- |||||||||| hydrocortisone / Generic mfg.
Biomarker, Journal: Predictors of bone mineral density in patients receiving glucocorticoid replacement for Addison's disease. (Pubmed Central) - May 7, 2024
Standard HC substitution does not considerably accelerate BMD loss in AD patients and their serum BTMs: CTX, osteocalcin, sclerostin, DKK-1, and ALP activity remain within the reference ranges. Independent predictors of low lumbar spine BMD, especially ALP activity, serum CTX and sclerostin, might be monitored during GC substitution.
- |||||||||| hydrocortisone / Generic mfg.
Trial completion date, Trial primary completion date: INSCORT: Treatment Study in Patients Treated With Both Insulin & Hydrocortisone (clinicaltrials.gov) - Apr 30, 2024
P=N/A, N=16, Not yet recruiting,
Conclusively, these snow-lantern cCVD Si particles do indeed appear suitable for drug delivery. Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Dec 2024 --> Dec 2025
- |||||||||| Simdax (levosimendan IV) / AbbVie
Clinical, Review, Journal: An Update on Pharmacologic Management of Neonatal Hypotension: When, Why, and Which Medication. (Pubmed Central) - Apr 27, 2024
Anti-hypotensive treatment, which includes dopamine, dobutamine, epinephrine, norepinephrine, milrinone, vasopressin, terlipressin, levosimendan, and glucocorticoids, is a long-established intervention in neonates with arterial hypotension (AH)...In this review, after a short review of AH definitions used in neonates and existing data on pathophysiology of AH, we discuss currently available data on pharmacokinetic and hemodynamic effects, as well as the effectiveness and safety of anti-hypotensive medications in neonates. In addition, data on the comparisons between anti-hypotensive medications and current suggestions for the main indications of each medication are discussed.
- |||||||||| hydrocortisone / Generic mfg., acetylcysteine solution / Generic mfg.
Journal: The effects of antioxidant supplementation on short-term mortality in sepsis patients. (Pubmed Central) - Apr 22, 2024
Antioxidant supplements can be a single-drug or multi-drug combination: HAT (hydrocortisone, ascorbic acid, and thiamine), ascorbic acid, thiamine, N-acetylcysteine and selenium. However, the meta-analysis of RCTs found that antioxidant therapy drugs, especially ascorbic acid, did substantially reduce short-term mortality(OR
- |||||||||| Cortone (cortisone acetate) / Merck (MSD)
Journal: Monitoring adrenal insufficiency through salivary steroids: a pilot study. (Pubmed Central) - Apr 22, 2024
SalE, SalF, and Z-score may be useful markers for monitoring and comparing different GRTs. Excess glucocorticoid in early afternoon best associated with depressive symptoms and worse life and sleep quality.
- |||||||||| Advantan (methylprednisolone aceponate) / Bayer
INTERESTING FACT: Delayed systemic allergic reactions to corticosteroids: Clinical symptoms y cross-reactivity (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_2472;
The ST were diagnostic in 37% of cases, two patients by PT with positive readings at D2 and D4 for the culprit drugs (hydrocortisone, budesonide, and methylprednisolone aceponate respectively), IDT were positive in only one patient with the culprit drug (dexamethasone)...The most commonly was intravenous hydrocortisone and oral methylprednisolone, both belonging to group 1...We considered necessary to prove CS from different groups to offer safe alternatives to the patients. None of them presented reactions to two or more groups of CS and although cross-reactivity exists between CS of the same group, all of our patients presented good tolerance.
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Immediate hypersensitivity reactions to corticosteroids: Clinical symptoms and cross-reactivity (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_2454;
Some patients reacted to more than one CS preparation but there are no cases of patients failing to tolerate at least one CS for each route of administration. We consider necessary to establish and validate protocols for testing of both CS themselves as well as the excipient used in various formulations.
- |||||||||| chlorpheniramine / Generic mfg., hydrocortisone / Generic mfg.
Allergy to Ceftazidime/Avibactam: diagnosis and desensitization (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_2450;
Among the limits of this test, there was the lack of possibility to study the effect of avibactam individually, which could increase or reduce the hypersensitivity. In conclusion, this case report highlight: I) the possibility of hypersensitivity reactions to new generation ?-lactam antibiotics, so the need to implement the research and diagnostics both in vivo and in vitro; II) the use of in vitro CFSE lymphocyte proliferation test to demonstrate also immediate reactions, not only for the delayed ones, especially in conditions where it is not possible to make diagnosis in vivo; III) the desensitization protocol used is safe and effective, demonstrating a successful rapid induction of tolerance for the ceftazidime/avibactam antibiotic, concluding the cycle of antibiotic therapy without further adverse reactions.
