- |||||||||| hydrocortisone / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: ROSES: Role Of Sensitivity to neuroEndocrine Systems in Social Decisions (clinicaltrials.gov) - Mar 2, 2024
P4, N=104, Not yet recruiting,
Trial completion date: Mar 2025 --> Jul 2025 | Initiation date: Mar 2024 --> Jul 2024 | Trial primary completion date: Mar 2025 --> Jul 2025
- |||||||||| hydrocortisone / Generic mfg.
The Long Reach of Prematurity - New Findings (Metro Toronto Convention Centre: 201 F) - Mar 1, 2024 - Abstract #PAS2024PAS_1935;
Learning Objectives: Upon completion, participants will be able to describe various outcomes of preterm infants Upon completion, participants will be able to develop a procedure for predicting academic performance in late preterm infants. Upon completion, participants will be able to weigh the benefits versus the costs of prophylactic hydrocortisone use in extremely preterm infants.
- |||||||||| hydrocortisone / Generic mfg.
Early Uses of Hydrocortisone Among Preterm Infants (Metro Toronto Convention Centre: 105) - Mar 1, 2024 - Abstract #PAS2024PAS_533;
Upon completion, participants will be able to weigh the benefits versus the costs of prophylactic hydrocortisone use in extremely preterm infants. Selected By: Neonatal.
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Systemic Corticosteroid Use in Neonates: Contemporary Controversies and Current Evidence (Metro Toronto Convention Centre: 105) - Mar 1, 2024 - Abstract #PAS2024PAS_531;
Recent trends suggest growing use of hydrocortisone (HCTZ) among preterm infants...Moreover, renewed interest in the potential value of dexamethasone as an alternative to HCTZ warrants careful consideration...Determine the strengths and limitations of evidence for systemic corticosteroid use among preterm infants. Discuss the need for clinical equipoise regarding treatment options, highlighting the value of pragmatic clinical trials to inform the practice of equity-focused, evidence-based medicine.
- |||||||||| pentoxifylline / Generic mfg., hydrocortisone / Generic mfg., dexamethasone injection / Generic mfg.
Review, Journal: Interventions for managing oral submucous fibrosis. (Pubmed Central) - Feb 28, 2024
High-quality, adequately powered intervention trials with a low risk of bias that compare biologically plausible treatments for OSF are needed. It is important that relevant participant-reported outcomes are evaluated.
- |||||||||| Sulonex (sulodexide) / Alfasigma, Enbrel (etanercept) / Pfizer, Amgen
Journal, Surgery: The significance of glycocalyx in surgery. (Pubmed Central) - Feb 25, 2024
No abstract available Further research needs to be performed to evaluate the effect of endothelium-protectives on glycocalyx damage prevention and repair in ischaemia and reperfusion models involving large laboratory animals or in clinical trials in patients undergoing surgical revascularisation procedures.
- |||||||||| Ninlaro (ixazomib) / Takeda
Enrollment closed, Trial completion date, Trial primary completion date, Combination therapy: T2017-002: PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (clinicaltrials.gov) - Feb 21, 2024
P1/2, N=31, Active, not recruiting,
Further research needs to be performed to evaluate the effect of endothelium-protectives on glycocalyx damage prevention and repair in ischaemia and reperfusion models involving large laboratory animals or in clinical trials in patients undergoing surgical revascularisation procedures. Recruiting --> Active, not recruiting | Trial completion date: Jun 2024 --> Jun 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
- |||||||||| cetirizine oral / Generic mfg., hydrocortisone / Generic mfg., fluticasone / Generic mfg.
Intracranial Hypertension as an Initial Sign of Adrenal Insufficiency Secondary to Inhaled Corticosteroids in a Child With Asthma (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6526;
9 mL daily, and cetirizine 10 mg daily...She gradually improved and was successfully extubated on day 4 and discharged home on a 2-week hydrocortisone taper...Unfortunately, there is more systemic absorption than originally understood. It is important to increase awareness of the risk and emphasize the importance of utilizing the minimal effective dose of ICS.
- |||||||||| Tezspire (tezepelumab-ekko) / AstraZeneca, Amgen, Xolair (omalizumab) / Roche, Novartis
A Combination of Tezepelumab and Omalizumab for Severe Persistent Asthma (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5640;
A while Later she was started on Azathioprine and Theophylline which showed a good effect with decreased exacerbations...Subsequently, she was desensitized to IV hydrocortisone which helped in managing her acute exacerbations, and then desensitized to oral prednisolone and kept on it chronically which helped in preventing her exacerbations...DiscussionSince Tezepelumab was added to the regimen along with Omalizumab, the patient had fewer exacerbations to 2 times/year compared to the previous year with 6 exacerbations. Theophylline was stopped completely, and prednisolone was tapered to 5 mg daily, hoping that it could be stopped completely in the near future.
