selegiline News - LARVOL Sigma

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|||||||||| selegiline / Generic mfg.
Preclinical, Journal: Selegiline Improves Cognitive Impairment in the Rat Model of Alzheimer's Disease. (Pubmed Central) - Jan 27, 2025
However, oral administration of SEL improved spatial cognitive decline in the A?-induced AD rats. The results suggest that improvement of neuroplasticity deficiency, regulation of oxidant/antioxidant status, and suppression of neuronal loss by SEL may be the mechanisms underlying its beneficial effect against AD-related spatial cognitive impairment.

|||||||||| selegiline / Generic mfg.
Journal: Fluorinated Coumarin Derivatives as Selective PET Tracer for MAO-B Imaging. (Pubmed Central) - Dec 19, 2024
Furthermore, the radioactivates from [18F]8 in regions of MAO-B expression could be effectively inhibited by Selegiline. All these positive findings supported that [18F]8 is a promising candidate for MAO-B PET imaging, which merits further evaluation.

|||||||||| selegiline / Generic mfg.
Journal: Feasibility of Simon 2-Stage Futility Trials in Early Parkinson Disease: Analysis of the PRECEPT and DATATOP Trial Datasets. (Pubmed Central) - Dec 6, 2024
All these positive findings supported that [18F]8 is a promising candidate for MAO-B PET imaging, which merits further evaluation. Based on our analysis of DATATOP and PRECEPT, phase 2 clinical trials using the Simon 2-Stage methodology are feasible in PD and may offer an opportunity to expedite the discovery of promising treatments in early PD.

|||||||||| selegiline / Generic mfg.
Journal: Enhancing selegiline hydrochloride efficacy: Box Behnken-optimized liposomal delivery via intranasal route for Parkinson's disease intervention. (Pubmed Central) - Nov 27, 2024
This extensive analysis emphasizes the possibility of intranasally administered SH-LP3 liposomes as a feasible treatment option for PD. The formulation not only delivers continuous drug release but also displays better safety and efficacy, providing a platform for additional studies and growth in the domain of PD treatment.

|||||||||| selegiline / Generic mfg., rasagiline / Generic mfg.
PK/PD data, Journal: Design, Synthesis, Molecular Docking, Pharmacokinetic Properties, and Molecular Dynamics Simulation of Sulfonyl Derivatives of Benzimidazole against Parkinson's Disease. (Pubmed Central) - Oct 25, 2024
The formulation not only delivers continuous drug release but also displays better safety and efficacy, providing a platform for additional studies and growth in the domain of PD treatment. This study indicates that the binding affinity of most of the hits was superior to that of known MAO inhibitors; therefore, these newly synthesized benzimidazole derivatives may be developed into essential drug candidates for the treatment of PD.

|||||||||| Akineton (biperiden) / Endo, AbbVie
Preclinical, Journal: Unveiling the Therapeutic Potential of Small Molecule of SVAK-12: A Comprehensive In Silico, In Vitro, and In Vivo Studies on its Neuroprotective Effects and Molecular Interactions in Parkinson's Disease. (Pubmed Central) - Oct 24, 2024
This study indicates that the binding affinity of most of the hits was superior to that of known MAO inhibitors; therefore, these newly synthesized benzimidazole derivatives may be developed into essential drug candidates for the treatment of PD. Overall, the study suggests that SVAK-12's neuro-biocompatibility, ability to reduce free radicals, and enhanced neurotrophic factors make it a promising candidate as a neuroprotective drug.

|||||||||| Comtan (entacapone) / Novartis, Orion Corp, Nourianz (istradefylline) / Kyowa Kirin
Observational data, Journal, Metastases: Prescription trends in Japanese advanced Parkinson's disease patients with non-motor symptoms: J-FIRST. (Pubmed Central) - Oct 23, 2024
There were significant changes in the prescriptions and dosing of selected anti-PD drugs, especially newer drugs. Anti-PD drug and NSAID prescriptions also varied by changes in NMS status and geographic region.

