abstract #BAD2022BAD_226;    
    This included organ transplant recipients (n = 28); patients with chronic lymphocytic leukaemia (n = 3); and one patient with Crohn disease on azathioprine (n = 1)...All had previously used 5-FU and 31 of 32 (97%) had received at least one other intervention for AK (cryotherapy, n = 28; surgery, n = 18; 5-FU/salicylic acid cutaneous solution, n = 11; imiquimod, n = 6; ingenol mebutate, n = 3; diclofenac gel, n = 2; photodynamic therapy, n = 4)...The majority (81%) found that that combination 5-FU–Cal was more effective than 5-FU monotherapy and, despite 47% reporting worse LSRs, most would prefer to use the 5-FU–Cal combination in the future. These data provide a rationale for the inclusion of combination 5-FU–Cal therapy in future studies using topical AK treatments for cSCC prevention in immunosuppressed individuals.
  • ||||||||||  diclofenac sodium topical / Generic mfg.
    Rare Case Of Simultaneous Thoracic Outlet Syndrome And Musculocutaneous Neuropathy In A Baseball Pitcher (30E) -  Jun 2, 2022 - Abstract #ACSM2022ACSM_1828;    
    However, pain did not improve and MRI of the brachial plexus with Thoracic Outlet syndrome technique, which confirmed TOS with isolated musculocutaneous neuropathy. Electromyography testing showed right sided variable SNAP configuration with mildly prolonged latency and reduced amplitudes confirming brachial plexopathy (TOS) but also showed a superimposed musculocutaneous neuropathyFinal Diagnosis:Thoracic Outlet Syndrome with superimposed musculocutaneous neuropathyTreatment outcomes:-Initially conservative treatment with limited throwing regimen with changes in pitching biomechanics.
  • ||||||||||  paracetamol / Generic mfg., diclofenac sodium topical / Generic mfg., naproxen / Generic mfg.
    Hit The Road Jack (32AB) -  Jun 2, 2022 - Abstract #ACSM2022ACSM_150;    
    Diffuse full-thickness and near full-thickness cartilage loss throughout the patella and the trochlea. One-cm subchondral insufficiency fracture of the lateral femoral condyle.FINAL/WORKING DIAGNOSIS:Subchondral insufficiency fractureTREATMENT AND OUTCOMES:1.Patient was provided a standard cane to off-load right knee2.Acetaminophen and diclofenac gel were used for pain control3.Daily calcium and vitamin D supplementation 4.Patient completed formal Physical Therapy 5.Patient gradually resumed his walking regimen at 10% increase per week.
  • ||||||||||  venlafaxine / Generic mfg.
    Journal:  Venlafaxine HCl Encapsulated in Niosome: Green and Eco-friendly Formulation for the Management of Pain. (Pubmed Central) -  May 29, 2022   
    The topical administration of the venlasosme gel also considerably increased the tail-flick and hot-plate response time when compared to the VFX simple gel, control groups, and diclofenac gel (p < 0.05). These findings suggest that niosomes can improve VFX efficacy as an antinociceptive and anti-inflammatory substance by improving the medicaments delivery to the specified site.
  • ||||||||||  diclofenac sodium topical / Generic mfg.
    Journal:  Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer. (Pubmed Central) -  May 6, 2022   
    Nanoemulgel of diclofenac containing essential oil showed stronger antinociceptive effects in formalin and tail-flick tests than simple diclofenac gel and marketed formulation. In conclusion, the study proved that nanoemulgel formulation containing cumin essential oil could be considered as a promising skin enhancer to enhance the therapeutic effect of drugs.
  • ||||||||||  diclofenac sodium topical / Generic mfg.
    Preclinical, Journal:  Analytical Quality by Design (AQbD) Approach to the Development of In Vitro Release Test for Topical Hydrogel. (Pubmed Central) -  Apr 24, 2022   
    The aim of our study was to adapt the analytical quality by design (AQbD) approach to design an effective in vitro release test method using USP apparatus IV with a semi-solid adapter (SSA) for diclofenac sodium hydrogel...With the results, it was possible to determine the high-risk parameters of the in vitro drug release studies performed with the USP apparatus IV with SSA, which were the pH of the medium and the sample weight of the product. Focusing on these parameters, we developed a test protocol for our hydrogel system.
  • ||||||||||  diclofenac sodium topical / Generic mfg.
