hydrocortisone / Generic mfg. 
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  • ||||||||||  indomethacin / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  Preparation and Application of Decanoic Acid/Arginine Hydrogels to a Transdermal Formulation. (Pubmed Central) -  Jun 26, 2024   
    On the other hand, the flux of IM decreased with increasing arginine concentration, likely due to the acid-base interaction between Arg and IM in C10/Arg gel. Adequate drug skin permeation enhancement by C10/Arg gel requires optimizing the gel composition for each specific drug.
  • ||||||||||  Rybelsus (semaglutide oral) / Novo Nordisk
    Anesthesia, Your Patient Is Almost Coded in the PACU After a Pituitary Surgery! Crisis Preparation and Management for Transsphenoidal Pituitary Surgery (126A) -  Jun 25, 2024 - Abstract #ASA2024ASA_3036;    
    Oral hydrocortisone was prescribed during last hospitalization for surgery but weaned off in the following months...Would you routinely give dexamethasone for post-op nausea and vomiting (PONV) in TSS?Case Continued: During surgical exploration, the surgeon informs you that there is profuse bleeding on the field, and they might injure the carotid artery.8.What is your blood pressure management target now?...11.What are your differential diagnoses and treatment?12.If the patient wakes up slow, is there a cognitive aid to help troubleshoot? How does the cognitive aid help during neuroanesthetic crises?$$graphic_{9CA3D4AD-3357-477A-921A-4E0D00A82435}$$$$graphic_{1D86D868-9821-42AC-A5FF-6985D06287C1}$$
  • ||||||||||  Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, Levemir (insulin detemir rDNA origin) / Novo Nordisk
    Stressful Dose Steroids: When Should I Worry About Perioperative Adrenal Insufficiency? (126A) -  Jun 25, 2024 - Abstract #ASA2024ASA_2551;    
    How does the cognitive aid help during neuroanesthetic crises?$$graphic_{9CA3D4AD-3357-477A-921A-4E0D00A82435}$$$$graphic_{1D86D868-9821-42AC-A5FF-6985D06287C1}$$ Medications of significance include 20 mg prednisone po qday for ulcerative colitis, detemir insulin 12 units SQ qday, aspirin 81 mg po qday, empagliflozin, metoprolol, albuterol inhaler prn, tiotropium qd and amlodipine...3.What is the equivalent potency of glucocorticoid and mineralocorticoid effect for this patient
  • ||||||||||  Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, Levemir (insulin detemir rDNA origin) / Novo Nordisk
    Stressful Dose Steroids: When Should I Worry About Perioperative Adrenal Insufficiency? (126A) -  Jun 25, 2024 - Abstract #ASA2024ASA_1591;    
    Medications of significance include 20 mg prednisone po qday for ulcerative colitis, detemir insulin 12 units SQ qday, aspirin 81 mg po qday, empagliflozin, metoprolol, albuterol inhaler prn, tiotropium qd and amlodipine...3.What is the equivalent potency of glucocorticoid and mineralocorticoid effect for this patient Medications of significance include 20 mg prednisone po qday for ulcerative colitis, detemir insulin 12 units SQ qday, aspirin 81 mg po qday, empagliflozin, metoprolol, albuterol inhaler prn, tiotropium qd and amlodipine...3.What is the equivalent potency of glucocorticoid and mineralocorticoid effect for this patient
  • ||||||||||  Rybelsus (semaglutide oral) / Novo Nordisk
    Anesthesia, Your Patient Is Almost Coded in the PACU After a Pituitary Surgery! Crisis Preparation and Management for Transsphenoidal Pituitary Surgery (126A) -  Jun 25, 2024 - Abstract #ASA2024ASA_479;    
    Oral hydrocortisone was prescribed during last hospitalization for surgery but weaned off in the following months...Would you routinely give dexamethasone for post-op nausea and vomiting (PONV) in TSS?Case Continued: During surgical exploration, the surgeon informs you that there is profuse bleeding on the field, and they might injure the carotid artery.8.What is your blood pressure management target now?...11.What are your differential diagnoses and treatment?12.If the patient wakes up slow, is there a cognitive aid to help troubleshoot? How does the cognitive aid help during neuroanesthetic crises?
  • ||||||||||  Journal:  A Rare Cyclic Cushing Syndrome Mystery Illustrates Diagnostic Principles. (Pubmed Central) -  Jun 25, 2024   
    This case underscores the importance of considering pheochromocytoma in ACTH-dependent hypercortisolism with elevated metanephrines and an adrenal mass. Timely diagnosis and treatment can reduce morbidity and improve quality of life.
