- |||||||||| fentanyl citrate / Generic mfg., ropivacaine / Generic mfg.
Is Pericapsular Nerve Group Block Better than Lumbar Plexus Block for Hip Fracture Surgery? (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1596;
Exclusion criteria included patient refusal, history of drug allergy to ropivacaine and fentanyl, coagulopathy, local infection etc. Preoperatively patients were randomised 1:1 to either Group I (PENG block) or Group II (LPB). In this prospective, randomized, controlled study, the PENG block has demonstrated effective analgesia with minimal adverse effects while allowing early postoperative mobilisation.
- |||||||||| MoxDuo IR (morphine + oxycodone) / QRxPharma, AbbVie
Restrictive Domains in Healthcare Opioid Legislation in Low- and Middle-Income Countries (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1524;
In this prospective, randomized, controlled study, the PENG block has demonstrated effective analgesia with minimal adverse effects while allowing early postoperative mobilisation. While analyses of associations of restrictive domains and HDI and QDI are ongoing and results are pending, this scoping review preliminarily calls attention to the specific restrictive domains of the legislative language that may negatively influence access to quality pain management.Individual models of success in facilitating access to opioids and developing palliative care programs were identified in Nepal, Mongolia, and Uganda.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Pain Management in Cancer Patients (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1351;
72 patients (86%) benefited of major opioids administration (Morphine, Fentanyl, Oxycodone), and for 51 patients co-analgesics were administered. Although in Romania palliative care at home is still not sufficiently well developed, it can represent a viable solution for controlling the pain of cancer patients at their home, and for improving their quality of life.
- |||||||||| Chirocaine (levobupivacaine) / Purdue, AbbVie
Case Report: Hip Radiofrecuency Ablation in a 12 years Old Cancer Pain Girl (Rhabdomyosarcoma) (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1270;
Using the hip denervation technique described, the sciatic innervation remains and reduces the possibility of a Charcot joint. Regardless, hip denervation in a pediatric patient should be considered a last resort in the treatment of hip pain.Hip denervation is a potentially useful pain intervention when conservative or surgical options fail.
- |||||||||| How Can We Make Pain Relief Accessible and Equitable for Children with Cancer Across the World? (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1059;
Nevertheless, the use of acetaminophen and ibuprofen in the context of pediatric pain related to cancer may be limited by concerns of masking fever or bleeding risks, respectively, and the efficacy of tramadol may be limited by its weak opioid effect. Difficulties with obtaining pediatric formulations have been identified and education of pharmacists in local preparation of morphine solution may improve availability.
- |||||||||| Neuropathic Pain in Steven Johnson Syndrome, a case report (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1010;
Healthcare workers should remain vigilant for serious adverse drug reactions. Timely introduction of most suitable pharmacological agent according to type of pain (neuropathic) results in favorable outcomes provided such interventions are carried out in expert hands in suitable clinical environment.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
An RCT of pre-anesthetic Subjective Effects of Morphine, Oxycodone, and Fentanyl (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_870;
Contrary to the general assumption that opioids enhance well-being but replicating our earlier results, we show a decrease in 'feeling good' after opioids. Patients also reported reduced anxiety.
- |||||||||| morphine sulphate / Generic mfg.
Uncovering genetic predictors for extreme morphine responses in infants and children (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_860;
Background & Aims: Morphine and fentanyl are commonly prescribed for relief of major pain in infants and children; however, responses range from inadequate pain relief (requiring higher doses/other analgesics) to adverse effects (e.g., respiratory depression, hypotension, allergic reaction), and the long-term consequences of opioid use on the developing brain remain unclear [1,2]. Knowledge of genetic variants that contribute to extreme opioid responses will facilitate development of predictive pharmacogenetic tests so that the safest and most effective pain management strategies are used.
- |||||||||| fentanyl citrate / Generic mfg., dexamethasone / Generic mfg., morphine sulphate / Generic mfg.
