zonisamide / Generic mfg. 
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 80 Diseases   11 Trials   11 Trials   865 News 


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  • ||||||||||  zonisamide oral suspension (ET-104) / Eton Pharma, Azurity Pharma
    Trial completion date, Trial initiation date, Trial primary completion date:  Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures (clinicaltrials.gov) -  Dec 12, 2024   
    P4,  N=40, Not yet recruiting, 
    Given the limitations from passive surveillance nature of FAERS, further surveillance and longitudinal studies are essential to evaluate and confirm our findings. Trial completion date: Jun 2025 --> Mar 2026 | Initiation date: Sep 2024 --> Feb 2025 | Trial primary completion date: Jun 2025 --> Mar 2026
  • ||||||||||  zonisamide / Generic mfg.
    Journal:  Iridium-catalyzed reductive sulfonamidation of alkoxy aryl alkynes. (Pubmed Central) -  Dec 3, 2024   
    This process was performed under mild conditions, resulting in the transformation of a variety of substituted benzene, heteroaromatic, and aliphatic sulfonamides. Particularly, the structural diversification of valdecoxib and zonisamide showcased the utility of this protocol.
  • ||||||||||  Understanding the Natural History of cyfip2-related Epilepsy (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2561;    
    Patients with CYFIP2-related DEE have developmental delay, epilepsy with multiple seizure types, and a hyperkinetic movement disorder. Ours is the only reported case of substantial improvement with timely treatment following initial seizure onset and prior to epileptic spasms.
  • ||||||||||  Fycompa (perampanel) / Eisai, Catalyst Pharma, lamotrigine liquid oral suspension / OWP Pharma
    The Use of Ketogenic Diet During Pregnancy to Treat NORSE (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2532;    
    KD therapy is one of a paucity of potentially effective treatments for NORSE, but in the setting of pregnancy therapeutic ketosis may not be achievable due to minimum protein requirements. Because other NORSE treatments also have teratogenic potential, a multidisciplinary discussion of the risks and benefits of all treatments, including possible short term protein restriction to maximize KD therapy, should be initiated early with family.
  • ||||||||||  Seizures in the Leukodystrophies Analyzed by Diagnosis and Pathogenetic Mechanism (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2443;    
    Patients with an astrocytopathy were more affected by seizures overall, and more often went on to develop focal epilepsy than patients with a myelinopathy. Lacosamide, levetiracetam, and zonisamide demonstrated the highest overall response rates.
  • ||||||||||  zonisamide / Generic mfg., clobazam / Generic mfg.
    Phenotypical Variants of ATP1A3 Within a Family (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_2353;    
    This emphasizes the complexity and heterogeneity of ATP1A3-related disorders, highlighting the need to understand the underlying mechanisms further. We also present a novel association of epilepsy with the phenotypic expressions of the c.1838C >T (p.Thr613Met) variant, which can aid in future diagnosis of childhood epilepsy.
  • ||||||||||  Fycompa (perampanel) / Eisai, Catalyst Pharma, Xcopri (cenobamate) / SK Bio
    Leveraging EPIC Workbench Reporting to Create an Epilepsy Clinic Dashboard (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1777;    
    Our results reveal that between 2013 and 2023, (i) the population of patients that we serve has almost doubled in size, (ii) their seizure severity has increased and (iii) rates of valproate and topiramate use have remained constant in female patients of reproductive age. We design a "clinic dashboard" prototype that can seamlessly sort and identify patients by polytherapy burden and visit compliance.
  • ||||||||||  Xcopri (cenobamate) / SK Bio
    Is It Forced Normalization or Toxicity Caused by Cenobamate? (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1758;    
    To our knowledge, this is the first case reported of such a condition with this ASM. However, we cannot totally exclude the possibility that the psychiatric phenomena were the expression of iatrogenic psychiatric symptoms caused by this ASM.
  • ||||||||||  Effect of Ketogenic Diet Initiation Free Patients with Super Refractory Status Epilepticus Case Series (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1620;    
    Total VPA concentrations decreased while free VPA concentrations increased after KD initiation, potentially increasing the risk of AEs. Critical illness, hypoalbuminemia, uremia, and elevated free fatty acids (FFAs) can increase VPA FF, and this series suggests KD initiation also increases VPA FF and that free VPA concentrations should be monitored in patients initiated on KD.
  • ||||||||||  A Novel Deletion in NEXMIF Is Associated with Continuous Spike-wave During Slow-wave Sleep (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_1454;    
    Patients with NEXMIF-related epilepsy must be evaluated for underlying CSWS, particularly in cases of medically refractory seizures, status epilepticus, or cognitive deterioration. Long-term EEG monitoring should be considered since routine EEG can be of low yield to detect CSWS.
  • ||||||||||  zonisamide / Generic mfg., phenobarbital / Generic mfg., topiramate / Generic mfg.
    Autonomic Nervous System Changes in Pediatric Patients with Epilepsy on Antiseizure Medications: A Literature Review (South Hall H - Level 1 - LACC) -  Nov 26, 2024 - Abstract #AES2024AES_958;    
    However, many of the included studies focused on general ANS changes with less attention to specific findings in the setting of ASMs. Better knowledge of how ASMs impact the ANS is needed to understand medication effectiveness and side effects and to investigate ASMs as a confounder in seizure prediction.1.
  • ||||||||||  zonisamide / Generic mfg.
