- |||||||||| CAR-20/19-T Cells / Medical College of Wisconsin, Miltenyi Biotec
Adaptive Manufacturing of LV20.19 CAR T-Cells for Relapsed, Refractory Mantle Cell Lymphoma (SDCC - Room 6A) - Nov 3, 2023 - Abstract #ASH2023ASH_5208;
P1/2
Adaptive MF enriched the final product with higher percentages of T-SCM/T-CM CAR cells and allowed most pts to receive CAR-T cells within 8 days of apheresis. Dual targeting of CD20 and CD19 with CAR-T cells may improve outcomes in pts with relapsed, refractory MCL.
- |||||||||| Outcome of Newly Diagnosed Children and Adolescents with Localized Lymphoblastic Lymphoma Treated on JPLSG-LLB-NHL03 Trial: A Report from the Japan Children's Cancer Group (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_3969;
Treatment consisted of 5 phases: induction (prednisolone 60mg/m 2 , day 0-27; vincristine 1.5mg/m 2 , day0,7,14,21; cyclophosphamide 1g/m 2 , day 0; daunorubicin 30mg/m 2 , day 0,7; E.coli L-asparaginase 6,000 units/m 2 , 9 total doses, and intrathecal methotrexate and hydrocortisone, day 0,14), consolidation (mercaptopurine 60mg/m 2 , day 0-27; cyclophosphamide 500mg/m 2 , day0,14; cytarabine 75mg/m 2 , 12 total doses and intrathecal therapy methotrexate and hydrocortisone, day 0,14) , CNS prophylaxis (high dose methotrexate 3g/m 2 , day0,7,14; and intrathecal methotrexate and hydrocortison, day 0. Standard leucovorin dosing, 15mg/m 2 intravenous every 6h, is delivered 36h after the start of the methotrexate infusion and is continued until methotrexate levels are less than 0.1
- |||||||||| Blincyto (blinatumomab) / Astellas, Amgen, Besponsa (inotuzumab ozogamicin) / Pfizer, UCB
Phase 2 Trial of Mini-Hyper-CVD Plus Inotuzumab Ozogamicin, with or without Blinatumomab, in Older Patients with Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic L... (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_3829;
Eight doses of rituximab 375mg/m 2 were given on D1, 8 of C1-4 if CD20 was =20% by flow cytometry...Ursodeoxycholic acid was given to all patients...Maintenance was initially with vincristine 2mg D1, prednisolone 50mg daily D1-5, 6-mercaptopurine 50mg BID & MTX 10mg/m 2 weekly (POMP) for three years...Conclusion Older patients with ND Ph-negative ALL treated with mHCVD plus InO, with or without blina had excellent response rates and deep remissions. However, further adjustment of the regimen is needed, especially in patients =70 years.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
Retrospective Review of Patients Treated with Intrathecal Rituximab for Primary and Secondary CNS Lymphoma and Leukemia (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_2194;
This patient developed tightening of the throat, flushing, and toe numbness after the first IT rituximab and symptoms resolved with administration of hydrocortisone and diphenhydramine. The use of IT rituximab appears safe and showed promising activity in B cell malignancies, specifically as part of induction in patients with leptomeningeal disease and PCNSL as those patients achieved cytologic response.
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Review, Journal: Role of Postnatal Corticosteroids in the Treatment or Prevention of Bronchopulmonary Dysplasia. (Pubmed Central) - Oct 30, 2023
It is seen that the use of hydrocortisone in the early period does not cause negative neuromotor development, but it cannot prevent the development of BPD as much as dexamethasone. All intensive care units must have their steroid protocol for BPD and use steroids in cases when the BPD development scale score is >60-65% and should have a goal of trying to keep the cumulative dose at the lowest level.
- |||||||||| hydrocortisone / Generic mfg.
Journal, CAR T-Cell Therapy: Intrathecal hydrocortisone for treatment of children and young adults with CAR T-cell immune-effector cell-associated neurotoxicity syndrome. (Pubmed Central) - Oct 28, 2023
We present five pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) who had progressively worsening ICANS despite systemic steroids, and received intrathecal hydrocortisone with rapid reversal of ICANS. Therapeutic lumbar punctures are routinely used in upfront ALL therapy in pediatrics, with a demonstrable safety profile, thus use of intrathecal hydrocortisone merits further prospective studies in patients with severe ICANS.
