budesonide / Generic mfg. 
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  • ||||||||||  budesonide / Generic mfg.
    Journal:  Mannosylation Of Budesonide Palmitate Nanoprodrugs For Improved Macrophage Targeting. (Pubmed Central) -  Mar 23, 2022   
    After LPS-induced inflammation, the anti-inflammatory effect of mannosylated nanoparticles was assessed. After 48 hours of incubation, cytokines (MCP-1 and TNFα) were reduced demonstrating that the functionalization of nanoprodrugs is possible and efficient.
  • ||||||||||  budesonide / Generic mfg.
    Preclinical, Journal:  Effect of pressure drop on the in vitro dispersion of adhesive mixtures of different blend states for inhalation. (Pubmed Central) -  Mar 23, 2022   
    Examination of powder captured in the pre-separator of the NGI led to the conclusion that the dispersion of these adhesive mixtures occurred by erosion of the adhesion layer, i.e. budesonide was liberated as single particles or micro-agglomerates. It is concluded that the FPF-ΔP relationships were dependent on the blend state and for the S2 and S3 mixtures, a critical pressure drop was identified above which the pressure drop had a limited effect on the FPF.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Spikevax (elasomeran) / Moderna, Takeda
    EVALUATION OF THERAPEUTIC CLINICAL TRIALS INVOLVING GERIATRIC PATIENTS FOR COVID-19 ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_1037;    
    More data is needed from randomized clinical trials on the safety and efficacy of therapeutic interventions for COVID-19 in geriatric patients. Based on current data, vaccine use should continue to be encouraged in adults 65 years and older.
  • ||||||||||  budesonide / Generic mfg.
    Review, Journal:  Inhaled corticosteroids for the treatment of COVID-19. (Pubmed Central) -  Mar 18, 2022   
    We expect to incorporate the findings of these studies in future versions of this review. We monitor newly published results of RCTs on inhaled corticosteroids on a weekly basis and will update the review when the evidence or our certainty in the evidence changes.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Treatment and Outcome of Autoimmune Hepatitis (AIH): Audit of 28 UK centres. (Pubmed Central) -  Mar 15, 2022   
    We observed higher death/transplant rates in patients with AIH who were untreated with steroids (including asymptomatic or non-cirrhotic sub-groups), those receiving higher Prednisolone doses and those who did not receive an SSA. Similar death/transplant rates were seen in those receiving Prednisolone or Budesonide, those continuing steroids after 12-months and patients attaining normal ALT within 12-months versus not.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Bile Acid Sequestrant Therapy in Microscopic Colitis. (Pubmed Central) -  Mar 11, 2022   
    BAS may be an effective corticosteroid-sparing option in the treatment of MC and should be considered after budesonide induction. Larger controlled studies are needed to confirm the efficacy for long-term maintenance and tolerability of BAS in patients with MC.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Current options and investigational drugs for the treatment of eosinophilic esophagitis. (Pubmed Central) -  Feb 26, 2022   
    These include monoclonal antibodies (including mepolizumab, reslizumab, benralizumab, dectrekumab, cendakimab, and dupilumab), JAK-STAT blockers, and S1PR agonists, among others...Therapies under investigation potentially can target multiple Th2-associated diseases that converge in EoE patients. Therapeutic strategies require a personalized and patient-centered approach to reduce the burden of the disease, and cost-effectiveness analysis to position their use in a complex therapeutic landscape.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Reactive Oxygen Species-Responsive Polyether Micelle Nanomaterials for Targeted Treatment of Ulcerative Colitis. (Pubmed Central) -  Feb 26, 2022   
    It is a self-assembled polyether micelle that can be oxidized at the inflammation site where the concentration of reactive oxygen increases, and effectively release the encapsulated budesonide (Bud)...Molecular mechanism studies have shown that it achieves its therapeutic effects by activating the peroxisome proliferators-activated receptors-γ (PPAR-γ) pathway and inhibiting the nuclear factor (NF)-κB pathway. This study proves that oral nano-micelles have an important impact on improving the efficacy of UC treatment drugs and have far-reaching significance for the targeted treatment of gastrointestinal diseases.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Preparation and Characterization of Colon-Targeted pH/Time-Dependent Nanoparticles Using Anionic and Cationic Polymethacrylate Polymers. (Pubmed Central) -  Feb 24, 2022   
    To overcome the inadequacy of only pH-dependent delivery systems, we developed in vitro evaluated both pH- and time-dependent nanoparticles loaded budesonide (BUD) for the treatment of IBD in this study...Nanoparticles containing 90% anionic-10% cationic polymethacrylate polymers inhibited burst BUD release under acidic conditions and exhibited sustained drug release at neutral pH. Consequently, in the medication of IBD, BUD-loaded pH and time-dependent nanoparticles may be a hopeful choice as a drug delivery system.