- |||||||||| hydrocortisone / Generic mfg.
The Silent Intruder: Recognizing Pituitary Metastasis in Small Cell Lung Cancer (San Diego Convention Center, Area J (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4516;
He was given hydrocortisone, but progressively worsened despite maximum support...Hormone replacement therapy can be used in hypopituitarism and chemotherapy to the primary malignancy can be considered. Unfortunately, the prognosis remains poor, with an average survival of six months and an overall mortality rate of 90%.
- |||||||||| dexamethasone / Generic mfg., prednisone / Generic mfg., hydrocortisone / Generic mfg.
Impact of Corticosteroids on Cardiovascular Events in Critically Ill Patients With COVIDd-19 (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4104;
Our results suggest that SCS may potentially improve individual CVE such as new heart failure and acute coronary syndrome, but not the CVE composite outcome, arrhythmia and all-cause mortality when compared to no-SCS. Further studies should address the mechanisms of why SCS may impact cardiovascular outcomes.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Dupilumab-Induced Hyper-Eosinophilia: A Call for Treatment Guideline (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3796;
04 mcg/min and hydrocortisone 50 mg every 6 hours (MAP >65mmHg)...This case highlights the importance of steroids in resolving dupilumab-induced hyper-eosinophilia and its sequelae including possibly anaphylaxis4. In short, more research is needed to guide monitoring, classifying the severity of dupilumab-induced hyper-eosinophilia, and a consensus on treatment.
- |||||||||| Imfinzi (durvalumab) / AstraZeneca
Durvalumab Induced Pneumonitis: A Case Report (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3786;
Patient was ultimately discharged on prednisone 40 mg twice daily with a slow, prolonged taper...Steroids with a long, low taper are used for grade 2-4 disease, with infliximab and mycophenolate mofetil reserved for grade 3-4 toxicity refractory to steroids. Although Immune Checkpoint Inhibitors can also cause delayed Radiation Pneumonitis (RP), RP is more commonly limited to the radiation field.
- |||||||||| Challenging Diagnosis and Management of Disseminated Histoplasmosis With Coexistent Adrenal Insufficiency (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3508;
Hydrocortisone and fludrocortisone were initiated due to suspected adrenal insufficiency in the setting of disseminated histoplasmosis and steroid dependence for her autoimmune hemolytic anemia...The patient's respiratory status continued to improve, and she was discharged later on oral Itraconazole and a close follow-up with Infectious Disease...Disseminated histoplasmosis can present with adrenal insufficiency, which may be overlooked, emphasizing the need for assessing adrenal function. Untreated Disseminated Histoplasmosis has a mortality of more than 50% necessitating the need for early diagnosis and timely management.
- |||||||||| methimazole / Generic mfg., hydrocortisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Double Trouble: When Myasthenia Gravis Crisis and Thyroid Storm Collide (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3360;
When physicians are faced with MGC, TS needs to be in the back of their minds with emphasis that laboratory markers of thyroid function are not always reflective of the clinical picture. Early diagnosis of thyroid storm is important to start aggressive treatment to reduce mortality.
- |||||||||| Opdivo (nivolumab) / BMS
Nivolumab Induced Myxedema Coma (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3353;
25), urine toxicology screen was positive for fentanyl and benzodiazepines, normal cortisol level of 13...He was supported with bilevel positive airway pressure ventilation, and the hyperkalemia was temporized with furosemide, insulin, and calcium gluconate...He was given hydrocortisone 50 mg every 6 hours and levothyroxine load of 200 mcg with subsequent improvement of acute kidney injury, hypercarbic respiratory failure, and encephalopathy within 24 hours...It carries a high mortality rate of 20-29. 5%, often in part due to delay in diagnosis.
- |||||||||| A Thyroid Tempest: Digitally Navigating a Bloody Storm (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3350;
Upon further medication reconciliation, the patient was noted to be on Methimazole as an outpatient and had a recent reduction in therapy...Gaps in HIE, when providers work in silos, are detrimental to patient care, as essential information may be lost if patients and family members are unable to fully disclose their medical history and medications. The use of electronic health records ultimately improves the quality, accuracy, and timeliness of patient information at the point of care.
- |||||||||| amiodarone / Generic mfg.