|||||||||| selegiline / Generic mfg.
Preclinical, Journal: Neurotoxicity, Neuroprotection, In Vitro MAOA/MAOB Inhibitory Activity Assessment, Molecular Docking, and Permeability Assay Studies of Newly Synthesized Hydrazones Containing a Pyrrole Ring. (Pubmed Central) - Sep 29, 2024
stabilization with the aromatic pyrrole ring. The preliminary PAMPA testing indicated that in relation to the blood-brain barrier (BBB) permeability, the tested pyrrole-based hydrazones may be considered as high permeable, except for 8a and 8e, which were established to be permeable in the medium range with -logP of 5.268 and 5.714, respectively, compared to the applied references.

|||||||||| selegiline / Generic mfg.
Journal: Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1?/Nrf2 pathway in Parkinson's disease models. (Pubmed Central) - Sep 25, 2024
The neuroprotective mechanisms of TBN are associated with activation of the PGC-1?/Nrf2 pathway, thereby reducing oxidative stress and maintaining mitochondrial function. These findings suggest that TBN may be a promising therapeutic candidate for PD, warranting further development and investigation.

|||||||||| selegiline / Generic mfg.
Preclinical, Journal: Plumbagin's Healing Effect on Motor Impairment in Rotenone-toxified Rodents. (Pubmed Central) - Sep 4, 2024
These findings underscore the potential therapeutic efficacy of plumbagin in mitigating behavioural deficits in rotenone-induced rodents. Considering this, plumbagin might be a feasible pharmacological strategy for the control of rotenone-triggered behavioural impairment in rats (in vivo), and it might display interesting interactions with MAO-B (in silico).

|||||||||| selegiline / Generic mfg., rasagiline / Generic mfg.
Review, Journal: Dietary Natural Flavonoids: Intervention for MAO-B Against Parkinson's Disease. (Pubmed Central) - Sep 3, 2024
Furthermore, this review underscores the significance of exploring natural products as valuable reservoirs of MAO-B inhibitors, offering new avenues for drug development and addressing the pressing need for improved treatments in PD-like pathological conditions. The authors of this review majorly explore the neuroprotective potential of natural flavonoids exhibiting notable MAO-B inhibitory activity and additionally multi-targeted approaches in the treatment of PD with clinical evidence and challenges faced in current therapeutic approaches.

|||||||||| selegiline / Generic mfg.
Design, synthesis and pharmacological evaluation of 16-pyridylmethylene derivatives of steroidal oximes as antiparkinsonian agents in MPTP-injected mice. (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_974;
The present study suggested that 16-(4-pyridylmethylene)-17-oximino-5-androsten-3?-ol acts as the most active compound. Hence, it could be useful for the prevention of chronic neuroinflammation and further for the treatment of Parkinson's disease.

|||||||||| Duodopa (levodopa/carbidopa intraduodenal gel infusion) / AbbVie
Two unusual cases of dopamine dysregulation syndrome in patients with Parkinson's disease (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_630;
These 2 cases illustrate the determination of some PD patients with DDS to gain access to additional dopaminergic medication. Clinicians should be mindful of the lengths some patients will go through to access additional dopaminergic medication when they suffer from DDS.

|||||||||| selegiline / Generic mfg.
Journal: Efficacy of exercise interventions combined with Selegiline in ameliorating freezing of gait in Parkinson's disease patients. (Pubmed Central) - Aug 8, 2024
Clinicians should be mindful of the lengths some patients will go through to access additional dopaminergic medication when they suffer from DDS. The combination of exercise interventions and Selegiline effectively rectifies the gait parameters, enhances the balance function, alleviates psychological distress, and improves the overall quality of life in PD patients experiencing FOG.

|||||||||| selegiline / Generic mfg.
Preclinical, Journal: Preliminary study on cytotoxicity of selegiline on different cancer cell lines: exploration of the induction of ROS-independent apoptosis in breast cancer cells. (Pubmed Central) - Jul 21, 2024
In addition, SEL was found to inhibit the phosphorylation of PKC, which may contribute to cell death. SEL induces apoptosis in breast cancer cells independently of reactive oxygen species and inhibits the phosphorylation of protein kinase C, which merits further exploration.

|||||||||| selegiline / Generic mfg.
Journal: Monoamine oxidase B inhibits epithelial-mesenchymal transition and trigger apoptosis via targeting ERK1/2 signaling pathway in head and neck squamous cell carcinoma. (Pubmed Central) - Jul 6, 2024
SEL induces apoptosis in breast cancer cells independently of reactive oxygen species and inhibits the phosphorylation of protein kinase C, which merits further exploration. We found that MAOB is a potent biomarker and a unique and essential indication of HNSCC carcinogenesis.

