- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
Subjects view use of STS101 favorably: subject impression data from the phase 3 open-label ASCEND study () - Jun 18, 2024 - Abstract #AHS2024AHS_399;
P3
Most subjects considered STS101 easy to use and indicated they would be likely to use the product if it were available. In comparison to their usual migraine medications, subjects indicated that STS101 worked faster and more consistently, and enabled them to more rapidly return to normal.
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
STS101 demonstrated long-term clinical benefit in the phase 3 open-label ASCEND study () - Jun 18, 2024 - Abstract #AHS2024AHS_398;
P3
Exploratory efficacy analyses in this long-term safety study show high rates of freedom from pain and MBS through 48 h post dose for STS101. These effects were consistent throughout 12 months of study showing that STS101 is a reliable and effective treatment of acute migraine headache attacks.
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
STS101 (dihydroergotamine nasal powder) shows long duration anti-migraine benefit on baseline photophobia, phonophobia, and nausea: Results from the phase 3 double-blind, randomized, placebo-controlled SUMMIT study () - Jun 18, 2024 - Abstract #AHS2024AHS_396;
P3
The results of the SUMMIT study show that STS101 demonstrated significant anti-migraine effects versus placebo on headache pain relief, including in difficult to treat migraine attacks such as migraine with allodynia, menstrually-related migraine, and migraine with severe impact. The results of the SUMMIT study show that, similar to its effects on migraine headache pain and most bothersome headache-associated symptom, STS101 showed significant anti-migraine effects versus placebo on baseline photophobia, phonophobia, and nausea from 3 through 48 h post-dose.
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
Journal: Impacts of land use/land cover and climate change on landscape sensitivity in Tunca River sub-basin: Use in spatial planning and sectoral decision processes. (Pubmed Central) - Jun 16, 2024
Future scenarios from 2050 to 2070 indicate noteworthy changes in landscape sensitivity, showing an increase in sensitivity in the upper regions of the basin...Protection and improvement strategies are recommended for areas with high and moderate sensitivity, while use-oriented strategies are suggested for those with low sensitivity. This study also establishes a scientific foundation for guiding the protection and management of ecologically sensitive basin areas, offering insights into the effects of landscape change processes at the micro-basin level in connection with climate change models.
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
Socioeconomic Burden of Ischemic Heart Diseases in the Japanese Healthcare System () - Mar 8, 2024 - Abstract #ISPOR2024ISPOR_1481;
Future research is needed to understand how greater mass timber adoption leads to changes in forest product markets, land use, and total forest sector carbon. METHODS : An SD model was developed to simulate the progression of MI to HF among the Japanese population aged ?40 years during 2010 to 2070...CONCLUSIONS : According to the latest epidemiological and cost evidence, the populations with MI and HF and the corresponding cost burdens in Japan will increase until the early 2050
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
Journal: Limited effects of crop foliar Si fertilization on a marginal soil under a future climate scenario. (Pubmed Central) - Jan 9, 2024
We tested this hypothesis by exposing spring barley growing on marginal soil macrocosms (three with, three without Si treatment) to 2070 climate projections in an ecotron facility...We interpreted these results as a less significant effect of Si treatment than expected as compared with literature, which could be explained by the high CO levels under future climate, that reduces need for stomata opening, and therefore sensitivity to drought. We conclude that making marginal soils climate proof using foliar Si treatments may not be a sufficient strategy, at least in this type of nutrient-poor, dry, sandy soil.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Cholera past and future in Nigeria: Are the Global Task Force on Cholera Control's 2030 targets achievable? (Pubmed Central) - May 15, 2023
The 2030 targets could potentially be reached by 2030 in some parts of Nigeria, but more effort is needed to reach these targets at a national level, particularly through access and incentives to cholera testing, sanitation expansion, poverty alleviation and urban planning. The results highlight the importance of and how modelling studies can be used to inform cholera policy and the potential for this to be applied in other contexts.
