- |||||||||| hydrocortisone / Generic mfg.
Journal: Glucocorticoid dysfunction in children with severe malaria. (Pubmed Central) - Jul 30, 2023
Interestingly, hydrocortisone induced increased levels of cAMP in AC, but not in clinical malaria patients. Altogether, this study shows that patients with SM have increased cortisol levels, but also a decreased sensitivity to GCs, which may clearly contribute to the severity of disease.
- |||||||||| thyroxine / Generic mfg., hydrocortisone / Generic mfg.
Rare Case of Severe Jaundice in Panhypopituitarism Patient (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_4342;
This case can remind clinicians of the importance of evaluating pituitary and endocrine disorder in patients with presentation of hyperbilirubinemia and transaminitis. Figure: Figure shows thin hair in the scalp and loss of hair in the eyebrows
- |||||||||| Invanz (ertapenem) / Merck (MSD)
Unusual Presentation of Ectopic ACTH from Pancreatic Neuroendocrine Tumor (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3444;
The patient was then readmitted with fever secondary to ESBL bacteremia for which he was treated with ertapenem...Subsequent serum ACTH levels decreased dramatically, and the patient was started on hydrocortisone...Despite the rarity of ACTH-producing pancreatic NETs, early diagnosis and prompt treatment are more likely to yield favorable outcomes. Figure: (Image A) PET/CT Ga dotatate scan with 1.8x2.4x1.7cm mass in the pancreas
- |||||||||| A Case Report of Partial Small Intestinal Obstruction Secondary to Lupus Enteritis With Bowel Ischemia, Portal Vein Thrombosis and Secondary Antiphospholipid Syndrome (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3153;
Eventually, anticoagulation with fondaparinux was started and overlapped with warfarin...Figure: Whole abdomen computed tomography scan with triple contrast showing persistent circumferential enhancing mucosal wall thickening (around 1 cm) in the distal jejunum, with associated mesenteric lymphadenopathies and mesenteric reactive changes (Figures A and B). Abdominal aortogram and venogram showing persistent intraluminal filling defect in the main portal vein, prior to the bifurcation of the left and right portal vein, suggestive of portal vein thrombosis (Figures C and D) with note of varices at the gallbladder fossa (Figure E) and peripancreatic region (Figure F)
- |||||||||| Invanz (ertapenem) / Merck (MSD)
Spontaneous Adrenal Insufficiency in a Decompensated Cirrhotic Patient (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_3069;
His home lactulose was uptitrated; he was hydrated with IV fluids and initiated on broad spectrum antibiotics which escalated to Ertapenem...He was pending discharge when he slowly became lethargic, hypotensive despite midodrine, hyponatremic to 124, and hyperkalemic to 6.1...Endocrine was consulted and recommended hydrocortisone and fludrocortisone...Diagnosis occurs through AM cortisol testing with ACT Stimulation tests. Definitive treatment and resolution of symptoms occur through corticosteroids.
- |||||||||| prednisone / Generic mfg., hydrocortisone / Generic mfg., sterile N-Acetylcysteine / Generic mfg.
Colon Cleanse Revenge Fenbendazole Causes Severe Drug-Induced Liver Injury (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2984;
Definitive treatment and resolution of symptoms occur through corticosteroids. Poison control was consulted and suggested a 21-hour IV N acetylcysteine protocol...Thus, the patient was determined not responding to NAC therapy and Cortef was started...After 9 days of hospitalization the patient
- |||||||||| prednisone / Generic mfg., carvedilol / Generic mfg., hydrocortisone / Generic mfg.
Myocarditis in Ulcerative Colitis - Complication of Disease or Therapy? (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2738;
Myocarditis can also develop as an extra-intestinal manifestation of UC flare-up. Irrespective of the cause, albeit mesalamine toxicity or UC flare-up, early recognition of myocarditis as an etiology of hemodynamic instability in UC patients and treatment with a combination of increased steroid dose and stopping mesalamine can prevent the cascade of shock and respiratory failure.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Entyvio (vedolizumab) / Takeda
Hyperbaric Oxygen Enabled a Transition to Oral Steroids in an Acute Severe Ulcerative Colitis Flare (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_2715;
Case Description/ 71-year-old female with extensive ulcerative colitis on infliximab presented with abdominal pain and more than 10 bloody bowel movements per day...She was started on hydrocortisone 100mg IV every eight hours and given one dose of vedolizumab with improvement in her CRP from 56 to 40...She was discharged on oral prednisone and outpatient vedolizumab infusions...Blue lines show stool frequency. She was discharged on HD 12 and had a follow up appointment on day 25 after admission.