Thyroid Tempest: Unravelling a Rare Case of Amiodarone-Induced Thyroid Storm (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3342;
Initial treatment with intravenous fluids, diltiazem, and metoprolol tartrate was ineffective...Diagnosed with thyroid storm (TS), she was started on hydrocortisone, propylthiouracil, and esmolol...She was switched from propylthiouracil to methimazole, and amiodarone was discontinued, leading to the worsening of her tachycardia...Standard treatment involves beta-blockers, typically propranolol...However, when LFTs deteriorated, we stopped the medication. This case underscores the challenges of diagnosing and treating the overlap of AIT and TS, where presentation can mimic cardiogenic shock, emphasizing the importance of a thorough differential diagnosis and individualized care strategy.
- |||||||||| hydrocortisone / Generic mfg.
Injecting Drama: The Shocking Twist of Steroids and the Sodium Slump (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3335;
She was started on hydrocortisone therapy and subsequently exhibited improved blood pressure as well as resolution of her hyponatremia...This can result in dangerously low serum sodium levels. This tandem of steroid-induced adrenal insufficiency and subsequent hyponatremia can present as a perplexing and challenging clinical conundrum, as is presented in this case, but should be considered in patients receiving these types of local injections for chronic pain syndromes.
- |||||||||| Lost in the Mix: A Challenging Diagnosis of Myxedema Coma in an Elderly Patient (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3334;
Patient developed hypotension intra-operatively for which he was put on nor-epinephrine...Patient required mechanical ventilation and was initiated on levothyroxine 200 mg stat followed by 50 mcg daily and hydrocortisone 50 mg IV 6 hourly...Factors like hypotension, bradycardia, need for mechanical ventilation, hypothermia unresponsive to treatment, sepsis, low Glasgow coma scale, advanced age and cardiovascular disease are associated with increased mortality in myxedema coma. To improve the patient outcomes, myxedema coma should be considered early in any patient who presents with altered mental state, hypothermia and hypotension irrespective of prior thyroid functions.
- |||||||||| Cold and Confused: A Case of Suspected Adrenal Insufficiency After COVID-19 (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3332;
The decision was made to initiate maintenance glucocorticoid therapy and levothyroxine...Although short-term corticosteroid treatment does not typically lead to adrenal insufficiency, it can occur even with low doses in select individuals (Scaroni 2020). Our patient's advanced age and comorbid conditions in the setting of recent hospitalization with COVID-19 infection likely predisposed her to hypothalamic-pituitary-adrenal axis suppression from steroid dosing.
- |||||||||| thyroxine / Generic mfg., hydrocortisone / Generic mfg.
Myxedema Coma: The Master of Disguise (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3330;
Early and aggressive management of myxedema coma is important for better patient outcomes. It is essential to keep myxedema coma in our mind as a differential, especially in patients with a known history of hypothyroidism with an insidious presentation.
- |||||||||| hydrocortisone / Generic mfg.
Salt, Seizures and SIADH: Pituitary (macro)adenoma and Symptomatic Hyponatremia (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3328;
He was treated with hydrocortisone and thyroid replacement...This case report highlights a severe acute presentation without other neurohormonal symptoms, and serves as a reminder to this uncommon etiology. This also emphasizes the need for thorough workup and continued co-management involving specialists including endocrinology, ophthalmology, and neurosurgery to prevent further complications.
- |||||||||| hydrocortisone / Generic mfg.
Severe Diabetic Ketoacidosis Resulting in Refractory Shock and Stress Cardiomyopathy (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3325;
Hydrocortisone 50 mg IV q6 hours, started on admission, was discontinued on day 1 given severe hyperglycemia...Shock in DKA is often attributed to common causes such sepsis and hypovolemia. Early recognition of alternate etiologies impacts management and outcomes, and should be considered in patients with severe DKA and refractory shock.
- |||||||||| hydrocortisone / Generic mfg.
Perplexing Pituitary (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_3323;
Early neurosurgical intervention is necessary to address visual impairment, mass effect upon the brain, or persistent hormonal dysfunction3. While rare, pituitary apoplexy should be considered as part of the differential in a patient with hemodynamic compromise, headaches, visual deficits, or hormonal deficits.
- |||||||||| Mekinist (trametinib) / Novartis, BeiGene
Trametinib and Lymphangiectasia in Noonan Syndrome: A Success Story (San Diego Convention Center, Area J (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1851;
Herein, we report the successful off label use of trametinib to manage symptomatic lymphangiectasia, refractory to any other medical intervention. This report participates to the scarce but growing evidence for use of MEK inhibitors in management of lymphangiectasia in patients with NS.
