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185 Diseases |  |
81 Trials |
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81 Trials |  |
6476 News |  |
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- cefepime hydrochloride / Generic mfg.
Clearing the Fog: Early Renal Replacement Therapy (RRT) in Cefepime-Induced Neurotoxicity () - Mar 13, 2025 - Abstract #NKFSCM2025NKF_SCM_566;
Early diagnosis involves high clinical suspicion, serum cefepime level measurement, and triphasic waves on EEG. Management includes stopping the drug, initiation of antiepileptics, and, if critical, early RRT.
- | Biomarker, Observational data, Retrospective data, Journal: Establishing discordance rate of estimated glomerular filtration rate between serum creatinine-based calculations and cystatin-C-based calculations in critically ill patients. (Pubmed Central) - Mar 13, 2025
Clinically significant discordance exists between SCr and SCr/cysC-based estimates of kidney function. This study established a discordance rate, as defined by drug dosing, of 32.3% in adult patients admitted to the ICU.
- | levetiracetam / Generic mfg., topiramate / Generic mfg., carbamazepine / Generic mfg.
Preclinical, Journal: Effects of Valproic Acid, Levetiracetam, Carbamazepine, Lamotrigine, and Topiramate on LIF, E-cadherin, and FOXO1 Mediator Molecules in Rat Embryo Implantation. (Pubmed Central) - Mar 12, 2025
This study established a discordance rate, as defined by drug dosing, of 32.3% in adult patients admitted to the ICU. In summary, antiseizure medication use had a negative effect on the expression of proteins that play key roles in embryo implantation in young non-epileptic rats to varying degrees.
- | Journal: Evaluation of antiseizure medication concentration ranges in blood samples using an automated big data approach. (Pubmed Central) - Mar 12, 2025
Furthermore, dose adjustment may be relevant for levetiracetam, topiramate, and lacosamide to account for age-related changes in metabolism. The lower concentration range for lamotrigine in the psychiatric population indicates that it may be effective at lower concentrations in patients with bipolar disorder compared to patients with epilepsy.
- | levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Comparative risk of major health events among individuals prescribed different antiseizure medications following ischemic stroke. (Pubmed Central) - Mar 12, 2025
At a population level, ASMs of different types showed no significant differences in the risk of hospitalization or emergency department presentation for seizure, fall or fracture, stroke, and mortality within 2?years of an incident stroke presentation, suggesting similar short-term health outcomes in a real-world setting. Future research should investigate decision-making around ASM choice for stroke survivors and examine the impact of long-term ASM exposure on health outcomes.
- | levetiracetam / Generic mfg.
Journal: Minimally invasive electrocorticography (ECoG) recording in common marmosets. (Pubmed Central) - Mar 10, 2025
This refined ECoG method enhances the study of cortical interactions in marmosets while minimizing surgical invasiveness and complication risks. It offers potential for broader application in other species and opens new avenues for long-term data collection, ultimately advancing both neuroscience and brain-machine interface research.
- levetiracetam / Generic mfg.
DOES SLEEP-TIME SUBCLINICAL EPILEPTIFORM ACTIVITY IN ALZHEIMER () - Mar 10, 2025 - Abstract #ADPD2025ADPD_2396;
The amount of epileptiform spiking during the post-learning sleep period was manipulated with either Lamotrigine (increased spiking), Levetiracetam (decreased spiking) or vehicle (baseline)... The preliminary results suggest that at an early phase of AD- like pathology mice are able to resist the effects of sleep associated SEA on memory consolidation.
- | levetiracetam / Generic mfg.
Retrospective data, Journal: Second-Line Medications for Women Aged 10 to 50 Years With Idiopathic Generalized Epilepsy. (Pubmed Central) - Mar 10, 2025
However, valproic acid remained the most effective second-line ASM when considering individual agents. In this comparative effectiveness study of second-line treatment strategies for women with IGE, no significant differences were observed between substitution monotherapy and add-on therapy.
