- |||||||||| budesonide / Generic mfg.
Journal: Intramural esophageal abscess as a complication of an eosinophilic esophagitis (Pubmed Central) - Oct 20, 2021
The diagnosis of eosinophilic esophagitis, complicated by an intramural abscess of the esophagus, was established. After spontaneous drainage of the abscess, antibiotic therapy and subsequent remission induction of eosinophilic esophagitis with orodispersible budesonide resulted in a good therapeutic outcome.
- |||||||||| Nefecon (budesonide) / Calliditas, Stada
[VIRTUAL] Targeted Release Formulation Budesonide (Nefecon) Selectively Reduces Circulating Levels of Chemokines Critical to Immune Cell Trafficking to Peyer Patches in IgA Nephropathy () - Oct 17, 2021 - Abstract #KIDNEYWEEK2021KIDNEY_WEEK_2557;
P2
These observations paralleled significant reductions in the levels of soluble CD23, CD27 and CD30, and are consistent with our previous reports describing a dose-dependent reduction in BAFF, soluble BCMA, TACI, IgA–IgG immune complexes, secretory IgA and galactose-deficient IgA levels with Nefecon. Conclusion Nefecon, which targets the PP-rich distal ileum, modulates key chemokine signals which direct immune cell trafficking to the intestine in IgAN.
- |||||||||| budesonide / Generic mfg.
Review, Journal: Eosinophilic Esophagitis: A Review. (Pubmed Central) - Oct 16, 2021
EoE has a prevalence of approximately 34.4/100 000 worldwide. Treatments consist of proton pump inhibitors, topical steroids, elemental diet, and empirical food elimination, with esophageal dilation reserved for patients with symptomatic esophageal narrowing.
- |||||||||| budesonide / Generic mfg.
Clinical, Review, Journal: Inhaled Corticosteroids and Endocrine Effects in Childhood. (Pubmed Central) - Oct 9, 2021
ICSs currently approved for and commonly used by children with asthma include beclomethasone dipropionate, budesonide, fluticasone propionate, mometasone furoate, ciclesonide, and triamcinolone acetonide. This article reviews 4 areas critical to understanding potential adverse endocrine outcomes of ICSs and placing them in proper perspective: (1) influence of drug/delivery device properties on systemic steroid burden; (2) adrenal insufficiency during ICS treatment; (3) growth effects of ICS and asthma itself; and (4) bone mineral accretion during ICS therapy.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Tepezza (teprotumumab) / Horizon Therapeutics, Roche
Clinical, Journal: New-Onset of Inflammatory Bowel Disease in a Patient Treated With Teprotumumab for Thyroid Associated Ophthalmopathy. (Pubmed Central) - Oct 6, 2021
Despite treatment with budesonide and mesalamine, the patient continued to be symptomatic one and a half months after cessation of teprotumumab and required infliximab to achieve good control of her inflammatory bowel disease. This case represents the first report of new-onset inflammatory bowel disease arising during treatment with teprotumumab.
- |||||||||| dexamethasone / Generic mfg., budesonide / Generic mfg.
Wich is the Altitude Sickness Treatment? () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4357;
Conclusion Relating to AS and BS the only evidenced preventive action is the acetazolamide. Regarding to therapy, the oxygen and descending, along with the dexamethasone, are the only evidenced methods in the case of AS.
- |||||||||| dexamethasone / Generic mfg., budesonide / Generic mfg.
Wich is the Altitude Sickness Treatment? () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4356;
Conclusion Relating to AS and BS the only evidenced preventive action is the acetazolamide. Regarding to therapy, the oxygen and descending, along with the dexamethasone, are the only evidenced methods in the case of AS.
- |||||||||| dexamethasone / Generic mfg., budesonide / Generic mfg.
Wich is the Altitude Sickness Treatment? () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4355;
Conclusion Relating to AS and BS the only evidenced preventive action is the acetazolamide. Regarding to therapy, the oxygen and descending, along with the dexamethasone, are the only evidenced methods in the case of AS.
- |||||||||| dexamethasone / Generic mfg., budesonide / Generic mfg.
