- |||||||||| fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: A comparison of balloon-assisted versus dilator in percutaneous gastrostomy tube placement. (Pubmed Central) - Oct 9, 2023
BAG is a safe and efficient technique for percutaneous gastrostomy tube placement. BAG patients required significantly lesser radiation, OR time, post-operative pain management, and recorded lower postoperative complications compared to their counterparts in gastrostomies utilizing dilators.
- |||||||||| fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg.
Journal: Vocal Cord Monitoring by Flexible Fiberoptic Laryngoscopy During Thyroid Radiofrequency Ablation. (Pubmed Central) - Oct 9, 2023
BAG patients required significantly lesser radiation, OR time, post-operative pain management, and recorded lower postoperative complications compared to their counterparts in gastrostomies utilizing dilators. The procedure was assisted by an anesthetist administering fentanyl 50?mcg, midazolam 1.5 to 5.0?mg, and propofol infusion 2?mg/(kg
- |||||||||| ropivacaine / Generic mfg.
Clinical, Journal, Surgery: Efficacy of lumbosacral and sacrococcygeal epidural ropivacaine in dogs undergoing surgery for perineal hernia. (Pubmed Central) - Oct 9, 2023
After premedication with IM acepromazine 0.02?mg/kg and butorphanol 0.3?mg/kg, general anesthesia was induced with propofol and maintained with sevoflurane in oxygen...Clinical failure was defined as the need of more than two boluses of fentanyl/h each dog received meloxicam 0.2?mg/kg IV at the end of the surgery...No significant differences between groups were detected in the GCPS-SF score, tactile sensitivity, pressure pain thresholds, need of post-operative methadone, or motor blockade. Both epidural techniques are valuable analgesic options for perineal hernia repair in dogs.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Educational Attainment and US Drug Overdose Deaths. (Pubmed Central) - Oct 6, 2023
In this cross-sectional study, lower educational attainment was found to be associated with higher growth in overdose deaths. As the opioid crisis has transitioned to fentanyl and polysubstance use, overdose deaths have become more prevalent in groups with lower socioeconomic status, potentially exacerbating existing life-expectancy disparities.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: 'Safer drug supply' measures in Canada to reduce the drug overdose fatality toll: Clarifying concepts, practices and evidence within a public health intervention framework. (Pubmed Central) - Oct 5, 2023
North America has been home to an unprecedented crisis of drug overdose deaths, driven largely by drug users' exposure to highly potent and toxic, illicit opioid drugs (e.g., fentanyl)...In this Perspective paper, we briefly address some of these issues, and clarify selected issues of elementary concepts, practices, and evidence related to 'safer supply' measures. These measures are also discussed in reference to other, comparable types of public health-oriented emergency health or survival care standards, while considering the extreme contexts of an ongoing, acute drug-death-crisis in Canada.
- |||||||||| fentanyl citrate / Generic mfg., ketamine / Generic mfg., sevoflurane / Generic mfg.
Preclinical, Journal: Comparison of the respiratory effects of commonly utilized general anaesthesia regimes in male Sprague-Dawley rats. (Pubmed Central) - Oct 4, 2023
Bronchial hyperresponsiveness in response to ketamine-xylazine anaesthesia should be considered when designing experiments using this regime. The findings of the present study indicate commonly used anaesthetic regimes allow fair comparison of respiratory mechanics in experimental animals undergoing any of the examined anaesthesia protocols.
- |||||||||| Zepatier (grazoprevir/elbasvir) / Merck (MSD), Vosevi (sofosbuvir/velpatasvir/voxilaprevir) / Gilead, Mavyret (glecaprevir/pibrentasvir) / AbbVie, Enanta Pharma
Journal, Adverse events: Reported adverse events related to use of hepatitis C virus direct-acting antivirals with opioids: 2017-2021. (Pubmed Central) - Oct 1, 2023
Low numbers of DAA AE reports with opioids may provide reassurance to prioritize HCV treatment in this population. These data contribute to evidence supporting the continued scale-up of DAA treatment among people who use drugs to achieve HCV elimination goals.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Hippocampal volume loss in individuals with a history of non-fatal opioid overdose. (Pubmed Central) - Oct 1, 2023
Voxel-based morphometry showed lower hippocampal volume in the OD group than in the NOD group, which on post hoc analysis was evident in the left but not the right hippocampus. These findings strengthen the evidence that hippocampal injury is associated with non-fatal opioid overdose, which is hypothesized to underlie overdose-related amnestic syndrome.
