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- eletriptan / Generic mfg.
Advancing migraine therapy with novel mucoadhesive eletriptan formulations (MCP Hall A) - Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_12965;
Additionally, analytical methods for eletriptan estimation using UV-visible spectroscopy and HPLC with UV detection were developed and validated. Results demonstrated the potential of mucoadhesive formulations to enhance drug absorption and efficacy, offering a promising avenue for improving migraine therapy outcomes.
- Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
Variations in prescribing patterns for acute and preventive migraine medications in young adults: A retrospective, observational study () - Jun 18, 2024 - Abstract #AHS2024AHS_432;
Ten acute medications were evaluated with statistically significant differences in prescription rates demonstrated in eletriptan (8.0% vs. 3.5%, p = 0.001) and frovatriptan (4.7% vs. 1.3%, p = 0.001). We demonstrate statistically significant differences in prescription rates of common acute and preventive migraine medications when analyzing by age group.
- eletriptan / Generic mfg., duloxetine / Generic mfg., sumatriptan succinate / Generic mfg.
Changing migraine patterns in a transgender man assigned female at birth undergoing gender-affirming hormone therapy () - Jun 18, 2024 - Abstract #AHS2024AHS_201;
For other patient populations, such as for transgender men receiving gender-affirming care, there is a lack of data in this regard. In this patient, we establish that his migraines began concurrently with initiation of gender-affirming hormone therapy with intramuscular testosterone.
- | Retrospective data, Journal: Simultaneous Comparisons of 25 Acute Migraine Medications Based on 10 Million Users' Self-Reported Records From a Smartphone Application. (Pubmed Central) - Jan 3, 2024
Using a big data approach, we analyzed patient-generated real-time records of 10 million migraine attacks and conducted simultaneous head-to-head comparisons of 25 acute migraine medications. Our findings that triptans, ergots, and antiemetics are the most effective classes of medications align with the guideline recommendations and offer generalizable insights to complement clinical practice.
- || Ganaton (itopride) / Abbott
PK/PD data, Preclinical, Journal: Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study. (Pubmed Central) - Nov 25, 2023
The drug was found to rapidly permeate across the buccal mucosa, leading to increased bioavailability of the drug: C of 130 and 119 ng/mL of ITHC and EHBR, respectively, as compared to 96 (ITHC) and 90 ng/mL (EHBR) of oral solution. The conclusion can be drawn that possible reasons for the enhanced bioavailability could be the increased surface area in the form of buccal films, its rapid disintegration, and faster dissolution, which led toward the rapid absorption of the drug into the blood stream.
- Unravelling the role of the putative proton-coupled organic cation antiporter in triptan transport across the blood-brain barrier (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_7786;
J Headache Pain. 2010; 11(1):5-12.
- | ONZETRA Xsail (sumatriptan intranasal) / Otsuka, Tosymra (intranasal sumatriptan) / Sawai Pharma, Neurelis, ZEMBRACE SymTouch (sumatriptan succinate) / Sawai Pharma
Journal: Comparison table: Triptans. (Pubmed Central) - Jun 6, 2023
2010; 11(1):5-12. No abstract available
- | Journal: Drugs for migraine. (Pubmed Central) - Jun 6, 2023
No abstract available No abstract available
- | eletriptan / Generic mfg.
Journal: Three-Dimensional Oral Mucosal Equivalents as Models for Transmucosal Drug Permeation Studies. (Pubmed Central) - May 27, 2023
No abstract available Using eletriptan hydrobromide as a model drug, we found that the full-thickness OME had similar drug flux to EpiOral
- || Review, Journal: The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review. (Pubmed Central) - May 20, 2023
We found that rizatriptan (good tolerability profile with a dose of 5 mg) and sumatriptan (oral administration) had higher efficiency as compared to other triptans. Regardless of type or dose, all triptans are generally well tolerated by patients, but a few adverse effects such as light-headedness (sumatriptan), nasopharyngitis, and, muscular spasms (sumatriptan/ naproxen), somnolence, and dry mouth (rizatriptan), and dizziness (zolmitriptan group) were reported with the triptans.
- Simultaneous Comparisons of 25 Acute Migraine Medications: A Big Data Analysis of 10 Million Patient Self-Reported Treatment Records From A Migraine Smartphone Application (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3806;
Individual medications with the highest ORs were eletriptan(OR 6.1), zolmitriptan(OR 5.7), and sumatriptan(OR 5.2)...Conclusions We analyzed patient-generated real-time records of 10 million migraine attacks and conducted simultaneous head-to-head comparisons of 25 acute migraine medications. Our findings that triptans, ergots and anti-emetics are the most effective classes of medications align with the guideline recommendations and offer generalizable insights to complement clinical practice.