|||||||||| selegiline / Generic mfg.
Journal: Effects of selegiline on neuronal autophagy involving ?-synuclein secretion. (Pubmed Central) - Jul 4, 2024
Additionally, fractionation experiments showed that selegiline-induced ?-syn secretion occurred in non-extracellular vesicle fractions of primary neurons and SH-SY5Y cells. Collectively, these findings show that selegiline promotes neuronal autophagy involving secretion of non-exosomal ?-syn via a change of cytosolic Ca2+ levels.

|||||||||| chlorogenic acid / Jiuzhang Biotech
Preclinical, Journal: Antidepressant-like Effects of Chinese Quince (Chaenomeles sinensis) Fruit Based on In Vivo and Molecular Docking Studies. (Pubmed Central) - Jun 19, 2024
Male ICR mice (5 weeks old) were orally administered various doses (30, 100, and 300 mg/kg) of CSFE and selegiline (10 mg/kg), a monoamine oxidase B (MAO-B) inhibitor, as a positive control following daily intraperitoneal injections of CORT (40 mg/kg) for 21 days...Moreover, molecular docking analysis indicated that CGA and neo-CGA from CSFE had stronger binding to the active site of MAO-B. Our results indicate that CSFE has potential antidepressant effects in a mouse model of repeated injections of CORT-induced depression.

|||||||||| selegiline / Generic mfg.
Journal: Protective effects of selegiline against amyloid beta-induced anxiety-like behavior and memory impairment. (Pubmed Central) - Jun 14, 2024
These findings provide evidence that SEL may alleviate anxiety-like behavior and cognitive deficits induced by A? through modulation of oxidative-antioxidant status.

|||||||||| selegiline / Generic mfg.
Journal: Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach. (Pubmed Central) - Apr 1, 2024
Herein, we report a new short chemoenzymatic approach (in 2 steps) towards the synthesis of (R)-selegiline via stereoselective biocatalytic reductive amination as the key step. The imine reductase IR36-M5 mutant showed high conversion (97%) and stereoselectivity (97%) toward the phenylacetone and propargyl amine substrates, offering valuable biocatalysts for synthesizing alkylated homobenzylic amines.

|||||||||| Savella (milnacipran) / AbbVie, Pierre Fabre
Journal: Identification of Potentially Repurposable Drugs for Lewy Body Dementia Using a Network-Based Approach. (Pubmed Central) - Feb 20, 2024
These potential anti-LBD drugs are either selective or non-selective inhibitors of serotonin, dopamine, and norepinephrine transporters. The validated selective serotonin and norepinephrine inhibitors like milnacipran, protriptyline, and venlafaxine are predicted to manage LBD along with the affecting symptomatic issues.

|||||||||| selegiline / Generic mfg.
Journal, MRI: Free-water diffusion magnetic resonance imaging under selegiline treatment in Parkinson's disease. (Pubmed Central) - Feb 19, 2024
The validated selective serotonin and norepinephrine inhibitors like milnacipran, protriptyline, and venlafaxine are predicted to manage LBD along with the affecting symptomatic issues. Selegiline treatment might reduce the white matter microstructural abnormalities detected by free-water imaging in Parkinson's disease.

|||||||||| Cognex (tacrine) / Shionogi
Preclinical, Journal: In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer's Disease. (Pubmed Central) - Feb 2, 2024
Lastly, 7d possessed well pharmacokinetic characteristics. In light of these results, it is clear that 7d could potentially serve as a promising multi-functional drug for the treatment of AD.

|||||||||| selegiline / Generic mfg., rasagiline / Generic mfg.
Review, Journal: Toxic interactions between dopamine, ?-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson's disease. (Pubmed Central) - Jan 10, 2024
Rasagiline and selegiline prevent ?-synuclein fibrillization, modulate this toxic collaboration, and exert neuroprotection in experimental studies. Complex interactions between these pathogenic factors play a decisive role in neurodegeneration in PD and should be further defined to develop new therapies for Parkinson's disease.