    Journal:  Results from a randomized controlled trial of zonisamide in the treatment of alcohol use disorder. (Pubmed Central) -  Sep 22, 2024   
    One serious adverse event was reported among individuals receiving ZON. Study findings indicate that ZON combined with TC does not demonstrate superior effectiveness for reducing average daily drinks in this clinical sample with principal AUD compared to placebo and TC, and treatment with ZON may be associated with reduced neurocognitive performance over time.
  • ||||||||||  Review, Journal:  Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers. (Pubmed Central) -  Sep 8, 2024   
    We conclude that there is strong variance in the pharmacological effects of these drugs, and in the available information. At present, GS967 and riluzole can be regarded bona fide INaP blockers, while phenytoin and lacosamide are blockers that only act on the slowly inactivating component of sodium currents.
  • ||||||||||  zonisamide / Generic mfg., carbamazepine / Generic mfg.
    Trial completion, Monotherapy:  Efficacy & Safety of Zonisamide in newly diagnosed partial epilepsy patients. (EUDRACT) -  Sep 6, 2024   
    P3,  N=582, Completed, 
    At present, GS967 and riluzole can be regarded bona fide INaP blockers, while phenytoin and lacosamide are blockers that only act on the slowly inactivating component of sodium currents. Not yet recruiting --> Completed
  • ||||||||||  pentylenetetrazole (BTD-001) / Balance Therap
    Bioinformatics guided rotenone adjuvant kindling in mice as a new animal model of drug resistant epilepsy. (MCP Hall A) -  Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_197;    
    In conclusion, rotenone kindling model is more advantageous than earlier described lamotrigine and corneal kindling models which respond to drug combinations. As a result, pre-clinical drug screening through rotenone kindling may uncover broad spectrum drugs with novel antiseizure mechanisms which is a pressing issue to deal with drug-resistant epilepsy.
  • ||||||||||  Clinical, Journal:  Comparison Table: Some oral antiseizure medications. (Pubmed Central) -  Jul 29, 2024   
    Combination therapy with small dose of levodopa and small dose of zonisamide will be recommended for the treatment in such cases. No abstract available
  • ||||||||||  Review, Journal:  Drugs for epilepsy. (Pubmed Central) -  Jul 29, 2024   
    No abstract available No abstract available
  • ||||||||||  zonisamide / Generic mfg., pregabalin / Generic mfg., pramipexole IR / Generic mfg.
    Parkinson's disease and Myasthenia Gravis: a case report and literature review (Poster Hall (Exhibit Hall A)) -  Jul 8, 2024 - Abstract #MDSCongress2024MDS_Congress_192;    
    Co-occurrence is rare, with limited cases reported since 1987(3). Most cases involve males aged 55-95, with PD preceding MG by 8 months to 20 years.
  • ||||||||||  zonisamide / Generic mfg.
    Trial completion date, Trial primary completion date:  The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study (clinicaltrials.gov) -  Jun 24, 2024   
    P2,  N=205, Recruiting, 
    Most cases involve males aged 55-95, with PD preceding MG by 8 months to 20 years. Trial completion date: Aug 2025 --> Aug 2026 | Trial primary completion date: Aug 2025 --> Aug 2026
  • ||||||||||  Ubrelvy (ubrogepant) / AbbVie, Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    The use of Lifestyle Redesign () -  Jun 18, 2024 - Abstract #AHS2024AHS_429;    
    She was also prescribed Ubrelvy in 2021, but she did not find it as effective as sumatriptan...She started Botox in 2022 and PT in 2023 and considers it to be helpful. She had also started Zonisamide 100 mg in 2023 which improved migraine severity (6
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda, Dopergin (lisuride) / Bayer
    Journal:  DReAmocracy: A Method to Capitalise on Prior Drug Discovery Efforts to Highlight Candidate Drugs for Repurposing. (Pubmed Central) -  May 25, 2024   
    Top-scored drugs for Alzheimer's Disease include agomelatine, mirtazapine and vortioxetine; for Parkinson's Disease, they include apomorphine, pramipexole and lisuride; for Huntington's, they include chlorpromazine, fluphenazine and perphenazine; and for Multiple Sclerosis, they include zonisamide, disopyramide and priralfimide. Overall, DReAmocracy is a methodology that focuses on leveraging the existing drug-related experimental and/or computational knowledge rather than a predictive model for drug repurposing, offering a quantified aggregation of existing drug discovery results to (1) reveal trends in selected tracks of drug discovery research with increased resolution that includes modes of action, targeted pathways and initial indications for the investigated drugs and (2) score new candidate drugs for repurposing against a selected disease.
  • ||||||||||  Savaysa (edoxaban) / Daiichi Sankyo
    Review, Journal:  Interactions between antiepileptic drugs and direct oral anticoagulants for primary and secondary stroke prevention. (Pubmed Central) -  May 7, 2024   
    No increased risk for stroke was reported only for topiramate, zonisamide, pregabalin and gabapentin, whereas for the remaining 12 AED conflicting results regarding the risk for stroke and bleeding were found...Knowledge about pharmacokinetic and pharmacodynamic DDI of AED and DOAC is limited and frequently restricted to in vitro and in vivo findings. Since no data about DDI with DOAC are available for 67% of AED and an increasing number of patients have a combined medication of DOAC and AED, there is an urgent need for research on this topic.