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20 Diseases |  |
17 Trials |
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17 Trials |  |
3666 News |  |
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- | Gattex (teduglutide) / Takeda
Journal: Therapeutic interventions targeting enteropathy in severe acute malnutrition modulate systemic and vascular inflammation and epithelial regeneration. (Pubmed Central) - Jan 16, 2025
Interventions aimed at ameliorating malnutrition enteropathy showed plausible effects on biomarkers of inflammation and epithelial regeneration, demonstrating an interdependence of systemic inflammation and enteropathy markers seen in structural analysis. Given the interplay between inflammation and tissue restoration in malnutrition, this mechanism of action supports larger trials to determine the clinical benefits of interventions, either alone or in combination, in children with complicated SAM.
- | prednisone / Generic mfg., budesonide / Generic mfg., azathioprine / Generic mfg.
Journal, HEOR, Real-world evidence, Real-world: Real-world evidence for factors associated with maintenance treatment practices among U.S. adults with autoimmune hepatitis. (Pubmed Central) - Jan 16, 2025
Long-term prednisone therapy remains common and unexpectedly higher among patients with comorbidities potentially aggravated by corticosteroids. The greater use of corticosteroid-based therapy with highly experienced providers may reflect more treatment-refractory disease.
- || budesonide / Generic mfg.
Clinical, Retrospective data, Review, Journal: Efficacy of pulmonary surfactant with budesonide in premature infants: A systematic review and meta-analysis. (Pubmed Central) - Jan 12, 2025
Our study showed that the administration of PS with budesonide significantly improved respiratory outcomes, including the incidence of BPD, duration of mechanical or invasive mechanical ventilation, duration requiring oxygen, and hospitalization time in preterm infants, without short-term adverse drug events. However, the evidence certainty was mostly low to very low.
- | Journal: Graft-versus-host disease-like gastroenteritis after autologous stem cell transplantation with busulfan/thiotepa conditioning for primary central nervous system lymphoma (Pubmed Central) - Jan 12, 2025
Treatment with systemic steroids and budesonide for more than 2 months led to remission. It is important to suspect autologous GI-GVHD and consider prompt and aggressive immunosuppressive therapy in patients that manifest persistent diarrhea after engraftment following ASCT with busulfan/thiotepa conditioning.
- | cyclophosphamide / Generic mfg., budesonide / Generic mfg., mycophenolate mofetil / Generic mfg.
Journal: Budesonide, Added to PTCy-Based Regimen, for Prevention of Acute GI GVHD After Allogeneic Stem Cell Transplantation. (Pubmed Central) - Jan 12, 2025
In conclusion, addition of budesonide to PTCy-based GVHD prophylaxis is safe and effective in preventing severe acute GI GVHD with significantly improved GRFS. These results could facilitate transition to peripheral blood grafts for all allogeneic transplant recipients.
- || budesonide / Generic mfg.
Clinical, Journal: DIAGNOSIS AND TREATMENT OF MICROSCOPIC COLITIS: POSITION PAPER ON BEHALF OF THE BRAZILIAN FEDERATION OF GASTROENTEROLOGY. (Pubmed Central) - Jan 12, 2025
This position paper provides evidence-based recommendations to optimize care and improve patient outcomes across diverse clinical settings in Brazil. Further research is needed to address the gaps in understanding the epidemiology and management of MC in underserved regions.
- || Dupixent (dupilumab) / Sanofi, Regeneron
Review, Journal: Eosinophilic oesophagitis in adults: from symptoms to therapeutic options. (Pubmed Central) - Dec 27, 2024
The evaluation of alarm signs and typical presentation patterns should allow a more straightforward recognition. The emergency and internal medicine doctors should actively be involved in this process and take part to the multidisciplinary care of patients with EoE, to allow better patient care and clinical outcomes.
- || Iqirvo (elafibranor) / Ipsen, Ocaliva (obeticholic acid) / Intercept, Livdelzi (seladelpar) / Gilead
Review, Journal: Up-to-Date Snapshot of Current and Emerging Medical Therapies in Primary Biliary Cholangitis. (Pubmed Central) - Dec 27, 2024
UDCA should remain the treatment of choice for PBC, though perhaps not as monotherapy. With further investigation, BF shows promise as a new second-line therapy alongside OCA, which it may outperform.
- | budesonide / Generic mfg.