- |||||||||| hydrocortisone / Generic mfg.
Cytokine release syndrome due to intravenous trastuzumab with tolerance of subcutaneous administration (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_1733;
In conclusion, this case report highlight: I) the possibility of hypersensitivity reactions to new generation ?-lactam antibiotics, so the need to implement the research and diagnostics both in vivo and in vitro; II) the use of in vitro CFSE lymphocyte proliferation test to demonstrate also immediate reactions, not only for the delayed ones, especially in conditions where it is not possible to make diagnosis in vivo; III) the desensitization protocol used is safe and effective, demonstrating a successful rapid induction of tolerance for the ceftazidime/avibactam antibiotic, concluding the cycle of antibiotic therapy without further adverse reactions. She was treated with hydrocortisone, dexchlorpheniramine and pethidine...After obtaining informed consent from the patients, we performed single-blind SC challenge with increasing doses of Phesgo
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Anaphylaxis during chemotherapy: when premedication is the problem (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_1480;
The patient maintained chemotherapy treatments with dexamethasone and AH as premedication without further reactions. We present a case report that highlights the importance of clinical history in allergic workup, emphasizing the potential oversight of unexpected triggers.
- |||||||||| Stelara (ustekinumab) / J&J
Allergy to Ustekinumab (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_1348;
This case report underscores the growing concern regarding mAB hypersensitivity and the need for accurate diagnosis and therapeutic interventions. Skin testing, especially for type I and IV hypersensitivity reactions, may be valuable but standardized testing protocols are still lacking for most mABs.
- |||||||||| hydrocortisone / Generic mfg.
Fatal anaphylaxis to iodinated contrast media (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_1299;
Atopic constitution, history of asthma, older age and use of beta-blockers increase the likelihood of severe allergic reactions, even among patients who have uneventfully undergone imaging in the past. Clinical assessment, risk stratification, and identification of the predisposing factors may lead to more critical patient selection and adequate premedication, and therefore lower the risk of fatal outcome.
- |||||||||| chlorpheniramine / Generic mfg., dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Anaphylaxis due to corticosteroids: a series of cases (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_1284;
He was successfully treated with intramuscular adrenaline. In vitro study showed a baseline tryptase of 5,8 ug/L.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS
Review, Journal, Cytokine release syndrome: Nivolumab-Induced Cytokine Release Syndrome: A Case Report and Literature Review. (Pubmed Central) - Apr 20, 2024
CASE REPORT We report a rare case of grade 3 CRS induced by nivolumab associated with 5-fluorouracil and oxaliplatin for gastric cancer...There was rapid resolution after infusion of hydrocortisone...Nivolumab-induced CRS is rarely described but can be severe and lead to multiple organ dysfunction; therefore, intensive care practitioners should be informed about this adverse effect. More studies are needed to better understand this condition and establish treatment guidelines.
- |||||||||| hydrocortisone / Generic mfg.
Preclinical, Journal: Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells. (Pubmed Central) - Apr 17, 2024
This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney-Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells...The data obtained from this study suggest that CLE could alleviate Kidney-Yang deficiency symptoms and stimulate testosterone production by upregulating the steroidogenic pathway. This research identifies CLE as a potential nutraceutical option for addressing testosterone deficiency diseases.
- |||||||||| Metopirone (metyrapone) / Perrigo Company
Retrospective data, Journal, Surgery: Basal cortisol in relation to metyrapone confirmation in predicting adrenal insufficiency after pituitary surgery. (Pubmed Central) - Apr 15, 2024
Orodispersible films containing flexible and low doses of personalised HC were successfully prepared, and the development of a code generator software oriented to medical use provided an additional, innovative, and revolutionary advantage to personalised medicine safety and accessibility. Early morning plasma cortisol cut-off values lower than 450
- |||||||||| hydrocortisone / Generic mfg.
Review, Journal: Alkindi Sprinkle for Pediatric Patients With Primary Adrenocortical Insufficiency: A Narrative Review. (Pubmed Central) - Apr 12, 2024
AI management primarily involves hormone replacement therapy, typically with oral hydrocortisone and MC supplementation...Alkindi offers several advantages, including accurate dosing, taste masking, and ease of administration. The present investigation describes AI, the management of AI, and the treatment of pediatric AI using Alkindi Sprinkle, including clinical efficacy.