Wich is the Altitude Sickness Treatment? () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4354;
Conclusion Relating to AS and BS the only evidenced preventive action is the acetazolamide. Regarding to therapy, the oxygen and descending, along with the dexamethasone, are the only evidenced methods in the case of AS.
- |||||||||| budesonide / Generic mfg.
Review, Journal: Treatment of post-viral olfactory dysfunction: an evidence-based review with recommendations. (Pubmed Central) - Oct 1, 2021
The use of short-term systemic and/or topical steroids is an option in select patients after careful consideration of potential risks of oral steroids. Though some pharmacological investigations offer promising preliminary results for systemic and topical medications alike, a paucity of high-quality studies limits the ability to make meaningful evidence-based recommendations for the use of these therapies for the treatment of PVOD.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Remaloce (infliximab biosimilar) / Yuhan Corp, Biogen, Ewopharma, Merck (MSD), Samsung
Clinical, Journal: Infusion-related angioedema associated with infliximab-abda: Case report. (Pubmed Central) - Oct 1, 2021
Discontinuation of the biosimilar product along with supportive care brought about resolution of angioedema. There are no prior published reports of infusion-related angioedema reactions secondary to infliximab-abda use.
- |||||||||| Gattex (teduglutide) / Takeda
Trial completion, Enrollment change, Trial completion date, Trial primary completion date: TAME: Therapeutic Approaches to Malnutrition Enteropathy (clinicaltrials.gov) - Sep 27, 2021
P2, N=125, Completed,
Since docetaxel and celecoxib could be co-administered for the treatment of a wide range of cancers such as non-small cell lung carcinoma, the developed method is particularly advantageous for routine therapeutic drug monitoring and pharmacokinetic studies of these drugs. Not yet recruiting --> Completed | N=235 --> 125 | Trial completion date: Sep 2020 --> Apr 2021 | Trial primary completion date: Sep 2020 --> Apr 2021
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Humira (adalimumab) / Eisai, AbbVie
Retrospective data, Review: Will the Inducing and Maintaining Remission of Non-biological Agents and Biological Agents Differ for Crohn's Disease? The Evidence From the Network Meta-Analysis. (Pubmed Central) - Sep 21, 2021
Besides, adalimumab, budesonide, natalizumab had lower withdrawals. Therefore, biological agents were not always better than non-biological agents and they have their own advantages in different treatment methods of Crohn's disease.
- |||||||||| budesonide / Generic mfg.
Journal: Results from the German registry for refractory celiac disease. (Pubmed Central) - Sep 18, 2021
Therapeutically, budesonide was used in 59% of the RCD patients regardless of the subtype...In summary, RCD needs to become a focus of national guidelines to increase awareness, establish standards, and thus enable the treating physician to make the correct diagnosis in a timely manner. Moreover, we concluded that when treating such patients, contacting a specialized center is recommended to ensure sufficient management.
- |||||||||| budesonide / Generic mfg.
Review, Journal: IgA Nephropathy: Core Curriculum 2021. (Pubmed Central) - Sep 15, 2021
Recent advances in our understanding of mucosal immunity and the role of the complement system in IgAN pathogenesis are leading to development of novel therapeutic options, which are being evaluated in ongoing clinical trials. In this installment of the AJKD Core Curriculum in Nephrology, IgAN pathogenesis, clinical manifestations, histology, prediction tools, and treatment are reviewed, and case examples are presented to illustrate the approach to the management of patients with IgAN.
- |||||||||| budesonide / Generic mfg.
Journal: Overview of microscopic colitis. (Pubmed Central) - Sep 10, 2021
Medications linked with the development of microscopic colitis, including proton pump inhibitors, non-steroidal anti-inflammatory drugs and selective serotonin-reuptake inhibitors, should be discontinued. If symptoms persist, budesonide is a licensed treatment for microscopic colitis which has been shown to be effective in clinical trials and real-world practice.
- |||||||||| aspirin / Generic mfg., budesonide / Generic mfg., clarithromycin / Generic mfg.
My cousin's wife had the same experience. She was symptom free after her 2nd dose The meds came too late for my cousin, who has diabetes & heart trouble, so it didn't work Dr Richard Bartlett cured him w Budesonide nebulizers, Ivermectin, zinc, Clarithromycin, aspirin, fluids (Twitter) - Sep 8, 2021
- |||||||||| budesonide / Generic mfg.