Journal: Effect of WeChat-Based Medication Guidance on Symptoms and Serological Parameters in Children with Mycoplasma Pneumoniae. (Pubmed Central) - Dec 24, 2024
The aim of this study was to assess the effect of microsoft-based medication guidance on the level of symptoms and serological indicators in children receiving budesonide nebulisation combined with terbutaline for the treatment of Mycoplasma pneumoniae pneumoniae (MPP)...After treatment, the levels of forceful spirometry (FVC), 1st-second expiratory volume (FEV1), peak expiratory flow rate (PEF), medication compliance score and family guidance satisfaction rate were higher in the WeChat group than in the conventional group (P < .05). WeChat-based medication guidance can optimize the therapeutic effect of MPP, improve children's medication compliance and satisfaction rate of family guidance, and reduce the occurrence of adverse drug events.
- | cyclopamine / University of Macau, Erivedge (vismodegib) / Roche
Preclinical, Journal: Impact of Hedgehog modulators on signaling pathways in primary murine and human hepatocytes in vitro: insights into liver metabolism. (Pubmed Central) - Dec 23, 2024
WeChat-based medication guidance can optimize the therapeutic effect of MPP, improve children's medication compliance and satisfaction rate of family guidance, and reduce the occurrence of adverse drug events. In our study, we investigated the effects of the Hh agonists SAG (300
- | ceftriaxone / Generic mfg., budesonide / Generic mfg., azithromycin / Generic mfg.
Journal: Prescription patterns and drug utilization in respiratory tract infections: implications for antimicrobial stewardship at a tertiary care teaching hospital. (Pubmed Central) - Dec 23, 2024
Ceftriaxone (12.68%) and azithromycin (11.88%) were the most commonly prescribed antibiotics...The study underscores the need for stricter adherence to clinical guidelines and targeted antimicrobial stewardship in RTI management. Enhanced DUE practices could improve patient outcomes and promote rational drug use.
- budesonide / Generic mfg.
Budesonide for Engraftment Fever Prophylaxis: A Single Center Randomized Study Interim Analysis (HCC Exhibit Hall 3; In-Person) - Dec 19, 2024 - Abstract #TCTASTCTCIBMTR2025TCT_ASTCT_CIBMTR_1323;
At this point, in this interim analysis, there seems to be a trend for less fever with budesonide without severe adverse events. Nothing is statistically significant so far.
- cyclophosphamide / Generic mfg.
Early Initiation of Tacrolimus Prior to Post-Transplant Cyclophosphamide in Peripheral Blood Haploidentical Transplantation (HCC Exhibit Hall 3; In-Person) - Dec 19, 2024 - Abstract #TCTASTCTCIBMTR2025TCT_ASTCT_CIBMTR_1321;
Initially, graft-versus-host disease (GVHD) prophylaxis consisted of tacrolimus (TAC) on Day+1, PTCy on Days+3/+4, mycophenolate on Day+5, and oral budesonide on Day+5 for those receiving PB haplo-HSCT...The median HCT-CI was 2 (range: 0-7) and 44 (77.2%) received a fludarabine/melphalan-based regimen...In univariable analysis, male sex (p<0.001) was associated with higher CI of severe acute/chronic GVHD, older age (p=0.004) was associated with higher CI of NRM, and lower T-cell dose (p=0.007) and lower-intensity conditioning (p<0.001) were associated with higher CI of relapse. Conclusion Earlier initiation of TAC prior to PTCy administration for PB haplo-HSCT resulted in similar rates of CRS, GVHD and other transplant outcomes as compared to D+5 initiation of TAC in BM haplo-HSCT.
- Results of a Prospective Observational Study Using Budesonide, Added to Ptcy-Based Gvhd Prophylaxis, for Prevention of Acute GI Gvhd after Allogeneic Transplantation and Comparison with CIBMTR Control (HCC Exhibit Hall 3; In-Person) - Dec 19, 2024 - Abstract #TCTASTCTCIBMTR2025TCT_ASTCT_CIBMTR_1100;
PTMB GVHD prophylaxis is feasible and appears to be very effective in preventing severe GI aGVHD with improved GRFS. Addition of budesonide could help transition to peripheral blood grafts for all patients receiving AHSCT.
- melphalan / Generic mfg., plerixafor / Generic mfg.
Incidence of Engraftment Syndrome with and without Budesonide Prophylaxis in Patient with Multiple Myeloma Undergoing Autologous Stem Cell Transplant (HCC Exhibit Hall 3; In-Person) - Dec 19, 2024 - Abstract #TCTASTCTCIBMTR2025TCT_ASTCT_CIBMTR_860;
The low overall rates of ES by Spitzer, Mailoloino, and provider documentation in this study suggest a preventative strategy may not be warranted. However, reduction in incidence of new onset febrile neutropenia in the peri-engraftment period warrants further study.