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
Trial completion: ASCEND: A Study to Evaluate the Safety of STS101 in the Acute Treatment of Migraine (clinicaltrials.gov) - Mar 16, 2023
P3, N=482, Completed,
Thereafter, the number of annual incident cases of HCC gradually declined over time in 2040: 5,429; 2050: 3,404; and 2060: 2,083, respectively. Active, not recruiting --> Completed
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Interim Analysis of STS101 Nasal Safety Data From the Phase 3 Open-Label ASCEND Migraine Study (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_4153;
P3
No clinically relevant findings were seen from nasal examinations, subjective nasal irritation assessments, or smell tests. Conclusions Nasal safety data from 5,571 treated attacks demonstrate the safety and tolerability of STS101 for the acute treatment of migraine.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Interim Analysis of Subject Impression Data for STS101 From the Phase 3 Open-Label ASCEND Study (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_4150;
P3
Over 80% of subjects reported a good/very good impression of STS101 at each time point (3 months, 83.8% [243/290]; 12 months, 91.0% [111/122]). Conclusions Subject impression data through 12 months suggest that STS101 was perceived very favorably by subjects on multiple measures, including in comparison to their usual migraine medications.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Climate and landuse change enhance spatio-temporal variability of Dongjiang river flow and ammonia nitrogen. (Pubmed Central) - Jan 13, 2023
The spatial distribution of NH-N load, in general, presented a downward trend and concentrated near the water body, while the monthly average NH-N load showed distinct peaks in spring and late summer temporally. Overall, the results highlight the significance of investigating the water availability under changing environment and more adaptive strategies should be proposed for better basin water management.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Data on the predictions of plant redistribution under interplays among climate change, land-use change, and dispersal capacity. (Pubmed Central) - Nov 26, 2022
The prediction and analyzed data provide essential information and insight for understanding the climate change effects on the warm-adapted plants in interactions with land-use change and the dispersal process. These data can be used for detecting restoration areas for increasing connectivity among habitats, establishing protected areas, and developing environmental policies related to restoration and conservation.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Monitoring riverine traffic from space: The untapped potential of remote sensing for measuring human footprint on inland waterways. (Pubmed Central) - Nov 25, 2022
Whilst HWF values correlated well with population density estimates (R = 0.59-0.61, p < 0.001), many riverine activity hotspots were located away from population centres and varied spatially across the investigated period, highlighting that more detailed information is needed to fully evaluate the extent, and type, of human footprint on waterways. High spatiotemporal resolution satellite imagery in combination with deep learning methods offers great promise for such monitoring, which can subsequently enable local and regional assessment of environmental impacts of anthropogenic activities on delta ecosystems around the globe.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
PROJECTING ANNUAL INCIDENT CASES OF HEPATOCELLULAR CARCINOMA AMONG THOSE LIVING WITH HCV/HIV CO-INFECTION: AN EPIDEMIOLOGIC DISEASE SIMULATION AT THE POPULATION-LEVEL () - Oct 23, 2022 - Abstract #AASLD2022AASLD_825;
A combination of purposeful public health and clinical efforts are needed to 1) increase awareness of HCC among patients living with HCV/HIV co-infection both at the population level and in clinical settings, 2) screen patients living with HCV/HIV co-infection for HCC, and 3) to treat and cure patients living with HCV/HIV co-infection of HCV with direct acting antivirals (DAAs). It is plausible that such purposeful public health and clinical efforts may be able to curb the high number of forthcoming annual incident cases of HCC and avert a high number of HCC-related complications and deaths among patients living with HCV/HIV co-infection.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Forecast of the U.S. Copper Demand: a Framework Based on Scenario Analysis and Stock Dynamics. (Pubmed Central) - Apr 14, 2022
In this study, we adapted the stock dynamics approach to forecast the U.S. copper in-use stock (IUS), consumption, and end-of-life (EOL) flows from 2016 to 2070 under various U.S.-specific scenarios...This stabilization trend of per capita IUS indicates that future copper consumption will largely recuperate IUS losses, allowing 34-39% of future demand to be met potentially by recycling 43% of domestic EOL copper. Despite the recent trends of "dematerialization", adaptive policies still need to be designed for enhancing the EOL recovery, especially in light of a potential transitioning to a "green technology" future with increased electrification dictating higher copper demand.