- | lacosamide / Generic mfg., Fycompa (perampanel) / Eisai, Catalyst Pharma, levetiracetam / Generic mfg.
Journal: Presentation, Treatment, and Outcome of a First Stroke-like Episode in a Carrier of the Compound Heterozygous Variants c.695G_A and c.2209G_C in POLG: A Case Report. (Pubmed Central) - Mar 10, 2025
After extubation, recurrent focal motor status epilepticus occurred, which could be stopped with midazolam. This case shows that POLG mutations can initially manifest phenotypically with polyneuropathy and SLE, which occurs before the onset of seizures, status epilepticus due to POLG variants may require thiopental anesthesia and that levetiracetam, lacosamide, and perampanel may have a favorable long-term effect on seizure activity in carriers of POLG mutations.
- | Journal: Case Report: White-Sutton syndrome and cannabidiol, an update on a reported patient with a successful response to off--label therapy. (Pubmed Central) - Mar 7, 2025
Although CBD shows promise in other epileptic syndromes, this case highlights its potential effectiveness in this specific condition. This manuscript aims to contribute to the understanding of WSS and advocate for further research into novel treatments, particularly the role of CBD in managing epilepsy within this complex clinical context.
- || levetiracetam / Generic mfg.
Retrospective data, Review, Journal: Retinal structural alterations in patients with epilepsy taking antiepileptic drugs: A systematic review and meta-analysis of OCT findings. (Pubmed Central) - Mar 6, 2025
This meta-analysis revealed the structural retinal alterations following AEDs administration in patients with epilepsy (PwE). OCT may serve as a reliable surrogate device that reflects retinal toxicity with AED consumption in PwE.
- | levetiracetam / Generic mfg.
Journal: Impact of levetiracetam on direct oral anticoagulant level and outcomes among older Asian patients with atrial fibrillation. (Pubmed Central) - Mar 6, 2025
Concurrent use of LEV and DOAC did not significantly affect DOAC exposure or clinical outcomes. LEV may be a safe anti-seizure medication for patients receiving DOAC therapy.
- | levetiracetam / Generic mfg.
Journal: Epilepsy in low- to middle-income countries. (Pubmed Central) - Mar 5, 2025
Apps, EEG prototypes, better access to ASMs and implementation of WHO iGAP offer current, tangible opportunities to improve epilepsy care in LMICs. Bidirectional learning must be facilitated to also help hard to reach communities in high-income settings.
- || riluzole / Generic mfg., levetiracetam / Generic mfg.
Review, Journal: Therapeutic strategies that modulate the acute phase of secondary spinal cord injury scarring and inflammation and improve injury outcomes. (Pubmed Central) - Mar 5, 2025
Monosialotetrahexosylganglioside Sodium Salt (GM-1) and riluzole are associated with favorable neurological outcomes. Granulocyte Colony-Stimulating Factor (G-CSF) and Hepatocyte Growth Factor (HGF) offer improved motor scores with fewer side effects.
- | prednisone / Generic mfg., levetiracetam / Generic mfg.
Journal: Identifying In-Hospital Risk Factors for Post-liver Transplant Seizures. (Pubmed Central) - Mar 3, 2025
Immunosuppressive regimens included prednisone with tacrolimus or mycophenolate...Treatment was administered to 85% of seizure patients, primarily with levetiracetam (75%)...With an AUC of 0.90, the model demonstrates strong discriminative ability, suggesting it is a robust tool for predicting seizures in the immediate post-LT period. Further prospective multicenter studies are needed to externally validate the model and risk score, thereby enhancing its clinical applicability.
- | Journal: Methylene Blue for the Treatment of Refractory Hypotension in Polysubstance Overdose. (Pubmed Central) - Mar 3, 2025
This, in turn, inhibits vascular smooth muscle relaxation and can be an effective method for refractory hypotension. Therefore, methylene blue can be used for the treatment of refractory vasoplegia unresponsive to other methods.
