- |||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Major Congenital Malformations Associated With Exposure to Antiepileptic Drugs During Pregnancy. (Pubmed Central) - Oct 2, 2019
In the AEDs associated with elevated risks, the extent to which the risks are due to confounding by indication is unknown. Importantly, confounding by indication notwithstanding, at conventional doses lamotrigine, levetiracetam, and oxcarbazepine, and possibly zonisamide and gabapentin, as well, are associated with absolute MCM risks that are no greater than the 2%-3% MCM risk in the general population.
- |||||||||| Fycompa (perampanel) / Eisai
Journal: Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model. (Pubmed Central) - Sep 28, 2019
The gene expression levels of Brain-Derived Neurotrophic Factor (BDNF), Neuropeptide Y (NPY) and Cyclic Adenosine Monophosphate (CAMP) Responsive Element Binding Protein 1 (CREB-1) were not found to be significantly different in AED treated zebrafish. Based on the experimental results, a decrease in brain glutamate levels due to AED treatment appears to be at least one of the major factors behind the observed cognitive impairment in the treated zebrafish.
- |||||||||| zonisamide / generics
ACUTE RESPIRATORY FAILURE AS AN INITIAL SIGN OF ZONISAMIDE-INDUCED STEVENS-JOHNSON SYNDROME (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) - Sep 25, 2019 - Abstract #CHEST2019CHEST_2800;
Early supportive care of the respiratory system, from oxygen supplementation to mechanical ventilation, is a crucial part of the multidisciplinary treatment of SJS/TEN. Nasotracheal tube can establish effective airway in SJS/TEN patients.
- |||||||||| zonisamide / generics
A novel heterozygous ANO3 mutation responsible for myoclonus-dystonia (Les Muses Terrace, Level 3) - Sep 24, 2019 - Abstract #MDSCongress2019MDS_1997;
Then, the clinical presentation slowly worsens and leads to a generalized dystonia combined with tremor and/or myoclonus. Interestingly there is, within this family a significant phenotypic variability. Furthermore, GPi deep brain stimulation was be partially effective in one patient of this series.
- |||||||||| Tafinlar (dabrafenib) / Novartis
Journal: Parkinson's Disease: amantadine, zonisamide, dabrafenib (Pubmed Central) - Sep 22, 2019
Amantadine and zonisamide are drugs that have been serendipitously developed in clinical settings for patients with PD. Meanwhile, the potential for repurposing dabrafenib was discovered by utilizing the results of genome-wide association studies, drug databases, and protein-protein interaction databases.
- |||||||||| warfarin / Generic Mfg., Aptiom (eslicarbazepine) / Sumitomo Dainippon, Eisai
Review, Journal: Cannabis for the Treatment of Epilepsy: an Update. (Pubmed Central) - Sep 20, 2019
Understanding of CBD's efficacy and safety in the treatment of TRE has expanded significantly in the last few years. Future controlled studies of various ratios of CBD and THC are needed as there could be further therapeutic potential of these compounds for patients with epilepsy.
- |||||||||| zonisamide / generics
Journal: Recurrent seizures in cats: Treatment - which antiepileptic drugs are recommended? (Pubmed Central) - Sep 14, 2019
Evidence base: Recommendations for diagnosis and management of feline seizure disorders have historically been extrapolated from the canine and human literature. The information and guidance provided in this two-part series is based on a review of the recent published literature addressing seizure disorders and antiepileptic treatment in cats, as well as the authors' clinical experience.
- |||||||||| zonisamide / generics
Clinical, Journal: Efficacy of zonisamide on interictal electroencephalography in familial spontaneous epileptic cats. (Pubmed Central) - Sep 11, 2019
Conclusions and relevance This study showed that ZNS, within the recommended therapeutic range suggested for use in humans and dogs (10-40 µg/ml), reduced the number of PDs recorded on EEG in FSECs that are considered a model for cats with idiopathic epilepsy. Although phenobarbital is the antiepileptic drug of choice for epileptic cats, the results of this research provide evidence to support the use of ZNS in cats with phenobarbital-resistant epilepsy or for cats that cannot use phenobarbital due to adverse side effects.