- | Stelara (ustekinumab) / J&J
Journal: Oral manifestations of Crohn disease managed with ustekinumab: A case report. (Pubmed Central) - Dec 18, 2024
It is a newer biologic medication, and its use has been increasing in the pediatric population with CD. Its use is typical after failure of an antitumor necrosis factor drug, like infliximab.
- || Dupixent (dupilumab) / Sanofi, Regeneron
Retrospective data, Review, Journal: Clinical, histological and safety outcomes with long-term maintenance therapies for eosinophilic esophagitis: A systematic review and meta-analysis. (Pubmed Central) - Dec 16, 2024
Maintenance therapies prevent histological relapse in the long term, without clear disadvantage of dose de-escalation from induction to maintenance phase. Low adverse events and withdrawal rates confirm long-term treatment is well tolerated.
- || budesonide / Generic mfg.
Clinical, Journal: Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants: The PLUSS Randomized Clinical Trial. (Pubmed Central) - Dec 10, 2024
P3
In extremely preterm infants receiving surfactant for respiratory distress syndrome, early intratracheal budesonide may have little to no effect on survival free of BPD. anzctr.org.au Identifier: ACTRN12617000322336.
- || budesonide / Generic mfg.
Retrospective data, Review, Journal: Effectiveness of Bile Acid Sequestrants in Microscopic Colitis and Utility of Bile Acid Testing: A Systematic Review and Meta-Analysis. (Pubmed Central) - Dec 3, 2024
One-third of patients with MC had BAM, and almost two-thirds of all patients responded to BAS with limited side effects. Patients with MC and BAM were more likely to respond to therapy, supporting the value of bile acid testing.
- | budesonide / Generic mfg.
Retrospective data, Journal: Pediatric eosinophilic esophagitis: a Belgian single-center retrospective analysis reveals real-life difficulties in diagnosis and treatment. (Pubmed Central) - Dec 3, 2024
Other treatment modalities, such as oral budesonide and exclusion diets either single or in combination, were also used...This study provides valuable insights into the clinical characteristics, diagnostic evaluation, treatment modalities, and outcomes of EoE in the pediatric population. It underscores the importance of early recognition, accurate diagnosis, and regular follow-up to effectively manage this chronic immune-mediated disorder but also demonstrates its complexity in real-life clinical setting.
- | Cervidil (dinoprostone) / Ferring
Journal: Common molecular basis for MASH and hepatitis C revealed via systems biology approach. (Pubmed Central) - Nov 28, 2024
We extracted 10 hub genes between MASH and hepatitis C, and performed a series of analyses on the genes. Molecular docking and in vitro studies have revealed that Budesonide can effectively suppress the progression of MASH and hepatitis C. This study can provide novel insights into the potential drug targets and biomarkers for MASH and hepatitis C.
- | budesonide / Generic mfg., Jorveza (budesonide orodispersible tablets) / Dr Falk
Journal: Comparing budesonide treatment in eosinophilic esophagitis: a specialized center cohort versus a population-based cohort. (Pubmed Central) - Nov 27, 2024
However, the authors acknowledge that further evidence is necessary before considering changes in clinical practice. Conflicting treatment responses, and discontinuation of treatment due to side effects remains a notable concern.
- | budesonide / Generic mfg.
Journal, Surgery: Effects of Nebulization With Ketamine and Budesonide on Postoperative Sore Throat in Patients Undergoing Elective Surgeries Under General Anesthesia: A Randomized Controlled Comparative Clinical Study. (Pubmed Central) - Nov 25, 2024
Conclusion Nebulized ketamine and budesonide both effectively reduce POST, with ketamine showing lower severity but higher hallucination rates. Budesonide was associated with fewer complications, making it a preferable option for managing postoperative discomfort.
- | ambroxol oral / Generic mfg., budesonide / Generic mfg., acetylcysteine solution / Generic mfg.
Journal: The AMSA (Pubmed Central) - Nov 20, 2024
Use of the AMSA manosonic nebulizer appears to be an effective way of improving chronic medical conditions in children - such as chronic otitis media with effusion and Eustachian tube defect - but only if patient compliance can be achieved. The most frequently used active substance was budesonide, irrespective of whether additional secretolic/mucolytic agent was administered.
- | budesonide / Generic mfg.