|||||||||| Marplan (isocarboxazid) / Validus
Review, Journal: Classics in Chemical Neuroscience: Selegiline, Isocarboxazid, Phenelzine, and Tranylcypromine. (Pubmed Central) - Dec 7, 2023
It is therefore timely to review key aspects of the four "classic" MAOIs: high-dose selegiline, isocarboxazid, phenelzine, and tranylcypromine. This review discusses their chemical synthesis, metabolism, pharmacology, adverse effects, and the history and importance of these drugs within the broader field of chemical neuroscience.

|||||||||| Emsam (selegiline transdermal) / Viatris
Journal: The novel design of an intelligent anti-depression transdermal drug delivery system. (Pubmed Central) - Dec 4, 2023
(3) A rat model of depression was established using chronic unpredictable mild stress (CUMS) combined with separation. From the aspects of behavior (body weight, sucrose preference test, forced swimming test, open field test) and biochemical indexes (serum proinflammatory cytokines (IL-1?, TNF-?), hippocampus HE staining observation), the therapeutic effect of hyperthermia, Selegiline oral administration and transdermal administration was discussed.

|||||||||| selegiline / Generic mfg.
Preclinical, Journal: Selegiline Modulates Lipid Metabolism by Activating AMPK Pathways of Epididymal White Adipose Tissues in HFD-Fed Obese Mice. (Pubmed Central) - Nov 25, 2023
Treating obese mice with selegiline significantly increased expression levels of UCP1 and promoted eWAT browning, indicating increased energy expenditure. These results suggest that selegiline, by inhibiting MAO-B activity, is a potential anti-obesity treatment.

|||||||||| Trivastal (piribedil) / Servier
Retrospective data, Journal: Comparison of the effectiveness, safety, and costs of anti-Parkinson drugs: A multiple-center retrospective study. (Pubmed Central) - Nov 20, 2023
These results suggest that selegiline, by inhibiting MAO-B activity, is a potential anti-obesity treatment. Carbidopa/levodopa or levodopa/benserazide might exhibit better clinical improvement with less medical cost, while piribedil presented less clinical improvement but a higher risk of headache/dizziness, gastrointestinal, and neuropsychiatric symptoms.

|||||||||| betahistine / Generic mfg., selegiline / Generic mfg.
P1 data, Journal, Combination therapy: Examination of betahistine bioavailability in combination with the monoamine oxidase B inhibitor, selegiline, in humans-a non-randomized, single-sequence, two-period titration, open label single-center phase 1 study (PK-BeST). (Pubmed Central) - Nov 5, 2023
P1
Carbidopa/levodopa or levodopa/benserazide might exhibit better clinical improvement with less medical cost, while piribedil presented less clinical improvement but a higher risk of headache/dizziness, gastrointestinal, and neuropsychiatric symptoms. Whether the increased bioavailability has an impact on the preventive treatment of Meni

|||||||||| selegiline / Generic mfg.
Protective effect of Korean herbal medicine Sihosogan-tang on dopaminergic neurons in the nigrostriatal pathway of a Parkinson (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_8731;
Male 8-week-old C57BL/6 mice were injected with vehicle or 30 mg/kg of MPTP at 24h intervals for 5 days, and orally treated SS (82 mg/kg, or 247 mg/kg) or intraperitoneally injected selegiline (2 mg/kg) once a day for 12 consecutive days from the first MPTP injection...MPTP administration caused motor dysfunction, dopaminergic neuronal death in the SN and striatum, and increased GFAP and Iba1 expressions in striatum; however, SS dose-dependently alleviated the MPTP-induced changes. These results suggest that SS suppresses MPTP-induced dopaminergic neuronal death in the nigrostriatal pathway and the activation of astrocytes and microglia in the striatum.

|||||||||| selegiline / Generic mfg.
Contribution of levodopa to brain iron accumulation (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_4699;
Supported By TL1TR002016The antiparkinson drug levodopa (L-DOPA) is the current standard of treatment for Parkinson's Disease (PD) and can be used as either a monotherapy or in combination with monoamine oxidase-B (MAO-B) inhibitors, such as selegiline to ameliorate dopamine depletion...The data suggests that L-DOPA affects iron transport by modifying the iron status of the ECs and mediating iron transport. The results suggest that the common antiparkinson treatment medication, L-DOPA, alters iron homeostasis that may promote neurodegeneration through iron accumulation; a novel concept requiring further study.