- |||||||||| hydrocortisone / Generic mfg.
Review, Journal: Sepsis and Adrenal Insufficiency. (Pubmed Central) - Oct 22, 2023
These studies have universally demonstrated reduced duration of shock, though the effects of corticosteroids on mortality have been inconsistent, and their use has been associated with adverse effects including hyperglycemia, neuromuscular weakness, and an increased risk of infection. In this article, we aim to provide a thorough, evidence-based, and practical review of the current recommendations for the diagnosis and management of patients with sepsis who develop CIRCI, explore the controversies surrounding this topic, and highlight what lies on the horizon as new evidence continues to shape our practice.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Impact of Newborn Screening on Adult Height in Patients with Congenital Adrenal Hyperplasia (CAH). (Pubmed Central) - Oct 22, 2023
In this article, we aim to provide a thorough, evidence-based, and practical review of the current recommendations for the diagnosis and management of patients with sepsis who develop CIRCI, explore the controversies surrounding this topic, and highlight what lies on the horizon as new evidence continues to shape our practice. Our data suggest that newborn screening might be associated with improved NAH in male CAH patients and in patients with simple-virilizing CAH.
- |||||||||| hydrocortisone / Generic mfg.
Journal: ChAdOx1 SARS-CoV-2 vaccination: A putative precipitant of adrenal crises. (Pubmed Central) - Oct 22, 2023
In individuals with adrenal insufficiency, adverse reactions to the initial dose of the ChAdOx1 SARS-CoV-2 vaccination can precipitate adrenal crises. We recommend that patients with AI should immediately increase their maintenance glucocorticoid dosage 2-3 fold on experiencing any symptoms in the initial 24?h following vaccination.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
Journal: Characteristics and predictors of infusion-related reactions to rituximab in patients with B-cell non-Hodgkin lymphoma. (Pubmed Central) - Oct 20, 2023
The multivariate analysis identified indolent lymphoma [OR 1.90, p?=?0.025], no hydrocortisone as premedication [OR 3.03, p?=?0.029], thrombocytopenia [OR 2.55, p?=?0.009], and absolute lymphocyte count ? 2000 lymphocytes/microL [OR 1.74, p?=?0.045] as independent predictors for IRRs.
- |||||||||| Isturisa (osilodrostat) / Novartis, Recordati
Journal: Severe Cushing's syndrome from an ectopic adrenocorticotropic hormone-secreting neuroendocrine tumour treated by osilodrostat. (Pubmed Central) - Oct 19, 2023
Pharmacotherapy of hypercortisolism by ketoconazole, metyrapone and osilodrostat is currently available...Transient hypocortisolism during treatment appeared but was easily treated by hydrocortisone...Rapid treatment is a key for preventing and reducing complications such as fractures, thromboembolism, bleeding, hyperglycaemia, and arterial hypertension. The novel potent steroidogenesis inhibitor osilodrostat can be used as first-line treatment for reducing hypercortisolism.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Glucocorticoid Replacement for Adrenal Insufficiency and the Development of Non-Alcoholic Fatty Liver Disease. (Pubmed Central) - Oct 14, 2023
We could not find any significant correlations between single, daily or cumulative doses of glucocorticoids and the grade of liver steatosis, nor with fibrosis measured via validated sonographic techniques. In patients with adrenal insufficiency, glucocorticoid replacement within a physiological range of 15-25 mg hydrocortisone equivalent per day does not appear to pose an additional risk for the development of NAFLD, subsequent liver fibrosis, or the cardiovascular morbidity associated with these conditions.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Gastric perforation secondary to incarcerated para-esophageal hiatal hernia in a French bulldog. (Pubmed Central) - Oct 8, 2023
Post-operative care required treatment for septic shock including vasopressor and hydrocortisone infusions and plasma transfusions for colloidal support...Gastric perforation and peritonitis can occur secondary to an incarcerated esophageal hiatal hernia, and if treated promptly can result in a successful outcome. This case demonstrates a novel etiology of gastric perforation which may be associated with brachycephalic breeds.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Multi-Residue Detection of Eight Glucocorticoids by Nano-Au/Fluticasone Propionate Electrochemical Immunosensor. (Pubmed Central) - Oct 2, 2023
The immunosensor presents attractive electrochemical performance with a wide linear range (between 0.1 and 1500 ng?mL) and low detection limit (between 0.057 and 0.357 ng?mL), realizing the rapid multi-residue detection of a large class of glucocorticoids. Two glucocorticoids (hydrocortisone, triamcinolone) were detected in actual skincare samples, which obtained satisfactory detection results.