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
Acute Hypoxic Respiratory Failure Secondary to Daptomycin-induced Eosinophilic Pneumonia (San Diego Convention Center, Area A (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1591;
A 6-week course of daptomycin and ceftriaxone was recommended by infectious disease, followed by long-term suppressive therapy with trimethoprim and sulfamethoxazole...Antibiotics were promptly changed to vancomycin and zosyn, and the patient was started on hydrocortisone 100mg twice daily for probable daptomycin-induced pulmonary toxicity...With rapid identification and cessation, this patient was able to avoid further pulmonary complications. Clinicians should be aware of this complication and include daptomycin-induced eosinophilic pneumonia in their differential diagnosis in the appropriate clinical context.
- |||||||||| hydrocortisone / Generic mfg.
Role of Methylene Blue in Patients With Refractory Shock (San Diego Convention Center, Area K (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_1181;
On arrival, the patient was found to be in refractory shock with rapidly progressive vasopressor requirements despite maximum support with 4 pressors along with stress dose hydrocortisone and broad-spectrum antibiotics...Our case highlights the utility of using methylene blue as a last resort in these patients with overwhelming shock with vasoplegia. Further studies are needed to evaluate the benefit of methylene blue administration in refractory shock with vasoplegia.
- |||||||||| hydrocortisone / Generic mfg.
Opening the Pandora's Box: Unveiling Severe Immune Dysregulation and Coinfections in an HIV-positive Male (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_973;
A multidisciplinary approach, including ART optimization, tailored antimicrobial therapy, and careful consideration of chemotherapy, is crucial to establish a delicate balance in care. The patient's recurrent admissions further underscore the multifaceted nature of managing advanced HIV and its complications.
- |||||||||| hydrocortisone / Generic mfg.
Journal: A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging. (Pubmed Central) - Feb 16, 2024
To understand the role of diffusion and partition coefficient on drug permeation, four drugs, namely hydrocortisone, trans-cinnamic acid, caffeine, and benzoic acid, are considered...Desirable drug characteristic is inferred to be a lower value of partition coefficient and a higher value of diffusion coefficient. This study could lead to real-time assessment of drugs reaching the bloodstream and beyond.
- |||||||||| Clinical, Review, Journal: Treatment and Prevention of Post-dural Puncture Headaches: A Systematic Review. (Pubmed Central) - Feb 16, 2024
On the other hand, neither neuraxial morphine nor epidural dexamethasone showed promising results...Epidural blood patches remain the more invasive but the gold standard and ultimate solution in patients resisting medical therapy. This study highlights the need for larger research to define the best approach to prevent and treat PDPH.
- |||||||||| hydrocortisone / Generic mfg.
Journal: A Rare Presentation of Homozygous Pathogenic Variant in MC2R Gene with Salt-Wasting Crisis in a Neonate. (Pubmed Central) - Feb 15, 2024
The patient was diagnosed as having primary adrenal insufficiency (PAI) with elevated plasma adrenocorticotropin hormone and reduced cortisol levels and hydrocortisone...FGD due to MC2R gene mutation may rarely present with a salt-wasting crisis in the neonatal period. Identifying the causative gene with the pathogenic variant in PAI may serve to individualize a treatment plan.
- |||||||||| Blincyto (blinatumomab) / Astellas, Amgen
USE OF BLINATUMOMAB TO ACHIEVE REMISSION AND CONSOLIDATION WITH HAPLOIDENTICAL TRANSPLANT WITH CYCLOPHOSPHAMIDE FOR THE TREATMENT OF CHILDREN WITH REFRACTORY ACUTE LYMPHOBLASTIC LEUKEMIA (ePoster area) - Feb 14, 2024 - Abstract #EBMT2024EBMT_2808;
As a strategy to achieve remission was used blinatumomab a dose 5 ?g/m2 for continous infusion of 48 hours during 7 days, increasing the dose to 15 ?g/m2 during 28 days, all patients received triple intrathecal therapy with methotrexate, arabinocide and hydrocortisone, two weeks after each cycle of blinatumomab, All patients received blinatumumab cycles hospitalized, during their stay the toxicity data related to blinatumumab was evaluated every day. The use of 2 cycles of blinatumumab is an efficient and safe strategy to achieve remission in children with relapsed/refractory ALL+19, consolidation with transplant is an efficient therapy, haploidentical transplant is an easily accessible and efficient strategy to consolidate to this group of patients in middle-income countries
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