|||||||||| selegiline / Generic mfg.
Journal: Improvement of Movement Disorder and Neurodevelopment under Selegiline in a CLTC-Deficient Patient. (Pubmed Central) - Sep 29, 2023
The results suggest that the common antiparkinson treatment medication, L-DOPA, alters iron homeostasis that may promote neurodegeneration through iron accumulation; a novel concept requiring further study. No abstract available

|||||||||| selegiline / Generic mfg.
Journal: Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord. (Pubmed Central) - Sep 26, 2023
FMD inhibits NETs formation and NETs-induced neuroinflammation by inhibiting the MAO-B/5-HIAA/GPR35 and MAO-B/ROS pathways in astrocytes and neurons, thereby relieving pain progression. Video Abstract.

|||||||||| selegiline / Generic mfg., rasagiline / Generic mfg.
Journal: Striking Neurochemical and Behavioral Differences in the Mode of Action of Selegiline and Rasagiline. (Pubmed Central) - Sep 13, 2023
We have concluded that selegiline acts as an MAO-B inhibitor and a dopaminergic enhancer drug, and the latter relates to an agonist effect on TAAR1. In contrast, rasagiline is devoid of enhancer activity but may act as an antagonist on TAAR1.

|||||||||| selegiline / Generic mfg.
Selegiline drives autophagic secretion of ?-synuclein () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1624;
These findings show that selegiline drives autophagy-based secretion of ?S through affecting intracellular Ca concentration and amphisome formation. Selegiline don

|||||||||| Xadago (safinamide) / Meiji Seika, Eisai, Valeo Pharma, Zambon, Supernus Pharma
The efficacy of dopamine agonists or monoamine oxidase type B inhibitors as monotherapy in patients with early Parkinson disease: A network meta-analysis () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1528;
Selegiline don This network meta-analysis suggests that pramipexole, rotigotine, rasagiline, and selegiline are effective monotherapy options for patients with early PD.

|||||||||| Ongentys (opicapone) / Ono Pharma, Neurocrine, BIAL
Supra-ON state freezing of gait: The unpredictable response to levodopa in Parkinson () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1242;
This network meta-analysis suggests that pramipexole, rotigotine, rasagiline, and selegiline are effective monotherapy options for patients with early PD. The presence of FOG in

|||||||||| selegiline / Generic mfg.
The monoamine oxidase-B inhibitor selegiline does not affect 18F-Florzolotau uptake in patients with progressive supranuclear palsy: a longitudinal case series () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_701;
The presence of FOG in The interpretation of F-Florzolotau PET images, with respect to tau pathology, is not confounded by MAO-B availability.

|||||||||| Cerebrolysin (porcine brain-derived proteolytic peptide fraction) / Novartis, EVER Pharma
Clinical, Review, Journal: Pharmacological treatment in early rehabilitation after ischemic stroke (Pubmed Central) - Aug 29, 2023
This review provided a summary of the evidence on pharmacological supportive care in early rehabilitation of post-acute ischemic stroke patients. This will make it possible to improve current recommendations with the aim of collaborating with health decision-making for this population.

|||||||||| betahistine / Generic mfg.
Preclinical, Journal: Dose- and application route-dependent effects of betahistine on behavioral recovery and neuroplasticity after acute unilateral labyrinthectomy in rats. (Pubmed Central) - Aug 4, 2023
This may be achieved by higher doses, inhibition of MAO-based metabolism, or a parenteral route. In vivo imaging suggests a drug-target engagement in central vestibular networks.

|||||||||| selegiline / Generic mfg.
Preclinical, Journal: Cycloartane Saponins from Astragalus glycyphyllos and Their In Vitro Neuroprotective, Antioxidant, and hMAO-B-Inhibiting Effects. (Pubmed Central) - Jul 29, 2023
It was found that the compounds had statistically significant dose-dependent in vitro protective activity on the sub-cellular fractions. The compounds exhibited a weak inhibitory effect on the enzyme activity of human recombinant monoamine oxidase type B (hMAO-B), compared to selegiline.