Neurolysis of Superior Hypogastric Plexus in Patient with Penile Cancer Pain and HIV: a Case Report (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_720;
Despite this, superior and inferior hypogastric plexus and ganglion impar block are choices for pelvic pain and genito-urinaria. Bilateral neurolysis of the superior hypogastric plexus was chosen to control pain relating to penile cancer pain at a level that can be acceptable to the patient.
- |||||||||| Pain Management Strategies Following Total Knee Arthroplasty During an Opioid Epidemic (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_662;
While most of these patients used these medications in addition to opioids, further research is needed to determine if these medications were used at the same time or consecutively due to limited opioid prescriptions. This study also demonstrated that patients required opioids to manage their postoperative pain following TKA and that additional non-opioid medications and non-pharmacologic strategies were also frequently needed.
- |||||||||| fentanyl citrate / Generic mfg.
A Correlation Of Fentanyl Patches Prescribing With Raised Opioid Awareness Over 10 Years in England (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_625;
The maximum dose of OME to 120mg/day would imply all fentanyl patches greater than a 25 microgram patch would exceed this target and therefore should be reviewed and titrated down. The encouraging results can be seen that NuTH and the surrounding primary care setting are working collaboratively to ensure the prescribing trends are in the correct direction.
- |||||||||| fentanyl citrate / Generic mfg., ketorolac / Generic mfg., nefopam / Generic mfg.
A RCT of opioid vs. non-opioid as PCA background for postoperative pain and complications in TKR (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_621;
The continuous chamber of the PCA device contained fentanyl 1200mcg for opioid group, and ketorolac tromethamine 150mg plus nefopam hydrochloride 100mg for non-opioid group (total volume 50ml, rate: 1cc/hr). In patients underwent total knee arthroplasty, PCA with opioid-based background infusion resulted in lower pain scores but higher complication rates than non-opioid infusion.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Journal: A (Pubmed Central) - Jul 17, 2024
The NAM alters orthosteric ligand kinetics in therapeutically desirable ways and works cooperatively with low doses of naloxone to effectively inhibit various morphine-induced and fentanyl-induced behavioural effects in vivo while minimizing withdrawal behaviours. Our results provide detailed structural insights into the mechanism of negative allosteric modulation of the
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg., hydromorphone hydrochloride / Generic mfg.
Review: Opioid analgesic use among patients with kidney disease: a systematic review. (Pubmed Central) - Jul 17, 2024
Greater caution and consideration of potential risks and benefits should be applied when using other opioids. Further high-quality studies examining clinical outcomes associated with the use of different opioids and opioid doses in renal disease are warranted.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: Patients presenting to the ED with nonfatal drug overdose: Self-reported history of overdose and naloxone use. (Pubmed Central) - Jul 17, 2024
This study demonstrated high rates of fentanyl exposure on toxicology testing at time of overdose across all participants including study participants without self-reported intentional opioid use. Data gathered in the ED at time of overdose can be used to inform upstream naloxone distribution and public health initiatives.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Tolerant or Intolerant? Learning From Studying Drug Concentrations in the Living and the Dead. (Pubmed Central) - Jul 17, 2024
To emphasize this approach, we compared fentanyl concentrations from JAN 2010 to OCT 2023 in individuals investigated for driving under the influence of drugs to postmortem cases. This comparison highlights the changing nature of tolerance, stresses the importance of not relying solely on reference ranges for result interpretations, and discusses the importance of the autopsy in identifying or ruling out other potential causes of death.
- |||||||||| fentanyl citrate / Generic mfg.
Retrospective data, Journal: Opioid Administration Practice Patterns in Patients With Acute Respiratory Failure Who Undergo Invasive Mechanical Ventilation. (Pubmed Central) - Jul 17, 2024
In the context of efforts to limit healthcare-associated opioid exposure, our findings highlight the considerable opioid exposure that accompanies mechanical ventilation and suggest potential under and over-treatment with analgesia. Our results facilitate benchmarking of hospitals' analgesia practices against risk-adjusted averages and can be used to inform usual care control arms of analgesia and sedation clinical trials.
