- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg., carbamazepine / Generic mfg.
Preclinical, Journal: Effects of Valproic Acid, Levetiracetam, Carbamazepine, Lamotrigine, and Topiramate on LIF, E-cadherin, and FOXO1 Mediator Molecules in Rat Embryo Implantation. (Pubmed Central) - Mar 12, 2025 This study established a discordance rate, as defined by drug dosing, of 32.3% in adult patients admitted to the ICU. In summary, antiseizure medication use had a negative effect on the expression of proteins that play key roles in embryo implantation in young non-epileptic rats to varying degrees.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Comparative risk of major health events among individuals prescribed different antiseizure medications following ischemic stroke. (Pubmed Central) - Mar 12, 2025 At a population level, ASMs of different types showed no significant differences in the risk of hospitalization or emergency department presentation for seizure, fall or fracture, stroke, and mortality within 2?years of an incident stroke presentation, suggesting similar short-term health outcomes in a real-world setting. Future research should investigate decision-making around ASM choice for stroke survivors and examine the impact of long-term ASM exposure on health outcomes.
- |||||||||| levetiracetam / Generic mfg.
Journal: Minimally invasive electrocorticography (ECoG) recording in common marmosets. (Pubmed Central) - Mar 10, 2025 This refined ECoG method enhances the study of cortical interactions in marmosets while minimizing surgical invasiveness and complication risks. It offers potential for broader application in other species and opens new avenues for long-term data collection, ultimately advancing both neuroscience and brain-machine interface research.
- |||||||||| levetiracetam / Generic mfg.
DOES SLEEP-TIME SUBCLINICAL EPILEPTIFORM ACTIVITY IN ALZHEIMER () - Mar 10, 2025 - Abstract #ADPD2025ADPD_2396; The amount of epileptiform spiking during the post-learning sleep period was manipulated with either Lamotrigine (increased spiking), Levetiracetam (decreased spiking) or vehicle (baseline)... The preliminary results suggest that at an early phase of AD- like pathology mice are able to resist the effects of sleep associated SEA on memory consolidation.
- |||||||||| levetiracetam / Generic mfg.
Retrospective data, Journal: Second-Line Medications for Women Aged 10 to 50 Years With Idiopathic Generalized Epilepsy. (Pubmed Central) - Mar 10, 2025 However, valproic acid remained the most effective second-line ASM when considering individual agents. In this comparative effectiveness study of second-line treatment strategies for women with IGE, no significant differences were observed between substitution monotherapy and add-on therapy.
- |||||||||| lacosamide / Generic mfg., Fycompa (perampanel) / Eisai, Catalyst Pharma, levetiracetam / Generic mfg.
Journal: Presentation, Treatment, and Outcome of a First Stroke-like Episode in a Carrier of the Compound Heterozygous Variants c.695G_A and c.2209G_C in POLG: A Case Report. (Pubmed Central) - Mar 10, 2025 After extubation, recurrent focal motor status epilepticus occurred, which could be stopped with midazolam. This case shows that POLG mutations can initially manifest phenotypically with polyneuropathy and SLE, which occurs before the onset of seizures, status epilepticus due to POLG variants may require thiopental anesthesia and that levetiracetam, lacosamide, and perampanel may have a favorable long-term effect on seizure activity in carriers of POLG mutations.
- |||||||||| levetiracetam / Generic mfg.
Journal: Epilepsy in low- to middle-income countries. (Pubmed Central) - Mar 5, 2025 Apps, EEG prototypes, better access to ASMs and implementation of WHO iGAP offer current, tangible opportunities to improve epilepsy care in LMICs. Bidirectional learning must be facilitated to also help hard to reach communities in high-income settings.
- |||||||||| prednisone / Generic mfg., levetiracetam / Generic mfg.
Journal: Identifying In-Hospital Risk Factors for Post-liver Transplant Seizures. (Pubmed Central) - Mar 3, 2025 Immunosuppressive regimens included prednisone with tacrolimus or mycophenolate...Treatment was administered to 85% of seizure patients, primarily with levetiracetam (75%)...With an AUC of 0.90, the model demonstrates strong discriminative ability, suggesting it is a robust tool for predicting seizures in the immediate post-LT period. Further prospective multicenter studies are needed to externally validate the model and risk score, thereby enhancing its clinical applicability.
- |||||||||| Review, Journal: Cognitive and behavioral impact of antiseizure medications, neuromodulation, ketogenic diet, and surgery in lennox-gastaut syndrome: A comprehensive review. (Pubmed Central) - Mar 2, 2025
Behavioral outcomes also vary: stability is observed with valproate, lamotrigine, rufinamide, cannabidiol, and fenfluramine, whereas medications like levetiracetam, perampanel, brivaracetam, clobazam, and zonisamide can increase aggression or irritability...Consideration of minimizing ASM polytherapy, careful evaluation of drug-drug interactions, pharmacogenomic implications, and the need for therapeutic drug monitoring in cases of cognitive adverse effects is essential. Future research should focus on developing assessment tools tailored to the unique needs of individuals with LGS, utilizing connectivity measures to assess intervention impacts, and advancing precision therapeutics to improve cognitive and behavioral outcomes.