- |||||||||| Entyvio (vedolizumab) / Takeda
A Rare Case of Mesalamine-Induced Myocarditis in a Patient With Ulcerative Colitis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_1285;
This case reinforces the significance of rare but potential side effects observed with mesalamine use in UC patients and can aid clinicians in prompt diagnosis and management to avoid complications. Figure: Retroflexion view of rectum with ulceration and inflammation.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
Tofacitinib-Induced Remission in a Case of Infliximab and Steroid Refractory Acute Severe Ulcerative Colitis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_1280;
The patient was biologic-naive and had received mesalamines, budesonide, and prednisone...As such, colectomy was cancelled, and the patient was discharged with a steroid taper and planned transition to upadacitinib due to insurance challenges...Figure 1B: Rectosigmoid colon following several days of IV hydrocortisone and two doses of infliximab. Figure 1C: Rectosigmoid colon demonstrating mucosal healing after five days of tofacitinib therapy.
- |||||||||| amiodarone / Generic mfg.
Review, Journal: Amiodarone-Induced Myxedema Coma in Elderly Patients: A Systematic Review of Case Reports. (Pubmed Central) - Jul 26, 2023
Despite the myriad potential causes of myxedema coma complicating the diagnosis, it was found that through a combination of clinical symptoms and serum TSH measurements, a confirmed diagnosis could be reached. Furthermore, it was observed that amiodarone-induced myxedema coma responded favorably to treatment with levothyroxine and glucocorticoids.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Hocus Pocus - Evaluating Shock Through The Magic Of Ultrasound. (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1346;
She also has HTN for which she takes furosemide 20 mg and lisinopril 10 mg daily, DM type I (HgbA1c 8.6) on glargine 29 U every morning as well as aspartate 6 mg before meals, hypothyroidism on 0.025 mcg levothyroxine, hyperlipidemia on simvastatin 20 mg daily, history of Charcot arthropathy and recent hardware removal...100 mg hydrocortisone bolus is given, and a cortisol level is sent...Why is dobutamine added?...Alteplase (TPA) 100 mg is infused over 2 hours...She becomes net neg of 1.5 liters for the day over the next 4 hours and bumetanide is further decreased to 0.05 mg/hr...She is given fluids of 300 cc over the next 4 hours. After 15 days in the ICU, she is transferred to the floor and after 1 month she has her left BKA and by the 7th week she is transferred to rehab.
- |||||||||| Bridion (sugammadex) / Merck (MSD)
Does Pre-emptive Dexamethasone Provide Prophylaxis Against Sugammadex-induced Bradycardia? A Retrospective Study (Hall D-9) - Jul 20, 2023 - Abstract #ASA2023ASA_78;
There was no significant change in heart rate slowing between the dexamethasone and non-dexamethasone group, potentially negating the theory of a transient early binding of sugammadex to corticosteroids with later more avid binding to rocuronium and unbinding the corticosteroids, or, it may be that other corticosteroids, such as hydrocortisone are required to prevent this effect. Prospective trials evaluating this effect with cortisol concentration measurement are needed to further evaluate the hypothesis.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Hocus Pocus - Evaluating Shock Through The Magic Of Ultrasound. (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_50;
She also has HTN for which she takes furosemide 20 mg and lisinopril 10 mg daily, DM type I (HgbA1c 8.6) on glargine 29 U every morning as well as aspartate 6 mg before meals, hypothyroidism on 0.025 mcg levothyroxine, hyperlipidemia on simvastatin 20 mg daily, history of Charcot arthropathy and recent hardware removal...100 mg hydrocortisone bolus is given, and a cortisol level is sent...Why is dobutamine added?...Alteplase (TPA) 100 mg is infused over 2 hours...She becomes net neg of 1.5 liters for the day over the next 4 hours and bumetanide is further decreased to 0.05 mg/hr...She is given fluids of 300 cc over the next 4 hours. After 15 days in the ICU, she is transferred to the floor and after 1 month she has her left BKA and by the 7th week she is transferred to rehab.