- |||||||||| aspirin / Generic mfg., hydrocortisone / Generic mfg., ibuprofen / Generic mfg.
Journal: Self-Healing Oxalamide Organogelators of Vegetable Oil. (Pubmed Central) - Sep 27, 2023
The oxalamide gelators showed thermoreversible and thixotropic properties in vegetable oils with a minimum gelation concentration of just 0.025 wt%. The substitution of palm fats with gelled sunflower oil applied in cocoa and milk spreads at gelator concentrations lower than 0.2 wt% have shown promising viscoelastic properties compared to that of the original food products.
- |||||||||| hydrocortisone / Generic mfg.
Preclinical, Journal: Sex-based impact of pancreatic islet stressors in GluCreERT2/Rosa26-eYFP mice. (Pubmed Central) - Sep 26, 2023
The present study examines differences in metabolic and pancreatic islet adaptative responses following streptozotocin (STZ) and hydrocortisone (HC) administration in male and female transgenic GluCreERT2/Rosa26-eYFP mice...The number of glucagon-positive alpha-cells altering their lineage to insulin-positive beta-cells was increased in male, but not female, STZ mice. Taken together, although there was no obvious sex-specific alteration of metabolic profile in STZ or HC mice, subtle differences in pancreatic islet morphology emphasises the impact of sex hormones on islets and importance of taking care when interpreting observations between males and females.
- |||||||||| hydrocortisone / Generic mfg., propylthiouracil / Generic mfg., labetalol / Generic mfg.
THYROTOXICOSIS IN PARTIAL MOLAR PREGNANCY, DIAGNOSTIC CHALLENGES AND THERAPEUTIC IMPLICATIONS () - Sep 20, 2023 - Abstract #ATA2023ATA_683;
Partial moles have a triploid karyotype resulting from fertilization of an ovum and two sperms, and their intact fetal tissue with focal hydropic villi, leads to delayed diagnosis (3). Therefore, in thyrotoxicosis and first?trimester bleeding with known triploid fetus, consideration of partial molar pregnancy is crucial for prompt medical intervention and dilation and curettage as definitive management.
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
TIME IS OF THE ESSENCE: MEDULLARY THYROID CANCER WITH ECTOPIC CUSHING'S SYNDROME: A CASE REPORT () - Sep 20, 2023 - Abstract #ATA2023ATA_573;
He received stress dose of steroids in OR and was placed on maintenance hydrocortisone therapy following his surgery which resulted a significant improvement in his symptoms.Time is of the essence in the management of ectopic ACTH syndrome with overt hypercortisolism. Due to the rarity of this disease, and lack of established guidelines, one should maintain high index of suspicion to ensure timely diagnosis and involvement of experienced multidisciplinary team to adapt the best therapeutic approach and prevent complications(1).
- |||||||||| RIDING THE STORM? A CASE OF THYROTOXICOSIS ENCEPHALOPATHY SECONDARY TO SOLITARY TOXIC ADENOMA () - Sep 20, 2023 - Abstract #ATA2023ATA_568;
The incidence of thyroid storm ranges from 0.56 to 0.76/100,000 persons per year and is lower when associated with subclinical hyperthyroidism secondary to a solitary toxic adenoma...However, all evidence pointed towards solitary toxic adenoma as causative. This case highlights the necessity of close follow?up of subclinical hyperthyroidism and early management with thionamides, radioactive iodine or surgery.
- |||||||||| amiodarone / Generic mfg.
WHEN ALL ELSE FAILS () - Sep 20, 2023 - Abstract #ATA2023ATA_533;
Severe thyrotoxicosis and thyroid storm refractory to medical therapy are indications for advanced treatment mechanisms such as SPAD. We would like to express in our opinion that SPAD continues to be a highly effective methodology and that it should be utilized more frequently and earlier to limit and avoid morbidity and mortality subsequent to thyroid storm.
