fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., epinephrine / Generic mfg.
    Journal:  Opioid-Free Anesthesia for Open Radical Cystectomy Is Feasible and Accelerates Return of Bowel Function: A Matched Cohort Study. (Pubmed Central) -  Jun 10, 2023   
    With regard to POI (OFA group: 1/22 patients (4.5%); control group: 2/22 (9.1%)) and PONV (OFA group: 5/22 patients (22.7%); control group: 10/22 (45.5%)), trends but no significant results were found (p = 0.99 and p = 0.203, respectively). OFA appears to be feasible in ORC and to improve postoperative functional gastrointestinal recovery by halving the time to first defecation compared with standard fentanyl-based intraoperative anesthesia.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Oxycodone, Morphine, and Fentanyl in Patients With Chronic Pain: Proposal of Dose-Specific Concentration Ranges. (Pubmed Central) -  Jun 10, 2023   
    OFA appears to be feasible in ORC and to improve postoperative functional gastrointestinal recovery by halving the time to first defecation compared with standard fentanyl-based intraoperative anesthesia. The proposed dose-specific ranges may be useful for interpreting steady-state opioid serum concentrations in clinical and forensic settings.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., isoflurane / Generic mfg.
    Journal, Surgery:  Effect of gonadectomy on pain assessment in dogs undergoing orthopaedic stifle surgery. (Pubmed Central) -  Jun 10, 2023   
    Gonadectomy affects pain sensitivity in dogs undergoing stifle surgery. Neutering status should be taken into consideration when planning individualized anaesthetic/analgesic protocols.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Drug checking in the fentanyl era: Utilization and interest among people who inject drugs in San Diego, California. (Pubmed Central) -  Jun 10, 2023   
    Neutering status should be taken into consideration when planning individualized anaesthetic/analgesic protocols. Our findings highlight low rates of DCS awareness and utilization, inequities by race/ethnicity and housing situation, high interest in advanced spectrometry DCS versus FTS, and the potential role of SSPs in improving access to DCS, especially among racial/ethnic minorities.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Comparison of Aptamer Signaling Mechanisms Reveals Disparities in Sensor Response and Strategies to Eliminate False Signals. (Pubmed Central) -  Jun 8, 2023   
    In this work, we have developed a series of sensors using aptamers for the small-molecule drugs flunixin, fentanyl, and furanyl fentanyl and compare their performance?in particular, focusing on their specificity...We also demonstrate strategies for improving the sensitivity and specificity of aptamer sensors with the development of a "hybrid beacon," wherein the incorporation of a complementary DNA competitor into an aptamer beacon selectively hinders interferent?but not target?binding and signaling, while simultaneously overcoming signal suppression by interferents. Our results highlight the need for systematic and thorough testing of aptamer sensor response and new aptamer selection methods that optimize specificity more effectively than traditional counter-SELEX.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  All Hands on Deck: We Need Multiple Approaches To Uncover the Neuroscience behind the Opioid Overdose Crisis. (Pubmed Central) -  Jun 8, 2023   
    The increase of fentanyl, fentanyl analogs, and adulterants in the illicit drug supply has further complicated treatment strategies...Here, we argue that researchers should be supportive of multiple models to promote new perspectives and discoveries and always consider the trends in human opioid use when designing preclinical studies. We describe the benefits of contingent and noncontingent models as well as models of opioid withdrawal and how each of these can help illuminate different components of OUD.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  Opioid prescribing patterns by drug type: The Pennsylvania experience. (Pubmed Central) -  Jun 8, 2023   
    While fewer prescriptions were being prescribed overall, the breakdown of drug type being prescribed remained similar in 2020 compared to 2016. Fentanyl and hydrocodone saw the largest decrease between 2016 and 2020.
  • ||||||||||  methadone / Generic mfg.
    Journal:  Methadone Induction for a Patient With Precipitated Withdrawal in the Emergency Department: A Case Report. (Pubmed Central) -  Jun 6, 2023   
    We describe a patient with opioid use disorder who presented to the emergency department in precipitated withdrawal who completed a same-day methadone induction with next-day dosing at an opioid treatment program as part of an emergency department methadone protocol. As opioid-related deaths rise, emergency department-initiated methadone is feasible for patients with opioid use disorder.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Public health and medical preparedness for mass casualties from the deliberate release of synthetic opioids. (Pubmed Central) -  Jun 3, 2023   
    Coordinated planning across the entire local community emergency response system is also critical. The ability to rapidly recognize the opioid toxidrome, education on personal protective actions, and training in medical management of individuals experiencing an opioid overdose are key components of preparedness for an opioid mass casualty incident.
