R-(-)-gossypol (AT 101) / Ascentage Pharma 
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  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  Effects of spent substrate of oyster mushroom (Pleurotus ostreatus) on ruminal fermentation, microbial community and growth performance in Hu sheep. (Pubmed Central) -  Nov 7, 2024   
    Conversely, the prevalence of Phanerochaete in PSMS15 was notably higher than in CON and PSMS10, and it was also significantly elevated in PSMS20 compared to CON (P?<?0.05); (4) Correlation analysis indicated no significant correlation between changes in the structure of bacterial and fungal communities. Considering these findings, a high percentage of P.SMS negatively impacted feed utilization efficiency, blood oxygen carrying capacity, and kidney function, while a moderate percentage of P.SMS promotes rumen absorption capacity, indicating that feeding 10% P.SMS is optimal.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  Effect of Gossypol on Gene Expression in Swine Granulosa Cells. (Pubmed Central) -  Oct 25, 2024   
    Specifically, in the GP6.25 group, pathways related to the cycle oocyte meiosis, progesterone-mediated oocyte maturation, and p53 signaling were prominently affected...Notably, genes linked to female reproductive function (CDK1, CCNB1, CPEB1, MMP3), cellular component organization (BIRC5, CYP1A1, TGFB3, COL1A2), and oxidation-reduction processes (PRDX6, MGST1, SOD3) exhibited differential expression in GP-treated groups. These findings offer valuable insights into the changes in GC gene expression in pigs exposed to GP.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  Fermented but Not Irradiated Cottonseed Meal Has the Potential to Partially Substitute Soybean Meal in Broiler Chickens. (Pubmed Central) -  Oct 16, 2024   
    Overall, our results indicated that microbial fermentation of CSM is a more effective approach than irradiation for enhancing the nutritional value of CSM. Therefore, FCSM is recommended as a viable alternative protein source that can safely replace up to 50% of SBM in broiler chicken diets, particularly during times of fluctuating SBM prices and availability issues.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Review, Journal:  The 4Fs of cotton: genome editing of cotton for fiber, food, feed, and fuel to achieve zero hunger. (Pubmed Central) -  Sep 27, 2024   
    Thus, CRISPR/Cas-mediated genome editing has emerged as a technique of choice to tailor crop phenotypes for better yield potential and environmental resilience. The review covers a comprehensive analysis of cotton phenotypic traits and their improvement with the help of the latest genome editing tools to improve fiber, food, feed, and fuel-associated genes of cotton to ensure food security.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Review, Journal:  Research progress on cottonseed meal as a protein source in pig nutrition: An updated review. (Pubmed Central) -  Sep 19, 2024   
    Subsequently, we comprehensively summarized the latest research progress of cottonseed meal application in pig nutrition over the past decade. The outcome of this review serves as a theoretical foundation and practical guidance for the research and application of cottonseed meal in pig nutrition and promotes the reduction of soybean meal utilization in the pig industry.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Review, Journal:  The anti-reproductive active compound gossypol: Progress in research (Pubmed Central) -  Aug 23, 2024   
    Recent studies show that it has an antiviral effect after structurally modified. This review focuses on the status quo of present studies on the effects of gossypol and its derivatives in anti-reproduction and anti-PCa, with an introduction of the application of the new compounds obtained from structural modification of gossypol in the treatment of PCa.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers. (Pubmed Central) -  Aug 13, 2024   
    Additionally, the second part discusses the use of polyphenolic moieties to create stable nanoparticles from infinite polymeric networks. Through a comprehensive examination of gossypol's properties and applications, this review emphasizes the broader implications of such a masking strategy for optimizing the therapeutic benefits of many similar bioactive compounds while minimizing adverse effects.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  Stable Europium(III) Metal-Organic Framework Fluorescence Probe for Intelligent Visualization Detection of Gossypol and Nitrofuran Antibiotics in Real Samples. (Pubmed Central) -  Jul 29, 2024   
    The MOF fluorescence probe could detect organic pollutants through the "shut-off" effect, with a fast response speed and a low detection limit [Gsp, nitrofurantoin (NFT), and nitrofurazone (NFZ) for 0.43, 0.38, and 0.41 ?M, respectively]...This paper introduced a deep learning model to recognize the fluorescence images, a portable intelligent logic detector designed for real-time detection of Gsp by logic gate strategy, and an anticounterfeiting mark prepared based on inkjet printing. Importantly, this work provides a new way of thinking for the detection of organic pollutants in water with high sensitivity and practicality by combining the fluorescence probe with machine learning and logical judgment.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  MiR-214_L-1R+4 regulate gossypol-induced immune response through MyD88-dependent signaling pathway in Cyprinus carpio. (Pubmed Central) -  Jul 21, 2024   