- |||||||||| hydrocortisone / Generic mfg.
Trial completion date, Trial primary completion date: Subcutaneous Hydrocortisone Children With Congenital Adrenal Hyperplasia (clinicaltrials.gov) - Jul 20, 2023
P1, N=11, Completed,
After 15 days in the ICU, she is transferred to the floor and after 1 month she has her left BKA and by the 7th week she is transferred to rehab. Trial completion date: Jan 2022 --> Feb 2023 | Trial primary completion date: Jan 2022 --> Feb 2023
- |||||||||| hydrocortisone / Generic mfg.
Trial completion: HAIRCUSH: Hair Cortisol and Cushing's Disease (clinicaltrials.gov) - Jul 20, 2023
P=N/A, N=51, Completed,
Trial completion date: Jan 2022 --> Feb 2023 | Trial primary completion date: Jan 2022 --> Feb 2023 Recruiting --> Completed
- |||||||||| hydrocortisone / Generic mfg.
Hydrocortisone! (Twitter) - Jul 9, 2023
- |||||||||| hydrocortisone / Generic mfg.
Journal: The Hypothalamus-Pituitary-Adrenocortical response to critical illness: a concept in need of revision. (Pubmed Central) - Jul 6, 2023
The new findings supersede earlier concepts such as "relative", as opposed to "absolute", adrenal insufficiency and generalized systemic glucocorticoid resistance in the critically ill. They also question the scientific basis for broad implementation of stress dose hydrocortisone treatment of patients suffering from acute septic shock solely based on assumption of cortisol insufficiency.
- |||||||||| hydrocortisone / Generic mfg.
Preclinical, Journal: Anti-fatigue effect of Lubian on kidney Yin deficiency and kidney Yang deficiency mice and mechanism based on PI3K-Akt pathway (Pubmed Central) - Jul 3, 2023
The kidney Yin deficiency model and kidney Yang deficiency model were prepared by daily regular oral administration of dexamethasone acetate and hydrocortisone, respectively, and meanwhile, corresponding drugs were provided...Compared with the kidney Yin deficiency model group, the kidney Yin deficiency-Lubian treatment groups showed increased body weight(P<0.01), relieved symptoms of Yin deficiency, increased content of cGMP(P<0.01), decreased cAMP/cGMP(P<0.01), prolonged exhausted swimming time(P<0.01), decreased LD(P<0.01), decreased BUN content(P<0.01), increased liver glycogen content(P<0.01), and increased protein expression of PI3K(P<0.05) and Akt in the liver(P<0.05). To sum up, Lubian can regulate Yin deficiency and Yang deficiency and increase glycogen synthesis by affecting the PI3K-Akt pathway, thereby exerting an anti-fatigue role.
- |||||||||| hydrocortisone / Generic mfg., mefenamic acid / Generic mfg., amoxicillin / Generic mfg.
Management of Chronic Vesicobullous Dermatitis with Secondary Bacterial Infection in Public Primary Health Care in Indonesia () - Jul 3, 2023 - Abstract #WCD2023WCD_7530;
Oral antihistamine (cetirizine) qd and topical corticosteroid (hydrocortisone 1%) bid was then given after secondary infection was resolved. KEY MESSAGE: This case illustrates the importance of thorough history taking, wound debridement and compress before application of topical therapies, and patient compliance in order to achieve successful diagnosis and treatment of skin diseases under the condition of limited resources and medication options available at a public primary health care facility
- |||||||||| Taltz (ixekizumab) / Eli Lilly, Japan Tobacco
Autoimmune phenomenon - psoriatic patient with coexisting psoriatic arthritis, vitiligo, and myasthenia gravis, treated with ixekizumab who was diagnosed with Addison () - Jul 3, 2023 - Abstract #WCD2023WCD_6731;
KEY MESSAGE: This case illustrates the importance of thorough history taking, wound debridement and compress before application of topical therapies, and patient compliance in order to achieve successful diagnosis and treatment of skin diseases under the condition of limited resources and medication options available at a public primary health care facility We provide a case of a 53-year-old man with psoriasis vulgaris and psoriatic arthritis, with a history of myasthenia gravis and vitiligo, who was treated with adalimumab and ixekizumab subsequently and who was diagnosed with Addison
- |||||||||| prednisolone / Generic mfg., hydrocortisone / Generic mfg., mycophenolate mofetil / Generic mfg.