- | levetiracetam / Generic mfg.
Biomarker, Journal, Monotherapy: Evaluation of quantitative EEG markers for predicting outcome after the initial treatment with levetiracetam monotherapy in newly diagnosed epilepsy. (Pubmed Central) - Mar 2, 2025
While significant above-chance predictions were not achieved in this study, a promising framework for the classification of treatment response on first-line monotherapy with levetiracetam based on pre-treatment EEG data alone was provided. Although negative, our results show trends that should encourage future, larger studies to develop EEG-based frameworks for the prediction of treatment response under specific anti-seizure medications.
- || Review, Journal: Cognitive and behavioral impact of antiseizure medications, neuromodulation, ketogenic diet, and surgery in lennox-gastaut syndrome: A comprehensive review. (Pubmed Central) - Mar 2, 2025
Behavioral outcomes also vary: stability is observed with valproate, lamotrigine, rufinamide, cannabidiol, and fenfluramine, whereas medications like levetiracetam, perampanel, brivaracetam, clobazam, and zonisamide can increase aggression or irritability...Consideration of minimizing ASM polytherapy, careful evaluation of drug-drug interactions, pharmacogenomic implications, and the need for therapeutic drug monitoring in cases of cognitive adverse effects is essential. Future research should focus on developing assessment tools tailored to the unique needs of individuals with LGS, utilizing connectivity measures to assess intervention impacts, and advancing precision therapeutics to improve cognitive and behavioral outcomes.
- | levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
Retrospective data, Journal: Clinical features and outcomes of late-onset epilepsy of unknown etiology: A retrospective study in West China. (Pubmed Central) - Mar 2, 2025
LOUE is generally a benign form of epilepsy with a high percentage of patients achieving seizure-free status. However, these patients are at a higher risk of memory decline and cognitive dysfunction.
- || levetiracetam / Generic mfg., brivaracetam / Generic mfg.
P2 data, Journal: A multicenter Phase II randomized, placebo-controlled single-blind trial with the SV2A ligand seletracetam in photosensitive epilepsy patients. (Pubmed Central) - Mar 2, 2025
Pharmacokinetics of SEL demonstrated rapid absorption and a linear dose:plasma level relationship. This proof-of-principle study demonstrates that - based on our own experience - SEL is the most potent compound ever tested in the photosensitivity model.
- || Review, Journal: Polypharmacology of carbonic anhydrase inhibitors and activators. (Pubmed Central) - Mar 1, 2025
Several antiepileptics (topiramate, zonisamide, lacosamide, levetiracetam), some atypical antipsychotics (sulpiride, veralipride), celecoxib, polmacoxib, pazopanib, the antiulcer agent famotidine and compounds in clinical trials (epacadostat and PCI-27483) as antitumor agents significantly inhibit several CA isoforms of the 15 human ones, apart their action on several other targets...Polypharmacology involving CA inhibitors/CAAs are understood from the chemical, structural and pharmacological viewpoints. The many other drug targets with which these modulators of activity interact allow for de novo design of such agents for the management of multifactorial conditions in need of innovative drugs.
- | Journal: A novel TSC2 variant cosegregating with TSC in the family: A case report. (Pubmed Central) - Feb 28, 2025
The many other drug targets with which these modulators of activity interact allow for de novo design of such agents for the management of multifactorial conditions in need of innovative drugs. The novel gene mutation sites to be found provide more research entry points for genetic diagnosis, providing new clinical data for tuberous sclerosis complex research.
- | levetiracetam / Generic mfg.
New P3 trial: KISS: Evaluation of Early Administration of Levetiracetam in the Prevention and Treatment Encephalopathy in Septic Shock: Randomized, Double-blind, Placebo-controlled Trial (clinicaltrials.gov) - Feb 28, 2025
P3, N=280, Not yet recruiting, Sponsor: Assistance Publique - H
- | Journal, Head-to-Head: Efficacy and tolerability of low versus standard daily doses of antiseizure medications in newly diagnosed focal epilepsy. A multicenter, randomized, single-blind, non-inferiority trial (STANDLOW). (Pubmed Central) - Feb 27, 2025
The study was stopped early due to slow enrollment, making it difficult to definitively prove that low doses were non-inferior to standard doses. Low doses of ASMs might be a reasonable option for adults with newly diagnosed epilepsy with no clear cause and few seizures.
