linagliptin/metformin / Generic mfg. 
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  • ||||||||||  Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Synjardy (empagliflozin/metformin) / Boehringer Ingelheim, Eli Lilly, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    Trial completion, Real-world evidence, Real-world:  DIA_CENTRAL:T2D Treatment Pattern in Central Europe (clinicaltrials.gov) -  Sep 17, 2021   
    P=N/A,  N=3735, Completed, 
    In people with prediabetes, 1-year treatment with metformin and linagliptin, combined or in monotherapy, was associated with a lower risk of SFPN, and with a better preservation of kidney function than with placebo. Active, not recruiting --> Completed
  • ||||||||||  Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Jentadueto (linagliptin/metformin) / Eli Lilly, Boehringer Ingelheim
    In #CDMX, Trayenta Duo is out... (Twitter) -  Dec 25, 2020   
  • ||||||||||  metformin / Generic mfg., Trijardy XR (empagliflozin/linagliptin/metformin XR) / Eli Lilly, Boehringer Ingelheim, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    Journal:  In brief: Trijardy XR - a new 3-drug combination for Type 2 diabetes. (Pubmed Central) -  Sep 16, 2020   
    Further follow up can be done to ensure these patients received the benefit of the DSM intervention. No abstract available
  • ||||||||||  metformin / Generic mfg., Glyxambi (empagliflozin / linagliptin) / Boehringer Ingelheim, Eli Lilly
    Clinical, Journal:  Triple fixed-dose combination empagliflozin, linagliptin, and metformin for patients with type 2 diabetes. (Pubmed Central) -  Aug 4, 2020   
    The evaluated doses of empagliflozin/linagliptin/metformin XR FDC tablets were bioequivalent to the corresponding free combinations. Based on these two bioequivalence studies and existing phase 3 data, the FDA has recently approved this triple FDC to improve glycemic control in adults with T2D.
  • ||||||||||  Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Synjardy (empagliflozin/metformin) / Boehringer Ingelheim, Eli Lilly, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    Trial completion date, Trial primary completion date, Real-world evidence, Real-world:  DIA_CENTRAL:T2D Treatment Pattern in Central Europe (clinicaltrials.gov) -  May 28, 2020   
    P=N/A,  N=4000, Active, not recruiting, 
    Based on these two bioequivalence studies and existing phase 3 data, the FDA has recently approved this triple FDC to improve glycemic control in adults with T2D. Trial completion date: May 2020 --> Jan 2021 | Trial primary completion date: May 2020 --> Jan 2021
  • ||||||||||  Review, Journal:  Drugs for type 2 diabetes. (Pubmed Central) -  Dec 22, 2019   
    Trial completion date: May 2020 --> Jan 2021 | Trial primary completion date: May 2020 --> Jan 2021 No abstract available
  • ||||||||||  Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Synjardy (empagliflozin/metformin) / Boehringer Ingelheim, Eli Lilly, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    Enrollment closed, Real-world evidence, Real-world:  DIA_CENTRAL:T2D Treatment Pattern in Central Europe (clinicaltrials.gov) -  Sep 18, 2019   
    P=N/A,  N=4000, Active, not recruiting, 
    A comparison of GV with HMET versus LMET + DPP4 suggested that LMET + DPP4 might reduce post-breakfast GV to a greater degree than HMET in type 2 diabetes patients receiving low-dose metformin monotherapy. Not yet recruiting --> Active, not recruiting
  • ||||||||||  Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Synjardy (empagliflozin/metformin) / Boehringer Ingelheim, Eli Lilly, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    Trial completion date, Trial primary completion date, Real-world evidence, Real-world:  DIA_CENTRAL:T2D Treatment Pattern in Central Europe (clinicaltrials.gov) -  May 14, 2019   
    P=N/A,  N=4000, Not yet recruiting, 
    Not yet recruiting --> Active, not recruiting Trial completion date: Aug 2019 --> May 2020 | Trial primary completion date: Aug 2019 --> May 2020
  • ||||||||||  Lantus (insulin glargine) / Sanofi, NovoLog (insulin aspart) / Novo Nordisk, Jentadueto (linagliptin+metformin) / Eli Lilly, Boehringer Ingelheim
    Clinical, Journal:  Utilising a milk-based meal replacement programme in a bariatric patient with poorly controlled type 2 diabetes mellitus. (Pubmed Central) -  Apr 9, 2019   
    ...However, 1 year later, despite further weight loss, his HbA1c deteriorated dramatically, requiring introduction of linagliptin and canagliflozin, with good response...Milk-based meal replacement in patients with insulin requiring type 2 diabetes causes rapid and profound reductions in insulin requirements, so rigorous monitoring of glucose levels by patients and their clinicians is necessary. In carefully selected and adequately monitored patients, the response to oral antidiabetic medications may help to differentiate between absolute and relative insulin deficiency.
  • ||||||||||  Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Synjardy (empagliflozin/metformin) / Boehringer Ingelheim, Eli Lilly, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    New trial, Real-world evidence, Real-world:  DIA_CENTRAL:T2D Treatment Pattern in Central Europe (clinicaltrials.gov) -  Jan 17, 2019   
    P,  N=4000, Not yet recruiting, 
  • ||||||||||  metformin / Generic mfg., Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Jentadueto (linagliptin/metformin) / Eli Lilly, Boehringer Ingelheim
    Journal:  Linagliptin plus metformin in patients with newly diagnosed type 2 diabetes and marked hyperglycemia. (Pubmed Central) -  Feb 7, 2017   
    P4
    Linagliptin/metformin combination in newly diagnosed T2D patients with marked hyperglycemia was well tolerated and elicited substantial improvements in glycemic control regardless of baseline HbA1c, age, BMI, renal function, or race. Thus, newly diagnosed, markedly hyperglycemic patients may be effectively treated by combinations of oral agents.