||||||||||  betahistine / Generic mfg., selegiline / Generic mfg.
New P1 trial:  PK-BesT: Pharmacokinetic Profile of Betahistine With and Without Selegiline in Healthy Volunteers (clinicaltrials.gov) -  Jul 10, 2023
P1, N=15, Completed,  Sponsor: Ludwig-Maximilians - University of Munich

|||||||||| selegiline / Generic mfg.
Update on [18F]ACI-12589: a novel and promising PET tracer for a-synuclein (Hall 2) - Jul 6, 2023 - Abstract #AAIC2023AAIC_6986;
[ 18 F]ACI-12589 displays the preclinical and clinical characteristics deemed necessary to become a reliable and accurate PET radiotracer for the detection of a-syn pathology in MSA. Additional evaluations of this tracer will focus on the longitudinal and early disease stage assessments.

|||||||||| donepezil / Generic mfg.
Donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer (In-Person) - Jul 6, 2023 - Abstract #AAIC2023AAIC_2473;
protein fragments that accumulate in the brain. The pharmacological profile of compound 11, as well as the fact that it is a readily available compound in a short synthetic sequence, in good chemical yields, prompts us to select it as a lead-compound for further optimization in our current research programme targeted to the preparation of new molecules for the potential treatment of AD.

|||||||||| Combivent (ipratropium/salbutamol) / Boehringer Ingelheim, selegiline / Generic mfg.
Eldepryl - combivent and soluble solpadeine (Twitter) - Jul 3, 2023

|||||||||| selegiline / Generic mfg.
Journal: Cognitive effects of thalamostriatal degeneration are ameliorated by normalizing striatal cholinergic activity. (Pubmed Central) - Jun 27, 2023
However, both effects were rescued by either the peripheral or the intra-DMS administration of selegiline, a monoamine oxidase B inhibitor that we found also enhances adenosine triphosphatase activity in CINs. These findings suggest a potential treatment for the cognitive deficits associated with neuroinflammation affecting the function of the Pf and related structures.

|||||||||| Emsam (selegiline transdermal) / Viatris
Retrospective data, Review, Journal: Efficacy and safety of selegiline across different psychiatric disorders: A systematic review and meta-analysis of oral and transdermal formulations. (Pubmed Central) - Jun 19, 2023
These findings suggest a potential treatment for the cognitive deficits associated with neuroinflammation affecting the function of the Pf and related structures. Selegiline did not differ from methylphenidate and ADHD scores (k

|||||||||| selegiline / Generic mfg.
Journal: Inhibition of MAOB Ameliorated High-Fat-Diet-Induced Atherosclerosis by Inhibiting Endothelial Dysfunction and Modulating Gut Microbiota. (Pubmed Central) - Jun 14, 2023
Specifically, selegiline treatment enriched the abundance of Faecalibaculum and Akkermansia, decreased the abundance of unclassified_f__Lachnospiraceae, Desulfovibrio, and Blautia, and these genera were significantly correlated with the serum biochemical indices. Taken together, our findings showed that MAOB controlled endothelial oxidative stress homeostasis, and revealed the anti-atherosclerotic effect of selegiline by ameliorating endothelial dysfunction and modulating the composition and function of gut microbiota.

|||||||||| phenelzine / Generic mfg., selegiline / Generic mfg.
Review, Journal: Virus infection participates in the occurrence and development of human diseases through monoamine oxidase. (Pubmed Central) - Jun 9, 2023
This review also describes the effects of MAO inhibitors such as phenelzine, clorgyline, selegiline, M-30, and isatin on viral infectious diseases. This information will not only help us to better understand the role of MAO in the pathogenesis of viruses but will also provide new insights into the treatment and diagnosis of these viral diseases.

|||||||||| clonazepam / Generic mfg., epinephrine / Generic mfg., selegiline / Generic mfg.
Psychomotor delay and movement disorder mimicking cerebral palsy: first two case reports of Aromatic L-amino acid decarboxylase deficiency (AADCd) from Iraq (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_740;
This report highlights the potential differential diagnosis of psychomotor delay with CP - like phenotype. It is important to alert for similar cases among pediatricians and pediatric neurologists to reduce the unnecessary tests and procedures if the diagnosis is suspected.



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