  • ||||||||||  fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
    Journal:  A Highly Sensitive and Specific Photonic Crystal-Based Opioid Sensor with Rapid Regeneration. (Pubmed Central) -  May 30, 2023   
    The sensor can selectively detect fentanyl from a mixture of morphine and fentanyl and be regenerated in 2 min with up to 93.66% recovery rate after five cycles. The efficacy of our sensor is further validated in artificial interstitial fluid and human urine samples.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Toward automated infrared spectral analysis in community drug checking. (Pubmed Central) -  May 30, 2023   
    The detection of MDA was demonstrated on three mixtures: (1) MDMA and MDA, (2) MDA and dimethylsulfone, and (3) fentanyl, etizolam, and benzocaine...Feature importance was calculated using shapely additive explanations to better explain the model predictions and k-nearest neighbors was used for visual comparison to labelled training data. This is a step toward building appropriate trust in computer-assisted interpretations in order to promote their use in a harm reduction context.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Suite of Aptamer-Based Sensors for the Detection of Fentanyl and Its Analogues. (Pubmed Central) -  May 29, 2023   
    These include colorimetric, fluorescent, and electrochemical sensors, which can detect and quantify minute quantities of fentanyl and many of its analogues with no response to other illicit drugs, cutting agents, or adulterants?even in interferent-ridden binary mixtures containing as little as 1% fentanyl. Given the high performance of these novel analytical tools, we foresee the potential for routine use by medical and law enforcement personnel as well as the general public to aid in rapid and accurate fentanyl identification.
  • ||||||||||  Nucynta (tapentadol) / Collegium Pharma, Grunenthal, pethidine / Samaritan Pharma
    Clinical, Journal:  Reducing Opioid Use for Chronic Pain With a Group-Based Intervention: A Randomized Clinical Trial. (Pubmed Central) -  May 27, 2023   
    In people with chronic pain due to nonmalignant causes, compared with usual care, a group-based educational intervention that included group and individual support and skill-based learning significantly reduced patient-reported use of opioids, but had no effect on perceived pain interference with daily life activities. isrctn.org Identifier: ISRCTN49470934.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal, Adverse events:  High and Hyper: Fentanyl Induces Psychomotor Side-Effects in Healthy Pigs. (Pubmed Central) -  May 27, 2023   
    fentanyl-induced motor and behavioral effects, and serotonergic transmission may be involved in some of them. The psychomotor side effects of fentanyl could potentially interfere with post-operative pain evaluation in pigs.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Feasibility study of using mobile phone-based experience sampling to assess drug checking by opioid street drug users. (Pubmed Central) -  May 27, 2023   
    Although resource intensive in comparison to retrospective reports, daily reporting potentially provides more detailed information on test strip use and its association with overdose risk reduction and, ultimately, fewer overdoses. Needed are larger trials and validation studies of daily experience sampling to identify the optimum protocol for collecting accurate information on drug checking and overdose risk reduction behavior.
  • ||||||||||  fentanyl citrate / Generic mfg., ropivacaine / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  The impact of epidural analgesia for acute pancreatitis on maternal and fetal outcome: a cohort study. (Pubmed Central) -  May 25, 2023   
    Needed are larger trials and validation studies of daily experience sampling to identify the optimum protocol for collecting accurate information on drug checking and overdose risk reduction behavior. Conservative medical management was done using intravenous (i.v.) analgesics, including fentanyl and tramadol...Boluses of 10-15
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Intentional use of both opioids and cocaine in the United States. (Pubmed Central) -  May 24, 2023   
    The combination of opioids and cocaine has been increasingly implicated in overdose fatalities, but it is unknown how much is intentional vs. fentanyl-adulterated drug supply...People who use opioids or cocaine commonly choose to use the other. Knowing the characteristics of those most likely to use both should guide interventions for prevention and harm reduction.