- | Farydak (panobinostat) / Secura Bio, givinostat (ITF2357) / Italfarmaco
Preclinical, Journal, Epigenetic controller: Histone Deacetylase Inhibitors Counteract CGRP Signaling and Pronociceptive Sensitization in a Rat Model of Medication Overuse Headache. (Pubmed Central) - Nov 9, 2022
The drugs, however, increased luciferase expression driven by CGRP promoter in cultured cells. Our findings provide evidence for a key role of HDACs and epigenetics in MOH pathogenesis, highlighting the therapeutic potential of HDAC inhibition in the prevention of migraine chronification.
- | eletriptan / Generic mfg.
Journal: Oral transmucosal delivery of Eletriptan for neurological diseases. (Pubmed Central) - Oct 21, 2022
Moreover, we show that the chemical permeation enhancer DMSO can be used to enhance the drug permeation significantly (i.e., 12 to 36-fold increase). Taken together, this study presents important findings on transmucosal delivery of eletriptan via the oral cavity and paves the way for clinical investigations for a fast and safe migraine treatment.
- | eletriptan / Generic mfg.
Preclinical, Journal: The Development of Eletriptan Hydrobromide Immediate Release Buccal Films Using Central Composite Rotatable Design: An In Vivo and In Vitro Approach. (Pubmed Central) - Oct 15, 2022
In-vivo results depict a mean half-life (t½) of 4.54 ± 0.18 h and a C of 128 ± 0.87 (ng/mL); T was achieved in 1 h. Furthermore, instability and histopathological studies buccal films were proven to be safe and act as an effective dosage form. In a nutshell, optimized and safe instant release EHBR buccal films were prepared that have the tendency to provide effect effectively.
- || rizatriptan / Generic mfg., eletriptan / Generic mfg., zolmitriptan / Generic mfg.
A ver, tengo la mitad de crisis. Pero es que yo tenía unas 24 crisis al mes. Y ahora unas 12-14 depende del mes. Pero ni el maxalt, ni el relpax, ni zomig, me quitan el dolor de las crisis. Me rebajan el dolor, pero no me lo quitan. (Twitter) - Sep 5, 2022
- | Onglyza (saxagliptin) / AstraZeneca
Journal: Microbial Proline Racemase-Proline Dehydrogenase Cascade for Efficient Production of D-proline and N-boc-5-hydroxy-L-proline from L-proline. (Pubmed Central) - Sep 2, 2022
N-boc-5-hydroxy-L-proline was also synthesized from L-glutamate semialdehyde, a dehydrogenated product of L-proline, in a 16.7% yield. The developed proline racemase-proline dehydrogenase cascade exhibits great potential and economic competitiveness for manufacturing D-proline and N-boc-5-hydroxy-L-proline from L-proline.
- | eletriptan / Generic mfg.
Journal: Chitosan/guar gum-based thermoreversible hydrogels loaded with pullulan nanoparticles for enhanced nose-to-brain drug delivery. (Pubmed Central) - Aug 5, 2022
In this study, poloxamers PF-127/PF-68 grafted chitosan HCl-co-guar gum-based thermoresponsive hydrogel loaded with eletriptan hydrobromide laden pullulan nanoparticles was synthesized and subjected to dynamic light scattering, Fourier transform infrared spectroscopy, thermal analysis, x-ray diffraction, scanning electron microscopy, stability studies, mucoadhesive strength and time, gel strength, cloud point assessment, rheological assessment, ex-vivo permeation, cell viability assay, histology studies, and in-vivo Pharmacokinetics studies, etc. It is quite evident that CSG-EH-NPs T-Hgel has an enhanced sustained release drug profile where approximately 86 % and 84 % of drug released in phosphate buffer saline and simulated nasal fluid respectively throughout 48 h compared to EH-NPs where 99.44 % and 97.53 % of the drug was released in PBS and SNF for 8 h. In-vivo PKa parameters i.e., mean residence time (MRT) of 11.9 ± 0.83 compared to EH-NPs MRT of 10.2 ± 0.92 and area under the curve (AUC) of 42,540.5 ± 5314.14 comparing to AUC of EH-NPs 38,026 ± 6343.1 also establish the superiority of CSG-EH-NPs T-Hgel.
- | Journal: Information on migraine drugs in commonly available Indian drug information sources - Whether we satisfied the community needs? (Pubmed Central) - Jul 19, 2022
The information for the antimigraine drugs available from various sources found to so much deficient. Necessary steps need to be taken in case of government public or hard documents to streamline drug information available with them as well the commercial documents as to provide reliable drug information uniformly for promoting rational use of the drug.