- || levetiracetam / Generic mfg.
PK/PD data, Journal: Levetiracetam dosing in continuous renal replacement therapy: A systematic review and development of a novel pharmacokinetic model to optimise dosing in critically ill patients. Do recommended doses achieve therapeutic drug concentrations? (Pubmed Central) - Feb 27, 2025
The use of reduced doses due to renal failure in critically ill patients may result in sub-therapeutic drug concentrations in a high number of patients. A twice daily dosing of 750-1000?mg with an initial loading dose of 60?mg/kg should be considered in such patients alongside therapeutic drug monitoring.
- | levetiracetam / Generic mfg.
Journal: KEPPRA: Key Epilepsy Prognostic Parameters with Radiomics in Acute Subdural Hematoma Before Craniotomy. (Pubmed Central) - Feb 26, 2025
Radiomic features, particularly elongation, may help predict epilepsy risk in aSDH patients undergoing craniotomy. Prospective validation is needed.
- || Review, Journal: Japanese guidelines for treatment of pediatric status epilepticus - 2023. (Pubmed Central) - Feb 23, 2025
For established SE, phenytoin/fosphenytoin and phenobarbital can be used for pediatric SE, and levetiracetam can be used in only adults in Japan...Although electrographic seizure and electrographic SE may lead to brain damages, it remains unclear whether treatment of NCSE improves outcomes in children. We plan to address this issue in an upcoming edition of the guideline.
- || levetiracetam / Generic mfg.
Review, Journal: Levetiracetam for pediatric migraine prophylaxis: A narrative review. (Pubmed Central) - Feb 23, 2025
We plan to address this issue in an upcoming edition of the guideline. Seven studies suggest levetiracetam, at doses ranging from 20 to 60
- || Clinical data, Review, Journal: Drug reaction with eosinophilia and systemic symptoms (DRESS) associated with the use of antiseizure medications-An overview of clinical data. (Pubmed Central) - Feb 22, 2025
Hence, our review focuses on DRESS associated with the use of antiseizure drugs, including Levetiracetam, Clobazam, Carbamazepine, Phenytoin, Phenobarbital, Valproate, Oxcarbazepine, and Lamotrigine...Management strategies for DRESS may include immediate discontinuation of offending medication, administration of systemic corticosteroids, and administration of cyclosporine and intravenous immunoglobulin in cases that are not responding to systemic corticosteroids...Early detection and discontinuation of the offending drug, coupled with systemic corticosteroids, are essential for effective management. Healthcare professionals must be vigilant in identifying DRESS to reduce mortality and improve patient outcomes.
- | Journal: Clinical value of saliva therapeutic drug monitoring of newer antiseizure medications. (Pubmed Central) - Feb 22, 2025
Yet, a very low saliva level has an appreciable discriminative ability for low plasma level. Unstimulated saliva represents a convenient non-invasive alternative to plasma, to readily identify compliance issues or major drug-drug interactions.
- || Review, Journal: Management of epilepsia partialis continua: A systematic review. (Pubmed Central) - Feb 22, 2025
In addition to treatment of the underlying cause of EPC, judicious antiseizure medication use has a role. However, care should be taken not to cause harm (such as respiratory depression) with antiseizure medications, particularly noting that seizures are likely to be prolonged irrespective of antiseizure medication choice.
- ||| P4 data, Journal, Adverse events: Post-marketing safety of antiseizure medications: Focus on serious adverse effects including drug reaction with eosinophilia and systemic symptoms (DRESS). (Pubmed Central) - Feb 22, 2025
Findings highlighted reporting risk signals of DRESS for levetiracetam/clobazam and alternative ASMs. Given the limitations from passive surveillance nature of FAERS, further surveillance and longitudinal studies are essential to evaluate and confirm our findings.