- |||||||||| zonisamide / generics
PK/PD data, Journal: Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction. (Pubmed Central) - Aug 30, 2019
These recommendations allow the treating physician to determine which intervention to recommend to an individual patient. To our knowledge, this is the only research study to date that has attempted to link basal metabolomic status with pharmacokinetic parameters of zonisamide.
- |||||||||| ondansetron / generics, fluoxetine / generics, dronabinol oral / generics
Efficacy of pharmacotherapy for OSA in adults: a systematic review and network meta-analysis (TP-13) - Aug 26, 2019 - Abstract #ERS2019ERS_4395;
There is currently insufficient evidence to recommend any pharmacotherapy for OSA and no phase-III trials are available. Future studies are advised to account for the underlying mechanisms of the intervention, as current evidence suggests that pharmacotherapy may not be a stand-alone therapy in OSA.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. (Pubmed Central) - Aug 17, 2019
No high-quality studies suggest clobazam, eslicarbazepine, ezogabine, felbamate, GBP, lacosamide, LEV, LTG, oxcarbazepine, perampanel, pregabalin, rufinamide, tiagabine, topiramate, vigabatrin, or ZNS is effective in treating new-onset epilepsy because no high-quality studies exist in adults of various ages. A recent Food and Drug Administration (FDA) strategy allows extrapolation of efficacy across populations; therefore, for focal epilepsy, eslicarbazepine and lacosamide (oral only for pediatric use) as add-on or monotherapy in persons ≥4 years old and perampanel as monotherapy received FDA approval.
- |||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Use of antiepileptic drugs during breastfeeding : What do we tell the mother? (Pubmed Central) - Aug 15, 2019
Since data on the use of mesuximide, clobazam, rufinamide, felbamate, lacosamide, sultiame, perampanel and retigabine are insufficient to adequately assess the risk for breastfed infants, use in breastfeeding women is in principle not recommended and should be carefully evaluated on a case by case basis. In practice, a risk-benefit analysis should be performed for each mother under antiepileptic treatment wishing to breastfeed her child, so that individual risk factors can adequately be taken into account when counseling the patient.
- |||||||||| carbamazepine / generics
Journal: Cross-sensitivity of Levetiracetam and Carbamazepine Induced Skin Rash. (Pubmed Central) - Aug 8, 2019
Drug rash including drug-induced hypersensitivity syndrome is a rare complication of LEV use. We report a case of maculopapular skin rash due to LEV with cross-sensitivity with CBZ which has not been reported till date.
- |||||||||| zonisamide / generics, levetiracetam / generics
A-DRESS-ing the Big Picture: Liver Injury as Evidence of DRESS Syndrome (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_3004;
Although our patient had many typical findings of DRESS, including fever, rash, abnormal LFTs, leukocytosis, and eosinophilia, diagnosis was challenging due to the patient’s multiple comorbidities and prior hospital admissions initially overlooked. As treatment hinges on cessation of the culprit agent, it is essential to get a complete history and evaluate the patient as a whole to avoid missing this potentially life-threatening condition.
- |||||||||| Fycompa (perampanel) / Eisai
Journal: Seizures and Anticonvulsants in Brain Tumours: Frequency, Mechanisms and Anti-Epileptic Management. (Pubmed Central) - Aug 1, 2019
...Levetiracetam followed by lacosamide or valproic acid are the agents of choice...Lamotrigine, perampanel, zonisamide or clobazam are other good choices...Plasma monitoring of AEDs for detecting drug insufficiency, interactions or toxicity helps in choosing the proper dose regimen. For practical use, tables on drug interactions between AEDs and cancer therapy are added together with a guideline on the medical management of seizure control including dose regimens.
- |||||||||| lacosamide / generics
Clinical, Journal, HEOR: Lacosamide as first-line treatment option in focal epilepsy: a cost-utility analysis for the Greek healthcare system. (Pubmed Central) - Aug 1, 2019
For practical use, tables on drug interactions between AEDs and cancer therapy are added together with a guideline on the medical management of seizure control including dose regimens. Lacosamide is a cost-effective option at a willingness-to-pay threshold of €30,000 per QALY, representing a valuable monotherapy treatment option for patients with focal epileptic seizures in the Greek setting.
