- |||||||||| dexamethasone / Generic mfg., levetiracetam / Generic mfg.
Journal, Metastases: Atypical Cutaneous Presentation and Diagnostic Challenges in Advanced Metastatic Testicular Cancer. (Pubmed Central) - Aug 22, 2024
The patient responded well to the treatment, showing significant improvement in neurological function and stabilization of his condition. This case underscores the diagnostic and therapeutic challenges of metastatic testicular cancer, particularly with rare presentations such as cutaneous involvement, and highlights the importance of comprehensive diagnostic evaluations and multidisciplinary care.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg., oxcarbazepine / Generic mfg.
Journal: Clinical study of the effect of 5 kinds of antiepileptic drugs on the postictal state. (Pubmed Central) - Aug 21, 2024
Levetiracetam, lamotrigine, oxcarbazepine, topiramate, and valproate demonstrate favorable efficacy in ameliorating the severity of post-seizure condition. Further investigations are warranted to assess the potential of other widely employed anti-seizure medications in enhancing post-seizure status.
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Journal: Maternal and fetal outcomes of antiepileptic treatments during pregnancy: A retrospective study. (Pubmed Central) - Aug 21, 2024
Furthermore, the use of anti-seizure medications appears to have a significant impact on pregnancy outcomes. Our findings highlight the need for comprehensive management strategies and informed decision making to reduce risks and optimise maternal and fetal outcomes among women with epilepsy.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Overview of acute seizure management in US nursing homes. (Pubmed Central) - Aug 21, 2024
Rescue medications are given regardless of seizure history and often older ASMs are used for long-term management. Our study highlights areas of knowledge deficits and treatment areas for improvement, identifying the need and potential for ASAPs in NHs.
- |||||||||| levetiracetam / Generic mfg.
Journal: Clinical and paraclinical features of first unprovoked seizures in the elderly. (Pubmed Central) - Aug 21, 2024
The use of LEV may significantly reduce serum calcium in patients with epilepsy, and regular monitoring of bone metabolism-related indicators is recommended. Our findings can contribute to the improved identification and characterization of patients with late-onset seizures, facilitating targeted diagnostics and appropriate treatment in this challenging patient population.
- |||||||||| Cerebral Venous Thrombosis as an Initial Presentation of Ulcerative Colitis: A Case Report and Literature Review (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4904;
Keppra was also administered for seizure prophylaxis...The literature review underscores the significant epidemiological association between IBD and increased risk of CVT, the complex pathophysiological mechanisms linking IBD to thrombotic events, and the multifaceted treatment strategies required for optimal patient outcomes. Figure: CT Head showing extensive cerebral venous thrombosis with involvement of the superior sagittal sinus and thrombus extension into the right transverse sinus, sigmoid sinus, and proximal internal jugular vein
- |||||||||| DRESS is More: A Rare Case of Acalculous Cholecystitis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4104;
Prednisone was initiated for presumed DRESS and ultimately skin biopsy demonstrated lymphohistiocytic inflammation consistent with drug eruption (Figure 1C-D)...While rare, the association between DRESS and acalculous cholecystitis should promptly be recognized to facilitate timely intervention. Figure: Figure 1: A) Desquamating rash on palms, B) Erythematous, pruritic rash on upper extremities, C) H&E stain, magnification 200x, Spongiotic dermatitis from left upper arm skin biopsy, D) H&E stain, magnification 200x, lichenoid dermatitis with lymphohistiocytic reaction from left upper arm skin biopsy
- |||||||||| levetiracetam / Generic mfg.
Drug-Induced Autoimmune-Like Hepatitis and Stevens Johnsons Syndrome Secondary to Levetiracetam (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3575;
DI-ALH is well described with medications such as nitrofurantoin and infliximab, but herein we present a unique case of DI-ALH secondary to levetiracetam...Magnetic resonance imaging confirmed a new early subacute infarction of the left coronal radiata and she was started on aspirin and clopidogrel...Given concern for DI-ALH and DI-SJS intravenous solumedrol was started and her levetiracetam was discontinued...Early identification of DILI and DI-ALH is crucial not only for patient recovery but also to avoid use of unnecessary immunosuppression. There has been only one previous case published of DI-ALH secondary to levetiracetam and we hope that this second case will further serve to raise awareness of this relationship.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health
Difficult Diagnosis of Disseminated Cryptococcosis in a Patient With Cirrhosis (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3512;
His seizures resolved after starting levetiracetam and was discharged...Lactulose was up titrated and rifaximin was added...A: Basal ganglia punctate infarct found on MRI during initial ED visit. B: Temporal lobe infarcts found on the same MRI.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health
Hyperammonemia-Induced Cerebral Edema Following Transjugular Intrahepatic Portosystemic Shunt (TIPS) (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3495;
Continuous renal replacement therapy (CRRT) is started and levetiracetam is administered...Hyperammonemia may rarely lead to astrocyte swelling due to glutamine accumulation. Cerebral edema is a rare, but serious complication that should be taken into consideration and monitored for following the TIPS procedure and TIPS reversal is suggested as soon as edema complications are discovered.