Concomitant Candidiasis and Lichen Planus Diagnosed in the Absence of Cutaneous Manifestations (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_2786;
Symptoms did not improve despite nystatin treatment and repeat EGD showed 9 mm stenosis that was empirically dilated to 12 mm...She was treated with a 2-month course of oral budesonide...More observational studies are needed to confirm a temporal association between ELP and fungal esophagitis.Figure: Figure 1. (A) Proximal Esophageal Stricture with White Plaques; (B) Low Power View shows Squamous Mucosa with Subepithelial Blistering; (C) Mixed Neutrophilic and Lymphocytic Infiltration in the Epithelium and Subepithelial Tissue; (D) Rare Apoptotic Bodies Present in the Squamous Mucosa
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Cronkhite-Canada Syndrome Manifested as Diffuse Gastrointestinal Polyps (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_2762;
Figure 1A shows multiple 2-30 mm pedunculated and sessile polyps with no bleeding and no stigmata of recent bleeding in the cardia and gastric body. Figure 1B shows multiple pseudopolyps in the sigmoid colon.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
Entero-Tubal Fistula and Abscess in the Setting of Crohn’s Disease (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_2520;
After being started on antibiotics and budesonide, the patient was lost to follow-up...Infliximab with azathioprine improved symptoms, but weight loss continued to a nadir of 71 pounds...Follow-up MRI shows ileal disease, enterocolic fistula (arrow) (B) and sinus tract (arrow) appearing to extend into right Fallopian tube or ovary suggestive of enterotubal fistula and abscess (C). Operative pathology shows salpingeal inflammation with granuloma formation at 100x (D) and 200x (E).
- |||||||||| budesonide / Generic mfg.
Elevated Fecal Calprotectin in an Adult Patient With Juvenile Hamartomatous Polyps: A Case Report (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_2494;
She was started on budesonide for suspected Crohn’s disease colitis...However, in our patient’s case and the prior case cited the patients’ fecal calprotectin decreased or normalized after polyp resection without evidence of inflammatory bowel disease. More studies are needed to see if normal calprotectin would make a polyp less likely as a cause or whether it would be useful in screening to ensure that there was complete removal of all polyps.Figure: (a), (b) 20 mm polyp in sigmoid colon, (c) Hamartomatous polyp pathology with disorganized cellular features
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Triple Treat Causing Chronic Diarrhea: A Case of Collagenous Gastritis, Collagenous Colitis, and Small Intestinal Bacterial Overgrowth (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_2457;
Case Description/ A 55-year-old woman with chronic GERD was referred to the gastroenterology clinic for evaluation of 6 months diarrhea which was not relieved by loperamide...A 14-day course of Rifaximin was prescribed to treat SIBO but diarrhea symptoms persisted although bloating improved...An individualized approach was developed in our case. Our patient was successfully treated by stopping the NSAIDs, treating SIBO with antibiotics, then prescribing budesonide for CG and CC.Figure: Figure A: Thickened subepithelial collagen with entrapped capillaries and inflammatory cells in stomach indicating collagenous gastritis; Figure B: Thickened subepithelial collagen (appears intensely blue) in colon suggesting collagenous colitis.
- |||||||||| budesonide / Generic mfg.
Crohn’s Disease in a Patient With Fibrodysplasia Ossificans Progressiva (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_2045;
It remains to be seen how the inflammatory milieu of Crohn’s disease impacts the course of fibrodysplasia ossificans progressiva, or if Crohn’s treatments could reduce the risk of future flares. Figure: Figure 1: Heterotopic ossification and scoliosis on chest xray Figure 2: Ileal inflammation on MR enterography
- |||||||||| budesonide / Generic mfg.
Small Duct Primary Sclerosing Cholangitis: A Difficult Diagnosis (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1938;
Five years later he was diagnosed with ulcerative colitis and was started on prednisone 40 mg daily...Portal veins appear mildly dilated, without significant sinusoidal dilatation or thrombosis. There is minimal (2%) macrovesicular steatosis.
- |||||||||| budesonide / Generic mfg.