- |||||||||| zonisamide / generics, ciprofloxacin / generics
Last 2 weeks on 1 of the #nephrology consults teams at @OchsnerNephro: Cipro-AIN, PLA2R-MN, SIADH, cryoglob HBV-DPGN, HRS-1, CRS-1 and 2, ischemic ATN, prerenal, rhabdo, SBE-IRGN, lambda MM castN, TMA, zonisamide-NAG met acid, immobiliz-hyperCa, tacro-hyperK...#renalrounds #MedEd (Twitter) - Jul 24, 2019
- |||||||||| zonisamide / generics
Clinical, P2 data, Journal: Adjunct zonisamide to levodopa for DLB parkinsonism: A randomized, double-blind phase 2 study. (Pubmed Central) - Jul 24, 2019
Lacosamide is a cost-effective option at a willingness-to-pay threshold of €30,000 per QALY, representing a valuable monotherapy treatment option for patients with focal epileptic seizures in the Greek setting. Zonisamide (adjunctive to levodopa) improved parkinsonism accompanying DLB without worsening cognitive function or psychiatric symptoms.
- |||||||||| dalfampridine / generics, carbamazepine / generics
Preclinical, Journal: The 4-Aminopyridine Model of Acute Seizures in vitro Elucidates Efficacy of New Antiepileptic Drugs. (Pubmed Central) - Jul 19, 2019
...Previous studies have shown that the 4-AP model is capable to recapitulate the antiepileptic efficacy of standard antiepileptic drugs (AEDs) such as valproate or carbamazepine...Specifically, levetiracetam reduced SLE frequency while lacosamide and zonisamide at higher doses completely blocked SLE incidence...Further studies with negative controls, e.g., penicillin as a proconvulsant, and other clinically relevant AEDs are needed to determine if this acute in vitro model might be useful as exploratory screening tool. In view of the increasing sensitivity toward animal welfare, an affective in vitro model may help to reduce the number of laboratory animals deployed in burdening in vivo experiments and to preselect substances for subsequent testing in time- and cost-laborious models of chronic epilepsy.
- |||||||||| zonisamide / generics
Journal: Zonisamide for DLB parkinsonism: An old drug used in a new context. (Pubmed Central) - Jul 19, 2019
In view of the increasing sensitivity toward animal welfare, an affective in vitro model may help to reduce the number of laboratory animals deployed in burdening in vivo experiments and to preselect substances for subsequent testing in time- and cost-laborious models of chronic epilepsy. No abstract available
- |||||||||| carbamazepine / generics
Journal: Update on pharmacological treatment of Progressive Myoclonus Epilepsies. (Pubmed Central) - Jul 11, 2019
Overall, the treatment of PMEs remains symptomatic (i.e. pharmacological treatment of seizures and myoclonus). Further dissection of the genetic background of the different PMEs might hopefully help in the future with individualised treatment options.
- |||||||||| Journal: Pharmacotherapeutic management of epilepsy in MERRF syndrome. (Pubmed Central) - Jun 25, 2019
Seizure-types associated with MERRF include focal myoclonic, focal clonic, and focal atonic seizures, generalized myoclonic, tonic-clonic, atonic, and myoclonic-atonic seizures, or typical absences. Treatment of myoclonic epilepsy relies on expert judgments recommending levetiracetam, together with clonazepam, or topiramate, zonisamide, or piracetam in monotherapy as the first line AEDs.
- |||||||||| Briviact (brivaracetam) / UCB
P3 data, Journal, Adverse events: Cognitive and fatigue side effects of anti-epileptic drugs: an analysis of phase III add-on trials. (Pubmed Central) - Jun 22, 2019
Due to their clinical relevance and impact on quality of life, new trials should make data related to the prevalence and discontinuation rates of these side effects publicly available. Given the clear dose response effect, physicians should consider aiming for lower drug loads and adjusting doses to improve tolerability.