Journal: Locally Acting Budesonide-Loaded Solid Self-Microemulsifying Drug Delivery Systems (SMEDDS) for Distal Ulcerative Colitis. (Pubmed Central) - Nov 19, 2024
Clinical and histopathological assessments revealed considerable improvements in animals treated with BUD-SMEDDS formulations. Overall findings confirmed the superior capability of solid SMEDDS as BUD carriers to manage distal colitis in tested animals.
- || Filspari (sparsentan) / Travere Therap
Review, Journal: Emerging perspectives in the management of IgA nephropathy: a comprehensive review. (Pubmed Central) - Nov 17, 2024
International collaborations resulted in multiple ongoing clinical trials that are providing new insights toward innovative therapeutic options such as SGLT2 inhibitors, dual endothelin and angiotensin receptor blockers, targeted-release budesonide, B-cell proliferation and differentiation inhibitors, and complement system blockers...In addition to the novelty in therapeutic agents, there is also a growing interest in new noninvasive biomarkers for IgAN screening, risk stratification to monitor the course of the disease, and the response to treatment. In this review, we discuss current knowledge on the pathophysiology of IgAN, disease management, and emerging advances in clinical translation of IgAN research.
- | budesonide / Generic mfg.
Journal: Voice treatment of school-aged children with vocal nodules with ABCLOVE rehabilitation. (Pubmed Central) - Nov 16, 2024
In this review, we discuss current knowledge on the pathophysiology of IgAN, disease management, and emerging advances in clinical translation of IgAN research. ABCLOVE therapy displayed effectiveness on school-aged children with vocal nodules after the treatment of budesonide.
- | budesonide / Generic mfg.
Retrospective data, Journal: Effect of electronic fibrobronchoscope alveolar lavage combined with local administration of budesonide on the efficacy of Mycoplasma pneumoniae pneumonia in children. (Pubmed Central) - Nov 15, 2024
Additionally, the incidence of complications in the experimental group was lower than in the control group (p<0.05). Electronic fibrobronchoscope alveolar lavage combined with local administration of budesonide improves the efficacy of treatment for children with MPP, enhances clinical indicators, reduces inflammation levels, and has high safety, making it worthy of clinical promotion.
- | budesonide / Generic mfg.
Journal, Immune cell: Exposure effects of synthetic glucocorticoid drugs on skeletal developmental and immune cell function in zebrafish. (Pubmed Central) - Nov 13, 2024
Electronic fibrobronchoscope alveolar lavage combined with local administration of budesonide improves the efficacy of treatment for children with MPP, enhances clinical indicators, reduces inflammation levels, and has high safety, making it worthy of clinical promotion. Here, we found that exposure of zebrafish (Danio rerio) to environmentally relevant concentrations of 4 of the most widely used synthetic GCs (beclomethasone dipropionate, budesonide, fluticasone propionate, and prednisolone), from 0 to 4
- | New P4 trial, Biopsy: IA-GRACE-IgANT: Which of the Commonly Available and Approved Drugs in Addition to Standard of Care Can Significantly Improve the Slope of Estimated Glomerular Filtration Rate At Two Years When Compared to Standard of Care Alone in South-Asian Kidney Biopsy-proven Adult (?18 Years) Primary IgA Nephropathy? (clinicaltrials.gov) - Nov 6, 2024
P4, N=585, Not yet recruiting, Sponsor: Christian Medical College, Vellore, India
- | budesonide / Generic mfg.
New trial: A Multi-center Open Label Prospective Study on Early Initiation of Targeted-release Formulation of Budesonide in Patients With Primary IgA Nephropathy (clinicaltrials.gov) - Nov 6, 2024
P=N/A, N=200, Not yet recruiting, Sponsor: Sichuan Provincial People's Hospital
- | Impracor (ketoprofen) / Harrow Health
Journal: Surprising results of patch testing with the baseline series in patients with photocontact allergy to ketoprofen. (Pubmed Central) - Nov 5, 2024
Contact allergy to fragrance mix I, Myroxylon pereirae, black rubber mix, PFR-2, PTBP-FR, and to a somewhat lower extent, to fragrance mix II and budesonide, is common in individuals photoallergic to ketoprofen. It remains to be seen whether sensitisation to ketoprofen leads to simultaneous sensitisation to a number of other, chemically non-related, substances.
- | budesonide / Generic mfg.
