fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal:  How to NAPS: A Discussion of the Safety and Implementation of a Nurse Administered Propofol Sedation (NAPS) Program. (Pubmed Central) -  Dec 23, 2024   
    Research shows that patients, providers, and health care organizations can see procedural and financial benefit of implementing a NAPS program. An outline of implementation and development of a NAPS program is presented covering equipment, supplies, resources, provider credentialing, nurse education and training requirements, patient eligibility criteria, propofol administration order sets, and a quality assurance program.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Behavioral and genetic markers of susceptibility to escalate fentanyl intake. (Pubmed Central) -  Dec 23, 2024   
    Our extended in silico identification of SNPs and transcription factors associated with the "addiction prone" high escalating rats highlights the importance of integrating findings from translational preclinical models. Through a precision medicine approach, our results may aid in the development of patient-centered treatment options for those with OUD.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Retrospective data, Journal, Surgery:  Impact of genetic variants on fentanyl metabolism in major breast surgery patients: a candidate gene association study. (Pubmed Central) -  Dec 23, 2024   
    There was also a weak but significant positive correlation between metabolic ratio and time for first analgesia in the postoperative period (r?=?0.17; p?=?0.01). There was no significant association with the selected candidate SNPs in CYP3A4 and ABCB1 genes and metabolic ratio of norfentanyl to fentanyl in South Indian patients undergoing major breast surgery.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  A Supramolecular-Quantum Dot System for Broad-Spectrum Detection of Fentanyl Analogs. (Pubmed Central) -  Dec 21, 2024   
    Detection of these agents is possible even at 0.01 mol% in the presence of common interferents. This simple, rapid, reliable, sensitive, and cost-effective approach couples supramolecular capture with graphene quantum dot nanomaterial quenchers to create a tool with the potential to advance public health and safety in the context of field-based detection of drugs in the fentanyl class.
  • ||||||||||  fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
    Journal:  National Trends in Drug Overdose Mortality Among Asian American, Native Hawaiian, and Pacific Islander Populations. (Pubmed Central) -  Dec 21, 2024   
    This simple, rapid, reliable, sensitive, and cost-effective approach couples supramolecular capture with graphene quantum dot nanomaterial quenchers to create a tool with the potential to advance public health and safety in the context of field-based detection of drugs in the fentanyl class. AANHPI populations experience distinct overdose mortality patterns, with NHPI individuals and certain subgroups disproportionately affected, warranting targeted public health interventions.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Impact of Intracellular Proteins on ?-Opioid Receptor Structure and Ligand Binding. (Pubmed Central) -  Dec 19, 2024   
    Docking studies confirm that multiple fentanyl conformations can bind to the receptor. Perhaps a variety of conformations of fentanyl can stabilize multiple conformations of the MOR, which can explain why fentanyl can induce different intracellular signaling and multiple physiological effects.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Preclinical, Journal:  Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro  (Pubmed Central) -  Dec 18, 2024   
    The results showed that all nitazenes bound to MOR with nanomolar affinities, and the functional potency of several of them was comparable to or exceeded that of fentanyl...The most potent analogue of the panel across all functional assays was ?'-methyl etonitazene. Taken together, through critical pharmacological evaluation, this work provides a framework for strengthened preparedness and risk assessments of current and future nitazenes that have the potential to cause harm to users.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Two Cases of Maggot-Associated Ignatzschineria Bacteremia in Xylazine-Induced Injection Wounds: An Emerging Threat. (Pubmed Central) -  Dec 18, 2024   
    Both cases were associated with maggot colonization in chronic lower extremity wounds from fentanyl/xylazine injections...This report underscores the emergence of Ignatzschineria bacteremia in individuals with a history of xylazine-associated wounds and substance use disorder. Successful management should prioritize wound care and adherence to antibiotic regimens to prevent complications in these challenging cases.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Changes in Recovery Capital Among Patients Receiving Buprenorphine Treatment for Opioid Use Disorder in a Telehealth Setting. (Pubmed Central) -  Dec 17, 2024   
    Older patients, those not requiring buprenorphine induction, and those not using heroin or fentanyl at intake were more likely to have remission-predictive baseline BARC-10 scores (P?<?.05)...Most patients had increased or sustained already high levels of recovery capital, an established predictor of sustained remission. Further research is required to better understand variability across patients and how it may relate to long-term outcomes.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Retrospective data, Review, Journal:  Comparison of the anesthetic effect of sufentanil versus fentanyl in pediatric surgical patients: a meta-analysis. (Pubmed Central) -  Dec 16, 2024   
    This study aimed to emphasize that TFPs can lead to dependence in pediatric patients as well; hence, they should be used more carefully to avoid any potential dependency. Among the children undergoing surgery, sufentanil demonstrates more advantages over fentanyl in maintaining stable hemodynamics and reducing postoperative agitation, offering better clinical benefits.
  • ||||||||||  fentanyl citrate / Generic mfg., methadone / Generic mfg.