- | eletriptan / Generic mfg.
Journal: Assessment of Nasal-Brain-Targeting Efficiency of New Developed Mucoadhesive Emulsomes Encapsulating an Anti-Migraine Drug for Effective Treatment of One of the Major Psychiatric Disorders Symptoms. (Pubmed Central) - Feb 27, 2022
Eletriptan Hydrobromide (EH) is a well-tolerated drug in migraine treatment, but suffers from low oral bioavailability and low brain targeting after oral delivery...Histopathology study showed no ciliotoxic effect on the nasal mucosa. From the results, it can be confirmed that the emulsomes formulation of EH proved safe direct nose-to-brain transport of EH after nasal administration of EH emulsomes.
- | dextromethorphan / Generic mfg.
Journal: Bromine K-Edge X-Ray Absorption Near-Edge Structure Analysis on Hydrobromide-Salt Crystals and the Solid Dispersion of Active Pharmaceutical Ingredients. (Pubmed Central) - Feb 19, 2022
Ratio of the eletriptan hydrobromide α-form crystal in mixed powders of α-form and monohydrate crystals could be quantified by the linear-combination fitting using their XANES spectra. These results indicated that the XANES spectroscopy are a potent method for evaluating the APIs of pharmaceutical formulations even at the higher energy region around the bromine K-edge of 13470 eV.
- eletriptan / Generic mfg., aspirin / Generic mfg., nitroglycerin / Generic mfg.
MORE THAN A HEADACHE: A CASE OF SPONTANEOUS CORONARY ARTERY DISSECTION IN A PATIENT WITH A HISTORY OF MIGRAINES ON TRIPTAN THERAPY (eAbstract site) - Jan 28, 2022 - Abstract #ACC2022ACC_1238;
In this case, a patient with a history of migraines on eletriptan developed NSTEMI in the setting of SCAD. The case highlights that SCAD should be strongly considered among potential diagnoses in patients with migraines on triptan therapy presenting with acute coronary syndrome, particularly those with no prior cardiovascular history.
- || sumatriptan succinate / Generic mfg.
Clinical, Journal: Twenty-five years of triptans - a nationwide population study. (Pubmed Central) - Dec 16, 2021
In a cohort with access to free clinical consultations and low medication costs, we observed low rates of triptan adherence, likely due to disappointing efficacy and/or unpleasant side effects rather than economic considerations. Triptan success continues to be hindered by poor implementation of clinical guidelines and high rates of treatment discontinuance.
- | sumatriptan succinate / Generic mfg.
Journal: Transfer of triptans into human breast milk and estimation of infant drug exposure through breastfeeding. (Pubmed Central) - Nov 21, 2021
Infant drug exposure through breastfeeding appears to be low and indicates that use of the triptans in this study is compatible with breastfeeding. Naratriptan may not be first choice in breastfeeding mothers initiating triptans during the neonatal period.
- | eletriptan / Generic mfg.
Journal: Development and validation of spectrophotometric methods for estimation of antimigraine drug eletriptan hydrobromide in pure form and pharmaceutical formulations. (Pubmed Central) - Oct 27, 2021
Statistical comparison of the results was performed using Student's t-test and variance ratio F-test at the 95% confidence level and there was no significant difference between the reported and proposed methods regarding accuracy and precision. Further, the validity of the proposed methods was confirmed by recovery studies via standard addition method.
- Reyvow (lasmiditan) / Eli Lilly, Nurtec ODT (rimegepant ODT) / Portage
[VIRTUAL] LasmiGepant: A case report of simultaneous administration of lasmiditan and rimegepant () - Jun 4, 2021 - Abstract #AHS2021AHS_366;
New treatments target specific migraine pathways with potentially less impact on unrelated neural activity or organ systems. As a result, no single, currently available treatment addresses the breadth of the pathophysiological cascade of migraine, nor demonstrates consistent efficacy across all patients.
- sumatriptan succinate / Generic mfg.
[VIRTUAL] Pharmacokinetic and pharmacodynamic variability of triptans. A review and some clinical implications () - Jun 4, 2021 - Abstract #AHS2021AHS_318;
In addition to the pharmacokinetic variability, probably mainly due to genetic differences in metabolizing enzymes, potential explanations for the total variability of triptans could be genetic variations in transporters mediating blood-cell transport, and brain drug disposition where uptake and efflux transporters possibly play a role. Finally, variations in target function, pharmacodynamics, most likely play a large role.
- duloxetine / Generic mfg.