  • ||||||||||  Zynyz (retifanlimab-dlwr) / Incyte
    Journal:  Secondary adrenocortical insufficiency after treatment with retifanlimab: a case report. (Pubmed Central) -  Jun 25, 2024   
    The vomiting resolved, and the electrolyte levels were corrected after 3 days of treatment with glucocorticoids (hydrocortisone, intravenous, 200 mg/day). When patients present with gastrointestinal symptoms, such as poor appetite and nausea, not only symptomatic treatment but also a search for the etiology behind the symptoms is needed, especially in immunotherapy patients who should undergo a thorough evaluation of the endocrine system and be alert for adrenocortical insufficiency.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg., tranylcypromine / Generic mfg.
    Preclinical, Journal:  Identification and Evaluation of Olive Phenolics in the Context of Amine Oxidase Enzyme Inhibition and Depression: In Silico Modelling and In Vitro Validation. (Pubmed Central) -  Jun 19, 2024   
    To validate the in silico studies, the inhibitory activity of phenolic compounds was compared to the clinically approved inhibitor tranylcypromine...Using a cell culture model system with corticosteroid-stimulated human BJ fibroblast cells, the results demonstrate the attenuation of dexamethasone- and hydrocortisone-induced MAO activity by phenolic compounds...Overall, the results indicate the inhibition of flavin adenine dinucleotide (FAD)-dependent amine oxidases by olive phenolics. More generally, our findings further support at least a partial mechanism accounting for the antidepressant effects associated with EVOO and the Mediterranean diet.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Chronic Stress Related to Cancer Incidence, including the Role of Metabolic Syndrome Components. (Pubmed Central) -  Jun 19, 2024   
    When including age as a confounder and gender as a moderator, LogHairE was statistically significantly associated with cancer incidence (HR: 6.403, 95%CI: 1.110-36.92). In a population-based cohort, chronic biological stress, measured by HairE, was associated with cancer incidence, after controlling for age and gender.
  • ||||||||||  Journal, Metastases:  Patient perceptions of advanced practice radiation therapists prescribing medication in radiation therapy. (Pubmed Central) -  Jun 16, 2024   
    The study revealed that although patients were happy with the process of prescribing medication, they all agreed that having an advanced practice radiation therapist prescribe would improve care. Patient responses further demonstrated the need for future research in regards to side effect management as a whole by APRTs as well as how role clarification can impact patient perceptions of APRTs.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Clinical, Review, Journal:  Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections: A Review. (Pubmed Central) -  Jun 12, 2024   
    A randomized clinical trial of 6425 patients hospitalized with COVID-19 who required supplemental oxygen or noninvasive or invasive mechanical ventilation reported that dexamethasone 6 mg daily for 10 days decreased 28-day mortality (23% vs 26%)...Treatment with low-dose corticosteroids is associated with decreased mortality for patients with severe COVID-19 infection, severe community-acquired bacterial pneumonia, and moderate to severe Pneumocystis pneumonia (for patients with HIV). Low-dose corticosteroids may also benefit critically ill patients with respiratory infections who have septic shock, acute respiratory distress syndrome, or both.
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  Diagnosis and management of secondary adrenal crisis. (Pubmed Central) -  Jun 8, 2024   
    In diagnosed patients, preventive education in sick-day rules adjustment of glucocorticoid replacement and hydrocortisone parenteral self-administration must be performed repeatedly by trained health care providers. Strategies to improve the adequate preventive education in patients at risk for secondary AI should be promoted in collaboration with various medical specialist societies and patients support associations.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  What is the materno-fetal prognosis of adrenal insufficiency and pregnancy in low-resource setting? a case report. (Pubmed Central) -  Jun 7, 2024   
    Treatment consisted to an obstetrical and endocrinological follow-up and corticosteroid replacement therapy with hydrocortisone...Through this case, the authors discuss the therapeutic and prognostic aspects of adrenal insufficiency in our setting. With the introduction of gluco-corticosteroid replacement therapy, pregnancy in adrenal insufficiency can progress normally.
  • ||||||||||  crinecerfont (NBI-74788) / Neurocrine
    P3 data, Journal:  Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia. (Pubmed Central) -  Jun 3, 2024   
    P3
    Among patients with CAH, the use of crinecerfont resulted in a greater decrease from baseline in the mean daily glucocorticoid dose, including a reduction to the physiologic range, than placebo following evaluation of adrenal androgen levels. (Funded by Neurocrine Biosciences; CAHtalyst ClinicalTrials.gov number, NCT04490915.).