- | levetiracetam / Generic mfg.
Journal: Autonomic Seizure as a Presenting Symptom of Glioblastoma (P5-1.015). (Pubmed Central) - Feb 20, 2025
CSF studies obtained were non contributory for any signs of infection, no cytology was performed and the patient was discharged home on Levetiracetam...Dr. Shah has nothing to disclose.
- | levetiracetam / Generic mfg.
Journal: A Case Report of KCNT1 Mutation Presenting as Isolated Apnea and Bradycardia Events (P7-1.006). (Pubmed Central) - Feb 20, 2025
Interestingly, seizures resolved with the initiation of Levetiracetam...Dr. Galan has nothing to disclose.
- | brivaracetam / Generic mfg.
Observational data, Journal: Effectiveness During 12-Month Adjunctive Brivaracetam Treatment in Patients with Focal-Onset Seizures in a Real-Life Setting: A Prospective, Observational Study in Europe. (Pubmed Central) - Feb 20, 2025
P=N/A
Galan has nothing to disclose. Adjunctive BRV was effective in clinical practice in patients with predominantly difficult-to-treat FOS, as shown by BRV retention rate of 57.7% at 12 months, which is in line with real-world retention rates for other new-generation ASMs.
- | levetiracetam / Generic mfg.
Journal: Focal to bilateral tonic-clonic seizures in newly diagnosed focal epilepsy. (Pubmed Central) - Feb 20, 2025
There was no significant difference in choice of initial ASM class (levetiracetam vs. sodium channel blockers) between participants who experienced FBTCS and those who did not...The majority of participants who experienced FBTCS were diagnosed with epilepsy after experiencing their first FBTCS despite preceding FAS/FIAS. The more frequent FAS/FIAS in participants whose FBTCS resolved may be a characteristic of their epilepsy.
- | levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Retrospective data, Journal: The clinical and radiographic features of eastern equine encephalitis: A single-center retrospective case series. (Pubmed Central) - Feb 19, 2025
Early diagnosis and treatment are crucial, but the variability in presentation and imaging findings complicates this process. Early use of high-dose steroids can improve outcomes.
- || levetiracetam / Generic mfg.
PK/PD data, Review, Journal: The Impact of Augmented Renal Clearance on the Pharmacokinetics of Levetiracetam in Critically Ill Patients: A Literature Review. (Pubmed Central) - Feb 19, 2025
An initial dosage regimen of 1500 mg BID would be recommended for patients exhibiting ARC. Therefore, careful monitoring of creatinine clearance and dosing optimization for patients experiencing ARC is essential.
- || PK/PD data, Retrospective data, Review, Journal: The impact of menstrual cycle on the pharmacokinetics of antiseizure medications and lithium: A systematic review and meta-analysis. (Pubmed Central) - Feb 18, 2025
The highest concentration ratio was reported for carbamazepine (1.27, range 0.89-2.13) with an MD of 0.57??g/mL, 95%CI: 0.41 to 0.72...Participants with vs. without catamenial exacerbation had larger phenytoin concentration decreases in the early follicular compared to the luteal phase. www.crd.york.ac.uk/prospero identifier is CRD42024527321.
- || Review, Journal: Assessing Environmental Risks Factors in Anorectal Malformations: Case Report and Literature Review. (Pubmed Central) - Feb 18, 2025
Some previously related environmental factors were found, such as mother's epilepsy, high lamotrigine dose, tobacco exposure, air pollution, and in a lesser risk the use of levothyroxine. The Green Page and the Pediatric Environmental History could contribute to identifying and reducing environmental risks related to birth defects.