[VIRTUAL] COVID-19 related headache exquisite response to therapy () - Jun 4, 2021 - Abstract #AHS2021AHS_184;
For patients with chronic migraine with superimposed head pain with mixed features related to COVID-19, Parafon Forte burst (500 mg TID x 5 days) may be a feasible and effective treatment modality since options as NSAIDS, triptans or steroids may be contradicted or ineffective. As the pandemic further evolves, headache being both a presenting symptom of COVID-19 and residual manifestation, further research into more effective and safe treatment for these patients will be necessary.
- [VIRTUAL] Simultaneous comparisons of 22 acute migraine medications: A big data analysis of 10 million patient self-reported treatment records from a migraine smartphone application () - May 16, 2021 - Abstract #AHS2021AHS_128;
The finding that triptans, compared to barbiturate, acetaminophen, NSAID, and opioids, are the most efficacious medications is generally consistent with treatment guidelines that are based on results from randomized controlled trials and clinical experience. By leveraging real-world patient reported outcome, this platform offers dynamic, generalizable real-time insights to complement clinical practice as treatment options are continuously updated.
- ||| eletriptan / Generic mfg., topiramate / Generic mfg.
I use Codeine for painful headaches not migraine. Take daily Topamax to prevent migraine, if one breaks thru, then I use Relpax. We all have different meds to deal with it. I've tried many. (Twitter) - May 13, 2021
- sumatriptan oral spray (SUD-001) / Suda, Strides Pharma Science
[VIRTUAL] Estimated migraine acute-therapy savings, from MMD reduction achieved with preventive treatment () - Mar 18, 2021 - Abstract #AAN2021AAN_1144;
Non-oral and/or branded triptans accounted for ~5% (Medicaid: 3.1% subcutaneous SS and 1.5% nasal sumatriptan; Medicare: 2.0% branded oral eletriptan and 1.6% nasal sumatriptan)... In migraineurs with high MMDs, reduced use of non-oral/branded triptans resulting from preventive treatment may yield large savings.
- ||| eletriptan / Generic mfg., paracetamol / Generic mfg., ibuprofen / Generic mfg.
Can SOMEONE please tell me if we should avoid advil and tylenol after a vax? I may have screwed up when I took 5 tylenol over the course of the weekend. I haven't heard a single guideline about this & reports differ. Thanks! Also, what about Relpax for migraine? (Twitter) - Mar 8, 2021
- | eletriptan / Generic mfg.
Journal: Assessment of the genotoxic potential of a migraine-specific drug by comet and cytokinesis-block micronucleus assays. (Pubmed Central) - Jan 23, 2021
While the comet parameters % DNA in tail, tail moment, and the olive moment was found to be significantly increased at 10 and 25 µg/ml, the cytokinesis-block proliferation index values were not. These findings suggest that eletriptan is non-cytotoxic but potentially weakly genotoxic at higher concentrations (10 and 25 µg/ml).
- | Botox (onabotulinumtoxin A) / GSK, AbbVie
Journal: Drugs for Migraine. (Pubmed Central) - Jan 23, 2021
These findings suggest that eletriptan is non-cytotoxic but potentially weakly genotoxic at higher concentrations (10 and 25 µg/ml). No abstract available
- ||| Aimovig (erenumab) / Amgen, Novartis
Hello there, we never found out if his rise in liver enzymes were connected to Aimovig but he stopped taking it after the second dose and months later his numbers came down. He now takes eletriptan and Topamax. He's doing okay, still has headaches. Eletriptan works most of time. (Twitter) - Dec 16, 2020
- | eletriptan / Generic mfg.
Preclinical, Journal: Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions. (Pubmed Central) - Dec 16, 2020
The ability of the excitation/inhibition modulator N-acetyl cysteine (NAC) and the 5-HT receptor agonist eletriptan to normalise the behavioural deficits observed was tested...The data suggest that 16p11.2 DEL mice show an autism-relevant phenotype that becomes overt after an acute stressor, emphasising the importance of gene-environmental interactions in phenotypic analysis. Further, they add to an emerging view that NAC, or 5-HT receptor agonist treatment, may be a promising strategy for further investigation as a future treatment.
- | Review, Journal: Why is the therapeutic effect of acute antimigraine drugs delayed? A review of controlled trials and hypotheses about the delay of effect. (Pubmed Central) - Sep 30, 2020
An increase in effect from 2 to 4 hours was observed after eletriptan 40 mg, frovatriptan 2.5 mg and lasmiditan 200 mg, and after rizatriptan 10 mg (T = 1 h) from 1 to 2 hours...In addition, E for triptans probably depends partly on the rise in plasma levels and not only on its maximum. The most likely explanation for the delay in effect is that a complex "antimigraine system" with more than one site of action is involved.
