fentanyl citrate / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg.
    Preclinical, Journal:  Changes in Percutaneous Absorption of Fentanyl Patches in Rats Treated with a Sebum-Like Secretion. (Pubmed Central) -  Sep 4, 2020   
    Furthermore, in vivo experiments indicated that the plasma FEN concentration in rats treated with the FEN-patch was significantly increased by treatment with 5% SLS. These results suggest that the sebum affected the release, accumulation, and absorption of FEN from the FEN-patch, and the FEN concentration in the blood was reflected by the balance of the suppression of drug release and the enhancement of drug accumulation in the skin with SLS.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, PK/PD data, Journal:  Individual variations in fentanyl pharmacokinetics and pharmacodynamics in preterm infants. (Pubmed Central) -  Sep 2, 2020   
    These results suggest that the sebum affected the release, accumulation, and absorption of FEN from the FEN-patch, and the FEN concentration in the blood was reflected by the balance of the suppression of drug release and the enhancement of drug accumulation in the skin with SLS. The inter-individual variation of fentanyl pharmacokinetics is large in preterm infants and the dose of 0.5μg/kg seems not effective for skin-breaking procedures.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Assessment of Pain Management During Interfacility Air Medical Transport of Intubated Patients. (Pubmed Central) -  Sep 2, 2020   
    Seventy-three percent of intubated patients transported by Ornge received an opioid analgesic, most commonly fentanyl. We found no clinically relevant difference in the administration of analgesics based on age, sex, past medical history of chronic pain, or reason for transfer other than repatriation to the originating hospital.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Predicting Opioid Overdose Deaths Using Prescription Drug Monitoring Program Data. (Pubmed Central) -  Sep 1, 2020   
    A model for predicting fatal opioid overdoses was developed using Prescription Drug Monitoring Program data. Given the recent national epidemic of deaths involving heroin and fentanyl, it is noteworthy that the model performed equally well in identifying those at risk for overdose deaths from both illicit and prescription opioids.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Assessment of Naloxone as a Therapeutic for Inhaled Carfentanil in the Ferret. (Pubmed Central) -  Sep 1, 2020   
    Carfentanil is a powerful synthetic opioid that is approximately 100 times more potent than fentanyl and 10,000 times more potent than morphine...Naloxone was able to quickly resolve the respiratory depression, significantly reducing the frequency of apneic periods in carfentanil-exposed ferrets. Our results suggest that naloxone, when administered via intramuscular injection following incapacitation, is a viable treatment against the effects of a potentially lethal dose of inhaled carfentanil.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] DEXMEDETOMIDINE FOR ULTRASOUND GUIDED RADIOFREQUENCY ABLATION OF HCC: A CHOICE OF SAFETY () -  Aug 30, 2020 - Abstract #WIP2020WIP_395;    
    At the begining of the procedure, 1.5 mcg/Kg IV Fentanyl and local anesthesia were administered and the Ramsay score was registred; VAS score, patient and operator satisfacion were measured postop- eratively...At the end of RFA, VAS was 0 in all patients, with patient satisfaction nearly 80% and operator satisfaction 90%. Dexmedetomidine can be successfully used for cooperative sedation in patients undergoing RFA of hepatocellular carcinoma, assuring pain relief, hemodynamic stability as well as maintanig regular spontaneous breathing pattern which helps US visualization during the entire procedure.
  • ||||||||||  Duragesic (fentanyl) / J&J
    Challenges of palliative care for patients with end-stage renal disease (Room 11 (North 4F G401+G402)) -  Aug 30, 2020 - Abstract #JSN2020JSN_148;    
    As mentioned above, the tentative title of the workshop was “Trial of standardization of palliative care for patients with end-stage renal disease”, but unfortunately it is not a situation where standardization can be tried. On the day, I would like to give a more constructive story, together with actual examples.
  • ||||||||||  gabapentin / Generic mfg.