Journal: Influence of budesonide and fluticasone propionate in the anti-osteoporotic potential in human bone marrow-derived mesenchymal stem cells via stimulation of osteogenic differentiation. (Pubmed Central) - Nov 5, 2024
Enrichment pathway analysis revealed genes involved in 3 Reactome pathways namely cytokine signaling in immune system, immune system and the interferon alpha/beta signaling pathways and identified 10 hub genes based on the PPI network to determine potential target pathways associated with osteoporosis. These findings provide preliminary insights into the relationship between the key target genes of dexamethasone, budesonide, and fluticasone propionate, and the pathways associated with regulated osteoporosis metabolism during osteogenic differentiation.
- | budesonide / Generic mfg.
Preclinical, Journal: Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination. (Pubmed Central) - Oct 30, 2024
This inhibits the Smo-mediated canonical signaling while activating the Liver Kinase B1 (LKB1)/ AMP-activated protein kinase (AMPK) pathway, leading to Myelin basic protein (MBP) expression. These insights pave the way for pharmacological targeting of Smo CRD to enhance oligodendrocyte precursor cells (OPCs) differentiation and improve remyelination.
- || budesonide / Generic mfg., loperamide / Generic mfg.
Review, Journal: Interventions for Adjunctive Care in Patients With Inflammatory Bowel Disease and Permanent Ileostomy: A Systematic Review. (Pubmed Central) - Oct 28, 2024
This study highlights that the evidence base to inform care for patients with IBD and PI is almost non-existent. There is an urgent need for focused research in this area to inform evidence-based treatment decisions.
- | budesonide / Generic mfg., omeprazole / Generic mfg.
Journal: S3260?An Interesting Case of Lymphocytic Esophagitis In Association With Pityriasis LichenoidesChronica and Rheumatoid Arthritis. (Pubmed Central) - Oct 24, 2024
These observations raise the possibility of an autoimmune etiology. There is no consensus on the lymphocyte count threshold for diagnosis, a challenge compounded by the rarity of the disease, leading to a lack of definitive guidelines for optimal management.JOURNAL/ajgast/04.03/00000434-202410001-03261/figure1/v/2024-10-11T031912Z/r/image-tiff.
- | budesonide / Generic mfg.
Preclinical, Journal: Expression of Concern: Multiple In Vitro and In Vivo Regulatory Effects of Budesonide in CD4+ T Lymphocyte Subpopulations of Allergic Asthmatics. (Pubmed Central) - Oct 18, 2024
There is no consensus on the lymphocyte count threshold for diagnosis, a challenge compounded by the rarity of the disease, leading to a lack of definitive guidelines for optimal management.JOURNAL/ajgast/04.03/00000434-202410001-03261/figure1/v/2024-10-11T031912Z/r/image-tiff. No abstract available
- | Jorveza (budesonide orodispersible tablets) / Dr Falk
Retrospective data, Journal, Real-world evidence, Real-world: A retrospective real-world study on the safety and efficacy of budesonide orodispersible tablets for the induction therapy of eosinophilic oesophagitis. (Pubmed Central) - Oct 18, 2024
No significant adverse events were identified. Budesonide orodispersible tablet is an effective induction therapy for eosinophilic oesophagitis, as evidenced by its high histologic remission rate and favourable safety profile.
- | budesonide / Generic mfg.
Journal: Inflammatory eye disease is a risk factor for future microscopic colitis: A nationwide population-based matched case control study. (Pubmed Central) - Oct 17, 2024
Inflammatory eye diseases are more common in patients subsequently being diagnosed with MC. Our findings highlight that these conditions may have shared causes and inflammatory pathways and are of clinical interest to gastroenterologists, ophthalmologists and general practitioners.
- | budesonide / Generic mfg.
Journal: Risks Associated with the Use of Intranasal Corticosteroids: An Analysis of Adverse Reactions Reported to EudraVigilance. (Pubmed Central) - Oct 16, 2024
These findings underscore the importance of continuous INCS monitoring to mitigate ADRs and safeguard public health. Further research is warranted to explore potential novel signs for safety arising from previously unreported ADRs.
- || Remicade (infliximab) / J&J, Entyvio (vedolizumab) / Takeda, Humira (adalimumab) / AbbVie
Review, Journal: Microscopic Colitis: An Underestimated Disease of Growing Importance. (Pubmed Central) - Oct 16, 2024
Treatment consists of budesonide oral (the gold standard) or enema. Alternatives include bile acid sequestrants (cholestyramine, colesevelam, and colestipol), biologics (infliximab, adalimumab, and vedolizumab), thiopurines, methotrexate, and rarely, surgery.