- |||||||||| Review, Journal: Pharmacological Management of Dementia with Lewy Bodies. (Pubmed Central) - Jun 6, 2019
Two agents targeting alpha-synuclein (NPT200-11 and ambroxol) currently hold promise as disease-modifying therapies for DLB, but they are yet to be tested in clinical trials. An agent (E2027) that offers hope of neuroprotection by increasing central cyclic guanosine monophosphate (cGMP) levels is currently being examined in clinical trials in DLB patients.
- |||||||||| Journal: Carbonic anhydrase enzymes: Likely targets for inhalational anesthetics. (Pubmed Central) - May 29, 2019
...Activation of GABA-A and inhibition of NMDA receptors are associated with the induction of anesthesia by the intravenous general anesthetics propofol and ketamine, respectively...Inhalational anesthetic molecules, which are lipophilic and inert in nature, have an ability to cross the membranes and inhibit carbonic anhydrases, which might not be accessible by topiramate and zonisamide...Therefore, this article presents a hypothesis that the anesthetic actions of inhalational anesthetics could be due to their inhibitory effects on the carbonic anhydrases. Investigating this hypothesis might lead to the development of new safer anesthetics, and more importantly it might reveal an endogenous anesthetic pathway, in which the carbonic anhydrase system is a component along with the GABA-A and NMDA receptor systems.
- |||||||||| zonisamide / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol Dependence (clinicaltrials.gov) - May 29, 2019
P2, N=30, Completed,
Investigating this hypothesis might lead to the development of new safer anesthetics, and more importantly it might reveal an endogenous anesthetic pathway, in which the carbonic anhydrase system is a component along with the GABA-A and NMDA receptor systems. Recruiting --> Completed | Trial completion date: Oct 2019 --> Jan 2019 | Trial primary completion date: Oct 2019 --> Jan 2019
- |||||||||| carbamazepine / generics
Clinical, Review, Journal: Strategies of using the new antiepileptic drugs for epilepsy in adults (Pubmed Central) - May 11, 2019
The new antiepileptic drugs can succesfully used for the treatment of special patients' groups as for the post stroke, poszttraumatic epilepsies, for the epilepsies accompanied with brain tumours as well as for epilepsies in the elderly. The new drugs are advantageous for the treatment of such patients who have psychiatric symptoms or signs of cognitive decline and high risk of these symptoms respectively.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
Journal: Therapeutic Drug Monitoring of Antiepileptic Drugs in Epilepsy: A 2018 Update. (Pubmed Central) - Apr 30, 2019
For the older first generation AEDs (carbamazepine, ethosuximide, phenobarbital, phenytoin, primidone and valproic acid), much data has accumulated in this regard. However, this is occurring increasingly for the new AEDs (brivaracetam, eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, perampanel, piracetam, pregabalin, rufinamide, stiripentol, sulthiame, tiagabine, topiramate, vigabatrin and zonisamide).
- |||||||||| zonisamide / generics, levetiracetam / generics, topiramate / generics
Clinical, Journal: The course and development of epilepsy in patients with typical variant of Rett syndrome and mutations (Pubmed Central) - Apr 10, 2019
One patient with resistant epilepsy was treated with the combination of drugs (levetiracetam, topiramate, zonisamide, benzodiazepine) that led to stopping of seizures during night sleep and decrease in the frequency of daytime seizures by 50%. Further research of epilepsy and efficacy of antiepileptic drugs in Rett syndrome is required.
- |||||||||| carbamazepine / generics
Journal: Making Rash Decisions in Epilepsy: Evaluating Hypersensitivity Reactions to Anti-seizure Medications. (Pubmed Central) - Apr 9, 2019
Although AEDs as a class were associated with 9 times the risk of SJS/TEN compared with non-AEDs, there were 6 AEDs with risk estimates greater than 20. Increased awareness of this risk among both prescribers and patients, particularly variations in risk among different AEDs, along with education on early recognition of SJS/TEN signs/symptoms, may help mitigate the number and severity of these adverse events.
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