  • ||||||||||  crinecerfont (NBI-74788) / Neurocrine
    P3 data, Journal:  Phase 3 Trial of Crinecerfont in Pediatric Congenital Adrenal Hyperplasia. (Pubmed Central) -  Jun 3, 2024   
    P3
    In this phase 3 trial, crinecerfont was superior to placebo in reducing elevated androstenedione levels in pediatric participants with CAH and was also associated with a decrease in the glucocorticoid dose from supraphysiologic to physiologic levels while androstenedione control was maintained. (Funded by Neurocrine Biosciences; CAHtalyst Pediatric ClinicalTrials.gov number, NCT04806451.).
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Upregulation of coagulation factor V by glucocorticoid in the preovulatory follicles of zebrafish. (Pubmed Central) -  May 30, 2024   
    Interestingly, successive incubation of hydrocortisone and the native ovulation-inducing steroid, progestin (17?,20?-dihydroxy-4-pregnen-3-one, DHP), further enhanced f5 expression in preovulatory follicles. Overall, our results indicate that the dramatic increase of f5 expression in preovulatory follicles is partially attributable to the regulation of glucocorticoid and Gr.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Preclinical, Journal, IO biomarker:  Effect of Shoutai Pills on expression of key glycolytic proteins and apoptosis related factors at maternal fetal interface in mouse model of threatened abortion with syndrome of kidney deficiency (Pubmed Central) -  May 30, 2024   
    At 16:00 every day, mice in the normal group were administrated with an equal volume of distilled water, while those in the model, Shoutai Pills, and dydrogesterone groups were administrated with hydrocortisone solution by gavage for 4 consecutive days...On day 6, mice were administrated with mifepristone by gavage to establish the model of kidney deficiency-induced abortion...Compared with the model group, dydrogesterone and Shoutai Pills reduced the apoptosis rate(P<0.05). In conclusion, Shoutai Pills can reduce the embryo loss rate and protect embryos by promoting aerobic glycolysis at the maternal-fetal interface and inhibiting the apoptosis of trophoblasts in mice.
  • ||||||||||  hydrocortisone / Generic mfg., desmopressin / Generic mfg.
    CLINICAL CHARACTERISTICS AND LITERATURE REVIEW OF 17 PATIENTS WITH IgG4-RELATED HYPOPHYSITIS () -  May 29, 2024 - Abstract #EULAR2024EULAR_4469;    
    All patients exhibited decreased ADH levels, suggesting that measuring hormone levels in IgG4-RD patients may prevent potential pituitary lesions from being overlooked. Maintenance therapy with glucocorticoids was administered to most patients, contributing to a low relapse rate.
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron, Proctofoam (pramoxine) / Viatris
    Review, Journal:  Chronic Pruritus: A Review. (Pubmed Central) -  May 29, 2024   
    Chronic pruritus can adversely affect quality of life and can be categorized into inflammatory, neuropathic, or a combined etiology. First-line therapies are topical steroids for inflammatory causes, such as hydrocortisone (2.5%) or triamcinolone (0.1%); topical neuropathic agents for neuropathic causes, such as menthol or pramoxine; and combinations of these therapies for mixed etiologies of chronic pruritus.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Corticosteroids hypersensitivity  (Poster Zone) -  May 25, 2024 - Abstract #EAACI2024EAACI_2870;    
    Additionally, information regarding cross-reactivity among different CST is limited. This emphasizes the importance of conducting a thorough workup to find safe alternatives and avoid unnecessary restrictions.
  • ||||||||||  progesterone / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  Linear growth in children and adolescents with congenital adrenal hyperplasia. (Pubmed Central) -  May 15, 2024   
    Quality auxological monitoring can avoid phases of growth suppression. New therapy with CRH receptor antagonists may lead to a more nuanced approach by allowing fine tuning of hydrocortisone replacement without the need to suppress ACTH secretion.
  • ||||||||||  Journal:  Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility. (Pubmed Central) -  May 9, 2024   
    Our study registers a day-night rhythm in chromatin accessibility that accompanies diurnal cycles in ventricular myocytes. Our approaches directly implicate the cardiac GR in the myocyte excitability rhythm and mechanistically link the ZT12 surge in glucocorticoids to intrinsic VA propensity at this time.
  • ||||||||||  hydrocortisone / Generic mfg.
    Biomarker, Journal:  Predictors of bone mineral density in patients receiving glucocorticoid replacement for Addison's disease. (Pubmed Central) -  May 7, 2024   
    Standard HC substitution does not considerably accelerate BMD loss in AD patients and their serum BTMs: CTX, osteocalcin, sclerostin, DKK-1, and ALP activity remain within the reference ranges. Independent predictors of low lumbar spine BMD, especially ALP activity, serum CTX and sclerostin, might be monitored during GC substitution.