    Journal:  Investigating the anti-inflammatory and analgesic properties of leaves ethanolic extracts of Cedrus libani and Pinus brutia. (Pubmed Central) -  Apr 19, 2022   
    In Formalin test, both extracts could significantly reduce paw licking time, and in tail flick test, each plant extract gel showed greater efficacy than diclofenac gel by calculating the maximum possible effect (MPE %) for both extracts and Diclofenac. We concluded that both extracts showed in vitro anti-inflammatory activity at different concentrations when compared to standard drug of diclofenac as well as analgesic activity in formalin and tail flick tests.
  • ||||||||||  diclofenac sodium topical / Generic mfg.
    Clinical, PK/PD data, Review, Journal:  Physiologically-based pharmacokinetic modeling to support bioequivalence and approval of generic products: a case for diclofenac sodium topical gel,1. (Pubmed Central) -  Mar 23, 2022   
    Based on the fit-for-purpose modeling principle, the V&V process involved assessing observed data of diclofenac concentrations in skin tissues and plasma, and the overall performance of the modeling platform for relevant products. Using this case as an example, this report provides current scientific considerations on good practices for model V&V and the establishment of BE for dermatological drug products when leveraging PBPK modeling and simulation for regulatory decision-making.
  • ||||||||||  tirbanibulin oral (KX2-391 oral) / Hanmi, Athenex, Klisyri (tirbanibulin ointment) / Hanmi, Almirall, Athenex
    Journal:  1% Tirbanibulin Ointment for the Treatment of Actinic Keratoses. (Pubmed Central) -  Mar 11, 2022   
    Using this case as an example, this report provides current scientific considerations on good practices for model V&V and the establishment of BE for dermatological drug products when leveraging PBPK modeling and simulation for regulatory decision-making. With a favorable safety profile and short regimen, tirbanibulin is an efficacious treatment for clinicians to utilize in their treatment toolbox when treating AKs on the face and scalp.
  • ||||||||||  eflornithine topical / Generic mfg.
    Trial completion date:  Topical Diclofenac and Topical DFMO Chemoprevention Trial in Subjects With a History of Skin Cancer (clinicaltrials.gov) -  Dec 15, 2021   
    P2,  N=138, Recruiting, 
    Thus we show that Ocimum sanctum gel showed potent anti-oxidant and anti-inflammatory effect and less toxic to brine shrimp nauplii as a promising agent for the treatment of periodontal diseases. Trial completion date: Mar 2022 --> Mar 2023
  • ||||||||||  aspirin / Generic mfg., diclofenac sodium topical / Generic mfg.
    [VIRTUAL] Avascular Necrosis: A Case Report () -  Nov 1, 2021 - Abstract #AAPMR2021AAPMR_300;    
    He was prescribed Voltaren gel, a steroid pack, and was given a script for an X-ray...The specialist’s recommendation was to stay non-weight bearing on his hip for 6 weeks using a walker when necessary, avoid medications, except for his daily aspirin for anti-inflammatory effects, and omit alcoholic intake... Rigid conservative management for stage-III avascular necrosis may prevent the need for invasive surgical procedures.
  • ||||||||||  naproxen / Generic mfg.
    Journal:  Exploration of nanoethosomal transgel of naproxen sodium for the treatment of Arthritis. (Pubmed Central) -  Oct 31, 2021   
    Rigid conservative management for stage-III avascular necrosis may prevent the need for invasive surgical procedures. The ethosomal gel was successfully developed and has shown the potential to be a good option for the replacement of conventional therapies of rheumatoid arthritis.
  • ||||||||||  diclofenac sodium topical / Generic mfg.
    Trial completion:  BoGon: Fenugreek Wraps in Osteoarthritis of the Knee (clinicaltrials.gov) -  Oct 6, 2021   
    P=N/A,  N=81, Completed, 
    The ethosomal gel was successfully developed and has shown the potential to be a good option for the replacement of conventional therapies of rheumatoid arthritis. Active, not recruiting --> Completed
  • ||||||||||  fluorouracil topical / Generic mfg., ingenol mebutate / Generic mfg., diclofenac sodium topical / Generic mfg.
    Journal:  Photodynamic therapy activated by intense pulsed light in the treatment of actinic keratosis. (Pubmed Central) -  Sep 12, 2021   
    The above method is a valid alternative to methods already in use. The results obtained demonstrate the efficacy and tolerability of the treatment described which, due to its versatility and speed of use, is preferable to the methods used so far.