- |||||||||| fentanyl citrate / Generic mfg., methadone / Generic mfg.
A Child and Adolescent Psychiatry Guide to Medications for Opioid Use Disorder (Mercury Ballroom (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1394;
A working knowledge and plan to intervene with patients who have OUD reduces personal, structural, and institutional discrimination. Clinicians who treat adolescents and TAY should understand the risks that fentanyl poses to their patients and have a plan for initiating or referring those with primary or co-occurring OUD for MOUD treatment.
- |||||||||| fentanyl citrate / Generic mfg.
Fentanyl and Fatal Opioid Overdoses Among Youth: Overdose Risk, Treatment, and Prevention Planning (Mercury Ballroom (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1393;
Naloxone kits are a powerful tool to reduce the risk of death from an overdose, but a simple prescription or provision of a kit does not insure proper utilization. Treatment planning and medications to reduce opioid overdose are increasingly needed as tools in the fight against fentanyl overdose among adolescents in the United States.
- |||||||||| fentanyl citrate / Generic mfg.
How Fentanyl Is Fueling the Opioid Epidemic Among Youth (Mercury Ballroom (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1392;
As a result, many youth are exposed to fentanyl unintentionally and are at risk of fatal opioid overdose, even among youth with minimal fentanyl exposure. Conclusions Fentanyl, a highly lipophilic synthetic opioid, exhibits high potency, rapid onset, and short duration of action, which increase the misuse potential and risk of fatal overdose among youth, including among youth with minimal or unintentional fentanyl exposure.
- |||||||||| fentanyl citrate / Generic mfg.
Clinical Perspectives 72 : Fentanyl and the Opioid Epidemic: Practical Guidance for Child and Adolescent Psychiatry Clinicians (Mercury Ballroom (New York Hilton Midtown); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_1391;
Conclusions It is vital to screen all youth for fentanyl exposure and intentional use, to engage youth in education and overdose prevention, and to provide naloxone to youth at risk of opioid overdose. Evidence-based treatments include medications for OUD combined with psychotherapy, which may be initiated in primary mental health settings while facilitating a referral to treatment.
- |||||||||| fentanyl citrate / Generic mfg., naltrexone / Generic mfg.
Opioid, Stimulant, and Hallucinogen Use Disorders in Consultation-Liaison Psychiatry (Empire Ballroom East (Sheraton New York Times Square Hotel); In-person) - Sep 30, 2023 - Abstract #AACAP2023AACAP_305;
There has also been a rise in overdose-related deaths among adolescents aged 14 to 18 years old, particularly due to fentanyl contamination of drug supply...This will include indications for and an approach to the use of naltrexone and buprenorphine in opioid use disorder treatment...A biopsychosocial clinical approach to maintenance treatment including pharmacotherapy, psychosocial interventions, and an outline of harm-reduction counseling points for each substance is key to improving outcomes. Conclusions The rising rates of stimulant, hallucinogen, and opioid use in the pediatric population highlight the need for the child and adolescent psychiatrist CL to update our knowledge base and skills on initiating evidence-based interventions in pediatric hospital settings.
- |||||||||| fentanyl citrate / Generic mfg., midazolam hydrochloride / Generic mfg., diazepam / Generic mfg.
Observational data, Journal: Electroencephalographic findings in preterm neonates (Pubmed Central) - Sep 28, 2023
Early postnatal screening is helpful, but additional records are usually needed to detect high-risk newborns. It would be important to continue studying this line of research in pediatrics.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Benzylfentanyl as a Surrogate Template for Fentanyl-Selective Imprinted Polymers. (Pubmed Central) - Sep 28, 2023
Important studies herein determined the optimum ratio of the template/functional monomer, with subsequent evaluations of selectivity of the MIP for the template and fentanyl versus the commonly encountered narcotics such as methamphetamine, cocaine, and heroin. The data obtained from the HPLC analysis showed that the Bfen-MIP was successful in selectively binding the template and actual fentanyl, better than other common narcotics.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Opioid-related deaths in Ontario correctional facilities and penitentiaries (2009-2019). (Pubmed Central) - Sep 26, 2023
Data also indicates the recent emergence of fentanyl-related analogues in this population. The results from this study provide valuable information about drug-related deaths in the Ontario prison system and provide insight into how the opioid crisis and the increased use of fentanyl and its analogues have affected this vulnerable population.