- | Ubrelvy (ubrogepant) / AbbVie, Reyvow (lasmiditan) / Eli Lilly
Journal: Lasmiditan (Reyvow) and ubrogepant (Ubrelvy) for acute treatment of migraine. (Pubmed Central) - Sep 16, 2020
The most likely explanation for the delay in effect is that a complex "antimigraine system" with more than one site of action is involved. No abstract available
- || eletriptan / Generic mfg.
Por cierto, si alguien igual que yo estaba buscando Relpax, les aviso que @PfizerMx ya no lo está produciendo. La buena es que ya venció su patente y el laboratorio Zydus lo está vendiendo mucho mas barato. (Twitter) - Aug 13, 2020
- | eletriptan / Generic mfg.
Que @PfizerMx me diga si hay desabasto de Relpax o solo he tenido muy mala suerte en las farmacias de mis rumbos. (Twitter) - Aug 4, 2020
- | eletriptan / Generic mfg.
@PfizerMx Buen día. Que pasa con el Relpax? No hay en ningún lado, ni de 40 ni de 80, como lo conseguimos? Gracias (Twitter) - Jul 29, 2020
- ||| eletriptan / Generic mfg.
RELPAX by @pfizer will get rid of your #MIGRAINE in 30 minutes. (Twitter) - Jul 15, 2020
- [VIRTUAL] Treating Red Ear Syndrome with Oxygen () - Jul 15, 2020 - Abstract #AHS2020AHS_282;
We hypothesize that oxygen treated the underlying trigeminal autonomic cephalalgia thus effectively treating the associated red ear syndrome. More research is necessary to confirm our findings.
- [VIRTUAL] Establishing a National Real-world Data Pediatric Migraine Registry: Proof of Principle () - Jul 15, 2020 - Abstract #AHS2020AHS_149;
A pediatric migraine registry that collects real-world data is feasible to create and maintain. In addition to collecting data in a regulatory compliant manner, the registry creates a ready for use infrastructure for the conduct of future clinical trials in children and adolescents with migraine.
- || eletriptan / Generic mfg.
Larga vida al eletriptan @pfizer ✔️ (Twitter) - Jul 13, 2020
- | eletriptan / Generic mfg.
@PfizerMx hay desabasto de Relpax, donde en la CDMX podemos conseguir. Lo necesitamos urgente para migrañas recurrentes. (Twitter) - Jun 27, 2020
- eletriptan / Generic mfg., ibuprofen / Generic mfg.
[VIRTUAL] Eletriptan (RelpaxaTm) Causing False Positive Elevations in Urinary Metanephrine () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_293;
Eletriptan, a second generation triptan drug, is a selective 5-hydroxytryptamine 1B/1D receptor agonist and has been shown to reduce carotid arterial blood flow, with only a small increase in arterial blood pressure at high doses. However, Eletriptan has no significant affinity or pharmacological activity at adrenergic α1, α2, or β; dopaminergic D1 or D2; muscarinic; or opioid receptors.
- Incidence of Abortive Migraine Medication Fills after Initiation of a Calcitonin Gene-Related Peptide (CGRP) Inhibitor for Migraine Prophylaxis () - May 6, 2020 - Abstract #AMCP2020AMCP_181;
Additional claims data are needed to determine statistical significance in number of claims for abortive migraine medications before and after CGRP inhibitor initiation. Sponsorship: Highmark, Inc
- Analgin (metamizole) / Sedico, eletriptan / Generic mfg., zolmitriptan / Generic mfg.
[VIRTUAL] Dialysis headache: 4 cases of a tertiary headache centre (Room: Screen B4) - Apr 9, 2020 - Abstract #EAN2020EAN_1945;
There is not a specific pattern for DH, besides its temporal profile and its relation to HD. Response to triptans in one suggests a migraine-type pathophysiology.
- Ubrelvy (ubrogepant) / Allergan, Reyvow (lasmiditan) / Eli Lilly, rimegepant (BHV-3000) / Portage
[VIRTUAL] LONG-TERM COST-EFFECTIVENESS OF LASMIDITAN, UBROGEPANT AND RIMEGEPANT FOR TREATMENT OF ACUTE MIGRAINE () - Mar 8, 2020 - Abstract #ISPOR2020ISPOR_341;
Lasmiditan, rimegepant, and ubrogepant may provide an important therapeutic alternative to current treatments for acute migraine in patients who cannot tolerate or have contraindications to triptans. Pricing of these drugs will determine whether they are cost effective at commonly accepted thresholds.