Collagenous Gastritis: A Rare Cause of Common Abdominal Symptoms (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1872;
Case Description/ A 27-year-old female with a past medical history of Anxiety, Depression, and Irritable bowel syndrome taking Librax, IBgard, and Dicyclomine presented to the emergency room with intermittent sharp epigastric pain, nausea, vomiting, and diarrhea for the past 4-6 weeks...The patient was started on budesonide for her diagnosis of collagenous gastritis...As such, therapies targeting CG can improve the quality of life of our patients. Figure: (a) Nodularity and scarring in the stomach body on endoscopy(b) Subendothelial deposition of collagen bands on histology
- |||||||||| Entyvio (vedolizumab) / Takeda
To Start or Not to Start: Early Initiation of Vedolizumab Post-Operatively in Crohn’s Disease (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1679;
Case Description/ A 28-year-old man with a 7-year history of Crohn’s disease currently managed with vedolizumab and budesonide, presented with one-week history of worsening left lower abdomen and groin pain...He was started on piperacillin-tazobactam and underwent percutaneous drainage of abscess...We present the case of a high-risk patient with active infection who restarted therapy within 7 days of resection with good surgical outcomes and no clinical recurrence at 3 month follow up. Early initiation of Vedolizumab may prove to be a viable strategy in preventing early PER and repeat surgery.
- |||||||||| budesonide / Generic mfg.
Lost Sleep over Melatonin Induced Colitis (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1406;
However, management LC is considerably different than other diarrheal diseases highlighting the importance of accurate diagnosis. Treatment of LC includes cessation of any precipitating medications and dietary restrictions as well as initiation of budesonide, the standard drug of choice.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
Colon Adenocarcinoma Metastasis Through Ileocolic Fistula to Small Bowel in the Setting of Crohn’s Disease (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1291;
The specimen was opened to reveal a 3.0 x 3.0 cm ulcerated concentric mass (asterisk) with a central area of tan-gray necrosis. Figure 4: Moderately differentiated adenocarcinoma with mucinous features (the same morphology as in the sigmoid colon specimen) is found in the adjacent terminal ileum (normal ileum mucosa shown by arrow) at the site of fistula (asterisk).* IBD; inflammatory bowel disease
- |||||||||| budesonide / Generic mfg.
The Crohn’s Con Artist You’ve Never Heard Of: Hermansky-Pudlak Syndrome (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1268;
The patient said at that point, “The only thing left was to try medicine for Crohn’s disease.” She was prescribed Budesonide and Biologics with limited improvement...Unfortunately, this therapy remains the best course of treatment due to the similarities of HPS to Crohn’s. 1El-Chemaly et al.,Clin Crest Med,2016,505-511 2Girot et al.,World Journal of Gastroenterology,2019,1031-1036 3Schinella et al.,Annals of Internal Medicine,1980,20-23Figure: Granulomatous colitis of HPS (El-Chemaly et al)
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Spikevax (elasomeran) / Moderna, Takeda
New Diagnosis of Severe Ulcerative Colitis Immediately Following mRNA-1273 SARS-CoV2 Vaccination (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1218;
She was treated with budesonide and mesalamine and symptoms resolved...Infliximab was initiated and re-dosed after 48 hours due to concern for protein-losing enteropathy...While the importance of vaccination and herd immunity cannot be understated, cases such as this are important to report, especially with regard to advice on administration of the second dose of the vaccine when an adverse event was noted following the first dose. This is especially important as many of the local and systemic reactions associated with the mRNA-1273 vaccine were more severe after the second dose.
- |||||||||| budesonide / Generic mfg.
Intestinal Spirochetosis and Crohn's Colitis: A Rare Co-Presentation (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_1180;
A presentation with both IS and Crohn’s as in the case of our patient is very rare. However, it highlights the importance of accurately diagnosing and treating concomitant infection in the setting of IBD medical therapy as immunomodulators carry their own infectious and neoplastic risks.Figure: Figure 1a: CT abdomen/pelvis W notable for multiple segmental areas of active inflammation in the distal ileum with numerous enteroenteric fistula tracts throughout the mesentery.b: Colonoscopy findings consistent with Crohn’s colitis.c: Warthin-Starry silver stain highlighting filamentous organisms protruding from the mucosal epithelium.
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