    Journal:  Patterns of Neonatal Co-Exposure to Gabapentin and Commonly Abused Drugs Observed in Umbilical Cord Tissue. (Pubmed Central) -  Aug 30, 2020   
    Notably, the concentration of gabapentin in gabapentin-positive umbilical cord specimens was higher in buprenorphine-containing specimens as compared to specimens containing other opioids, stimulants, or benzodiazepines. Identification of neonatal co-exposure to gabapentin and opioids, particularly buprenorphine, may guide clinicians in rapid initiation of monitoring and intervention for neonatal abstinence syndrome.
  • ||||||||||  fentanyl citrate / Generic mfg.
    [VIRTUAL] Retroperitoneoscopic living donor nephrectomy: Experience of 2500 cases at a single center (E-Poster Hall) -  Aug 29, 2020 - Abstract #TTS2020TTS_1042;    
    Child and adolescent psychiatrists can encounter a variety of challenges in treating patients using products that contain fentanyl, including the lack of understanding that fentanyl has the potential to be lethal.  The modified approach of retroperitoneal laparoscopic donor nephrectomy could be a cost effective and safe alternative for developing countries.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Carfentanil: a narrative review of its pharmacology and public health concerns. (Pubmed Central) -  Aug 29, 2020   
    Carfentanil is a synthetic fentanyl analogue approved for veterinary use...Rare reports of suspected accidental poisoning of first responders have not been analytically confirmed and are unlikely to represent true poisoning. General occupational hygiene measures, including regular decontamination with soap and water, basic personal protective equipment (nitrile gloves, N95 mask, and eye goggles), and ready access to naloxone are generally sufficient in most circumstances.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  People who inject drugs (PWID) and HIV/aids cases in Mexico City: 1987-2015. (Pubmed Central) -  Aug 29, 2020   
    It is not far-fetched to think that in the coming years there will be an increase in the number of individuals who inject drugs due to the high production and availability of heroin in Mexico and the emergence of fentanyl use as indicated by ethnographic research in Mexico City and the deaths linked to its consumption. The latest reports, published in 2018, documented at least five cases of fentanyl users.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Review, Journal:  Pain management during labor and vaginal birth. (Pubmed Central) -  Aug 29, 2020   
    Maintenance of analgesia is best achieved with a background regimen (either programmed intermittent boluses or a continuous epidural infusion) supplemented with patient-controlled epidural analgesia and using dilute local anesthetics combined with opioids such as fentanyl...Appropriate choice of drug should take into account the stage and progression of labor, local safety protocols, and maternal and fetal/neonatal side effects. Pain in labor is complex, and women should fully participate in the decision-making process before any one modality is selected.
  • ||||||||||  fentanyl citrate / Generic mfg., epinephrine / Generic mfg.
    Journal:  Effectiveness of intra-articular anesthesia in knee arthroscopy (Pubmed Central) -  Aug 29, 2020   
    The advantages in favor of intraarticular anesthesia were: shortened hospital stays, less pain at 24 hours, safety in its application. Its disadvantage is the possibility of pain during surgery and sedation is sufficient as adjuvant.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Clinical, Journal:  Comparison of Paravertebral Block with Conventional Spinal Anesthesia in Patients Undergoing Unilateral Inguinal Hernia Repair. (Pubmed Central) -  Aug 28, 2020   
    Hemodynamic responses, time to first analgesia and ambulation, time required to perform the block, Bromage score, satisfaction score, failure rate, and intra- and postoperative drugs used showed a statistically significant difference between the groups (P < 0.001). PVB is not a sole anesthetic technique due to a higher failure rate and increased intraoperative fentanyl requirement but has advantages such as prolonged analgesia, stable hemodynamics, and early ambulation.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Retrospective data, Journal:  The Efficacy of Hypotensive Agents on Intraoperative Bleeding and Recovery Following General Anesthesia for Nasal Surgery: A Network Meta-Analysis. (Pubmed Central) -  Aug 28, 2020   
    Dexmedetomidine resulted in the greatest differences in intraoperative bleeding (-0.971; 95% confidence interval [CI], -1.161 to -0.781), intraoperative fentanyl administration (-3.683; 95% CI, -4.848 to -2.518), and postoperative pain (-2.065; 95% CI, -3.170 to -0.960) compared with placebo...This study demonstrated the superiority of the systemic use of dexmedetomidine as a perioperative hypotensive agent compared with the other five tested agents. However, the other agents were also superior to placebo in improving operative time, intraoperative bleeding, and postoperative pain.