- |||||||||| CHALLENGES IN THE MANAGEMENT OF GRAVES' DISEASE COINCIDING WITH AML () - Sep 20, 2023 - Abstract #ATA2023ATA_531;
Shortly thereafter, the patient started induction chemotherapy.Methimazole was discontinued in the presence of anticipated neutropenia, however it was restarted at a lower dose with the addition of cholestyramine due to worsening hyperthyroidism and in anticipation of count recovery...With persistent hyperthyroidism, the patient was transitioned to hydrocortisone with continued use of cholestyramine and propranolol...This complex case illustrates the tremendous importance of assessing the anticipated risks and benefits and understanding the unique limitations of treatment in a patient with Graves' disease requiring cytotoxic chemotherapy for AML. We highlight the importance of strict lab monitoring and consideration of second and third?line therapies in these cases.
- |||||||||| hydrocortisone / Generic mfg., propylthiouracil / Generic mfg., labetalol / Generic mfg.
THYROTOXICOSIS IN PARTIAL MOLAR PREGNANCY, DIAGNOSTIC CHALLENGES AND THERAPEUTIC IMPLICATIONS () - Sep 20, 2023 - Abstract #ATA2023ATA_331;
Partial moles have a triploid karyotype resulting from fertilization of an ovum and two sperms, and their intact fetal tissue with focal hydropic villi, leads to delayed diagnosis (3). Therefore, in thyrotoxicosis and first?trimester bleeding with known triploid fetus, consideration of partial molar pregnancy is crucial for prompt medical intervention and dilation and curettage as definitive management.
- |||||||||| hydrocortisone / Generic mfg.
Preclinical, Journal: Effects of CBD (Cannabidiol) on the physiology of Nile tilapia (Oreochromisn niloticus) as a chronic stress mitigating agent In-vivo. (Pubmed Central) - Sep 19, 2023
Tilapia were fed with and without CBD (0.001% of feed weight) and with and without hydrocortisone stress hormone (0.01% of body weight) every day for four weeks...Although not significant, the stress reducing effect of CBD on stress biomarkers such as glucose and HSI also seemed promising. Further investigation into the matter may not just be useful in stress mediation in aquatic organisms but may also have implications in human medicine as well.
- |||||||||| hydrocortisone / Generic mfg.
A Case of Aquagenic Palmoplantar Keratoderma In A School-Aged Male (Monitor 09) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_848;
He was initially evaluated by Pediatric Dermatology, diagnosed with atopic dermatitis(AD), and prescribed hydrocortisone which alleviated his AD symptoms...Discussion APK pathophysiology is not well known and is thought to be related to aberrant sweat ducts. It can occur sporadically or in families and should be considered in refractory hand and food dermatitis that worsens with water exposure.
- |||||||||| hydrocortisone / Generic mfg.
DAVID Syndrome Associated With Common Variable Immunodeficiency (Monitor 05) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_823;
She was started on hydrocortisone replacement with physiologic doses for life...There is variable severity and manifestations including recurrent respiratory infections, asthma, nephrotic syndrome, hypoplastic anterior pituitary, central adrenal insufficiency, recurrent infections, hypogammaglobulinemia, low memory B cells, and autoimmune diseases. In this case, initial immunological abnormalities were thought to be due to prolonged use of steroids, however further investigation revealed genetic cause, that ultimately changed management of the disease.
- |||||||||| diphenhydramine / Generic mfg., hydrocortisone / Generic mfg.
Allergic Reaction to PEG Asparaginase with Successful Desensitization (Monitor 02) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_809;
Hypersensitivity reactions are associated with neutralizing antibody formation, and lower asparaginase levels and therefore worse outcomes. Though desensitization to PEG-asparaginase includes risk of serious allergic reaction, the benefit of improved outcome often outweighs this risk when desensitization is performed in a closely observed and controlled environment.
- |||||||||| hydrocortisone / Generic mfg.
Variable Expression Of The AIRE Gene In Autoimmune Polyglandular Syndrome Type 1 (Monitor 06) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_651;
Subsequently, his father was found to have the same heterozygous pathogenic variant, although he only has chronic cutaneous candidiasis. Discussion Through this case, we highlight that our patients with heterozygous pathogenic variants of the AIRE gene developed significant symptoms with variable expression within the same family.
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