  • ||||||||||  budesonide / Generic mfg.
    Clinical, Journal:  Major Difference in Particle Size, Minor Difference in Release Profile: A Case Study of Solid Lipid Nanoparticles. (Pubmed Central) -  Feb 12, 2022   
    SLN were synthesized via the hot high-pressure homogenization (HPH) method, budesonide (BUD) was used as the model drug, and BUD-SLN1-BUD-SLN4 with increasing particle size was obtained, i.e. 120, 240, 360, and 480 nm...Noticeably, the release behavior of SLN was to some extent related to the average particle size of SLN, but the correlation was insignificant when the intersection degree of particle size distribution was great. This study provides a new idea for the understanding of in vitro release of SLN, and has a certain referencing value for the research and development of novel nanomedicines.
  • ||||||||||  Sutent (sunitinib) / Pfizer
    Clinical, Journal:  Sunitinib induced colitis manifesting as invasive diarrhea in a patient with renal cell carcinoma. (Pubmed Central) -  Feb 10, 2022   
    Diarrhea is a frequent symptom in patients treated with tyrosine kinase inhibitors, however the described pathologic findings have rarely been reported. Our aim is to emphasize the importance of close follow-up in patients treated with tyrosine kinase inhibitors, and to raise awareness on the management of sunitinib induced colitis.
  • ||||||||||  budesonide / Generic mfg., cyclosporine / Generic mfg.
    Review, Journal:  A reasoned approach to the treatment of autoimmune hepatitis. (Pubmed Central) -  Feb 8, 2022   
    Alternative first-line treatment with budesonide is effective in adults, but less so in the juvenile form of AIH; first-line treatment with ciclosporin does not provide convincing advantages compared to standard treatment...Mycophenolate mofetil is the most widely used second-line drug, and has good efficacy particularly for patients intolerant to azathioprine, but is teratogenic...Biologicals, including anti-tumour necrosis factor- α and anti-CD20 monoclonal antibodies, have given ambivalent results and may have severe side-effects. Clinical trials with new therapeutic options aiming at targeting B lymphocytes and proinflammatory cytokines, or expanding regulatory T cells to restore tolerance are ongoing.
  • ||||||||||  budesonide / Generic mfg.
    Autoimmune hepatitis developing after SARS-CoV-2 vaccination: series of three cases (PAVILLON 1; ROOM: BRUSSELS [VIRTUAL]) -  Feb 7, 2022 - Abstract #BWG2022BWG_254;    
    A 57-year-old woman was referred for progressive elevation of liver function tests (LFTs) four weeks following the first dose of Moderna mRNA-1273 vaccination...However, six weeks later budesonide 9mg was initiated for an increase in LFTs (transaminases x10 ULN)...Azathioprine 50mg was associated two weeks later. Currently she is doing well with marginal AST and ALT elevation (
  • ||||||||||  fluvoxamine / Generic mfg., budesonide / Generic mfg., fluoxetine / Generic mfg.
    Trial completion date, Trial primary completion date:  Repurposed Approved and Under Development Therapies for Patients With Early-Onset COVID-19 and Mild Symptoms (clinicaltrials.gov) -  Feb 1, 2022   
    P3,  N=4669, Recruiting, 
    The majority (> 90%) of patients treated with budesonide achieved remission, although nearly half subsequently relapsed. Trial completion date: Mar 2022 --> Nov 2023 | Trial primary completion date: Feb 2022 --> Oct 2023