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- ALK.CAR-T / Celldex
ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells (Section 2) - Mar 5, 2024 - Abstract #AACR2024AACR_2818;
These findings provide insights into the potential of ALK.CAR-T cells as a novel therapeutic strategy for neuroblastoma. A Phase I clinical trial to test ALK.CAR-T cells in combination with ALK TKIs in children with refractory/relapsed neuroblastoma is being implemented based on these results.