- |||||||||| duloxetine / Generic mfg.
Duloxetine Dilemma: Unmasking the Hidden Threat of Liver Injury (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_1905;
Diagnosis hinges on exclusion, necessitating thorough evaluation to rule out alternative causes of liver injury. Swift discontinuation of duloxetine coupled with vigilant liver function monitoring is imperative for managing suspected cases of drug-induced hepatotoxicity.
- |||||||||| teriflunomide / Generic mfg.
Teriflunomide Induced Dysbiosis and Colitis in a Multiple Sclerosis Patient (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_840;
Teriflunomide is among the few orally administered therapies available for Relapsing Remitting Multiple Sclerosis (RRMS), alongside Dimethyl fumarate, Fingolimod, etc. It is an immunomodulator recently implicated in gut microbiota dysbiosis...Her medications included Teriflunomide for MS initiated in February, along with Levetiracetam, Baclofen, Amlodipine, and Lisinopril...A diagnosis of probable C. difficile infection (CDI) was made and oral vancomycin was administered...Additionally, they reported an increasing population of Enterococci and Enterobacteriaceae, associated with C. difficile infection. This incidence supports the notion that Teriflunomide induces gut microbiota dysbiosis Figure: Ulcerations in the descending colon
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Review, Journal: Neurological consequences after portosystemic shunt attenuation in cats: a meta-analysis study. (Pubmed Central) - Aug 15, 2024
PANS occurrence ranged from 26.8% to 56.5% in cats with congenital extrahepatic portosystemic shunts The cause of PANS in cats is still unknown, and there is only limited evidence to justify the use of preventive antiepileptic medications such as levetiracetam. The treatment primarily aims to control neurologic symptoms, and the long-term outlook varies, with the potential for the reappearance of symptoms.
- |||||||||| Ztalmy (ganaxolone oral) / Marinus
Journal: Ganaxolone (Ztalmy) for CDKL5 deficiency disorder. (Pubmed Central) - Aug 13, 2024
In addition, the article summarizes the gene mutation characteristics and clinical manifestations of children with KCNQ2-related epilepsy, with the expectation of providing a certain theoretical basis for the diagnosis and treatment of such patients. No abstract available
- |||||||||| levetiracetam / Generic mfg.
Journal: Is 5-Oxoprolinase Deficiency More than Just a Benign Condition? (Pubmed Central) - Aug 12, 2024
His past medical history revealed postnatal macrocephaly, hydrocephalus, and well-controlled epilepsy with levetiracetam...The nature of this inherited metabolic disorder must be determined through long-term observation. We wish to emphasize the significance of molecular genetic analysis in symptomatic patients with persistently elevated levels of 5-oxoproline in the urine, as measured by organic acid analysis.
- |||||||||| lacosamide / Generic mfg., phenytoin / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: Subacute encephalopathy with seizures in alcoholics (SESA) syndrome. (Pubmed Central) - Aug 10, 2024
SESA syndrome represents a well-defined subtype of focal NCSE in patients with chronic alcoholism. Its prompt recognition can facilitate the initiation of early ASM therapy and help implement a video-EEG evaluation and neuroimaging strategy.
- |||||||||| levetiracetam / Generic mfg.
Review, Journal: Sleep in juvenile myoclonic epilepsy: A systematic review. (Pubmed Central) - Aug 10, 2024
These findings underlined the need for more sufficient evidence of sleep studies in JME. Future research should prioritize understanding the nature of sleep in JME and its impact on management.
- |||||||||| levetiracetam / Generic mfg.