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
Enrollment closed, Enrollment change: ASCEND: A Study to Evaluate the Safety of STS101 in the Acute Treatment of Migraine (clinicaltrials.gov) - Jan 14, 2022
P3, N=426, Active, not recruiting,
STS101 was well tolerated and did not show clinically relevant cardiovascular adverse events in subjects with migraine when used long-term and on a PRN basis. Recruiting --> Active, not recruiting | N=300 --> 426
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Exploring relationships between drought and epidemic cholera in Africa using generalised linear models. (Pubmed Central) - Nov 24, 2021
Despite an effect of drought in explaining recent cholera outbreaks, future projections highlighted the potential for sustainable development gains to offset drought-related impacts on cholera risk. Future work should build on this research investigating the impacts of drought on cholera on a finer spatial scale and potential non-linear relationships, especially in high-burden countries which saw little cholera change in the scenario analysis.
- |||||||||| dihydroergotamine intranasal (STS101) / Shin Nippon Biomedical Labs
Trial completion date, Trial primary completion date: ASCEND: A Study to Evaluate the Safety of STS101 in the Acute Treatment of Migraine (clinicaltrials.gov) - Nov 8, 2021
P3, N=300, Recruiting,
Future work should build on this research investigating the impacts of drought on cholera on a finer spatial scale and potential non-linear relationships, especially in high-burden countries which saw little cholera change in the scenario analysis. Trial completion date: Oct 2021 --> Dec 2022 | Trial primary completion date: Oct 2021 --> Dec 2022
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Widely tunable silicon-fiber laser at 2 µm. (Pubmed Central) - Oct 2, 2021
By introducing a silicon-integrated Vernier filter in a fiber laser, we achieved continuous wavelength tuning over a range of 100 nm, from 1970 to 2070 nm. Fiber-coupled output power up to 28 mW was measured with a full-width-half-maximum linewidth smaller than 260 kHz and a side-mode-suppression ratio greater than 40 dB over the spectral range.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Clinical, P1 data, Journal: A Phase 1, Randomized, Open-Label, Safety, Tolerability, and Comparative Bioavailability Study of Intranasal Dihydroergotamine Powder (STS101), Intramuscular Dihydroergotamine Mesylate, and Intranasal DHE Mesylate Spray in Healthy Adult Subjects. (Pubmed Central) - Sep 22, 2021
P1
Additionally, the C was sufficiently low to avoid any significant nausea reported with IV DHE. Thus, STS101 is an easy to administer, non-injected, acute treatment for migraine, with a favorable tolerability profile and is expected to provide rapid and consistent freedom from pain and associated migraine symptoms without recurrence.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Clinical, Journal: Appreciation for food, an important concept in mindful eating: association with home and school education, attitude, behavior, and health status in Japanese elementary school children. (Pubmed Central) - Sep 3, 2021
Data were obtained from self-administered anonymous questionnaires sent to 2070 elementary school students in Tokyo, Japan, during October and December 2006...Surveys were completed by 1994 children (response rate: 96.3%) and significant correlations were indicated by gender, educational experiences at home and school, attitudes toward healthy food, recommended food preferences, breakfast consumption, and body mass index. We concluded that appreciation for food plays an important role in children's health.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Effects of climate changes on the distribution of Rhipicephalus microplus in China (Pubmed Central) - Jul 22, 2021
We concluded that appreciation for food plays an important role in children's health. Climate changes affect the distribution of suitable habitats of R. microplus in China, and annual mean precipitation may be a key factor affecting the distribution of suitable habitats of R. microplus.
- |||||||||| dihydroergotamine intranasal (STS101) / Satsuma Pharma
Journal: Knee surgery trends and projections in France from 2008 to 2070. (Pubmed Central) - Jun 26, 2021
Not yet recruiting --> Recruiting The number of knee surgery procedures per year has increased over the past few years in France and should continue to increase.
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