- |||||||||| ODM-208 / Orion Corp, Merck (MSD)
Trial completion date, Trial primary completion date, Metastases: A Study of Opevesostat (MK-5684) in China Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC) (MK-5684-001) (clinicaltrials.gov) - Apr 11, 2024
P1, N=14, Recruiting,
The present investigation describes AI, the management of AI, and the treatment of pediatric AI using Alkindi Sprinkle, including clinical efficacy. Trial completion date: Feb 2026 --> Oct 2027 | Trial primary completion date: Oct 2025 --> Apr 2026
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Review, Journal: When Hormones are Being Difficult: A Rare Case and the Literature Review of Pembrolizumab-Induced Polyendocrinopathy. (Pubmed Central) - Apr 10, 2024
The patient was started on hydrocortisone therapy with improvement in symptoms...Only a few cases of pembrolizumab-induced polyendocrinopathy have been reported so far which we have mentioned in this article. While patients are on immunotherapy, close monitoring for clinical signs & symptoms can lead to an early diagnosis, substantially improving morbidity and mortality.
- |||||||||| Zoryve foam (topical roflumilast foam) / Arcutis, Daliresp (roflumilast) / AstraZeneca, Takeda, AbbVie, Zoryve (roflumilast cream) / Arcutis
Journal: Roflumilast foam (Zoryve) for seborrheic dermatitis. (Pubmed Central) - Apr 9, 2024
While patients are on immunotherapy, close monitoring for clinical signs & symptoms can lead to an early diagnosis, substantially improving morbidity and mortality. No abstract available
- |||||||||| Algeron (cepeginterferon alfa-2b) / Biocad, hydrocortisone / Generic mfg.
Preclinical, Journal: Wound healing potential of Cystoseira/mesenchymal stem cells in immunosuppressed rats supported by overwhelming immuno-inflammatory crosstalk. (Pubmed Central) - Apr 8, 2024
From constructed PPI network for wound healing and further analysis through molecular docking and molecular dynamics (MD) simulation experiments suggested that cystalgerone metabolite may be responsible for the wound healing-promoting effect of Cystoseira extract...Sixteen d after immunity suppression (by 40 mg/kg hydrocortisone daily), an incision was made in the dorsal skin of the rat...Our research indicates that the primary compounds of Cystoseira holds potential wound healing therapeutic activity. Although more safety testing and clinical studies are required, the combination has great potential for regenerative medicine and could be a revolutionary advance in the healing of the wounds of immunosuppressed patients.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Acute heart failure in a neonate (Pubmed Central) - Apr 5, 2024
Upon initiating hydrocortisone replacement therapy, cardiac function rapidly returned to normal...By the 18-month follow-up, the patient was growing and developing well. In neonates, unexplained acute heart failure requires caution for possible endocrine hereditary metabolic diseases, and timely cortisol testing and genetic testing should be conducted.
- |||||||||| Remicade (infliximab) / J&J
Successful desensitization to infliximab (E-TPS Display Only Digital section) - Apr 5, 2024 - Abstract #EAACI2024EAACI_491;
He underwent treatment with corticosteroids, immunosuppressors (oral mesalazine, rectal budesonide an azathioprine) with an inadequate response...Another dose of 200mg of hydrocortisone was administered and he was remitted to our department...We premedicated the patient with montelukast, acetyl salicylic acid, dexchlorpheniramine and paracetamol half an hour prior the initiation of the desensitization protocol, which we describe in Table 1...CONCLUSION Once an anaphylactic reaction has happened, it is important for the patient to be evaluated by an allergy specialist, in order to individualize the way of action. The final goal should be to reach the best approach regarding the treatment of the patient, after a proper review of the latest scientifical evidence available.
- |||||||||| Xolair (omalizumab) / Roche, Novartis
Delabeling of diagnosis of acquired c1 inhibitor deficiency (E-TPS Display Only Digital section) - Apr 5, 2024 - Abstract #EAACI2024EAACI_429;
In addition to antiIge, desloratidine 10mg daily is also combined. Discussing: chronic spontaneous urticaria (CSU) is a debilitating skin disease characterized by intensely itchy wheals, angioedema, or both.
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Corticosteroids hypersensitivity (Palma) - Apr 5, 2024 - Abstract #EAACI2024EAACI_313;
Additionally, information regarding cross-reactivity among different CST is limited. This emphasizes the importance of conducting a thorough workup to find safe alternatives and avoid unnecessary restrictions.
- |||||||||| cabergoline / Generic mfg., hydrocortisone / Generic mfg.
Journal: Pituitary Adenoma Prevalence and Characteristics of Omani Patients: A Single Center Experience. (Pubmed Central) - Apr 3, 2024
The most common presentation symptom was headaches; most female patients had menstrual irregularities. Medical treatment was the primary approach for the applicable types of PAs, while surgery and radiotherapy were found to be secondary and tertiary treatment options, respectively.
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