    Journal:  Retromer Opposes Opioid-Induced Downregulation of the Mu Opioid Receptor. (Pubmed Central) -  Dec 16, 2024   
    We identified 146 hits including all three subunits of the endosomal Retromer complex. We show that the LENL motif in MOR is a novel Retromer recycling motif and that LENL is a necessary, sufficient, and conserved mechanism to give MOR access to the Retromer recycling pathway and protect MOR from agonist-induced downregulation to multiple clinically relevant opioids including fentanyl and methadone.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Can Medical Licensing Boards Swing the Pendulum Towards Judicious Opioid Prescribing Practices? (Pubmed Central) -  Dec 16, 2024   
    Although opioid prescriptions have decreased by 44.4 percent between 2011-2020,1 the number of deaths linked to prescription opioids has decreased only marginally.2 The marked fall in opioid prescribing without a concomitant reduction in opioid-related deaths suggests that an at-risk population continued to receive prescription opioids, whether directly or indirectly, from a medical professional. Currently, illicitly manufactured fentanyl (IMF) is the culprit for the majority of the approximately 81,000 annual opioid-related deaths.3 This finding has been misleadingly used to suggest that prescription opioids for chronic pain are no longer (and never were) a relevant concern,4 while the reality is that their lethal consequences are simply dwarfed by the marked rise in IMF deaths.5.
  • ||||||||||  fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal, Intubation:  Choice of Postintubation Sedation Strategy by Sex: A Conjoint Analysis. (Pubmed Central) -  Dec 12, 2024   
    Physicians managing postintubation sedation reported sex rarely affected decision-making when choosing propofol, midazolam, or fentanyl as sedation strategies, despite evidence that these medications are metabolized differently in females. Further research is needed to identify ideal postintubation sedation strategies that account for patient sex.
  • ||||||||||  Review, Journal:  Pharmacological Pain Treatment in Older Persons. (Pubmed Central) -  Dec 11, 2024   
    The choice of analgesic(s) and the route of administration should be guided by the pain characteristics, as well as by the patient's comorbidities, organ function and medications. Several directions have been highlighted to optimise pharmacological pain management in older individuals: (1) before starting pain treatment adequately detect and assess pain and always perform a full geriatric assessment, (2) consider kidney function systematically to adjust the doses of analgesics and avoid the risks of overdose, (3) start with the lowest dose of an analgesic and increase it gradually under the control of the effect, (4) involve the older persons and family in their treatment, (5) reevaluate pain regularly during treatment and (6) combine pharmacological treatment with non-pharmacological approaches.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Pediatric exposure to illicit fentanyl is associated with drug availability in the community. (Pubmed Central) -  Dec 11, 2024   
    We report a strong association between drug availability in the community and pediatric exposures, suggesting that drug seizure data may be a valuable tool for poison centers, medical toxicologists, and public health officials. Our data suggest that monitoring regional drug seizure data may be a tool to determine new trends in pediatric exposure, guide research in the area, and target outreach and education.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Comparison of Adequacy of Anaesthesia (AoA) monitors with CONOX (Pubmed Central) -  Dec 11, 2024   
    Both AoA and CONOX measure anaesthetic depth similarly. However, interpreting qNOX values requires caution, as the patient's consciousness status influences them.
  • ||||||||||  fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
    Retrospective data, Journal:  Analgesic effect of external oblique intercostal block in laparoscopic cholecystectomy: A retrospective study. (Pubmed Central) -  Dec 10, 2024   
    Furthermore, Group E demonstrated significantly lower NRS scores at 0, 1, 2, 4, and 6?h postoperatively and a reduced need for rescue analgesia compared to Group C. However, at 12?h post-surgery, Group E's NRS scores were slightly higher than Group C's. The EOIB is associated with reduced pain within the first 24 postoperative hours following laparoscopic cholecystectomy.
  • ||||||||||  fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
    Journal, Surgery:  Consequences of Legal Infractions on the General Surgery Residency Application Process. (Pubmed Central) -  Dec 9, 2024   
    Legal infractions occurring during college are less consequential than those in medical school. Regardless of the timing, being arrested for drunk and disorderly or marijuana possession had less impact than a DUI, possession of cocaine, methamphetamine or fentanyl.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Large decrease in syringe distribution following the introduction of fentanyl in King County, Washington. (Pubmed Central) -  Dec 9, 2024   
    A precipitous decline in syringe distribution through King County SSPs began in 2020 and continued through 2023, which coincided with increasing availability of fentanyl in the local drug market. Nevertheless, the trends in client encounters highlight that PWUD continued to seek harm reduction services, with preliminary evidence that distribution of safer smoking supplies may increase the number of client visits.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  A New Neuroanesthetic Protocol of Rendering Specialized Care in Treating Degenerative Lumbar Spine Diseases in High-Risk Patients: Prospective Analysis of the Results. (Pubmed Central) -  Dec 9, 2024   
    A new neuroanesthetic protocol was used in the experimental group (EG, n=25), while the control group (CG, n=25) underwent intravenous anesthesia based on propofol and fentanyl...A new neuroanesthetic protocol of rendering a specialized care to patients with a high risk of anesthesia and surgery, assessed by the authors-developed CDSS, has resulted in effective elimination of the local postoperative pain syndrome, reduction of perioperative application of opioids, and stabilization of intraoperative indicators of cardiovascular activity. In addition, no postoperative cognitive disorders, anesthetic side-effects, adverse pharmacological consequences of the complex usage of non-steroidal anti-inflammatory drugs, prolonged local anesthetics, alpha-2-agonist, and non-narcotic analgesics have been registered.