  • ||||||||||  fentanyl citrate / Generic mfg., methadone / Generic mfg.
    Journal:  CYP2D6 Expression in Veterans Experiencing Opioid Overdose: A Postmortem Review. (Pubmed Central) -  Aug 28, 2020   
    The small sample size precludes a conclusion that the frequency of UM phenotype is greater than expected in North American Caucasian groups. The findings in this study do not support the hypothesis that the UM phenotype is over-represented in opioid overdose.
  • ||||||||||  fentanyl citrate / Generic mfg., Duragesic (fentanyl) / J&J
    Preclinical, Journal:  Fentanyl Inhibits Air Puff-Evoked Sensory Information Processing in Mouse Cerebellar Neurons Recorded in vivo. (Pubmed Central) -  Aug 28, 2020   
    The fentanyl-induced decrease of inhibitory responses in PCs was partially prevented by a PKA inhibitor, H-89. These results suggest that fentanyl binds to MORs in MLIs to reduce GABAergic neurotransmission in MLI-PC projections and one potential mechanism is via modulation of the cAMP-PKA pathway.
  • ||||||||||  fentanyl citrate / Generic mfg., ketamine / Generic mfg.
    Clinical, Journal:  Intravenous Low-Dose Ketamine Provides Greater Pain Control Compared to Fentanyl in a Civilian Prehospital Trauma System: A Propensity Matched Analysis. (Pubmed Central) -  Aug 27, 2020   
    These results suggest that fentanyl binds to MORs in MLIs to reduce GABAergic neurotransmission in MLI-PC projections and one potential mechanism is via modulation of the cAMP-PKA pathway. The significant reduction in pain, significantly high proportion of ketamine responders, and the lack of clinically significant AEs characterizing patients receiving low-dose ketamine IV compared to fentanyl IV, all provide further support for its use as an effective prehospital analgesic.
  • ||||||||||  fentanyl citrate / Generic mfg., ondansetron / Generic mfg.
    Clinical, Journal:  Impact of ondansetron on withdrawal signs, fentanyl requirement and pain relief in opioid addicted patients under general anesthesia. (Pubmed Central) -  Aug 27, 2020   
    The significant reduction in pain, significantly high proportion of ketamine responders, and the lack of clinically significant AEs characterizing patients receiving low-dose ketamine IV compared to fentanyl IV, all provide further support for its use as an effective prehospital analgesic. This study demonstrated a few evidence for beneficial treatment of ondansetron for control of withdrawal symptoms and pain in addicted patients, and more clinical studies are suggested in this regard.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Biomarker, Journal:  Fentanyl overdoses and pharmacogenetics. (Pubmed Central) -  Aug 27, 2020   
    Few data are available on low frequency variants, variants from racially/ethnically diverse populations, or on other phenotypes. Given the genetic diversity of low frequency variants, DNA sequencing may be needed to determine whether pharmacogenetic differences may contribute to lethal opioid overdoses.
  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Wearable electrochemical glove-based sensor for rapid and on-site detection of fentanyl. (Pubmed Central) -  Aug 26, 2020   
    The integrated sampling and sensing methodology on the thumb and index fingers, respectively, enables rapid screening of fentanyl in the presence of a mixture of cutting agents and offers considerable promise for timely point-of-need screening for first responders. Such a glove-based "swipe, scan, sense, and alert" strategy brings chemical analytics directly to the user's fingertips and opens new possibilities for detecting substances of abuse in emergency situations.
  • ||||||||||  fentanyl citrate / Generic mfg., ketamine / Generic mfg.
    Clinical, Journal:  Sedation with ketamine and fentanyl combination improves patient outcomes in intensive care units. (Pubmed Central) -  Aug 26, 2020   
    We have shown that appropriate combinations of ketamine and fentanyl are effective, and if further supplementation is needed, we utilize additional pharmacological agents in low doses and regional techniques that ultimately lower the overall opioid consumption. We acknowledge that a variety of medication supplementations tailored to the patient's clinical needs and nature of surgery improves a patient's outcome in ICU and overall quality of life.