- | Fycompa (perampanel) / Eisai, Catalyst Pharma
Journal: Potential Role of Perampanel in Reducing Barbiturate Dependency in Febrile Infection-Related Epilepsy Syndrome: A Case Report. (Pubmed Central) - Feb 17, 2025
This case suggested that perampanel is a valuable addition to FIRES treatment. Further studies are required to confirm its efficacy.
- | Journal, Monotherapy: Effect of antiepileptic drug monotherapy on endogenous sex hormonal profile in men and women with epilepsy. (Pubmed Central) - Feb 15, 2025
Further studies are required to confirm its efficacy. Our findings emphasize the importance of screening the endogenous sex hormonal profile in PWE on AED monotherapies to evaluate the associated endocrine-related perturbations which may impact reproductive functions.
- | Journal: Assessment of temporal changes in cognitive effects induced by antiseizure medications in epilepsy patients. (Pubmed Central) - Feb 15, 2025
This study demonstrated that the detrimental cognitive effects associated with CBZ, VPA, and ZNS could be reversible. Although some improvement was observed over time with TPM, the absence of significant recovery suggests that additional time may be required for a substantial reversal of these effects.
- | levetiracetam / Generic mfg.
Journal: Trends in antiseizure medication prescription in Idiopathic generalized epilepsy over the last 10 (Pubmed Central) - Feb 15, 2025
Although some improvement was observed over time with TPM, the absence of significant recovery suggests that additional time may be required for a substantial reversal of these effects. The use of VPA has decreased during the last decade for all IGEs and particularly in women of childbearing potential, along with an increase in the use of LEV and LTG.
- ||| Journal, Adverse events, Real-world evidence: Updated Insights on Levetiracetam-Associated Severe Cutaneous Adverse Reactions: A Real-World Pharmacovigilance Analysis. (Pubmed Central) - Feb 15, 2025
Despite certain limitations, this study offers updated insights into the association between LEV and SCARs. These findings underscore the significance of monitoring and actively managing LEV-associated SCARs to promote its safe and effective use.
- | levetiracetam / Generic mfg.
Journal: The Safety and Tolerability of High Dose Intravenous Push Levetiracetam. (Pubmed Central) - Feb 15, 2025
One patient experienced erythema at the injection site and another patient was noted to have nystagmus. Significance: This study adds to the body of literature that rapid administration of undiluted LEV, including doses of 2500
- ||| lacosamide / Generic mfg., levetiracetam / Generic mfg., Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Journal, Adverse events: Adverse events of dual anti-seizure medication: Real-life data from a tertiary epilepsy clinic. (Pubmed Central) - Feb 15, 2025
While dual ASM therapy is associated with an increased burden of AE, this increase appears to be moderate when therapies are individually tailored. Increased awareness and systematic screening of AE, particularly cognitive side effects, are essential to optimize treatment outcomes.
- | levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Journal: Childhood-onset focal epilepsy and acute para-infectious encephalopathy in a patient with biallelic QARS1 variants. (Pubmed Central) - Feb 14, 2025
The episode of steroid-responsive acute para-infectious encephalopathy, previously reported in another patient harboring the p.Y435C variant, suggests that milder cases might be more susceptible to encephalopathy caused by intercurrent illnesses (e.g., infection). As recommended for other aminoacyl-tRNA synthetase-related diseases, it is important to provide this cohort with an early genetic diagnosis in order to encourage precision medicine and personalized treatment.
- | levetiracetam / Generic mfg.
Journal: Is remission in women with idiopathic generalized epilepsy possible without valproate? (Pubmed Central) - Feb 14, 2025
However, some patients still require VPA for optimal seizure control. Further large-scale, randomised studies are needed to confirm these findings.
- | levetiracetam / Generic mfg.
Journal: High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations. (Pubmed Central) - Feb 14, 2025
Thus, high-frequency oscillations can function as a biomarker of hyperexcitability in Alzheimer's disease and may be more pathological when asymmetric and coinciding with presence of epileptic activity. Levetiracetam has the potential for treating hyperactivity in patients with epileptic Alzheimer's disease.