- | aspirin / Generic mfg., budesonide / Generic mfg.
Observational data, Retrospective data, Journal: Prescribed cumulative dosage of corticosteroids to patients with inflammatory bowel disease diagnosed between 2006 and 2020: a retrospective observational study. (Pubmed Central) - Oct 15, 2024
The use of five-acetyl salicylic acid (5-ASA) decreased in patients with CD (rs?=?-201, p?=?0.012). There was a decrease in the prescription of prednisolone and an increase in the prescription of budesonide treatment from 2006 to 2023; however, the cumulative exposure to corticosteroids in patients with IBD remains at a relatively high level.
- Filspari (sparsentan) / Travere Therap, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
A Novel Therapeutic Approach to ANCA-Negative Crescentic IgA Nephropathy () - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5288;
On follow-up, the patient was transitioned to empagliflozin, budesonide, and sparsentan with improvement of Cr to 1.9mg/dl and UPCR of 0.5...While standard treatment includes steroids and cyclophosphamide or mycophenolate mofetil, the prognosis remains poor...Cellular crescents and necrosis. . IgA.
- prednisone / Generic mfg., budesonide / Generic mfg.
Optimizing IgAN Treatment: Comparing Prednisone and Budesonide Efficacy and Safety (Room 6D, Convention Center) - Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_4717;
This study reveals that while both prednisone and budesonide are effective in managing IgAN, budesonide offers a more favourable safety profile with significantly lower rates of ESRD and proteinuria. These findings support the use of budesonide as a viable and superior alternative to prednisone for the long-term management of IgA nephropathy.
- | budesonide / Generic mfg.
Journal: Gastrointestinal Segmental Remission with Oral Budesonide therapy for Eosinophilic Gastrointestinal Diseases. (Pubmed Central) - Oct 9, 2024
These findings support the use of budesonide as a viable and superior alternative to prednisone for the long-term management of IgA nephropathy. No abstract available
- || Tarpeyo (budesonide) / Calliditas, Stada
Clinical, Journal: Efficacy and Safety of Nefecon in Patients with Immunoglobulin A Nephropathy from Mainland China: 2-Year NefIgArd Trial Results. (Pubmed Central) - Oct 9, 2024
The efficacy outcomes were consistent with global study results, with a numerically greater treatment benefit observed in patients from China. Nefecon was well tolerated, with no unexpected safety signals.
- | Koselugo (selumetinib) / Merck (MSD), AstraZeneca
Journal: Single-Cell Sequencing Combined with Transcriptome Sequencing to Explore the Molecular Mechanisms Related to Psoriasis. (Pubmed Central) - Oct 8, 2024
Our study reveals the potential drugs and pathogenesis of psoriasis. These potential pathway and hub genes may provide new ideas for further mechanism research.
- || Filspari (sparsentan) / Travere Therap
Review, Journal: State-of-Art Therapeutics in IgA Nephropathy. (Pubmed Central) - Oct 7, 2024
Other investigational therapies target the complement cascade by inhibiting proteins of the lectin or alternative pathways. As the therapeutic landscape evolves, it will be important to revise treatment guidelines and develop updated standards of care.
- | budesonide / Generic mfg.
Journal: An Exploration of Dissolution Tests for Inhalation Aerosols. (Pubmed Central) - Oct 2, 2024
Budesonide was used as a model drug...The method employed in this study could offer a potential avenue for exploring the relationship between the orifice size of the actuator and the dissolution behavior of inhaled corticosteroids. This dissolution method was simple, reproducible, and suitable for determining the dissolution of inhalation aerosols.
- | budesonide / Generic mfg.
Journal: Experimental measurement, thermodynamic analysis, and mathematical modeling for budesonide solubility in 1-propanol?+?water mixtures at T?=?(293.2 to 313.2) K. (Pubmed Central) - Sep 29, 2024
Thermodynamic studies demonstrated that BDS dissolution procedures were obtained as endothermic and entropy-driven in almost all cases. The overall MRDs% values for the back-computed BDS solubility in the aqueous mixture of 1-propanol based on van't Hoff model, Buchowski-Ksiazczak equation, CNIBS/R-K model, modified Wilson model, Jouyban-Acree model, Jouyban-Acree-van't Hoff model, MRS model, and Williams-Amidon excess Gibbs energy model were found 1.93%, 1.80%, 11.68%, 33.32%, 12.30%, 9.24%, 10.70%, and 6.57%, respectively.