- |||||||||| Flagyl (metronidazole) / SLA, Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, Humira (adalimumab) / Eisai, AbbVie
Review, Journal: Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. (Pubmed Central) - Jun 19, 2019
The effects of antibiotics, probiotics and other interventions for treating and preventing pouchitis are uncertain. Well designed, adequately powered studies are needed to determine the optimal therapy for the treatment and prevention of pouchitis.
- |||||||||| prednisolone / generics, budesonide / generics, azathioprine orodispersible / generics
Review, Journal: Important problems in the diagnosis and treatment of autoimmune hepatitis (based on the Russian consensus 2017). (Pubmed Central) - Jun 17, 2019
The analysis of publications devoted to the Russian Consensus on the Diagnostic and Treatment of Autoimmune Hepatitis (AIH), which was considered at the 43rd annual Scientific Session of the CNIIG From Traditions to Innovation (March 4, 2017) is carried out. The presence of clear algorithms and recommendations for the diagnosis and treatment of AIH significantly help the doctor in real clinical practice, but do not exclude a personified approach to the patient.
- |||||||||| budesonide / generics
Journal: Effects of flow pattern, device and formulation on particle size distribution of nebulized aerosol. (Pubmed Central) - Jun 15, 2019
...Two types of nebulizer (i.e., breath-enhanced nebulizer and vibrating-mesh nebulizer) and two formulations (i.e., budesonide suspension and albuterol solution) were chosen for comparison...We conclude that it will be more conducive to the evaluation of particle size to use a laser diffractometer under a realistic pattern and make up for the shortcomings of cascade impactors. The effects of flow pattern, nebulizer and formulation should be taken into account in the evaluation of the qualities of nebulizer products in pharmaceutical practice.
- |||||||||| methylprednisolone / generics
Journal: Comparison of Corticosteroids by 3 Approaches to the Treatment of Chronic Rhinosinusitis With Nasal Polyps. (Pubmed Central) - Jun 7, 2019
The addition of nebulized budesonide to standard asthma treatment might result in more improvement in O2 saturation and less patient's distress. A short course of BIS transnasal nebulization is more efficacious compared to BNS in the management of ECRSwNP and is safer than oral methylprednisolone with respect to hypothalamic-pituitary-adrenal axis function.
- |||||||||| Uceris (budesonide rectal foam) / Bausch Health, Dr Falk
Clinical, Journal: Recalcitrant pouchitis treated by budesonide foam:a case report (Pubmed Central) - Jun 7, 2019
There was a marked improvement in his symptoms following the administration of twice-daily budesonide 2mg foam injection for two months. Budesonide foam is suggested as a new therapy for pouchitis.
- |||||||||| Remicade (infliximab) / Mitsubishi Tanabe, J&J
Clinical, Journal: Pulmonary tuberculosis following anti-tumor necrosis factor-α therapy in Crohn's disease:a case report (Pubmed Central) - Jun 7, 2019
The standard short-course anti-TB regimen was initiated to treat pulmonary TB, whereas IFX was discontinued and replaced with budesonide. Our case suggests that the risk of developing TB should not be excluded, despite the initial negative TB screening, particularly when a patient develops respiratory symptoms during anti-TNF-α therapy.
- |||||||||| budesonide / Generic mfg.
Enrollment open, Trial initiation date: Budesonide in Patients With Immune Mediated Enteropathies (clinicaltrials.gov) - Jun 5, 2019
P4, N=20, Recruiting,
Our case suggests that the risk of developing TB should not be excluded, despite the initial negative TB screening, particularly when a patient develops respiratory symptoms during anti-TNF-α therapy. Not yet recruiting --> Recruiting | Initiation date: Mar 2019 --> Jul 2019
- |||||||||| budesonide / generics
Journal: Surface engineered lipid nanoparticle-mediated site-specific drug delivery system for the treatment of inflammatory bowel disease. (Pubmed Central) - Jun 5, 2019
...Taking this into consideration, we proposed development of mannosylated nanostructured lipid carrier system (Mn-NLCs) for active targeting and site-specific delivery of budesonide to the inflamed tissues...The in vivo evaluation depicted that Mn-NLCs showed significant reduction in clinical activity scoring, macroscopic and microscopic indexing, colonic myeloperoxidase activity and inflammatory cytokines. In conclusion, the developed Mn-NLCs appear to be promising for the treatment of IBD by selectively targeting inflamed colonic region as compared to unconjugated nanoparticulate system.
- |||||||||| ciprofloxacin / generics, gentamicin sulfate / generics
Journal: The wet bridge transfer system: a novel tool to assess exogenous surfactant as a vehicle for intrapulmonary drug delivery. (Pubmed Central) - Jun 5, 2019
Anti-inflammatory agents (Budesonide and a host defense peptide, CATH-2) with and without exogenous surfactant were examined using stimulated macrophages in the remote well and IL-6 concentration as an outcome...We conclude that the wet-bridge system can be used to rapidly screen surfactant-based therapies prior to their assessment in vivo. Furthermore, exogenous surfactant was an effective delivery vehicle for several antimicrobial and anti-inflammatory therapeutics.
- |||||||||| budesonide / generics
Journal: Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma. (Pubmed Central) - May 30, 2019
In an open-label trial involving adults with mild asthma, budesonide-formoterol used as needed was superior to albuterol used as needed for the prevention of asthma exacerbations. (Funded by AstraZeneca and the Health Research Council of New Zealand; Novel START Australian New Zealand Clinical Trials Registry number, ACTRN12615000999538.).