- |||||||||| fentanyl citrate / Generic mfg., morphine sulphate / Generic mfg.
Review, Journal: Endogenous Opiates and Behavior: 2022. (Pubmed Central) - Sep 25, 2023
This paper is the forty-fifth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2022 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
- |||||||||| Journal: Prescription of off-label and unlicensed medication for newborns hospitalized in the Intensive Care Unit. (Pubmed Central) - Sep 24, 2023
This study showed a large percentage of prescriptions made in the off-label (50.7%) and unlicensed (37.2%) form in the Neonatal Intensive Care Unit, corroborating the worrying world scenario. The most exposed neonates were precisely the most vulnerable ones and, among the most commonly prescribed medications, ampicillin and gentamicin stood out in off-label form and caffeine in unlicensed form.
- |||||||||| Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Opioid Withdrawal Causing a Broken Heart! (Zone 2, Science and Technology Hall, Level 2) - Sep 21, 2023 - Abstract #AHA2023AHA_8123;
Although it was previously thought of as a benign self-limiting condition, it is now known to be associated with significant morbidity and mortality.Case: A 26-year-old male patient with past medical history of Fentanyl abuse now on methadone, presented with features of opioid withdrawal...Due to excessive agitation and vomiting, he was given IV haloperidol and ondansetron...He was diagnosed with takotsubo cardiomyopathy and was initiated on dapagliflozin, metoprolol succinate and losartan...Approximately 4.5% of these patients can die during their hospitalization and 4% can die within 30 days of discharge. So, clinicians must keep a high index of suspicion for this syndrome in patients with history of substance use disorder, especially in the setting of troponin elevation.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: America's Opioid Ecosystem: How Leveraging System Interactions Can Help Curb Addiction, Overdose, and Other Harms. (Pubmed Central) - Sep 18, 2023
Illegally manufactured opioids (such as fentanyl) are involved in a majority of U.S. drug overdoses, but the problems are broader and deeper than drug fatalities...The primary audience for this study is policymakers, but it should also be useful for foundations looking for opportunities to create change that have often been overlooked. This study can help researchers better consider the full consequences of policy changes and help members of the media identify the dynamics of interactions that deserve more attention.
- |||||||||| fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
Journal: Modern approaches to the components of multimodal antinociceptive protection in patients with ovarian cancer (Pubmed Central) - Sep 18, 2023
Our results provide insight into the mechanisms behind some of the emergent evidence on the impact of safer supply prescribing. The introduction of Remaxol into MMA improves the quality of antinociceptive protection, promotes regression of POL products, and prevents the progression of hepatopathy and EI, contributing to the development of stress-limiting mechanisms of long-term adaptation in patients with ovarian cancer in the intra and near perioperative period.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for ? Opioid receptor for Safer and long-lasting analgesia. (Pubmed Central) - Sep 18, 2023
In this study, we investigated the development of dual-targeted ligands that bind to both ?-opioid receptor (MOR) and carbonic anhydrase (CA) enzymes, using fentanyl structure as a template...Our results suggest that targeting both MOR and CA enzymes can lead to the development of new class of potent analgesic agents with fewer side effects and reduced tolerance development. Further studies are needed to explore the potential mechanisms underlying these effects and to further optimize the therapeutic potential of these compounds.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: A case study for local data surveillance in opioid overdose fatalities in Cuyahoga County, OH 2016-2020. (Pubmed Central) - Sep 15, 2023
Fentanyl and fentanyl analogs have increased the overdose mortality rates in the United States, significantly impacting states like Ohio...Significant trending shifts can also be observed for the presence of carfentanil in decedent and seizure county data. Local data of drug-related overdose deaths and drug seizures from a medical examiner's office and affiliated forensic laboratory lab can be used for timely public health surveillance, and informing prevention, and intervention at the county level.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Validation of Two Diagnostic Assessments for Opioid and Stimulant Use Disorder for Use by Non-Clinicians. (Pubmed Central) - Sep 15, 2023
The United States is in the fourth wave of the opioid epidemic marked by the increase in fentanyl and co-occurring stimulant use related overdose deaths...The ROUDA and RSUDA are efficient and valid measures that can be administered in various settings by non-clinical staff to rapidly diagnose opioid and stimulant use disorders and allow for immediate treatment and harm reduction interventions. The ROUDA and RSUDA are efficient and valid measures that can be administered by non-clinicians to rapidly diagnose opioid and stimulant use disorders.
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