- |||||||||| Journal: Drug disposition in neonatal G (Pubmed Central) - Jul 16, 2024
Four drugs-midazolam (MDZ), fentanyl (FNT), phenobarbital (PHB), and topiramate (TPM)-were intravenously administered under four conditions: control (C), therapeutic hypothermia (TH), hypoxia (H), and hypoxia plus TH (H+TH). Significance Statement The overarching goal of this study using the neonatal G
- |||||||||| fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Duration-Dependent Risk of Hypoxemia in Colonoscopy Procedures. (Pubmed Central) - Jul 13, 2024
This study underscores the importance of optimizing procedural efficiency and tailoring sedation protocols to individual patient risk profiles to enhance the safety of colonoscopy. Further research is needed to develop strategies that minimize procedure duration without compromising the quality of care, thereby reducing the risk of hypoxemia and improving patient safety.
- |||||||||| fentanyl citrate / Generic mfg., naltrexone / Generic mfg.
Journal: Exploring Opioid Prescription Patterns and Overdose Rates in South Carolina (2017-2021): Insights into Rising Deaths in High-Risk Areas. (Pubmed Central) - Jul 13, 2024
Additionally, we incorporated data from opioid treatment programs, healthcare professionals prescribing naltrexone, clinicians with buprenorphine waivers, and county-level overdose fatality statistics...Our study showed that between 2017 and 2021, opioid prescriptions decreased from 64,223 to 41,214 per 100,000 residents, while fentanyl-related overdose deaths increased by 312%...To effectively combat the opioid crisis, we advocate for improved local healthcare infrastructure, broader treatment access, stricter management of out-of-state prescriptions, and vigilant tracking of prescription patterns. Tailored local strategies are essential for mitigating the opioid epidemic in these communities.
- |||||||||| fentanyl citrate / Generic mfg.
Biomarker, Journal: Temperature and pH-dependent stability of fentanyl analogs: Degradation pathways and potential biomarkers. (Pubmed Central) - Jul 13, 2024
Ester and amide hydrolysis, demethylation at the propanamide, and O-demethylation were observed for selected fentalogs only. The potential for analyte loss should be considered during the pre-analytical phase (i.e., shipping and transport) where environmental conditions may not be controlled, as well as during the analysis itself.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Submersible voltammetric sensing probe for rapid and extended remote monitoring of opioids in community water systems. (Pubmed Central) - Jul 12, 2024
The intensifying global opioid crisis, majorly attributed to fentanyl (FT) and its analogs, has necessitated the development of rapid and ultrasensitive remote/on-site FT sensing modalities...This sensing platform enables wireless data acquisition on a smartphone via Bluetooth. Such effective remote operation of submersible opioid sensing probes could enable stricter surveillance of community water systems toward timely alerts, countermeasures, and legal enforcement.
- |||||||||| pregabalin / Generic mfg., gabapentin / Generic mfg., diazepam / Generic mfg.
Preclinical, Journal: Discriminative stimulus properties of two training doses of gabapentin in rats: Substitution by pregabalin, diazepam, and pentobarbital. (Pubmed Central) - Jul 11, 2024
These findings demonstrate that gabapentin establishes a robust discriminative cue and exhibits stimulus effects closely similar to pregabalin, pentobarbital, and diazepam. Since pregabalin, pentobarbital, and diazepam carry a risk of problematic use and are classified as controlled substances, further evaluations of gabapentin's risks in this regard are warranted.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Dependency of fentanyl analogue protomer ratios on solvent conditions as measured by ion mobility-mass spectrometry. (Pubmed Central) - Jul 11, 2024
Lastly, increasing conditions to pH???4.0 also prompted the appearance of new mobility peaks for ortho- and para-methyl acetyl fentanyl, where all previous studies had only showed one single distribution. Because these ratios have promise to be used qualitatively for identification of these (and emerging) fentanyl analogues, understanding how various conditions (i.e., mobile phase selection and/or chromatographic gradient) affect their ratios is critically important to the development of advanced ion mobility and mass spectrometry methodologies to identify fentanyl analogues.
- |||||||||| fentanyl citrate / Generic mfg.