- |||||||||| Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol) / GSK, Innoviva, Anoro Ellipta (umeclidinium + vilanterol) / Innoviva, GSK
Clinical, Journal, HEOR: Once-Daily Triple Therapy in Patients with COPD: Patient-Reported Symptoms and Quality of Life. (Pubmed Central) - May 30, 2019
P3
These findings demonstrate sustained daily symptom and HRQoL benefits of FF/UMEC/VI versus BUD/FOR. The inclusion of the CAT may provide data that are readily generalizable to everyday clinical practice.
- |||||||||| Ocaliva (obeticholic acid) / Intercept
Review, Journal: Modern treatment of primary biliary cholangitis (Pubmed Central) - May 26, 2019
...This changed at the end of 2016 when obeticholic acid was licensed in Europe for PBC patients not responding to UDCA...One issue that remains unresolved is the therapeutic management of extrahepatic symptoms associated with PBC, namely fatigue and pruritus, which are the main factors influencing the quality of life of affected individuals. Their pathophysiological basis is poorly understood and treatment remains unsatisfactory.
- |||||||||| Review, Journal: Contact Dermatitis to Medications and Skin Products. (Pubmed Central) - May 26, 2019
Finally, we examine the ingredients in the excipients of these products, such as the formaldehyde releasers (quaternium-15, 2-bromo-2-nitropropane-1,3 diol, diazolidinyl urea, imidazolidinyl urea, DMDM hydantoin), the non-formaldehyde releasers (isothiazolinones, parabens, methyldibromo glutaronitrile, iodopropynyl butylcarbamate, and thimerosal), fragrance mixes, and Myroxylon pereirae (Balsam of Peru) for contact allergy incidence and prevalence. Furthermore, strategies, recommendations, and two online tools (SkinSAFE and the Contact Allergen Management Program) on how to avoid these allergens in commercial skin care products will be discussed at the end.
- |||||||||| budesonide / generics
Biomarker, Journal: Staphylococcus aureus on Sinus Culture Is Associated With Recurrence of Chronic Rhinosinusitis After Endoscopic Sinus Surgery. (Pubmed Central) - May 22, 2019
Objectives: Identify whether identification of S. aureus on conventional culture is a predictor of success or failure after ESS followed by budesonide nasal irrigations (BUD) in chronic rhinosinusitis (CRS) patients at high risk of recurrence...This suggests that S. aureus negatively influences outcome, possibly via a number of mechanisms, including interactions with the (i) immune system, (ii) regeneration and repair of the sinus epithelium, or (iii) via interference with the sinus microbiome. This suggests that S. aureus may be a simple and inexpensive biomarker for disease severity and indicates a clear need to better appreciate S. aureus on how it contributes mechanistically to disease development and persistence in order to develop targeted therapeutic strategies.
- |||||||||| budesonide / Generic mfg.
Enrollment change, Trial termination: Budesonide for Mycophenolic Acid-induced Diarrhea in Renal Transplant Recipients (clinicaltrials.gov) - May 20, 2019
P2, N=9, Terminated,
This suggests that S. aureus may be a simple and inexpensive biomarker for disease severity and indicates a clear need to better appreciate S. aureus on how it contributes mechanistically to disease development and persistence in order to develop targeted therapeutic strategies. N=30 --> 9 | Recruiting --> Terminated; Enrollment not continued
- |||||||||| doxycycline / generics, ibuprofen / generics
Review, Journal: Inflammatory arthritis: a unique presentation of human anaplasmosis. (Pubmed Central) - May 14, 2019
Because of an Anaplasma phagocytophilum IgM of 1:320 (normal < 1:20; IgG < 1:64; normal < 1:64) that returned few weeks after presentation, he was prescribed 4 weeks of doxycycline...HGA presents acutely with a spectrum of manifestations ranging from a flu-like illness to severe complications such as respiratory failure. Myalgias and arthralgias are common, but an inflammatory arthritis has not been described.
- |||||||||| prednisone / generics, budesonide / generics
Journal: Airway pathology in severe asthma is related to airflow obstruction but not symptom control. (Pubmed Central) - May 13, 2019
Myalgias and arthralgias are common, but an inflammatory arthritis has not been described. Symptom control in severe asthmatics was not associated with airway tissue inflammation and remodeling, although persistent airflow obstruction in these patients was associated with bronchial inflammation and airway structural changes.
- |||||||||| budesonide / generics
Journal: Characterization of A dextran-budesonide prodrug for inhalation therapy. (Pubmed Central) - May 11, 2019
Spray-drying the 40 kDa dextran-succinate-budesonide produced respirable particles of the conjugate with a mass median aerodynamic particle size (MMAD) of 4 μm. The slow generation of budesonide from the chemical delivery system might further improve the pharmacological profile of budesonide.
- |||||||||| budesonide / generics
Clinical, Journal: Discovering Pediatric Asthma Phenotypes Based on Response to Controller Medication Using Machine Learning. (Pubmed Central) - May 1, 2019
The results suggest that budesonide represents a promising antiviral and anti-inflammatory drug candidate for the treatment of human rhinovirus infection. Advanced statistical machine learning approaches can be a powerful tool to discover phenotypes based upon treatment response and to predict outcomes in complex medical conditions such as asthma.
- |||||||||| budesonide / generics
Journal, Combination therapy: Design of Inhalable Solid Dosage Forms of Budesonide and Theophylline for Pulmonary Combination Therapy. (Pubmed Central) - Apr 30, 2019
In contrast, the depositions of budesonide and theophylline deviated from the starting weight ratio in the aerodynamic assessment of spray-dried powders obtained from the 3-fluid nozzle spray drier, i.e., (iii) and (iv). Based on these results, the powders spray-dried from the suspension by using the 2-fluid nozzle spray drier, i.e., (ii), offered the best formulation properties given the physically stable crystalline solid-state properties and the co-deposition profile.
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