Journal: Epilepsy as a Novel Phenotype of BPTF-Related Disorders. (Pubmed Central) - Aug 10, 2024
Early-childhood-onset epilepsy occurs in 19% of subjects, all presenting with a well-organized EEG background associated with generalized interictal epileptiform abnormalities in half of these cases. Drug resistance is rare.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
SLC39A8-CDG with manganese deficiency in an adult individual: a case report (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1865;
MG deficiency associated to SLC39A8-CDG is a rare condition which may be seen in adults. Given that it is a condition amenable to treatment, pursuit via (WES) is warranted in all instances of idiopathic cerebellar ataxia.
- |||||||||| levetiracetam / Generic mfg.
When Jerks and Stumbles Become More Than Just Clumsiness (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1639;
This case highlights the diagnostic challenge of involuntary movement disorders presenting in adolescence and demonstrates the utility of genetic testing in establishing prognosis and recurrence risk to guide family planning. When jerks and stumbles become more than just clumsiness, an expanded differential and definitive diagnosis can help make sense of the senseless.
- |||||||||| levetiracetam / Generic mfg.
Myoclonus and Encephalitis as an Adverse Event of mRNA COVID-19 Vaccine (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1531;
In most reported cases, they improved spontaneously or a result of immunotherapy such as steroid, IVIG, or plasmapheresis. Although the patient in the recent case did not have any symptoms suggestive of encephalitis, such as decreased consciousness or disorientation, we concluded her symptom was triggered by the COVID-19 vaccine.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg.
Holmes Tremor Treated with Pallidal Stimulation (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_1299;
Additionally, Vim DBS for HT may also have some limitations including the development of recurrence over time and a limited effect on proximal and intention tremor. 64% and 78% improvement in tremor scale has been reported with pallidal stimulation in some HT cases.
- |||||||||| carbamazepine / Generic mfg.
Case Report: Carbamazepine-Induced Dystonia, Tremor and Negative Myoclonus (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_658;
Carbamazepine can cause a wide range of pharmacological movement disorders, such as myoclonus, tremor, and dystonia, but also parkinsonism and tic-like behavior. No treatment is required, as discontinuation or replacement of the incriminated drug leads to complete disappearance of clinical signs.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Association between Antiepileptic Drugs and Parkinson's Disease: A Strong or Weak Link? (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_403;
No treatment is required, as discontinuation or replacement of the incriminated drug leads to complete disappearance of clinical signs. Among the exposure to routinely used AEDs, all showed significant association which is Carbamazepine(OR: 1.44; 95% CI: 1.23
- |||||||||| levetiracetam / Generic mfg.
Navigating Perioperative Challenges in Patients with Global Developmental Delay (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_5594;
The complexities encountered during admission, particularly in history-taking, physical examination, and perioperative care, underscore the necessity for bespoke anesthesia protocols and meticulous perioperative strategies tailored to individuals with global developmental delay. This case seeks to elevate clinical standards and optimize patient welfare.
- |||||||||| lacosamide / Generic mfg., phenobarbital / Generic mfg., levetiracetam / Generic mfg.
Management of Severe Neonatal Seizures in a Patient with KARS1 Variant (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_5009;
Eventually, the seizures subsided with a serum phenobarbital level of 80 mcg/ml. Multiple anti-seizure medications were weaned and the patient discharged on maintenance lacosamide, levetiracetam and phenobarbital.
- |||||||||| levetiracetam / Generic mfg.
Management of Coagulopathies in the Setting of Liver Failure (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4783;
Recently transitioning from Keppra to Depakote, he was diagnosed with Depakote-induced Dress syndrome and acute cholecystitis...A comprehensive diagnostic regimen, including CT scans, ultrasounds, MRCP, blood cultures, and KUB, was initiated, alongside antibiotic therapy. This case illuminates the complexities of managing coagulopathies in liver failure, emphasizing personalized care pathways and meticulous monitoring for optimal outcomes.
- |||||||||| Opdivo (nivolumab) / BMS
Unraveling drug-associated bullous pemphigoid pathophysiology with lymphocyte transformation tests (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2504;
Our findings provide objective evidence confirming the existence of an immune reaction following exposure to certain drugs in BP patients. Conducting lymphocyte transformation tests could help identify drugs potentially associated with BP development, contributing to better understanding its etiopathogenesis and subsequently improving the management of these patients.
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