Journal, Reflex: Images in Anesthesiology: Carotid Sinus Reflex From Neck Mass and Opioids. (Pubmed Central) - Jul 11, 2024
Because these ratios have promise to be used qualitatively for identification of these (and emerging) fentanyl analogues, understanding how various conditions (i.e., mobile phase selection and/or chromatographic gradient) affect their ratios is critically important to the development of advanced ion mobility and mass spectrometry methodologies to identify fentanyl analogues. Additionally, many anesthetic agents have sympatholytic properties that can exacerbate this imbalance further toward
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Fentanyl and xylazine crisis: Crafting coherent strategies for opioid overdose prevention. (Pubmed Central) - Jul 10, 2024
A multifaceted approach is imperative in effectively combating the opioid overdose epidemic. This approach should include expansion of treatment access, broadening the availability of medications for opioid use disorder, implementation of harm reduction strategies, and enaction of legislative reforms and diminishing stigma associated with opioid use disorder.
- |||||||||| fentanyl citrate / Generic mfg., hydromorphone hydrochloride / Generic mfg., ropivacaine / Generic mfg.
Journal, Surgery: Ultrasound-guided erector spinae plane block for postoperative analgesia in patients undergoing minimally invasive direct (Pubmed Central) - Jul 9, 2024
This approach should include expansion of treatment access, broadening the availability of medications for opioid use disorder, implementation of harm reduction strategies, and enaction of legislative reforms and diminishing stigma associated with opioid use disorder. Erector spinae plane block provided early effective postoperative analgesia and reduced opioid consumption, time to extubation, and ICU discharge in patients undergoing MIDCAB.
- |||||||||| morphine sulphate / Generic mfg.
Review, Journal: Efficacy and Safety of Intrathecal Morphine for Cesarean Delivery: A Narrative Review. (Pubmed Central) - Jul 8, 2024
ITM is a safe and effective option for post-cesarean analgesia, with comparable pain relief to alternative forms of pain control, and side effects that are generally manageable. Further research is warranted to explore beneficial combinations with other methods of pain management and optimal dosing strategies.
- |||||||||| fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
Journal, HEOR, Cost-effectiveness, Cost effectiveness: Cost-effectiveness and efficacy of scalp block for elective supratentorial craniotomy in resource-limited settings: A randomized controlled trial. (Pubmed Central) - Jul 8, 2024
Remifentanil is favored for neurosurgical pain management, but its utilization in low- and middle-income countries (LMICs) is limited...This study compares costs and perioperative outcomes of scalp block versus fentanyl infusion in patients undergoing elective supratentorial craniotomy...However, prudent opioid use is imperative. This study underscores the need for ongoing research to optimize neurosurgical pain management and evaluate long-term safety implications.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: A Postmortem Case Report involving Fentanyl, Desalkylgidazepam and Bromazolam. (Pubmed Central) - Jul 5, 2024
Additionally, fentanyl was detected in the blood (11 ng/mL) and fentanyl, norfentanyl, and gabapentin were detected in the urine. The present study aims to provide the toxicological community with information regarding a fit-for-purpose analysis of two NPS benzodiazepines.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Fentanyl-Related Deaths in Ontario, Canada: Toxicological Findings and Circumstances of Death in 4395 Cases (2020-2022). (Pubmed Central) - Jul 5, 2024
Detailed reports for select cases were included to provide additional insight into the different case types and to show the difficulty in interpreting blood concentrations without additional detailed case histories. This study provides valuable information for the scientific and medical community regarding the continued use of fentanyl and how patterns of fentanyl use have evolved since it began to appear in forensic casework.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Plasma concentrations of buprenorphine administered via matrix-type transdermal patches applied at three different anatomical locations in healthy adult horses. (Pubmed Central) - Jul 4, 2024
Although this has been investigated in horses with fentanyl, there is no literature available on location-dependent plasma buprenorphine concentrations when administered as a transdermal matrix-type patch...The metacarpal and gaskin regions presented more erratic and inconsistent buprenorphine uptake and plasma concentrations as compared to the ventral aspect of the tail base. Further research must be directed at investigating the optimal dose, achievable duration of analgesia, change in measurable plasma concentrations, and behavioral and systemic effects.
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