    Moreover, miR-214_L-1R+4 antagomir were intraperitoneally administered to C. carpio, down-regulated miR-214_L-1R+4 could increase MyD88a expression, as well as inflammatory cytokines and anti-inflammatory cytokines expression. These findings revealed that miR-214_L-1R+4 via the MyD88-dependent signaling pathway modulate the immune response to gossypol in C. carpio spleen.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  Loss of Gcn2 exacerbates gossypol induced oxidative stress, apoptosis and inflammation in zebrafish. (Pubmed Central) -  Jul 21, 2024   
    Remarkably, administering the antioxidant N-acetylcysteine (NAC) was effective in reversing the gossypol induced oxidative stress and apoptosis, thereby increasing the gossypol tolerance of gcn2-/- zebrafish...These results reveal that gcn2 plays a protective role in reducing gossypol-induced oxidative stress and apoptosis, attenuating inflammation responses, and enhancing the survivability of zebrafish in gossypol-challenged conditions. Therefore, maintaining appropriate activation of Gcn2 may be beneficial for fish fed diets containing gossypol.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  GhHAM regulates GoPGF-dependent gland development and contributes to broad-spectrum pest resistance in cotton. (Pubmed Central) -  Jul 14, 2024   
    Exogenous application of GA3 restored stem cell elongation but not gland formation, thereby indicating that GhHAM controls gland morphogenesis independently of GA. Our study sheds light on the functional differentiation of HAM proteins among plant species, highlights the significant role of pigment glands in influencing pest feeding preference, and provides a theoretical basis for breeding pest-resistant cotton varieties to address the challenges posed by frequent outbreaks of pests.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  A Malpighian Tubule-Specific P450 Gene SlCYP9A75a Contributes to Xenobiotic Tolerance in Spodoptera litura. (Pubmed Central) -  Jul 2, 2024   
    The gain-of-function and loss-of-function analyses indicate that SlCYP9A75a contributes to cyantraniliprole, nicotine, and ?-cypermethrin tolerance, and SlCYP9A75a is capable of binding to these xenobiotics. This study indicates the roles of inducible SlCYP9A75a in detoxifying man-made insecticides and phytochemicals and may provide an insight into the development of cross-tolerance in omnivorous insects.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  Keap1 Negatively Regulates Transcription of Three Counter-Defense Genes and Susceptibility to Plant Toxin Gossypol in Helicoverpa armigera. (Pubmed Central) -  May 24, 2024   
    These data indicate that the suppression of the Keap1 gene activates the Keap1-Nrf2-ARE signaling pathway, up-regulates the expressions of counter-defense genes involved in the resistance of oxidative stress and finally contributes to reducing the susceptibility of gossypol. Our results provide more knowledge about the transcriptional regulation mechanisms of counter-defense genes that enable the cotton bollworm to adapt to the diversity of host plants including cotton.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  An Enzymatic and Proteomic Analysis of Panus lecomtei during Biodegradation of Gossypol in Cottonseed. (Pubmed Central) -  May 24, 2024   
    A total of 143 and 49 differentially abundant proteins were observed across the two contrasting growth conditions after 6 and 12 days of cultivation, respectively, revealing a dynamic protein profile during FG degradation, initially related to constitutive metabolism, then later associated with responses to oxidative stress. The findings advance our understanding of the mechanisms involved in gossypol degradation and highlight the potential of P. lecomtei BRM044603 in cotton waste biotreatment, relevant for animal supplementation, sustainable resource utilization, and bioremediation.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  Molecular-Scale Investigations Reveal the Effect of Natural Polyphenols on BAX/Bcl-2 Interactions. (Pubmed Central) -  Mar 17, 2024   
    Combined with surface free energy and molecular docking, the results revealed that polyphenols are driven by multiple forces that affect the orientation freedom of PPIs, with hydrogen bonding, hydrophobic interactions, and van der Waals forces being the major contributors. Overall, our work provides valuable insights into how molecules tune PPIs to modulate their function.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal, Adverse events:  Effective Degradation of Free Gossypol in Defatted Cottonseed Meal by Bacterial Laccases: Performance and Toxicity Analysis. (Pubmed Central) -  Feb 24, 2024   
    Moreover, in vitro and in vivo studies confirmed that the hepatotoxicity of FG was effectively eliminated after oxidative degradation by CotA laccase. Furthermore, the addition of CotA laccase could achieve 87% to 98% FG degradation in defatted CSM within 2 h. In conclusion, CotA laccase can be developed as an effective biocatalyst for the detoxification of FG in CSM.
  • ||||||||||  R-(-)-gossypol (AT 101) / Ascentage Pharma
    Journal:  The dual role of GoPGF reveals that the pigment glands are synthetic sites of gossypol in aerial parts of cotton. (Pubmed Central) -  Dec 11, 2023   
    Our study revealed that the pigment glands are synthetic sites of gossypol in aerial parts of cotton and that GoPGF plays a dual role in regulating gland morphogenesis and gossypol biosynthesis. The study provides new insights for exploring the complex relationship between glands and the metabolites they store in cotton and other plant species.