- |||||||||| Review, Journal: Polypharmacology of carbonic anhydrase inhibitors and activators. (Pubmed Central) - Mar 1, 2025
Several antiepileptics (topiramate, zonisamide, lacosamide, levetiracetam), some atypical antipsychotics (sulpiride, veralipride), celecoxib, polmacoxib, pazopanib, the antiulcer agent famotidine and compounds in clinical trials (epacadostat and PCI-27483) as antitumor agents significantly inhibit several CA isoforms of the 15 human ones, apart their action on several other targets...Polypharmacology involving CA inhibitors/CAAs are understood from the chemical, structural and pharmacological viewpoints. The many other drug targets with which these modulators of activity interact allow for de novo design of such agents for the management of multifactorial conditions in need of innovative drugs.
- |||||||||| Journal: A novel TSC2 variant cosegregating with TSC in the family: A case report. (Pubmed Central) - Feb 28, 2025
The many other drug targets with which these modulators of activity interact allow for de novo design of such agents for the management of multifactorial conditions in need of innovative drugs. The novel gene mutation sites to be found provide more research entry points for genetic diagnosis, providing new clinical data for tuberous sclerosis complex research.
- |||||||||| Review, Journal: Japanese guidelines for treatment of pediatric status epilepticus - 2023. (Pubmed Central) - Feb 23, 2025
For established SE, phenytoin/fosphenytoin and phenobarbital can be used for pediatric SE, and levetiracetam can be used in only adults in Japan...Although electrographic seizure and electrographic SE may lead to brain damages, it remains unclear whether treatment of NCSE improves outcomes in children. We plan to address this issue in an upcoming edition of the guideline.
- |||||||||| Clinical data, Review, Journal: Drug reaction with eosinophilia and systemic symptoms (DRESS) associated with the use of antiseizure medications-An overview of clinical data. (Pubmed Central) - Feb 22, 2025
Hence, our review focuses on DRESS associated with the use of antiseizure drugs, including Levetiracetam, Clobazam, Carbamazepine, Phenytoin, Phenobarbital, Valproate, Oxcarbazepine, and Lamotrigine...Management strategies for DRESS may include immediate discontinuation of offending medication, administration of systemic corticosteroids, and administration of cyclosporine and intravenous immunoglobulin in cases that are not responding to systemic corticosteroids...Early detection and discontinuation of the offending drug, coupled with systemic corticosteroids, are essential for effective management. Healthcare professionals must be vigilant in identifying DRESS to reduce mortality and improve patient outcomes.
- |||||||||| Review, Journal: Management of epilepsia partialis continua: A systematic review. (Pubmed Central) - Feb 22, 2025
In addition to treatment of the underlying cause of EPC, judicious antiseizure medication use has a role. However, care should be taken not to cause harm (such as respiratory depression) with antiseizure medications, particularly noting that seizures are likely to be prolonged irrespective of antiseizure medication choice.
- |||||||||| levetiracetam / Generic mfg.
Journal: Focal to bilateral tonic-clonic seizures in newly diagnosed focal epilepsy. (Pubmed Central) - Feb 20, 2025 There was no significant difference in choice of initial ASM class (levetiracetam vs. sodium channel blockers) between participants who experienced FBTCS and those who did not...The majority of participants who experienced FBTCS were diagnosed with epilepsy after experiencing their first FBTCS despite preceding FAS/FIAS. The more frequent FAS/FIAS in participants whose FBTCS resolved may be a characteristic of their epilepsy.
- |||||||||| levetiracetam / Generic mfg.
Journal: Trends in antiseizure medication prescription in Idiopathic generalized epilepsy over the last 10 (Pubmed Central) - Feb 15, 2025 Although some improvement was observed over time with TPM, the absence of significant recovery suggests that additional time may be required for a substantial reversal of these effects. The use of VPA has decreased during the last decade for all IGEs and particularly in women of childbearing potential, along with an increase in the use of LEV and LTG.
- |||||||||| levetiracetam / Generic mfg.
Journal: The Safety and Tolerability of High Dose Intravenous Push Levetiracetam. (Pubmed Central) - Feb 15, 2025 One patient experienced erythema at the injection site and another patient was noted to have nystagmus. Significance: This study adds to the body of literature that rapid administration of undiluted LEV, including doses of 2500
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Journal, Adverse events: Adverse events of dual anti-seizure medication: Real-life data from a tertiary epilepsy clinic. (Pubmed Central) - Feb 15, 2025 While dual ASM therapy is associated with an increased burden of AE, this increase appears to be moderate when therapies are individually tailored. Increased awareness and systematic screening of AE, particularly cognitive side effects, are essential to optimize treatment outcomes.
- |||||||||| levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Journal: Childhood-onset focal epilepsy and acute para-infectious encephalopathy in a patient with biallelic QARS1 variants. (Pubmed Central) - Feb 14, 2025 The episode of steroid-responsive acute para-infectious encephalopathy, previously reported in another patient harboring the p.Y435C variant, suggests that milder cases might be more susceptible to encephalopathy caused by intercurrent illnesses (e.g., infection). As recommended for other aminoacyl-tRNA synthetase-related diseases, it is important to provide this cohort with an early genetic diagnosis in order to encourage precision medicine and personalized treatment.
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