- |||||||||| Instanyl (fentanyl) / Takeda
Pricing, Retrospective data, Journal, HEOR: Efficacy and cost savings with the use of a minimal sedation / anxiolysis protocol for intra-articular corticosteroid injections in children with juvenile idiopathic arthritis: a retrospective review of prospectively collected data. (Pubmed Central) - Mar 29, 2019 Conclusion Clopidogrel dose-adjusted plasma concentration in STEMI patients, as well as multivessel coronary artery disease, showed significance in predicting an unfavorable composite clinical outcome after 40-month follow-up. A minimal sedation/anxiolysis protocol (including nitrous oxide, intranasal fentanyl, a topical numbing agent, acetaminophen, ibuprofen, ondansetron and child life intervention), provides safe and effective analgesia for intra-articular corticosteroid injection in a subset of patients with juvenile idiopathic arthritis and offers a lower cost alternative to general anesthesia.
- |||||||||| Duragesic (fentanyl) / J&J
Journal: Opioids delay healing of spinal fusion: a rabbit posterolateral lumbar fusion model. (Pubmed Central) - Mar 27, 2019 Systemic opioids led to an inferior quality fusion mass with delay in maturation and remodeling at six-weeks in this rabbit spinal fusion model. These preliminary results lay foundation for further research to investigate underlying cellular mechanisms, temporal fusion process, and dose-duration relationship of opioids responsible for our findings.
- |||||||||| Bridion (sugammadex) / Merck (MSD)
Clinical, Retrospective data, Journal: Sugammadex affects emergence agitation in children undergoing strabismus surgery. (Pubmed Central) - Mar 27, 2019 In the propensity-matched analysis, patients in the sugammadex group showed rapid recovery, but there was no difference in the EA incidence or severity. Conclusion Sugammadex did not affect EA incidence or severity compared with conventional cholinesterase inhibitors, although it showed a favorable recovery profile in children undergoing strabismus surgery.
- |||||||||| 3-day fentanyl transdermal patcht / Generic mfg., megestrol / Generic mfg., Avastin (bevacizumab) / Roche
Clinical, Review, Journal: Paraneoplastic Encephalopathy in a Patient With Metastatic Lung Cancer: A Case Study. (Pubmed Central) - Dec 28, 2018 According to her husband, RS was diagnosed with stage IIIA large cell lung cancer 8 months earlier and was treated with concurrent chemotherapy (carboplatin, pemetrexed, and bevacizumab) and radiation therapy that was completed 4 months prior to admission...Home medications included transdermal fentanyl 12 μg/hr patch changed every 72 hours; oxycodone-acetaminophen tablets 5-325 mg, two every 4 hours as needed for pain; prednisone 10 mg, one tablet daily; and megestrol 40 mg/mL suspension, 20 mL once daily for appetite stimulation...These types of encephalopathies have been seen in patients with cancer and have thus been termed paraneoplastic. The presence of anti-VGKC antibodies on RS's paraneoplastic panel directed the inpatient medical oncology team toward a paraneoplastic neurologic disorder (PND) as the most likely diagnosis.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Impact of Fellowship Training Level on Colonoscopy Quality and Efficiency Metrics. (Pubmed Central) - Dec 22, 2018 Efficiency of detecting and resecting polyps improved throughout training without reaching attending level. Fellow involvement led to greater use of moderate sedation, which may relate to a longer procedure duration and an evolving experience in endoscopic technique.
- |||||||||| methamphetamine / Generic mfg.
Journal: Evaluation of Intraosseous Fluid as an Alternative Biological Specimen in Postmortem Toxicology. (Pubmed Central) - Oct 4, 2018 This novel study supports the use of IOF as an alternative postmortem specimen for toxicological investigations as a potentially less-compromised tissue in decomposed or traumatized bodies. Preliminary data is provided for the screening of common drugs of abuse in IOF that may show to be subject to alternative rates of postmortem redistribution than to that of other biological specimens in future studies that quantitate IOF drug concentrations.
- |||||||||| Trial termination: Local Anesthetic Cream in Younger Patients Undergoing Lumbar Punctures (clinicaltrials.gov) - Jul 27, 2018
P2, N=33, Terminated, Preliminary data is provided for the screening of common drugs of abuse in IOF that may show to be subject to alternative rates of postmortem redistribution than to that of other biological specimens in future studies that quantitate IOF drug concentrations. Suspended --> Terminated
- |||||||||| Vycavert (10 mg hydrocodone bitartrate/325 mg acetaminophen) / Acura Pharma, 3-day fentanyl transdermal patcht / Generic mfg.
Clinical, Journal, HEOR: Self-reported prevalence, description and management of pain in adults with haemophilia: methods, demographics and results from the Pain, Functional Impairment, and Quality of life (P-FiQ) study. (Pubmed Central) - Mar 21, 2018 Patients with chronic pain, particularly those with both acute/chronic pain, frequently experience psychological issues, functional disability and reduced HRQoL. Treatment strategies for acute pain (e.g. routine infusions to prevent bleeding) and for chronic pain (e.g. long-acting opioids) may be underused.
- |||||||||| fentanyl citrate / Generic mfg., 3-day fentanyl transdermal patcht / Generic mfg., fentanyl buccal / Generic mfg.
Enrollment open: Fentanyl Effect on Blood Pressure in Elderly Patients After Induction of General Anesthesia (clinicaltrials.gov) - Mar 9, 2018 P2/3, N=105, Recruiting, Treatment strategies for acute pain (e.g. routine infusions to prevent bleeding) and for chronic pain (e.g. long-acting opioids) may be underused. Not yet recruiting --> Recruiting
- |||||||||| fentanyl citrate / Generic mfg., 3-day fentanyl transdermal patcht / Generic mfg., fentanyl buccal / Generic mfg.
Trial initiation date, Trial primary completion date: Fentanyl Effect on Blood Pressure in Elderly Patients After Induction of General Anesthesia (clinicaltrials.gov) - Apr 28, 2017 P2/3, N=105, Not yet recruiting, Phase classification: P=N/A --> P2 Initiation date: Jul 2013 --> Jul 2017 | Trial primary completion date: Jul 2018 --> Jul 2020
- |||||||||| dexmedetomidine / Generic mfg.
Surgery: Dexmedetomidine and Desflurane Consumption (clinicaltrials.gov) - Nov 10, 2016 P=N/A, N=40, Completed, ClinicalTrials.gov identifier: NCT00538850. Recruiting --> Completed | Trial primary completion date: Feb 2017 --> Oct 2016
- |||||||||| dexmedetomidine / Generic mfg.
Surgery: Dexmedetomidine and Desflurane Consumption (clinicaltrials.gov) - Nov 1, 2016 P=N/A, N=40, Recruiting, Recruiting --> Completed | Trial primary completion date: Feb 2017 --> Oct 2016 Not yet recruiting --> Recruiting | Trial primary completion date: Jun 2017 --> Feb 2017
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