Toxic epidermal necrolysis like presentation of lupus erythematosus: A series of two pediatric cases () - Jul 3, 2023 - Abstract #WCD2023WCD_6508;
One of the cases with two consecutive episodes was later started on oral prednisolone and mycophenolate mofetil, because of grade 4 lupus nephritis...There may be history of intake of antipyretics and analgesics for fever and joint pain which may again add to the diagnostic dilemma. Less severe mucosal involvement as compared the extent of skin lesions may help in differentiation
- |||||||||| A Rare Case of a Recurrent Epidermal Necrolysis in a Filipino Pediatric Patient () - Jul 3, 2023 - Abstract #WCD2023WCD_6304;
OBSERVATION: A 13-year-old Filipino male was admitted at a tertiary hospital due to progressive development of tender erythema with flaccid blisters and erosions on the mouth, trunk, extremities and anogenital areas (BSA >8% to 38%); with associated dysphagia and dysuria <24 hours after ampicillin administration...Past history revealed a diagnosis of Stevens-Johnson Syndrome with Amoxicillin three (3) years prior...A 4mm punch biopsy confirmed Toxic epidermal necrolysis and was managed with hydrocortisone, ranitidine, diphenhydramine, saline compress, emollients and active guidance from other specialties for a comprehensive multidisciplinary approach...For physicians, a keen sense of identifying an emerging epidermal necrolysis and abrupt withdrawal of causal drug is key. A multidisciplinary approach is still best for managing dermatological emergencies with utilization of scoring systems: algorithm of drug causality for Epidermal Necrolysis (ALDEN) for drug causation and Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN) modified for pediatric population for better prognosis.
- |||||||||| methotrexate / Generic mfg., hydrocortisone / Generic mfg., tazarotene topical / Generic mfg.
Controlled drug delivery using smart functional nanofibers for efficient therapy of psoriasis () - Jul 3, 2023 - Abstract #WCD2023WCD_6202;
Electrospinning imparted multiple functions to the resulting fabrics and therefore such materials have potential to achieve better efficacy with improved safety profile. The integration of drug delivery technologies with smart functionalized electrospun magnetic nanofibers is a versatile strategy to increase possibilities of psoriasis therapy and may have numerous clinical applications
- |||||||||| hydrocortisone / Generic mfg.
Fuchs syndrome following AstraZeneca () - Jul 3, 2023 - Abstract #WCD2023WCD_5183;
As the lesion worsened, she remained hospitalized in another center, where she was subsequently medicated with hydrocortisone, still showing no improvement...KEY MESSAGE: It is important to consider Fuchs syndrome (FS) in absence of typical cutaneous signs of erythema multiforme or Steven Johnson syndrome with only oral, ocular or genital lesions. Also we would like to emphasize that microbiologic diagnostic methods, including M. pneumoniae serology and PCR (most common cause of FS) must be done along with the notification of adverse effects to medications, specially if it is secondary to a being tested vaccine
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Novel intralesional rituximab regimen in recalcitrant oral pemphigus vulgaris () - Jul 3, 2023 - Abstract #WCD2023WCD_3884;
They were started on intralesional rituximab in the ulcers after premedication with hydrocortisone, pheniramine, and paracetamol at 25mg/week (5mg/cm2) for four weeks...The intralesional dose ensures an adequate drug concentration reaching the lesion, which could have led to improvement in our patients, and systemic absorption might have led to a reduction in the circulating antibodies and CD19 cells. Large-scale studies would be required to establish this effective, safer, and relatively cheaper treatment modality in the management guidelines
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